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Published in: Current Urology Reports 4/2017

01-04-2017 | Endourology (P Mucksavage, Section Editor)

Update on Renal Mass Biopsy

Authors: Miki Haifler, Alexander Kutikov

Published in: Current Urology Reports | Issue 4/2017

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Abstract

Renal masses are diagnosed with an increasing frequency. However, a significant proportion of these masses are benign, and the majority of malignant tumors are biologically indolent. Furthermore, renal tumors are often harbored by the elderly and comorbid patients. As such, matching of renal tumor biology to appropriate treatment intensity is an urgent clinical need. Renal mass biopsy is currently a very useful clinical tool that can assist with critical clinical decision-making in patients with renal mass. Yet, renal mass biopsy is associated with limitations and, as such, may not be appropriate for all patients.
Literature
3.
go back to reference Smaldone MC, Egleston B, Hollingsworth JM, Hollenbeck BK, Miller DC, Kim S et al., editors. Understanding treatment disconnect and mortality trends in renal cell carcinoma using tumor registry data. ASCO Annual Meeting Proceedings; 2014 Smaldone MC, Egleston B, Hollingsworth JM, Hollenbeck BK, Miller DC, Kim S et al., editors. Understanding treatment disconnect and mortality trends in renal cell carcinoma using tumor registry data. ASCO Annual Meeting Proceedings; 2014
4.
go back to reference Kutikov A, Smaldone MC, Egleston BL, Manley BJ, Canter DJ, Simhan J, et al. Anatomic features of enhancing renal masses predict malignant and high-grade pathology: a preoperative nomogram using the RENAL Nephrometry score. Eur Urol. 2011;60(2):241–8.CrossRefPubMedPubMedCentral Kutikov A, Smaldone MC, Egleston BL, Manley BJ, Canter DJ, Simhan J, et al. Anatomic features of enhancing renal masses predict malignant and high-grade pathology: a preoperative nomogram using the RENAL Nephrometry score. Eur Urol. 2011;60(2):241–8.CrossRefPubMedPubMedCentral
5.
go back to reference Pierorazio PM, Patel HD, Johnson MH, Sozio SM, Sharma R, Iyoha E et al. Distinguishing malignant and benign renal masses with composite models and nomograms: A systematic review and meta‐analysis of clinically localized renal masses suspicious for malignancy. Cancer. 2016 Pierorazio PM, Patel HD, Johnson MH, Sozio SM, Sharma R, Iyoha E et al. Distinguishing malignant and benign renal masses with composite models and nomograms: A systematic review and meta‐analysis of clinically localized renal masses suspicious for malignancy. Cancer. 2016
7.
go back to reference • Kutikov A, Smaldone MC, Uzzo RG, Haifler M, Bratslavsky G, Leibovich BC. Renal mass biopsy: always, sometimes, or never? Eur Urol. 2016;70(3):403–6. doi:10.1016/j.eururo.2016.04.001. The current clinical role of RMB is delineated in this editorial. • Kutikov A, Smaldone MC, Uzzo RG, Haifler M, Bratslavsky G, Leibovich BC. Renal mass biopsy: always, sometimes, or never? Eur Urol. 2016;70(3):403–6. doi:10.​1016/​j.​eururo.​2016.​04.​001. The current clinical role of RMB is delineated in this editorial.
9.
go back to reference Leppert JT, Hanley J, Wagner TH, Chung BI, Srinivas S, Chertow GM, et al. Utilization of renal mass biopsy in patients with renal cell carcinoma. Urology. 2014;83(4):774–80.CrossRefPubMedPubMedCentral Leppert JT, Hanley J, Wagner TH, Chung BI, Srinivas S, Chertow GM, et al. Utilization of renal mass biopsy in patients with renal cell carcinoma. Urology. 2014;83(4):774–80.CrossRefPubMedPubMedCentral
17.
go back to reference •• Patel HD, Johnson MH, Pierorazio PM, Sozio SM, Sharma R, Iyoha E, et al. Diagnostic accuracy and risks of biopsy in the diagnosis of a renal mass suspicious for localized renal cell carcinoma: systematic review of the literature. J Urol. 2016;195(5):1340–7. doi:10.1016/j.juro.2015.11.029. meta-analysis provide the highest level of evidence available on RMB performance.CrossRefPubMed •• Patel HD, Johnson MH, Pierorazio PM, Sozio SM, Sharma R, Iyoha E, et al. Diagnostic accuracy and risks of biopsy in the diagnosis of a renal mass suspicious for localized renal cell carcinoma: systematic review of the literature. J Urol. 2016;195(5):1340–7. doi:10.​1016/​j.​juro.​2015.​11.​029. meta-analysis provide the highest level of evidence available on RMB performance.CrossRefPubMed
18.
go back to reference Ambani SN, Morgan TM, Montgomery JS, Gadzinski AJ, Jacobs BL, Hawken S et al. Predictors of Delayed Intervention for Patients on Active Surveillance for Small Renal Masses: Does Renal Mass Biopsy Influence Our Decision? Urology. 2016. doi:10.1016/j.urology.2016.04.067 Ambani SN, Morgan TM, Montgomery JS, Gadzinski AJ, Jacobs BL, Hawken S et al. Predictors of Delayed Intervention for Patients on Active Surveillance for Small Renal Masses: Does Renal Mass Biopsy Influence Our Decision? Urology. 2016. doi:10.​1016/​j.​urology.​2016.​04.​067
20.
go back to reference Richard PO, Jewett MA, Tanguay S, Saarela O, Liu ZA, Pouliot F et al. Safety, reliability and accuracy of small renal tumour biopsies: results from a multi-institution registry. BJU international. 2016. doi: 10.18632/oncotarget.1227610.1111/bju.13630 Richard PO, Jewett MA, Tanguay S, Saarela O, Liu ZA, Pouliot F et al. Safety, reliability and accuracy of small renal tumour biopsies: results from a multi-institution registry. BJU international. 2016. doi: 10.18632/oncotarget.1227610.1111/bju.13630
21.
go back to reference •• Marconi L, Dabestani S, Lam TB, Hofmann F, Stewart F, Norrie J, et al. Systematic review and meta-analysis of diagnostic accuracy of percutaneous renal tumour biopsy. Eur Urol. 2016;69(4):660–73. doi:10.1016/j.eururo.2015.07.072. meta-analysis provides the highest level of evidence available on RMB performance.CrossRefPubMed •• Marconi L, Dabestani S, Lam TB, Hofmann F, Stewart F, Norrie J, et al. Systematic review and meta-analysis of diagnostic accuracy of percutaneous renal tumour biopsy. Eur Urol. 2016;69(4):660–73. doi:10.​1016/​j.​eururo.​2015.​07.​072. meta-analysis provides the highest level of evidence available on RMB performance.CrossRefPubMed
23.
go back to reference Cheville JC, Lohse CM, Zincke H, Weaver AL, Blute ML. Comparisons of outcome and prognostic features among histologic subtypes of renal cell carcinoma. Am J Surg Pathol. 2003;27(5):612–24.CrossRefPubMed Cheville JC, Lohse CM, Zincke H, Weaver AL, Blute ML. Comparisons of outcome and prognostic features among histologic subtypes of renal cell carcinoma. Am J Surg Pathol. 2003;27(5):612–24.CrossRefPubMed
24.
25.
go back to reference Rioux-Leclercq N, Karakiewicz PI, Trinh QD, Ficarra V, Cindolo L, de la Taille A, et al. Prognostic ability of simplified nuclear grading of renal cell carcinoma. Cancer. 2007;109(5):868–74. doi:10.1002/cncr.22463.CrossRefPubMed Rioux-Leclercq N, Karakiewicz PI, Trinh QD, Ficarra V, Cindolo L, de la Taille A, et al. Prognostic ability of simplified nuclear grading of renal cell carcinoma. Cancer. 2007;109(5):868–74. doi:10.​1002/​cncr.​22463.CrossRefPubMed
27.
go back to reference Richard PO, Jewett MA, Tanguay S, Saarela O, Liu ZA, Pouliot F, Kapoor A, Rendon R, Finelli A. Safety, reliability and accuracy of small renal tumour biopsies: results from a multi-institution registry. BJU Int. 2016 Aug 16. doi:10.1111/bju.13630. Richard PO, Jewett MA, Tanguay S, Saarela O, Liu ZA, Pouliot F, Kapoor A, Rendon R, Finelli A. Safety, reliability and accuracy of small renal tumour biopsies: results from a multi-institution registry. BJU Int. 2016 Aug 16. doi:10.​1111/​bju.​13630.
28.
go back to reference Osawa T, Hafez KS, Miller DC, Montgomery JS, Morgan TM, Palapattu GS, et al. Comparison of percutaneous renal mass biopsy and R.E.N.A.L. Nephrometry score nomograms for determining benign vs malignant disease and low-risk vs high-risk renal tumors. Urology. 2016;96:87–92. doi:10.1016/j.urology.2016.05.044.CrossRefPubMed Osawa T, Hafez KS, Miller DC, Montgomery JS, Morgan TM, Palapattu GS, et al. Comparison of percutaneous renal mass biopsy and R.E.N.A.L. Nephrometry score nomograms for determining benign vs malignant disease and low-risk vs high-risk renal tumors. Urology. 2016;96:87–92. doi:10.​1016/​j.​urology.​2016.​05.​044.CrossRefPubMed
29.
30.
go back to reference Osawa T, Hafez KS, Miller DC, Montgomery JS, Morgan TM, Palapattu GS, et al. Age, gender and R.E.N.A.L. Nephrometry score do not improve the accuracy of a risk stratification algorithm based on biopsy and mass size for assigning surveillance versus treatment of renal tumors. J Urol. 2016;195(3):574–80. doi:10.1016/j.juro.2015.10.137.CrossRefPubMed Osawa T, Hafez KS, Miller DC, Montgomery JS, Morgan TM, Palapattu GS, et al. Age, gender and R.E.N.A.L. Nephrometry score do not improve the accuracy of a risk stratification algorithm based on biopsy and mass size for assigning surveillance versus treatment of renal tumors. J Urol. 2016;195(3):574–80. doi:10.​1016/​j.​juro.​2015.​10.​137.CrossRefPubMed
31.
go back to reference • Richard PO, Jewett MA, Bhatt JR, Kachura JR, Evans AJ, Zlotta AR, et al. Renal tumor biopsy for small renal masses: a single-center 13-year experience. Eur Urol. 2015;68(6):1007–13. doi:10.1016/j.eururo.2015.04.004. This represent the largest series of RMB to date. This paper highlights the importance of high volume in RMB in order to achieve accurate results.CrossRefPubMed • Richard PO, Jewett MA, Bhatt JR, Kachura JR, Evans AJ, Zlotta AR, et al. Renal tumor biopsy for small renal masses: a single-center 13-year experience. Eur Urol. 2015;68(6):1007–13. doi:10.​1016/​j.​eururo.​2015.​04.​004. This represent the largest series of RMB to date. This paper highlights the importance of high volume in RMB in order to achieve accurate results.CrossRefPubMed
33.
go back to reference Parker PA, Alba F, Fellman B, Urbauer DL, Li Y, Karam JA, et al. Illness uncertainty and quality of life of patients with small renal tumors undergoing watchful waiting: a 2-year prospective study. Eur Urol. 2013;63(6):1122–7.CrossRefPubMed Parker PA, Alba F, Fellman B, Urbauer DL, Li Y, Karam JA, et al. Illness uncertainty and quality of life of patients with small renal tumors undergoing watchful waiting: a 2-year prospective study. Eur Urol. 2013;63(6):1122–7.CrossRefPubMed
34.
go back to reference Patel HD, Riffon MF, Joice GA, Johnson MH, Chang P, Wagner AA, McKiernan JM, Trock BJ, Allaf ME, Pierorazio PM. A prospective, comparative study of quality of life among patients with small renal masses choosing active surveillance and primary intervention. J Urol. 2016 Nov;196(5):1356–1362 Patel HD, Riffon MF, Joice GA, Johnson MH, Chang P, Wagner AA, McKiernan JM, Trock BJ, Allaf ME, Pierorazio PM. A prospective, comparative study of quality of life among patients with small renal masses choosing active surveillance and primary intervention. J Urol. 2016 Nov;196(5):1356–1362
35.
go back to reference Ljungberg B, Bensalah K, Canfield S, Dabestani S, Hofmann F, Hora M, et al. EAU guidelines on renal cell carcinoma: 2014 update. Eur Urol. 2015;67(5):913–24.CrossRefPubMed Ljungberg B, Bensalah K, Canfield S, Dabestani S, Hofmann F, Hora M, et al. EAU guidelines on renal cell carcinoma: 2014 update. Eur Urol. 2015;67(5):913–24.CrossRefPubMed
38.
go back to reference •• Gorin MA, Rowe SP, Baras AS, Solnes LB, Ball MW, Pierorazio PM, et al. Prospective evaluation of (99m)Tc-sestamibi SPECT/CT for the diagnosis of renal oncocytomas and hybrid oncocytic/chromophobe tumors. Eur Urol. 2016;69(3):413–6. doi:10.1016/j.eururo.2015.08.056. The first publication examining an imaging modality the could potentially differentiate between benign and malignant renal tumors.CrossRefPubMed •• Gorin MA, Rowe SP, Baras AS, Solnes LB, Ball MW, Pierorazio PM, et al. Prospective evaluation of (99m)Tc-sestamibi SPECT/CT for the diagnosis of renal oncocytomas and hybrid oncocytic/chromophobe tumors. Eur Urol. 2016;69(3):413–6. doi:10.​1016/​j.​eururo.​2015.​08.​056. The first publication examining an imaging modality the could potentially differentiate between benign and malignant renal tumors.CrossRefPubMed
41.
42.
go back to reference Lapini A, Minervini A, Masala A, Schips L, Pycha A, Cindolo L, et al. A comparison of hexaminolevulinate (Hexvix((R))) fluorescence cystoscopy and white-light cystoscopy for detection of bladder cancer: results of the HeRo observational study. Surg Endosc. 2012;26(12):3634–41. doi:10.1007/s00464-012-2387-0.CrossRefPubMed Lapini A, Minervini A, Masala A, Schips L, Pycha A, Cindolo L, et al. A comparison of hexaminolevulinate (Hexvix((R))) fluorescence cystoscopy and white-light cystoscopy for detection of bladder cancer: results of the HeRo observational study. Surg Endosc. 2012;26(12):3634–41. doi:10.​1007/​s00464-012-2387-0.CrossRefPubMed
47.
go back to reference Wagstaff PG, Swaan A, Ingels A, Zondervan PJ, van Delden OM, Faber DJ et al. In vivo, percutaneous, needle based, optical coherence tomography of renal masses. Journal of visualized experiments : JoVE. 2015(97). doi:10.3791/52574 Wagstaff PG, Swaan A, Ingels A, Zondervan PJ, van Delden OM, Faber DJ et al. In vivo, percutaneous, needle based, optical coherence tomography of renal masses. Journal of visualized experiments : JoVE. 2015(97). doi:10.​3791/​52574
48.
go back to reference Mourant JR, Freyer JP, Hielscher AH, Eick AA, Shen D, Johnson TM. Mechanisms of light scattering from biological cells relevant to noninvasive optical-tissue diagnostics. Appl Opt. 1998;37(16):3586–93.CrossRefPubMed Mourant JR, Freyer JP, Hielscher AH, Eick AA, Shen D, Johnson TM. Mechanisms of light scattering from biological cells relevant to noninvasive optical-tissue diagnostics. Appl Opt. 1998;37(16):3586–93.CrossRefPubMed
49.
51.
go back to reference Su SF, de Castro Abreu AL, Chihara Y, Tsai Y, Andreu-Vieyra C, Daneshmand S, et al. A panel of three markers hyper- and hypomethylated in urine sediments accurately predicts bladder cancer recurrence. Clin Cancer Res. 2014;20(7):1978–89. doi:10.1158/1078-0432.ccr-13-2637.CrossRefPubMed Su SF, de Castro Abreu AL, Chihara Y, Tsai Y, Andreu-Vieyra C, Daneshmand S, et al. A panel of three markers hyper- and hypomethylated in urine sediments accurately predicts bladder cancer recurrence. Clin Cancer Res. 2014;20(7):1978–89. doi:10.​1158/​1078-0432.​ccr-13-2637.CrossRefPubMed
Metadata
Title
Update on Renal Mass Biopsy
Authors
Miki Haifler
Alexander Kutikov
Publication date
01-04-2017
Publisher
Springer US
Published in
Current Urology Reports / Issue 4/2017
Print ISSN: 1527-2737
Electronic ISSN: 1534-6285
DOI
https://doi.org/10.1007/s11934-017-0674-y

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