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Current Urology Reports
Published in: Current Urology Reports 4/2016

01-04-2016 | Prostate Cancer (A Kibel, Section Editor)

Novel Insights into Molecular Indicators of Response and Resistance to Modern Androgen-Axis Therapies in Prostate Cancer

Authors: John L. Silberstein, Maritza N. Taylor, Emmanuel S. Antonarakis

Published in: Current Urology Reports | Issue 4/2016

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Abstract

While androgen ablation remains a mainstay for advanced prostate cancer therapy, nearly all patients will inevitably develop disease escape with time. Upon the development of castration-resistant prostate cancer, other androgen-axis-targeted treatments may be added in an effort to starve the disease of its androgen signaling. Nevertheless, additional androgen-pathway resistance usually develops to these novel hormonal therapies. In this review, we will discuss the resistance mechanisms to modern androgen-axis modulators and how these alterations can influence a patient’s response to novel hormonal therapy. We conceptualize these resistance pathways as three broad categories: (1) reactivation of androgen/AR-signaling, (2) AR bypass pathways, and (3) androgen/AR-independent mechanisms. We highlight examples of each, as well as potential therapeutic approaches to overcome these resistance mechanisms.
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Metadata
Title
Novel Insights into Molecular Indicators of Response and Resistance to Modern Androgen-Axis Therapies in Prostate Cancer
Authors
John L. Silberstein
Maritza N. Taylor
Emmanuel S. Antonarakis
Publication date
01-04-2016
Publisher
Springer US
Published in
Current Urology Reports / Issue 4/2016
Print ISSN: 1527-2737
Electronic ISSN: 1534-6285
DOI
https://doi.org/10.1007/s11934-016-0584-4

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