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Published in: Current Urology Reports 3/2011

01-06-2011

Current Perspectives on Gleason Grading of Prostate Cancer

Authors: Kenneth A. Iczkowski, M. Scott Lucia

Published in: Current Urology Reports | Issue 3/2011

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Abstract

The 5-tier Gleason grading system for prostate cancer, introduced in 1966, has been proven to be one of the main independent predictors of prostate cancer outcome. This review addresses interobserver concordance in Gleason grading; the persistence of grading discrepancies with frequent upgrading from the biopsy to the prostatectomy specimen; the 2005 International Society of Urologic Pathologists’ modifications to Gleason grading; the impact of this modified grading on grade migration and outcome prediction; and molecular correlates of cancer morphology. Data from the most recent years are emphasized.
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Metadata
Title
Current Perspectives on Gleason Grading of Prostate Cancer
Authors
Kenneth A. Iczkowski
M. Scott Lucia
Publication date
01-06-2011
Publisher
Current Science Inc.
Published in
Current Urology Reports / Issue 3/2011
Print ISSN: 1527-2737
Electronic ISSN: 1534-6285
DOI
https://doi.org/10.1007/s11934-011-0181-5

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