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01-12-2019 | Erectile Dysfunction | Female Sexual Dysfunction and Disorders (T Lorenz & R Nappi, Section Editors)

Female Sexual Dysfunction as a Warning Sign of Chronic Disease Development

Authors: Vincenza Di Stasi, Nunzia Verde, Elisa Maseroli, Irene Scavello, Sarah Cipriani, Tommaso Todisco, Mario Maggi, Linda Vignozzi

Published in: Current Sexual Health Reports | Issue 4/2019

Abstract

Purpose of Review

Female sexual dysfunctions (FSD) in chronic diseases are often multi-factorial, integrating several bio-psychological and socio-environmental components. The aim of this review is to summarize existing evidence on the association between the most common chronic conditions and FSD and also to frame systematically experimental findings into a comprehensive overview on candidate mechanisms through which chronic diseases drive FSD pathogenesis.

Recent Findings

In men, it is now clear that several chronic diseases favour the development of sexual dysfunction (SD), especially erectile dysfunction (ED), by an integration of multiple pathogenic factors. More importantly, in men, ED has been recognized as a harbinger of several serious underlying medical conditions, including the cardiovascular ones. Conversely, the nature of the relationship between SD and chronic diseases in women remains controversial and, in contrast to the well-established associations with ED in men, FSD is not yet acknowledged as a warning sign of other systemic diseases. In this review of literature, we try to demonstrate that this is changing because there are some clinical and research evidences about the importance to recognize FSD in chronic disease. Specifically, we summarize the recent findings about the relation between cardio-metabolic, respiratory, renal, neurologic and rheumatic diseases and FSD.

Summary

Management of FSD is an important task to improve the overall quality of life of patients suffering from chronic, longstanding and often progressive diseases. It is also possible that sexual symptoms might be a warning sign for unrecognized conditions, although this is far to be completely understood. Further studies are needed to fully understand and treat this emerging topic in specific clinical settings.

Rastrelli G, Corona G, Lotti F, Aversa A, Bartolini M, Mancini M, et al. Flaccid penile acceleration as a marker of cardiovascular risk in men without classical risk factors. J Sex Med. 2014;11(1):173–86. https://doi.org/10.1111/jsm.12342.CrossRefPubMed

Carter J, Lacchetti C, Andersen BL, Barton DL, Bolte S, Damast S, et al. Interventions to address sexual problems in people with cancer: American Society of Clinical Oncology Clinical Practice Guideline Adaptation of Cancer Care Ontario Guideline. J ClinOncol. 2018;36(5):492–511. https://doi.org/10.1200/JCO.2017.75.8995.CrossRef

Nowosielski K, Drosdzol A, Sipiński A, Kowalczyk R, Skrzypulec V. Diabetes mellitus and sexuality--does it really matter? J Sex Med. 2010;7:723–35. https://doi.org/10.1111/j.1743-6109.2009.01561.x.CrossRefPubMed

Mazzilli R, Imbrogno N, Elia J, Delfino M, Bitterman O, Napoli A, et al. Sexual dysfunction in diabetic women: prevalence and differences in type 1 and type 2 diabetes mellitus. Diabetes Metab Syndr Obes. 2015;8:97–101. https://doi.org/10.2147/DMSO.S71376.CrossRefPubMedPubMedCentral

Maiorino MI, Bellastella G, Castaldo F, PetrizzoM GD, Esposito K, et al. Sexual function in young women with type 1 diabetes: the METRO study. J Endocrinol Investig. 2017;40(2):169–77. https://doi.org/10.1007/s40618-016-0542-5.CrossRef

Flotynska J, Uruska A, Michalska A, Araszkiewicz A, Zozulinska-Ziolkiewicz D, et al. Sexual dysfunction is a more common problem in young women with type 1 diabetes than in healthy women. J Sex Marital Ther. 2019;21:1–9. https://doi.org/10.1080/0092623X.2019.1610121.CrossRef

Ahmed MR, Shaaban MM, Sedik WF, Mohamed TY. Prevalence and differences between type 1 and type 2 diabetes mellitus regarding female sexual dysfunction: a cross-sectional Egyptian study. J Psychosom Obstet Gynaecol. 2018;39:176–81. https://doi.org/10.1080/0167482X.2017.1318123.CrossRefPubMed

Chaudhary R, Kumar P, Chopra A, Chabbra S, Singh P. Comparative study of psychiatric manifestations among type I and type II diabetic patients. Indian J Psychol Med. 2017;39:342–6. https://doi.org/10.4103/IJPSYM.IJPSYM_35_17.CrossRefPubMedPubMedCentral

Anderson RJ, Freedland KE, Clouse RE, Lustman PJ. The prevalence of comorbid depression in adults with diabetes: a meta-analysis. Diabetes Care. 2001;24:1069–78.CrossRef

10.

Clayton AH, Goldstein I, Kim NN, Althof SE, Faubion SS, Faught BM, et al. The International Society for the Study of Women’s Sexual Health process of care for management of Hypoactive Sexual Desire Disorder in women. Mayo Clin Proc. 2018;93:467–87. https://doi.org/10.1016/j.mayocp.2017.11.002.CrossRefPubMed

11.

Giraldi A, Kristensen E. Sexual dysfunction in women with diabetes mellitus. J Sex Res. 2010;47:199–211. https://doi.org/10.1080/00224491003632834.CrossRefPubMed

12.

Zsoldos M, Pajor A, Pusztafalvi H. Relation between sexual dysfunction and metabolic syndrome. OrvHetil. 2019;160:98–103. https://doi.org/10.1556/650.2019.31235.CrossRef

13.

Ballester J, Muñoz MC, Domínguez J, Palomo MJ, Rivera M, Rigau T, et al. Tungstate administration improves the sexual and reproductive function in female rats with streptozotocin-induced diabetes. Hum Reprod. 2007;22(8):2128–35.CrossRef

14.

Hashimoto H, Moritani N, Terada M, Kromkhun P, Fungfuaug W, Nakada T, et al. Improvement of hyperglycemia and sexual dysfunction in diabetic female rats by an artificial endocrine pancreas developed from mouse beta cells. Exp Anim. 2010;59(4):515–9. https://doi.org/10.1538/expanim.59.515.CrossRefPubMed

15.

Hernández-Munive AK, Rebolledo-Solleiro D, Ventura-Aquino E, Fernández-Guasti A. reduced lordosis and enhanced aggression in paced and non-paced mating in diabetic female rats. J Sex Med. 2018;15(2):124–35. https://doi.org/10.1016/j.jsxm.2017.11.018.CrossRefPubMed

16.

• Maseroli E, Scavello I, Vignozzi L. Cardiometabolic risk and female sexuality-part I. Risk factors and potential pathophysiological underpinnings for female vasculogenic sexual dysfunction syndromes. Sex Med Rev. 2018;6:508–24. https://doi.org/10.1016/j.sxmr.2018.02.009This review gives a complete explanation on the influence of cardio-metabolic diseases on FSD. CrossRefPubMed

17.

Maseroli E, Fanni E, Cipriani S, Scavello I, Pampaloni F, Battaglia C, et al. Cardiometabolic risk and female sexuality: focus on clitoral vascular resistance. J Sex Med. 2016;13:1651–61. https://doi.org/10.1016/j.jsxm.2016.09.009.CrossRefPubMed

18.

Caruso S, Rugolo S, Mirabella D, Intelisano G, Di Mari L, Cianci A. Changes in clitoral blood flow in premenopausal women affected by type 1 diabetes after single 100-mg administration of sildenafil. Urology. 2006;68:161–5. https://doi.org/10.1016/j.urology.2006.01.059.CrossRefPubMed

19.

Caruso S, Cianci A, Cianci S, Monaco C, Fava V, Cavallari V. Ultrastructural study of clitoral cavernous tissue and clitoral blood flow from type 1 diabetic premenopausal women on phosphodiesterase-5 inhibitor. J Sex Med. 2019;16(3):375–82. https://doi.org/10.1016/j.jsxm.2019.01.003.CrossRefPubMed

20.

Esposito K, Ciotola M, Maiorino MI, Giugliano F, Autorino R, De Sio M, et al. Hyperlipidemia and sexual function in premenopausal women. J Sex Med. 2009;6:1696–703. https://doi.org/10.1111/j.1743-6109.2009.01284.x.CrossRefPubMed

21.

Baldassarre M, Alvisi S, Mancini I, Moscatiello S, Marchesini G, Seracchioli R, et al. Impaired lipid profile is a risk factor for the development of sexual dysfunction in women. J Sex Med. 2016;13:46–54. https://doi.org/10.1016/j.jsxm.2015.11.005.CrossRefPubMed

22.

Duncan LE, Lewis C, Jenkins P, Pearson TA. Does hypertension and its pharmacotherapy affect the quality of sexual function in women? Am J Hypertens. 2000;13:640–7.CrossRef

23.

Lunelli RP, Irigoyen MC, Goldmeier S. Hypertension as a risk factor for female sexual dysfunction: cross-sectional study. Rev Bras Enferm. 2018;71:2477–82. https://doi.org/10.1590/0034-7167-2017-0259.CrossRefPubMed

24.

Santana LM, Perin L, Lunelli R, Inácio JFS, Rodrigues CG, Eibel B, et al. Sexual dysfunction in women with hypertension: a systematic review and meta-analysis. Curr Hypertens Rep. 2019;21(3):25–10. https://doi.org/10.1007/s11906-019-0925-z.CrossRefPubMed

25.

Choy CL, Sidi H, Koon CS, Ming OS, Mohamed IN, Guan NC, et al. Systematic review and meta-analysis for sexual dysfunction in women with hypertension. J Sex Med. 2019;16(7):1029–48. https://doi.org/10.1016/j.jsxm.2019.04.007.CrossRefPubMed

26.

Nascimento ER, Maia AC, Nardi AE, Silva AC. Sexual dysfunction in arterial hypertension women: the role of depression and anxiety. J Affect Disord. 2015;181:96–100. https://doi.org/10.1016/j.jad.2015.03.050.CrossRefPubMed

27.

Löwhagen O. Diagnosis of asthma - new theories. J Asthma. 2015;52:538–44. https://doi.org/10.3109/02770903.2014.991971.CrossRefPubMed

28.

Soto Campos JG, RojasVillegas J, PadillaGalo A, Marina Malanda N, Garcia Rivero JL, Pinedo Sierra C, et al. Impact of asthma on the sexual functioning of patients. A case-control study. Arch Bronconeumol. 2017;53:667–74. https://doi.org/10.1016/j.arbres.2017.05.011.CrossRefPubMed

29.

Başar MM, Ekici A, Bulcun E, Tuğlu D, Ekici MS, Batislam E. Female sexual and hormonal status in patients with bronchial asthma: relationship with respiratory function tests and psychological and somatic status. Urology. 2007;69:421–5. https://doi.org/10.1016/j.urology.2006.12.001.CrossRefPubMed

30.

Meyer IH, Sternfels P, Fagan JK, Ford JG. Asthma-related limitations in sexual functioning: an important but neglected area of quality of life. Am J Public Health. 2002;92:770–2.CrossRef

31.

Steinke E, Palm Johansen P, Fridlund B, Broström A. Determinants of sexual dysfunction and interventions for patients with obstructive sleep apnoea: a systematic review. Int J ClinPract. 2016;70:5–19. https://doi.org/10.1111/ijcp.12751.CrossRef

32.

Yilmaz Z, Sirinocak PB, Voyvoda B, Ozcan L. Sexual dysfunction in premenopausal women with obstructive sleep apnea. Urol J. 2017;14:5051–6. https://doi.org/10.22037/uj.v14i6.3891.CrossRefPubMed

33.

Onem K, Erol B, Sanli O, Kadioglu P, Yalin AS, Canik U, et al. Is sexual dysfunction in women with obstructive sleep apnea-hypopnea syndrome associated with the severity of the disease? A pilot study. J Sex Med. 2008;5:2600–9. https://doi.org/10.1111/j.1743-6109.2008.00934.x.CrossRefPubMed

34.

Fanfulla F, Camera A, Fulgoni P, Chiovato L, Nappi RE. Sexual dysfunction in obese women: does obstructive sleep apnea play a role? Sleep Med. 2013;14:252–6. https://doi.org/10.1016/j.sleep.2012.11.023.CrossRefPubMed

35.

Kahal H, Kyrou I, Tahrani AA, Randeva HS. Obstructive sleep apnoea and polycystic ovary syndrome: a comprehensive review of clinical interactions and underlying pathophysiology. ClinEndocrinol (Oxf). 2017;87(4):313–9. https://doi.org/10.1111/cen.13392.CrossRef

36.

Bixler EO, Vgontzas AN, Lin HM, Ten Have T, Rein J, Vela-Bueno A, et al. Prevalence of sleep-disordered breathing in women: effects of gender. Am J Respir Crit Care Med. 2001;163(3 Pt 1):608–13.CrossRef

37.

Ip MS, Lam B, Chan LY, Zheng L, Tsang KW, Fung PC, et al. Circulating nitric oxide is suppressed in obstructive sleep apnea and is reversed by nasal continuous positive airway pressure. Am J Respir Crit Care Med. 2000;162:2166–71. https://doi.org/10.1164/ajrccm.162.6.2002126.CrossRefPubMed

38.

Liu L, Kang R, Zhao S, Zhang T, Zhu W, Li E, et al. Sexual dysfunction in patients with obstructive sleep apnea: a systematic review and meta-analysis. J Sex Med. 2015;12:1992–2003. https://doi.org/10.1111/jsm.12983.CrossRefPubMed

39.

Elborn JS. Cystic fibrosis. Lancet. 2016;388:2519–31. https://doi.org/10.1016/S0140-6736(16)00576-6.CrossRefPubMed

40.

Kazmerski TM, Sawicki GS, Miller E, Jones KA, Abebe KZ, Tuchman LK, et al. Sexual and reproductive health behaviors and experiences reported by young women with cystic fibrosis. J Cyst Fibros. 2018;17:57–63. https://doi.org/10.1016/j.jcf.2017.07.017.CrossRefPubMed

41.

Aguiar KCA, Marson FAL, Gomez CCS, Pereira MC, Paschoal IA, Ribeiro AF, et al. Physical performance, quality of life and sexual satisfaction evaluation in adults with cystic fibrosis: an unexplored correlation. Rev Port Pneumo (2006). 2017;23:179–92. https://doi.org/10.1016/j.rppnen.2017.02.009.CrossRef

42.

Tuchman LK, Kalogiros ID, Forke CM, Schwarz DF, Kinsman SB. Reproductive knowledge and preferences of adolescents and adults with cystic fibrosis: a web-based assessment. Int J Sex Health. 2010;22:72–83.CrossRef

43.

Nixon GM, Glazner JA, Martin JM, Sawyer SM. Urinary incontinence in female adolescents with cystic fibrosis. Pediatrics. 2002;110:1–9.CrossRef

44.

Tsang A, Moriarty C, Towns S. Contraception, communication, and counseling for sexuality and reproductive health in adolescents and young adults with CF. Paediatr Respir Rev. 2010;11(2):84–9. https://doi.org/10.1016/j.prrv.2010.01.002.CrossRefPubMed

45.

Frayman KB, Sawyer SM. Sexual and reproductive health in cystic fibrosis: a life-course perspective. Lancet Respir Med. 2015;3(1):70–86. https://doi.org/10.1016/S2213-2600(14)70231-0.CrossRefPubMed

46.

Navaneethan SD, Vecchio M, Johnson DW, Saglimbene V, Graziano G, Pellegrini F, et al. Prevalence and correlates of self-reported sexual dysfunction in CKD: a meta-analysis of observational studies. Am J Kidney Dis. 2010;56:670–85. https://doi.org/10.1053/j.ajkd.2010.06.016.CrossRefPubMed

47.

Noohi S, Azar M, Behzadi AH, Barbati ME, Haghshenas A, Amoozgar B, et al. Comparison of sexual function in females receiving haemodialysis and after renal transplantation. J Ren Care. 2010;36:212–7. https://doi.org/10.1111/j.1755-6686.2010.00198.x.CrossRefPubMed

48.

Saglimbene V, Natale P, Palmer S, Scardapane M, Craig JC, Ruospo M, et al. The prevalence and correlates of low sexual functioning in women on hemodialysis: a multinational, cross-sectional study. PLoS One. 2017;12(6):e0179511. https://doi.org/10.1371/journal.pone.0179511.CrossRefPubMedPubMedCentral

49.

Pertuz W, Castaneda DA, Rincon O, Lozano E. Sexual dysfunction in patients with chronic renal disease: does it improve with renal transplantation? Transplant Proc. 2014;46(9):3021–6. https://doi.org/10.1016/j.transproceed.2014.07.017.CrossRefPubMed

50.

Basok EK, Atsu N, Rifaioglu MM, Kantarci G, Yildirim A, Tokuc R. Assessment of female sexual function and quality of life in predialysis, peritoneal dialysis, hemodialysis, and renal transplant patients. Int Urol Nephrol. 2009;41:473e81. https://doi.org/10.1007/s11255-008-9475-z.CrossRef

51.

Raggi MC, Siebert SB, Friess H, Schremmer-Danninger E, Thorban S, Dinkel A. Sexual and relationship functioning before and after renal transplantation: a descriptive study with patients and partners. Scand J UrolNephrol. 2012;46:431–6. https://doi.org/10.3109/00365599.2012.693132.CrossRef

52.

Filocamo MT, Zanazzi M, Li Marzi V, Lombardi G, Del Popolo G, Mancini G, et al. Sexual dysfunction in women during dialysis and after renal transplantation. J Sex Med. 2009;6:3125–31. https://doi.org/10.1111/j.1743-6109.2009.01400.x.CrossRefPubMed

53.

Kurtulus FO, Salman MY, Fazlioglu A. FazliogluB. Effects of renal transplantation on female sexual dysfunction: comparative study with hemodialysis and a control group. Transplant Proc. 2017;49(9):2099–104. https://doi.org/10.1016/j.transproceed.2017.07.014.CrossRefPubMed

54.

Premužić V, Jelaković B. Sexual dysfunction as a determinant of cardiovascular outcome in patients undergoing chronic hemodialysis. Int J Impot Res. 2018;30(1):14–20. https://doi.org/10.1038/s41443-017-0001-7 Epub 2017 Nov 27.CrossRefPubMed

55.

Vlachopoulos C, Ioakeimidis N, Aznaouridis K, Terentes-Printzios D, Rokkas K, Aggelis A, et al. Prediction of cardiovascular events with aortic stiffness in patients with erectile dysfunction. Hypertension. 2014;64:672–8. https://doi.org/10.1161/HYPERTENSIONAHA.114.03369.CrossRefPubMed

56.

Montorsi P, Ravagnani PM, Galli S, Rotatori F, Briganti A, Salonia A, et al. The artery size hypothesis: a macrovascular link between erectile dysfunction and coronary artery disease. Am J Cardiol. 2005;96:19M–23M. https://doi.org/10.1016/j.amjcard.2005.07.006.CrossRefPubMed

57.

Lipton RB, Scher AI, Kolodner K, Liberman J, Steiner TJ, Stewart WF. Migraine in the United States: epidemiology and patterns of health care use. Neurology. 2002;58(6):885–94.CrossRef

58.

Ghajarzadeh M, Jalilian R, Togha M, Azimi A, Hosseini P, Babaei N. Depression, poor sleep, and sexual dysfunction in migraineurs women. Int J Prev Med. 2014;5(9):1113–8.PubMedPubMedCentral

59.

Abdollahi M, Toghae M, Raisi F, Saffari E. The prevalence of female sexual dysfunction among migraine patients. Iran J Neurol. 2015;14(1):8–11.PubMedPubMedCentral

60.

Solmaz V, Ceviz A, Aksoy D, Cevik B, Kurt S, Gencten Y, et al. Sexual dysfunction in women with migraine and tension-type headaches. Int J Impot Res. 2016;28(6):201–4. https://doi.org/10.1038/ijir.2016.22.CrossRefPubMed

61.

Aydın M, Bitkin A, İrkılata L, Yılmaz A, Moral C, Atilla MK. The effect of migraine and tension-type headaches on female sexual functions: a prospective, cross-sectional, controlled study. Turk J Urol. 2018;44(5):418–22. https://doi.org/10.5152/tud.2018.45228.CrossRefPubMedPubMedCentral

62.

Bond DS, Pavlović JM, Lipton RB, Graham Thomas J, Digre KB, Roth J, et al. Sexual dysfunction in women with migraine and overweight/obesity: relative frequency and association with migraine severity. Headache. 2017;57(3):417–27. https://doi.org/10.1111/head.13019.CrossRefPubMed

63.

Dogan VB, Dagdeviren H, Dirican A, Dirican AC, Tutar NK, Yayla VA, et al. Hormonal effect on the relationship between migraine and female sexual dysfunction. Neurol Sci. 2017;38(9):1651–5. https://doi.org/10.1007/s10072-017-3023-5.CrossRefPubMed

64.

Nasimbera A, Rosales J, Silva B, Alonso R, Bohorquez N, Lepera S, et al. Everything you always wanted to know about sex and Neurology: neurological disability and sexuality. Arq Neuropsiquiatr. 2018;76(7):430–5. https://doi.org/10.1590/0004-282X20180061.CrossRefPubMed

65.

Kaufmann H, Goldstein DS. Autonomic dysfunction in Parkinson disease. Handb Clin Neurol. 2013;117:259–78. https://doi.org/10.1016/B978-0-444-53491-0.00021-3.CrossRefPubMed

66.

Malek N, Lawton MA, Grosset KA, Bajaj N, Barker RA, Burn DJ, et al. Autonomic dysfunction in early Parkinson’s disease: results from the United Kingdom tracking Parkinson’s study. Mov Disord Clin Pract. 2016;4(4):509–16. https://doi.org/10.1002/mdc3.12454.CrossRefPubMedPubMedCentral

67.

Deng X, Tang CY, Zhang J, Zhu L, Xie ZC, Gong HH, et al. The cortical thickness correlates of clinical manifestations in the mid-stage sporadic Parkinson’s disease. Neurosci Lett. 2016;633:279–89. https://doi.org/10.1016/j.neulet.2016.09.042.CrossRefPubMed

68.

Bronner G, Royter V, Korczyn AD, Giladi N. Sexual dysfunction in Parkinson’s disease. J Sex Marital Ther. 2004;30(2):95–105. https://doi.org/10.1080/00926230490258893.CrossRefPubMed

69.

Brown RG, Jahanshahi M, Quinn N, Marsden CD. Sexual function in patients with Parkinson’s disease and their partners. J Neurol Neurosurg Psychiatry. 1990;53(6):480–6.CrossRef

70.

Buhmann C, Dogac S, Vettorazzi E, Hidding U, Gerloff C, Jürgens TP. The impact of Parkinson disease on patients’ sexuality and relationship. J Neural Transm. 2017;124(8):983–96. https://doi.org/10.1007/s00702-016-1649-8.CrossRefPubMed

71.

Giladi N, Treves TA, Paleacu D, Shabtai H, Orlov Y, Kandinov B, et al. Risk factors for dementia, depression and psychosis in long-standing Parkinson’s disease. J Neural Transm. 2000;107(1):59–71. https://doi.org/10.1007/s007020050005.CrossRefPubMed

72.

Bhattacharyya KB, Rosa-Grilo M. Sexual dysfunctions in Parkinson’s disease: an underrated problem in a much discussed disorder. Int Rev Neurobiol. 2017;134:859–76. https://doi.org/10.1016/bs.irn.2017.05.019.CrossRefPubMed

73.

Csoka AB, Bahrick A, Mehtonen OP. Persistent sexual dysfunction after discontinuation of selective serotonin reuptake inhibitors. J Sex Med. 2008;5(1):227–33. https://doi.org/10.1111/j.1743-6109.2007.00630.x.CrossRefPubMed

74.

Montejo AL, Llorca G, Izquierdo JA, Rico-Villademoros F. Incidence of sexual dysfunction associated with antidepressant agents: a prospective multicenter study of 1022 outpatients. Spanish working group for the study of psychotropic-related sexual dysfunction. J Clin Psychiatry. 2001;62(Suppl 3):10–21.PubMed

75.

Webber MP, Hauser WA, Ottman R, Annegers JF. Fertility in persons with epilepsy: 1935-1974. Epilepsia. 1986;27(6):746–52.CrossRef

76.

Kolárský A, Freund K, Machek J, Polák O. Male sexual deviation. Association with early temporal lobe damage. Arch Gen Psychiatry. 1967;17(6):735–43.CrossRef

77.

Mameniškienė R, Guk J, Jatužis D. Family and sexual life in people with epilepsy. Epilepsy Behav. 2017;66:39–44. https://doi.org/10.1016/j.yebeh.2016.10.012.CrossRefPubMed

78.

Zelena V, Kuba R, Soška V, Rektor I. Depression as a prominent cause of sexual dysfunction in women with epilepsy. Epilepsy Behav. 2011;20(3):539–44. https://doi.org/10.1016/j.yebeh.2011.01.014.CrossRefPubMed

79.

Feeney DM, Gullotta FP, Gilmore W. Hyposexuality produced by temporal lobe epilepsy in the cat. Epilepsia. 1998;39(2):140–9.CrossRef

80.

Jensen P, Jensen SB, Sorensen PS, et al. Sexual dysfunction in male and female patients with epilepsy: a study of 86 outpatients. Arch Sex Behav. 1990;19(1):1–14.CrossRef

81.

Duncan S, Blacklaw J, Beastall GH, Brodie MJ. Sexual function in women with epilepsy. Epilepsia. 1997;38(10):1074–81.CrossRef

82.

Bergen D, Daugherty S, Eckenfels E. Reduction of sexual activities in females taking antiepileptic drugs. Psychopathology. 1992;25(1):1–4. https://doi.org/10.1159/000284746.CrossRefPubMed

83.

Morrell MJ, Sperling MR. SteckerMet al. Sexual dysfunction in partial epilepsy: a deficit in physiologic sexual arousal. Neurology. 1994;44(2):243–7.CrossRef

84.

Harden CL. Sexual dysfunction in women with epilepsy. Seizure2008;17 (2): 131–135. doi:https://doi.org/10.1016/j.seizure.2007.11.010

85.

Herzog AG, Drislane FW, Schomer DL, Pennell PB, Bromfield EB, Kelly KM, et al. Differential effects of antiepileptic drugs on sexual function and reproductive hormones in men with epilepsy: interim analysis of a comparison between lamotrigine. Epilepsia. 2004;45(7):764–8. https://doi.org/10.1111/j.0013-9580.2004.60703.x.CrossRefPubMed

86.

Isojarvi J. Disorders of reproduction in patients with epilepsy: antiepileptic drug related mechanisms. Seizure. 2008;17(2):111–9. https://doi.org/10.1016/j.seizure.2007.11.007.CrossRefPubMed

87.

Hess MJ, Hough S. Impact of spinal cord injury on sexuality: Broad-based clinical practice intervention and practical application. J Spinal Cord Med. 2012;35(4):211–8. https://doi.org/10.1136/jnnp-2018-318666.CrossRefPubMed

88.

Dusenbury W, Palm Johansen P, Mosack V, Steinke EE. Determinants of sexual function and dysfunction in men and women with stroke: a systematic review. Int J ClinPract. 2017 ;71(7). https://doi.org/10.1111/ijcp.12969.

89.

Bugnicourt JM, Hamy O, Canaple S, Lamy C, Legrand C. Impaired sexual activity in young ischaemic stroke patients: an observational study. Eur J Neurol. 2014;21:140–6. https://doi.org/10.1111/ene.12277.CrossRefPubMed

90.

Seymour LM, Wolf TJ. Participation changes in sexual functioning after mild stroke. OTJR (Thorofare N J). 2014 Spring;34(2):72–80. https://doi.org/10.3928/15394492-20131217-01.CrossRef

91.

Hatzichristou D, Rosen RC, Derogatis LR, Low WY, Meuleman EJ, Sadovsky R, et al. Recommendations for the clinical evaluation of men and women with sexual dysfunction. J Sex Med. 2010;7:337–48. https://doi.org/10.1111/j.1743-6109.2009.01619.x.CrossRefPubMed

92.

Brandstater M, Kim M. The challenge of altered sexual function in stroke survivors undergoing rehabilitation. Top Geriatr Rehabil. 2016;32:199–203 https://changingstroke.com/journal-club-archive/journal-club-2016/altered-sexual-function/. Accessed 17 Dec 2018

93.

Choi-Kwon S, Kim JS. Poststroke emotional incontinence and decreased sexual activity. Cerebrovasc Dis. 2002;13:31–7. https://doi.org/10.1159/000047743.CrossRefPubMed

94.

Kellogg-Spadt S, Bowes C. Hypersexual behavior following a stroke. Am J Nurse Pract. 2007;11:42–3, 73. https://doi.org/10.1111/ijcp.12969.CrossRef

95.

Taman Y, Taman L, Akil E, et al. Post-stroke sexual functioning in first stroke patients. Eur J Neurol. 2008;15:660–6. https://doi.org/10.1111/j.1468-1331.2008.02184.x.CrossRef

96.

Akinpelu AO, Osose AA, Odole AC, Odunaiya NA. Sexual dysfunction in Nigerian stroke survivors. AfrHealth Sci. 2013;13:639–45. https://doi.org/10.4314/ahs.v13i3.17.CrossRef

97.

McGrath M, Lever S, McCluskey A, Power E. How is sexuality after stroke experienced by stroke survivors and partners of stroke survivors? A systematic review of qualitative studies. Clin Rehabil. 2019;33(2):293–303. https://doi.org/10.1177/0269215518793483.CrossRefPubMed

98.

McGrath M, Lever S, McCluskey A, Power E. Developing interventions to address sexuality after stroke: findings from a four-panel modified Delphi study. JRehabil Med. 2019;51(5):352–60. https://doi.org/10.2340/16501977-2548.CrossRef

99.

Courtois F, Alexander M, McLain ABJ. Women’s sexual health and reproductive function after SCI. Top Spinal Cord InjRehabil. 2017;23(1):20–30. https://doi.org/10.1310/sci2301-20.CrossRef

100.

Bérard E. The sexuality of spinal cord injured women: physiology and pathophysiology. A Rev Paraplegia. 1989;27(2):99–112. https://doi.org/10.1038/sc.1989.16.CrossRef

101.

Sipski ML, Alexander CJ, Rosen RC. Physiological parameters associated with psychogenic sexual arousal in women with complete spinal cord injuries. Arch Phys Med Rehabil. 1995;76(9):811–8.CrossRef

102.

New PW, Currie KE. Development of a comprehensive survey of sexuality issues including a self-report version of the International Spinal Cord Injury sexual function basic data sets. Spinal Cord. 2016;54(8):584–91. https://doi.org/10.1038/sc.2015.216.CrossRefPubMed

103.

Kreuter M, Taft C, Siösteen A, Biering-Sørensen F. Women’s sexual functioning and sex life after spinal cord injury. Spinal Cord. 2011;49(1):154–60. https://doi.org/10.1038/sc.2010.51.CrossRefPubMed

104.

Basson R, Leiblum S, Brotto L, et al. Revised definitions of women’s sexual dysfunction. J Sex Med. 2004;1:40–8. https://doi.org/10.1111/j.1743-6109.2004.10107.x.CrossRefPubMed

105.

Courtois F, Charvier K. Sexual dysfunction in patients with spinal cord lesions. HandbClin Neurol. 2015;130:225–45. https://doi.org/10.1016/B978-0-444-63247-0.00013-4.CrossRef

106.

Hubscher CH, Herrity AN, Williams CS, Montgomery LR, Willhite AM, Angeli CA, et al. Improvements in bladder, bowel and sexual outcomes following task-specific locomotor training in human spinal cord injury. PLoS One. 2018;13(1):e0190998. https://doi.org/10.1371/journal.pone.0190998.CrossRefPubMedPubMedCentral

107.

Gardiner PF. Changes in alpha-motoneuron properties with altered physical activity levels. Exerc Sport Sci Rev. 2006;34(2):54–8.CrossRef

108.

Harkema SJ, Hurley SL, Patel UK, Requejo PS, Dobkin BH, Edgerton VR. Human lumbosacral spinal cord interprets loading during stepping. J Neurophysiol. 1997;77(2):797–811. https://doi.org/10.1152/jn.1997.77.2.797.CrossRefPubMed

109.

Donati AR, Shokur S, Morya E, Campos DS, Moioli RC, Gitti CM, et al. Long-term training with a brain-machine interface-based gait protocol induces partial neurological recovery in paraplegic patients. Sci Rep. 2016;6:30383. https://doi.org/10.1038/srep30383.CrossRefPubMedPubMedCentral

110.

Shokur S, Donati ARC, Campos DSF, Gitti C, Bao G, Fischer D, et al. Training with brain-machine interfaces, visuo-tactile feedback and assisted locomotion improves sensorimotor, visceral, and psychological signs in chronic paraplegic patients. PLoS One. 2018;13(11):e0206464. https://doi.org/10.1371/journal.pone.0206464.CrossRefPubMedPubMedCentral

111.

Dasgupta R, Wiseman OJ, Kanabar G, Fowler CJ, Mikol D. Efficacy of sildenafil in the treatment of female sexual dysfunction due to multiple sclerosis. J Urol. 2004;71(3):1189–93. https://doi.org/10.1097/01.ju.0000113145.43174.24.CrossRef

112.

Basson R, Brotto LA. Sexual psychophysiology and effects of sildenafil citrate in oestrogenised women with acquired genital arousal disorder and impaired orgasm: a randomised controlled trial. BJOG. 2003;110(11):1014–24.CrossRef

113.

Jaspers L, Feys F, Bramer WM, Franco OH, Leusink P, Laan ET. Efficacy and safety of flibanserin for the treatment of hypoactive sexual desire disorder in women: a systematic review and meta-analysis. JAMA Intern Med. 2016;176(4):453–62. https://doi.org/10.1001/jamainternmed.2015.8565.CrossRefPubMed

114.

Wilson SK, Delk JR 2nd, Billups KL. Treating symptoms of female sexual arousal disorder with the eros-clitoral therapy device. J Gend Specif Med. 2001;4(2):54–8.PubMed

115.

Goodin DS. The epidemiology of multiple sclerosis: insights to disease pathogenesis. Handb Clin Neurol. 2014;122:231–66. https://doi.org/10.1016/B978-0-444-52001-2.00010-8.CrossRefPubMed

116.

Marck CH, Jelinek PL, Weiland TJ, et al. Sexual function in multiple sclerosis and associations with demographic, disease and lifestyle characteristics: an international cross sectional study. BMC Neurol. 2016;4:16Y21. https://doi.org/10.1186/s12883-016-0735-8.CrossRef

117.

Nortvendt MW, Riise T, Myhr KM, Landtblom AM, Bakke A, Nyland HI. Reduced quality of life among multiple sclerosis patients with sexual disturbance and bladder dysfunction. Mult Scler J. 2001;7:231–5. https://doi.org/10.1177/135245850100700404.CrossRef

118.

Merghati-Khoei E, Qaderi K, Amini L, Korte JE. Sexual problems among women with multiple sclerosis. J Neurol Sci. 2013;331(1-2):81–5. https://doi.org/10.1016/j.jns.2013.05.014.CrossRefPubMedPubMedCentral

119.

Salhofer-Polanyi S, Wöber C, Prohazka R, Dal-Bianco A, Bajer-Kornek B, Zebenholzer K. Similar impact of multiple sclerosis and migraine on sexual function in women: is the multiple sclerosis impact scale questionnaire useful? Wien Klin Wochenschr. 2017;129(3-4):115–20. https://doi.org/10.1007/s00508-016-1066-x.CrossRefPubMed

120.

Bartnik P, Wielgoś A, Kacperczyk J, Pisarz K, Szymusik I, Podlecka-Piętowska A, et al. Sexual dysfunction in female patients with relapsing-remitting multiple sclerosis. Brain Behav. 2017;7(6):e00699. https://doi.org/10.1002/brb3.699.CrossRefPubMedPubMedCentral

121.

Calabrò RS, Russo M, Dattola V, De Luca R, Leo A, Grisolaghi J, et al. Sexual function in young individuals with multiple sclerosis: does disability matter? J Neuro Sci Nurs. 2018;50(3):161–6. https://doi.org/10.1097/JNN.0000000000000367.CrossRef

122.

• Zhao S, Li E, Wang J, Luo L, Luo J, Zhao Z. Rheumatoid arthritis and risk of sexual dysfunction: a systematic review and metaanalysis. J Rheumatol. 2018;45:1375–82. https://doi.org/10.3899/jrheum.170956In this review and meta-analysis, the authors confirm the importance and high frequency of sexual dysfunction in patients with rheumatoid arthritis. CrossRefPubMed

123.

Gerosa M, De Angelis V, Riboldi P, Meroni PL. Rheumatoid arthritis: a female challenge. Womens Health (Lond). 2008;4:195–201. https://doi.org/10.2217/17455057.4.2.195.CrossRef

124.

Maasoumi R, Moridi M, Farhadi F, Moshfeghi Z. Sexual function in women with rheumatoid arthritis. Womens Health Bull. 2014;1:e20098. https://doi.org/10.17795/whb-20098.CrossRef

125.

Hari A, Rostom S, Lahlou R, Bahiri R, Hajjaj-Hassouni N. Sexual function in Moroccan women with rheumatoid arthritis and its relationship with disease activity. Clin Rheumatol. 2015;34:1047–51. https://doi.org/10.1007/s10067-015-2888-z.CrossRefPubMed

126.

Coskun B, Coskun BN, Atis G, Ergenekon E, Dilek K. Evaluation of sexual function in women with rheumatoid arthritis. Urol J. 2014;10:1081–7.PubMed

127.

Aras H, Aras B, Icagasioglu A, Yumusakhuylu Y, Kemahli E, Haliloglu S, et al. Sexual dysfunction in women with rheumatoid arthritis. Med Glas (Zenica). 2013;10:327–31.

128.

Khnaba D, Rostom S, Lahlou R, Bahiri R, Abouqal R, Hajjaj-Hassouni N. Sexual dysfunction and its determinants in Moroccan women with rheumatoid arthritis. Pan Afr Med J. 2016;24:16. https://doi.org/10.11604/pamj.2016.24.16.9081.CrossRefPubMedPubMedCentral

129.

Dorner TE, Berner C, Haider S, Grabovac I, Lamprecht T, Fenzl KH, et al. Sexual health in patients with rheumatoid arthritis and the association between physical fitness and sexual function: a cross-sectional study. Rheumatol Int. 2018;38:1103–14. https://doi.org/10.1007/s00296-018-4023-3.CrossRefPubMedPubMedCentral

130.

Puchner R, Sautner J, Gruber J, Bragagna E, Trenkler A, Lang G, et al. High burden of sexual dysfunction in female patients with rheumatoid arthritis: results of a cross-sectional study. J Rheumatol. 2019;46:19–26. https://doi.org/10.3899/jrheum.171287.CrossRefPubMed

131.

Boone D, Ronson A, Karsh J. Comparison of Female Sexual Function Index in patients with psoriatic and rheumatoid arthritis and healthy controls. Musculoskeletal Care. 2019. https://doi.org/10.1002/msc.1405.

132.

Generali E, Costanzo A, Mainetti C, Selmi C. Cutaneous and mucosal manifestations of Sjögren’s syndrome. Clin Rev Allergy Immunol. 2017;53(3):357–70. https://doi.org/10.1007/s12016-017-8639-y.CrossRefPubMed

133.

Both T, Dalm VA, Van Hagen PM, Van Daele PL. Reviewing primary Sjögren’s syndrome: beyond the dryness - from pathophysiology to diagnosis and treatment. Int J Med Sci. 2017;14:191–200. https://doi.org/10.7150/ijms.17718.CrossRefPubMedPubMedCentral

134.

MaddaliBongi S, Del Rosso A, Orlandi M, Matucci-Cerinic M. Gynaecological symptoms and sexual disability in women with primary Sjögren’s syndrome and sicca syndrome. ClinExpRheumatol. 2013;31:683–90.

135.

Van Nimwegen JF, Arends S, van Zuiden GS, Vissink A, Kroese FG, Bootsma H. The impact of primary Sjögren’s syndrome on female sexual function. Rheumatology (Oxford). 2015;54:1286–93. https://doi.org/10.1093/rheumatology/keu522.CrossRef

136.

Priori R, Minniti A, Derme M, Antonazzo B, Brancatisano F, Ghirini S, et al. Quality of sexual life in women with primary Sjögren syndrome. J Rheumatol. 2015;42:1427–31. https://doi.org/10.3899/jrheum.141475.CrossRefPubMed

137.

Golder V, Hoi A. Systemic lupus erythematosus: an update. Med J Aust. 2017;206(5):215–20.CrossRef

138.

Godoy Junior AC, Gaertner H, Skare T, Nisihara R. Sexual dysfunction in systemic lupus erythematosus patients. Acta Reumatol Port. 2017;42:341–2.PubMed

139.

Shen B, He Y, Chen H, Zhao C, Zhu L, Gao Y, et al. Body image disturbances have impact on the sexual problems in Chinese systemic lupus erythematosus patients. J Immunol Res. 2015;2015:204513. https://doi.org/10.1155/2015/204513.CrossRefPubMedPubMedCentral

Title: Female Sexual Dysfunction as a Warning Sign of Chronic Disease Development
Authors: Vincenza Di Stasi
Nunzia Verde
Elisa Maseroli
Irene Scavello
Sarah Cipriani
Tommaso Todisco
Mario Maggi
Linda Vignozzi
Publication date: 01-12-2019
Publisher: Springer US
Keywords: Erectile Dysfunction
Obstructive Sleep Apnea Syndrome
Published in: Current Sexual Health Reports / Issue 4/2019
Print ISSN: 1548-3584
Electronic ISSN: 1548-3592
DOI: https://doi.org/10.1007/s11930-019-00229-4

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Female Sexual Dysfunction as a Warning Sign of Chronic Disease Development

Abstract

Purpose of Review

Recent Findings

Summary

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose of Review

Recent Findings

Summary

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