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Published in: Current Psychiatry Reports 6/2017

01-06-2017 | Mood Disorders (MA Oquendo and MF Grunebaum, Section Editors)

Biomarkers of Suicide Attempt Behavior: Towards a Biological Model of Risk

Authors: Katherin Sudol, J. John Mann

Published in: Current Psychiatry Reports | Issue 6/2017

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Abstract

Purpose of Review

The rising suicide rate in the USA will not be reversed without improved risk assessment and prevention practices. To date, the best method for clinicians to assess a patient’s risk for suicide is screening for past suicide attempts in the patient and their family. However, neuroimaging, genomic, and biochemical studies have generated a body of findings that allow description of an initial heuristic biological model for suicidal behavior that may have predictive value.

Recent Findings

We review studies from the past 3 years examining potential biological predictors of suicide attempt behavior. We divide findings into two major categories: (1) structural and functional brain imaging findings and (2) biochemical and genomic findings encompassing several systems, including major neurotransmitters (serotonin, catecholamines, GABA, and glutamate), the hypothalamic pituitary adrenal (HPA) axis, the inflammasome, lipids, and neuroplasticity.

Summary

The biomarkers that appear promising for assessing suicide risk in clinical settings include indices of serotonergic function, inflammation, neuronal plasticity, and lipids.
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Metadata
Title
Biomarkers of Suicide Attempt Behavior: Towards a Biological Model of Risk
Authors
Katherin Sudol
J. John Mann
Publication date
01-06-2017
Publisher
Springer US
Published in
Current Psychiatry Reports / Issue 6/2017
Print ISSN: 1523-3812
Electronic ISSN: 1535-1645
DOI
https://doi.org/10.1007/s11920-017-0781-y

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