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Current Psychiatry Reports
Published in: Current Psychiatry Reports 2/2012

01-04-2012 | GENETIC DISORDERS (JF CUBELLS AND EB BINDER, SECTION EDITORS)

Animal Models of Stress Vulnerability and Resilience in Translational Research

Authors: Sebastian H. Scharf, Mathias V. Schmidt

Published in: Current Psychiatry Reports | Issue 2/2012

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Abstract

Stress has been identified as a key risk factor for a multitude of human pathologies. However, stress by itself is often not sufficient to induce a disease, as a large contribution comes from an individual’s genetic background. Therefore, many stress models have been created to investigate this so-called gene–environment interaction for different diseases. Recently, evidence has been accumulating to indicate that not only the exposure to stress, but also the vulnerability to such an exposure can have a significant impact on the development of disease. Herein we review recent animal models of stress vulnerability and resilience, with special attention devoted to the readout parameters and the potential for translatability of the results.
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Metadata
Title
Animal Models of Stress Vulnerability and Resilience in Translational Research
Authors
Sebastian H. Scharf
Mathias V. Schmidt
Publication date
01-04-2012
Publisher
Current Science Inc.
Published in
Current Psychiatry Reports / Issue 2/2012
Print ISSN: 1523-3812
Electronic ISSN: 1535-1645
DOI
https://doi.org/10.1007/s11920-012-0256-0

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