Skip to main content
Top
Published in: Current Psychiatry Reports 1/2012

01-02-2012 | PERSONALITY DISORDERS (H KOENIGSBERG, SECTION EDITOR)

Developmental Pathways to Borderline Personality Disorder

Authors: Andrew M. Chanen, Michael Kaess

Published in: Current Psychiatry Reports | Issue 1/2012

Login to get access

Abstract

This paper reviews recent studies of biological and environmental risk and protective factors and patterns of continuity leading to borderline personality disorder (BPD). It focuses on prospective studies of children and adolescents and studies of young people with borderline pathology, reporting findings from genetics, neurobiology, experimental psychopathology, environmental risk, and precursor signs and symptoms. Studies of individuals earlier in the course of BPD demonstrate relatively consistent environmental risk factors, but neurobiological and experimental psychopathology findings are still inconsistent. Also, temperamental and mental state abnormalities that resemble aspects of the BPD phenotype emerge in childhood and adolescence and presage the BPD syndrome in adolescence or adulthood. Further work is required to better understand the roles that all these factors play in the developmental pathways to BPD and to increase their specificity for BPD in order to facilitate prevention and early intervention.
Literature
1.
go back to reference Leichsenring F, Leibing E, Kruse J, New AS, Leweke F. Borderline personality disorder. Lancet. 2011;377:74–84.PubMedCrossRef Leichsenring F, Leibing E, Kruse J, New AS, Leweke F. Borderline personality disorder. Lancet. 2011;377:74–84.PubMedCrossRef
2.
go back to reference Coid J, Yang M, Tyrer P, Roberts A, Ullrich S. Prevalence and correlates of personality disorder in Great Britain. Br J Psychiatry. 2006;188:423–31.PubMedCrossRef Coid J, Yang M, Tyrer P, Roberts A, Ullrich S. Prevalence and correlates of personality disorder in Great Britain. Br J Psychiatry. 2006;188:423–31.PubMedCrossRef
3.
go back to reference Trull TJ, Jahng S, Tomko RL, Wood PK, Sher KJ. Revised NESARC personality disorder diagnoses: gender, prevalence, and comorbidity with substance dependence disorders. J Personal Disord. 2010;24:412–26.CrossRef Trull TJ, Jahng S, Tomko RL, Wood PK, Sher KJ. Revised NESARC personality disorder diagnoses: gender, prevalence, and comorbidity with substance dependence disorders. J Personal Disord. 2010;24:412–26.CrossRef
4.
go back to reference Korzekwa MI, Dell PF, Links PS, Thabane L, Webb SP. Estimating the prevalence of borderline personality disorder in psychiatric outpatients using a two-phase procedure. Compr Psychiatry. 2008;49:380–6.PubMedCrossRef Korzekwa MI, Dell PF, Links PS, Thabane L, Webb SP. Estimating the prevalence of borderline personality disorder in psychiatric outpatients using a two-phase procedure. Compr Psychiatry. 2008;49:380–6.PubMedCrossRef
5.
go back to reference APA. Diagnostic and statistical manual of mental disorders. 3rd ed. Washington, DC: American Psychiatric Association; 1980. APA. Diagnostic and statistical manual of mental disorders. 3rd ed. Washington, DC: American Psychiatric Association; 1980.
6.
go back to reference Chanen AM, McCutcheon LK. Personality disorder in adolescence: the diagnosis that dare not speak its name. Personal Ment Heal. 2008;2:35–41.CrossRef Chanen AM, McCutcheon LK. Personality disorder in adolescence: the diagnosis that dare not speak its name. Personal Ment Heal. 2008;2:35–41.CrossRef
7.
go back to reference Tackett JL, Balsis S, Oltmanns TF, Krueger RF. A unifying perspective on personality pathology across the life span: developmental considerations for the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders. Dev Psychopathol. 2009;21:687–713.PubMedCrossRef Tackett JL, Balsis S, Oltmanns TF, Krueger RF. A unifying perspective on personality pathology across the life span: developmental considerations for the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders. Dev Psychopathol. 2009;21:687–713.PubMedCrossRef
8.
go back to reference Cicchetti D, Rogosch FA. A developmental psychopathology perspective on adolescence. J Consult Clin Psychol. 2002;70:6–20.PubMedCrossRef Cicchetti D, Rogosch FA. A developmental psychopathology perspective on adolescence. J Consult Clin Psychol. 2002;70:6–20.PubMedCrossRef
9.
go back to reference Chanen AM, Jovev M, McCutcheon L, Jackson HJ, McGorry PD. Borderline personality disorder in young people and the prospects for prevention and early intervention. Curr Psychiatry Rev. 2008;4:48–57.CrossRef Chanen AM, Jovev M, McCutcheon L, Jackson HJ, McGorry PD. Borderline personality disorder in young people and the prospects for prevention and early intervention. Curr Psychiatry Rev. 2008;4:48–57.CrossRef
10.
go back to reference Torgersen S, Czajkowski N, Jacobson K, et al. Dimensional representations of DSM-IV cluster B personality disorders in a population-based sample of Norwegian twins: a multivariate study. Psychol Med. 2008;38:1617–25.PubMedCrossRef Torgersen S, Czajkowski N, Jacobson K, et al. Dimensional representations of DSM-IV cluster B personality disorders in a population-based sample of Norwegian twins: a multivariate study. Psychol Med. 2008;38:1617–25.PubMedCrossRef
11.
go back to reference Distel MA, Rebollo-Mesa I, Willemsen G, et al. Familial resemblance of borderline personality disorder features: genetic or cultural transmission? PLoS One. 2009;4:e5334.PubMedCrossRef Distel MA, Rebollo-Mesa I, Willemsen G, et al. Familial resemblance of borderline personality disorder features: genetic or cultural transmission? PLoS One. 2009;4:e5334.PubMedCrossRef
12.
go back to reference Distel MA, Trull TJ, Derom CA, et al. Heritability of borderline personality disorder features is similar across three countries. Psychol Med. 2008;38:1219–29.PubMedCrossRef Distel MA, Trull TJ, Derom CA, et al. Heritability of borderline personality disorder features is similar across three countries. Psychol Med. 2008;38:1219–29.PubMedCrossRef
13.
go back to reference Kendler KS, Aggen SH, Czajkowski N, et al. The structure of genetic and environmental risk factors for DSM-IV personality disorders: a multivariate twin study. Arch Gen Psychiatry. 2008;65:1438–46.PubMedCrossRef Kendler KS, Aggen SH, Czajkowski N, et al. The structure of genetic and environmental risk factors for DSM-IV personality disorders: a multivariate twin study. Arch Gen Psychiatry. 2008;65:1438–46.PubMedCrossRef
14.
go back to reference Bornovalova MA, Hicks BM, Iacono WG, McGue M. Stability, change, and heritability of borderline personality disorder traits from adolescence to adulthood: a longitudinal twin study. Dev Psychopathol. 2009;21:1335–53.PubMedCrossRef Bornovalova MA, Hicks BM, Iacono WG, McGue M. Stability, change, and heritability of borderline personality disorder traits from adolescence to adulthood: a longitudinal twin study. Dev Psychopathol. 2009;21:1335–53.PubMedCrossRef
15.
go back to reference Distel MA, Carlier A, Middeldorp CM, Derom CA, Lubke GH, Boomsma DI. Borderline personality traits and adult attention-deficit hyperactivity disorder symptoms: a genetic analysis of comorbidity. Am J Med Genet. 2011. doi:10.1002/ajmg.b.31226. Distel MA, Carlier A, Middeldorp CM, Derom CA, Lubke GH, Boomsma DI. Borderline personality traits and adult attention-deficit hyperactivity disorder symptoms: a genetic analysis of comorbidity. Am J Med Genet. 2011. doi:10.​1002/​ajmg.​b.​31226.
16.
go back to reference Distel MA, Hottenga J-J, Trull TJ, Boomsma DI. Chromosome 9: linkage for borderline personality disorder features. Psychiatr Genet. 2008;18:302–7.PubMedCrossRef Distel MA, Hottenga J-J, Trull TJ, Boomsma DI. Chromosome 9: linkage for borderline personality disorder features. Psychiatr Genet. 2008;18:302–7.PubMedCrossRef
17.
go back to reference •• Distel MA, Middeldorp CM, Trull TJ, Derom CA, Willemsen G, Boomsma DI. Life events and borderline personality features: the influence of gene-environment interaction and gene-environment correlation. Psychol Med. 2011;41:849–60. This was the first study to test the joint effect of genetic and environmental influences and the exposure to life events on BPD features in the general population. Findings indicate the importance of both genetic vulnerability and life events. PubMedCrossRef •• Distel MA, Middeldorp CM, Trull TJ, Derom CA, Willemsen G, Boomsma DI. Life events and borderline personality features: the influence of gene-environment interaction and gene-environment correlation. Psychol Med. 2011;41:849–60. This was the first study to test the joint effect of genetic and environmental influences and the exposure to life events on BPD features in the general population. Findings indicate the importance of both genetic vulnerability and life events. PubMedCrossRef
18.
go back to reference Ni X, Bismil R, Chan K, et al. Serotonin 2A receptor gene is associated with personality traits, but not to disorder, in patients with borderline personality disorder. Neurosci Lett. 2006;408:214–9.PubMedCrossRef Ni X, Bismil R, Chan K, et al. Serotonin 2A receptor gene is associated with personality traits, but not to disorder, in patients with borderline personality disorder. Neurosci Lett. 2006;408:214–9.PubMedCrossRef
19.
go back to reference Ni X, Chan D, Chan K, McMain S, Kennedy JL. Serotonin genes and gene-gene interactions in borderline personality disorder in a matched case-control study. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33:128–33.PubMedCrossRef Ni X, Chan D, Chan K, McMain S, Kennedy JL. Serotonin genes and gene-gene interactions in borderline personality disorder in a matched case-control study. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33:128–33.PubMedCrossRef
20.
go back to reference Ni X, Chan K, Bulgin N, et al. Association between serotonin transporter gene and borderline personality disorder. J Psychiatr Res. 2006;40:448–53.PubMedCrossRef Ni X, Chan K, Bulgin N, et al. Association between serotonin transporter gene and borderline personality disorder. J Psychiatr Res. 2006;40:448–53.PubMedCrossRef
21.
go back to reference Steiger H, Richardson J, Joober R, et al. The 5HTTLPR polymorphism, prior maltreatment and dramatic-erratic personality manifestations in women with bulimic syndromes. J Psychiatry Neurosci. 2007;32:354–62.PubMed Steiger H, Richardson J, Joober R, et al. The 5HTTLPR polymorphism, prior maltreatment and dramatic-erratic personality manifestations in women with bulimic syndromes. J Psychiatry Neurosci. 2007;32:354–62.PubMed
22.
go back to reference Perez-Rodriguez MM, Weinstein S, New AS, et al. Tryptophan-hydroxylase 2 haplotype association with borderline personality disorder and aggression in a sample of patients with personality disorders and healthy controls. J Psychiatr Res. 2010;44:1075–81.PubMedCrossRef Perez-Rodriguez MM, Weinstein S, New AS, et al. Tryptophan-hydroxylase 2 haplotype association with borderline personality disorder and aggression in a sample of patients with personality disorders and healthy controls. J Psychiatr Res. 2010;44:1075–81.PubMedCrossRef
23.
go back to reference Wilson ST, Stanley B, Brent DA, Oquendo MA, Huang YY, Mann JJ. The tryptophan hydroxylase-1 A218C polymorphism is associated with diagnosis, but not suicidal behavior, in borderline personality disorder. Am J Med Genet B Neuropsychiatr Genet. 2009;150B:202–8.PubMedCrossRef Wilson ST, Stanley B, Brent DA, Oquendo MA, Huang YY, Mann JJ. The tryptophan hydroxylase-1 A218C polymorphism is associated with diagnosis, but not suicidal behavior, in borderline personality disorder. Am J Med Genet B Neuropsychiatr Genet. 2009;150B:202–8.PubMedCrossRef
24.
go back to reference Ni X, Sicard T, Bulgin N, et al. Monoamine oxidase a gene is associated with borderline personality disorder. Psychiatr Genet. 2007;17:153–7.PubMedCrossRef Ni X, Sicard T, Bulgin N, et al. Monoamine oxidase a gene is associated with borderline personality disorder. Psychiatr Genet. 2007;17:153–7.PubMedCrossRef
25.
go back to reference Wagner S, Baskaya O, Lieb K, Dahmen N, Tadic A. The 5-HTTLPR polymorphism modulates the association of serious life events (SLE) and impulsivity in patients with borderline personality disorder. J Psychiatr Res. 2009;43:1067–72.PubMedCrossRef Wagner S, Baskaya O, Lieb K, Dahmen N, Tadic A. The 5-HTTLPR polymorphism modulates the association of serious life events (SLE) and impulsivity in patients with borderline personality disorder. J Psychiatr Res. 2009;43:1067–72.PubMedCrossRef
26.
go back to reference Pascual JC, Soler J, Barrachina J, et al. Failure to detect an association between the serotonin transporter gene and borderline personality disorder. J Psychiatr Res. 2008;42:87–8.PubMedCrossRef Pascual JC, Soler J, Barrachina J, et al. Failure to detect an association between the serotonin transporter gene and borderline personality disorder. J Psychiatr Res. 2008;42:87–8.PubMedCrossRef
27.
go back to reference Tadic A, Elsasser A, Storm N, et al. Association analysis between gene variants of the tyrosine hydroxylase and the serotonin transporter in borderline personality disorder. World J Biol Psychiatry. 2010;11:45–58.PubMedCrossRef Tadic A, Elsasser A, Storm N, et al. Association analysis between gene variants of the tyrosine hydroxylase and the serotonin transporter in borderline personality disorder. World J Biol Psychiatry. 2010;11:45–58.PubMedCrossRef
28.
go back to reference Hankin BL, Barrocas AL, Jenness J, et al. Association between 5-HTTLPR and borderline personality disorder traits among youth. Front Psychiatry. 2011;2:6.PubMedCrossRef Hankin BL, Barrocas AL, Jenness J, et al. Association between 5-HTTLPR and borderline personality disorder traits among youth. Front Psychiatry. 2011;2:6.PubMedCrossRef
29.
go back to reference Joyce PR, McHugh PC, McKenzie JM, et al. A dopamine transporter polymorphism is a risk factor for borderline personality disorder in depressed patients. Psychol Med. 2006;36:807–13.PubMedCrossRef Joyce PR, McHugh PC, McKenzie JM, et al. A dopamine transporter polymorphism is a risk factor for borderline personality disorder in depressed patients. Psychol Med. 2006;36:807–13.PubMedCrossRef
30.
go back to reference Nemoda Z, Lyons-Ruth K, Szekely A, Bertha E, Faludi G, Sasvari-Szekely M. Association between dopaminergic polymorphisms and borderline personality traits among at-risk young adults and psychiatric inpatients. Behav Brain Funct. 2010;6:4.PubMedCrossRef Nemoda Z, Lyons-Ruth K, Szekely A, Bertha E, Faludi G, Sasvari-Szekely M. Association between dopaminergic polymorphisms and borderline personality traits among at-risk young adults and psychiatric inpatients. Behav Brain Funct. 2010;6:4.PubMedCrossRef
31.
go back to reference Chanen AM, Velakoulis D, Carison K, et al. Orbitofrontal, amygdala and hippocampal volumes in teenagers with first-presentation borderline personality disorder. Psychiatry Res Neuroimaging. 2008;163:116–25.CrossRef Chanen AM, Velakoulis D, Carison K, et al. Orbitofrontal, amygdala and hippocampal volumes in teenagers with first-presentation borderline personality disorder. Psychiatry Res Neuroimaging. 2008;163:116–25.CrossRef
32.
go back to reference • Brunner R, Henze R, Parzer P, et al. Reduced prefrontal and orbitofrontal gray matter in female adolescents with borderline personality disorder: is it disorder specific? Neuroimage. 2010;49:114–20. This is one of the few studies to use a clinical comparison group in addition to a healthy control group, bringing into question the specificity of volumetric changes found in young people with BPD. PubMedCrossRef • Brunner R, Henze R, Parzer P, et al. Reduced prefrontal and orbitofrontal gray matter in female adolescents with borderline personality disorder: is it disorder specific? Neuroimage. 2010;49:114–20. This is one of the few studies to use a clinical comparison group in addition to a healthy control group, bringing into question the specificity of volumetric changes found in young people with BPD. PubMedCrossRef
33.
go back to reference Goodman M, Hazlett EA, Avedon JB, Siever DR, Chu KW, New AS. Anterior cingulate volume reduction in adolescents with borderline personality disorder and co-morbid major depression. J Psychiatr Res. 2011;45:803–7.PubMedCrossRef Goodman M, Hazlett EA, Avedon JB, Siever DR, Chu KW, New AS. Anterior cingulate volume reduction in adolescents with borderline personality disorder and co-morbid major depression. J Psychiatr Res. 2011;45:803–7.PubMedCrossRef
34.
go back to reference Whittle S, Chanen AM, Fornito A, McGorry PD, Pantelis C, Yucel M. Anterior cingulate volume in adolescents with first-presentation borderline personality disorder. Psychiatry Res Neuroimaging. 2009;172:155–60.CrossRef Whittle S, Chanen AM, Fornito A, McGorry PD, Pantelis C, Yucel M. Anterior cingulate volume in adolescents with first-presentation borderline personality disorder. Psychiatry Res Neuroimaging. 2009;172:155–60.CrossRef
35.
go back to reference Walterfang M, Chanen AM, Barton S, et al. Corpus callosum morphology and relationship to prefrontal cortical and lateral ventricular volume in teenagers with first-presentation borderline personality disorder. Psychiatry Res Neuroimaging. 2010;183:30–7.CrossRef Walterfang M, Chanen AM, Barton S, et al. Corpus callosum morphology and relationship to prefrontal cortical and lateral ventricular volume in teenagers with first-presentation borderline personality disorder. Psychiatry Res Neuroimaging. 2010;183:30–7.CrossRef
36.
go back to reference Rusch N, Luders E, Lieb K, et al. Corpus callosum abnormalities in women with borderline personality disorder and comorbid attention-deficit hyperactivity disorder. J Psychiatry Neurosci. 2007;32:417–22.PubMed Rusch N, Luders E, Lieb K, et al. Corpus callosum abnormalities in women with borderline personality disorder and comorbid attention-deficit hyperactivity disorder. J Psychiatry Neurosci. 2007;32:417–22.PubMed
37.
go back to reference Zanetti MV, Soloff PH, Nicoletti MA, et al. MRI study of corpus callosum in patients with borderline personality disorder: a pilot study. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31:1519–25.PubMedCrossRef Zanetti MV, Soloff PH, Nicoletti MA, et al. MRI study of corpus callosum in patients with borderline personality disorder: a pilot study. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31:1519–25.PubMedCrossRef
38.
go back to reference Nunes PM, Wenzel A, Borges KT, Porto CR, Caminha RM, de Oliveira IR. Volumes of the hippocampus and amygdala in patients with borderline personality disorder: a meta-analysis. J Personal Disord. 2009;23:333–45.CrossRef Nunes PM, Wenzel A, Borges KT, Porto CR, Caminha RM, de Oliveira IR. Volumes of the hippocampus and amygdala in patients with borderline personality disorder: a meta-analysis. J Personal Disord. 2009;23:333–45.CrossRef
39.
go back to reference Takahashi T, Chanen AM, Wood SJ, et al. Midline brain structures in teenagers with first-presentation borderline personality disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33:842–6.PubMedCrossRef Takahashi T, Chanen AM, Wood SJ, et al. Midline brain structures in teenagers with first-presentation borderline personality disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33:842–6.PubMedCrossRef
40.
go back to reference Zimmerman DJ, Choi-Kain LW. The hypothalamic-pituitary-adrenal axis in borderline personality disorder: a review. Harv Rev Psychiatry. 2009;17:167–83.PubMedCrossRef Zimmerman DJ, Choi-Kain LW. The hypothalamic-pituitary-adrenal axis in borderline personality disorder: a review. Harv Rev Psychiatry. 2009;17:167–83.PubMedCrossRef
41.
go back to reference Nater UM, Bohus M, Abbruzzese E, et al. Increased psychological and attenuated cortisol and alpha-amylase responses to acute psychosocial stress in female patients with borderline personality disorder. Psychoneuroendocrinology. 2010;35:1565–72.PubMedCrossRef Nater UM, Bohus M, Abbruzzese E, et al. Increased psychological and attenuated cortisol and alpha-amylase responses to acute psychosocial stress in female patients with borderline personality disorder. Psychoneuroendocrinology. 2010;35:1565–72.PubMedCrossRef
42.
go back to reference Kaess M, Hille M, Parzer P, Maser-Gluth C, Resch F, Brunner R. Alterations in the neuroendocrinological stress response to acute psychosocial stress in adolescents engaging in nonsuicidal self-injury. Psychoneuroendocrinology. 2011. Kaess M, Hille M, Parzer P, Maser-Gluth C, Resch F, Brunner R. Alterations in the neuroendocrinological stress response to acute psychosocial stress in adolescents engaging in nonsuicidal self-injury. Psychoneuroendocrinology. 2011.
43.
go back to reference Jovev M, Garner B, Phillips L, et al. An MRI study of pituitary volume and parasuicidal behavior in teenagers with first-presentation borderline personality disorder. Psychiatry Res Neuroimaging. 2008;163:273–7.CrossRef Jovev M, Garner B, Phillips L, et al. An MRI study of pituitary volume and parasuicidal behavior in teenagers with first-presentation borderline personality disorder. Psychiatry Res Neuroimaging. 2008;163:273–7.CrossRef
44.
go back to reference von Ceumern-Lindenstjerna IA, Brunner R, Parzer P, Mundt C, Fiedler P, Resch F. Initial orienting to emotional faces in female adolescents with borderline personality disorder. Psychopathology. 2010;43:79–87.CrossRef von Ceumern-Lindenstjerna IA, Brunner R, Parzer P, Mundt C, Fiedler P, Resch F. Initial orienting to emotional faces in female adolescents with borderline personality disorder. Psychopathology. 2010;43:79–87.CrossRef
46.
go back to reference von Ceumern-Lindenstjerna IA, Brunner R, Parzer P, Mundt C, Fiedler P, Resch F. Attentional bias in later stages of emotional information processing in female adolescents with borderline personality disorder. Psychopathology. 2010;43:25–32.CrossRef von Ceumern-Lindenstjerna IA, Brunner R, Parzer P, Mundt C, Fiedler P, Resch F. Attentional bias in later stages of emotional information processing in female adolescents with borderline personality disorder. Psychopathology. 2010;43:25–32.CrossRef
47.
go back to reference Jennings T, Hulbert C, Jackson H, Chanen A. Social perspective coordination in youth with borderline personality pathology. J Personal Disord. 2011 in press. Jennings T, Hulbert C, Jackson H, Chanen A. Social perspective coordination in youth with borderline personality pathology. J Personal Disord. 2011 in press.
48.
go back to reference Sharp C, Pane H, Ha C, et al. Theory of mind and emotion regulation difficulties in adolescents with borderline traits. J Am Acad Child Adolesc Psychiatry. 2011;50:563–73 e1.PubMedCrossRef Sharp C, Pane H, Ha C, et al. Theory of mind and emotion regulation difficulties in adolescents with borderline traits. J Am Acad Child Adolesc Psychiatry. 2011;50:563–73 e1.PubMedCrossRef
49.
go back to reference Lawrence KA, Allen JS, Chanen AM. Impulsivity in borderline personality disorder: reward-based decision-making and its relationship to emotional distress. J Personal Disord. 2010;24:786–99.CrossRef Lawrence KA, Allen JS, Chanen AM. Impulsivity in borderline personality disorder: reward-based decision-making and its relationship to emotional distress. J Personal Disord. 2010;24:786–99.CrossRef
50.
go back to reference Maughan B, Rutter M. Retrospective reporting of childhood adversity: assessing long-term recall. J Personal Disord. 1997;11:19–33.CrossRef Maughan B, Rutter M. Retrospective reporting of childhood adversity: assessing long-term recall. J Personal Disord. 1997;11:19–33.CrossRef
51.
go back to reference Zanarini MC, Williams AA, Lewis RE, et al. Reported pathological childhood experiences associated with the development of borderline personality disorder. Am J Psychiatry. 1997;154:1101–6.PubMed Zanarini MC, Williams AA, Lewis RE, et al. Reported pathological childhood experiences associated with the development of borderline personality disorder. Am J Psychiatry. 1997;154:1101–6.PubMed
52.
go back to reference Afifi TO, Mather A, Boman J, et al. Childhood adversity and personality disorders: results from a nationally representative population-based study. J Psychiatr Res. 2011;45:814–22.PubMedCrossRef Afifi TO, Mather A, Boman J, et al. Childhood adversity and personality disorders: results from a nationally representative population-based study. J Psychiatr Res. 2011;45:814–22.PubMedCrossRef
53.
go back to reference Bradley R, Jenei J, Westen D. Etiology of borderline personality disorder: disentangling the contributions of intercorrelated antecedents. J Nerv Ment Dis. 2005;193:24–31.PubMedCrossRef Bradley R, Jenei J, Westen D. Etiology of borderline personality disorder: disentangling the contributions of intercorrelated antecedents. J Nerv Ment Dis. 2005;193:24–31.PubMedCrossRef
54.
go back to reference Cohen P, Crawford TN, Johnson JG, Kasen S. The children in the community study of developmental course of personality disorder. J Personal Disord. 2005;19:466–86.CrossRef Cohen P, Crawford TN, Johnson JG, Kasen S. The children in the community study of developmental course of personality disorder. J Personal Disord. 2005;19:466–86.CrossRef
55.
56.
go back to reference Johnson JG, Cohen P, Brown J, Smailes E, Bernstein DP. Childhood maltreatment increases risk for personality disorders during early adulthood. Arch Gen Psychiatry. 1999;56:600–6.PubMedCrossRef Johnson JG, Cohen P, Brown J, Smailes E, Bernstein DP. Childhood maltreatment increases risk for personality disorders during early adulthood. Arch Gen Psychiatry. 1999;56:600–6.PubMedCrossRef
57.
go back to reference Cohen P. Childhood risks for young adult symptoms of personality disorder: method and substance. Multivar Behav Res. 1996;31:121–48.CrossRef Cohen P. Childhood risks for young adult symptoms of personality disorder: method and substance. Multivar Behav Res. 1996;31:121–48.CrossRef
58.
go back to reference Crawford TN, Cohen PR, Chen H, Anglin DM, Ehrensaft M. Early maternal separation and the trajectory of borderline personality disorder symptoms. Dev Psychopathol. 2009;21:1013–30.PubMedCrossRef Crawford TN, Cohen PR, Chen H, Anglin DM, Ehrensaft M. Early maternal separation and the trajectory of borderline personality disorder symptoms. Dev Psychopathol. 2009;21:1013–30.PubMedCrossRef
59.
go back to reference Cohen P, Chen H, Gordon K, Johnson J, Brook J, Kasen S. Socioeconomic background and the developmental course of schizotypal and borderline personality disorder symptoms. Dev Psychopathol. 2008;20:633–50.PubMedCrossRef Cohen P, Chen H, Gordon K, Johnson J, Brook J, Kasen S. Socioeconomic background and the developmental course of schizotypal and borderline personality disorder symptoms. Dev Psychopathol. 2008;20:633–50.PubMedCrossRef
60.
go back to reference Bezirganian S, Cohen P, Brook JS. The impact of mother-child interaction on the development of borderline personality disorder. Am J Psychiatry. 1993;150:1836–42.PubMed Bezirganian S, Cohen P, Brook JS. The impact of mother-child interaction on the development of borderline personality disorder. Am J Psychiatry. 1993;150:1836–42.PubMed
61.
go back to reference Johnson JG, Cohen P, Chen H, Kasen S, Brook JS. Parenting behaviors associated with risk for offspring personality disorder during adulthood. Arch Gen Psychiatry. 2006;63:579–87.PubMedCrossRef Johnson JG, Cohen P, Chen H, Kasen S, Brook JS. Parenting behaviors associated with risk for offspring personality disorder during adulthood. Arch Gen Psychiatry. 2006;63:579–87.PubMedCrossRef
62.
go back to reference • Carlson EA, Egeland B, Sroufe LA. A prospective investigation of the development of borderline personality symptoms. Dev Psychopathol. 2009;21:1311–34. This is one of the few studies to use a prospective, longitudinal design to examine potential antecedents of BPD from infancy through to adulthood. PubMedCrossRef • Carlson EA, Egeland B, Sroufe LA. A prospective investigation of the development of borderline personality symptoms. Dev Psychopathol. 2009;21:1311–34. This is one of the few studies to use a prospective, longitudinal design to examine potential antecedents of BPD from infancy through to adulthood. PubMedCrossRef
63.
go back to reference Eaton WW, Badawi M, Melton B. Prodromes and precursors: epidemiologic data for primary prevention of disorders with slow onset. Am J Psychiatry. 1995;152:967–72.PubMed Eaton WW, Badawi M, Melton B. Prodromes and precursors: epidemiologic data for primary prevention of disorders with slow onset. Am J Psychiatry. 1995;152:967–72.PubMed
64.
go back to reference Mervielde I, De Clercq B, De Fruyt F, Van Leeuwen K. Temperament, personality, and developmental psychopathology as childhood antecedents of personality disorders. J Personal Disord. 2005;19:171–201.CrossRef Mervielde I, De Clercq B, De Fruyt F, Van Leeuwen K. Temperament, personality, and developmental psychopathology as childhood antecedents of personality disorders. J Personal Disord. 2005;19:171–201.CrossRef
65.
go back to reference Roberts BW, DelVecchio WF. The rank-order consistency of personality traits from childhood to old age: a quantitative review of longitudinal studies. Psychol Bull. 2000;126:3–25.PubMedCrossRef Roberts BW, DelVecchio WF. The rank-order consistency of personality traits from childhood to old age: a quantitative review of longitudinal studies. Psychol Bull. 2000;126:3–25.PubMedCrossRef
66.
go back to reference Caspi A, Silva PA. Temperamental qualities at age three predict personality traits in young adulthood: longitudinal evidence from a birth cohort. Child Dev. 1995;66:486–98.PubMedCrossRef Caspi A, Silva PA. Temperamental qualities at age three predict personality traits in young adulthood: longitudinal evidence from a birth cohort. Child Dev. 1995;66:486–98.PubMedCrossRef
67.
go back to reference Kim-Cohen J, Caspi A, Moffitt TE, Harrington H, Milne BJ, Poulton R. Prior juvenile diagnoses in adults with mental disorder: developmental follow-back of a prospective-longitudinal cohort. Arch Gen Psychiatry. 2003;60:709–17.PubMedCrossRef Kim-Cohen J, Caspi A, Moffitt TE, Harrington H, Milne BJ, Poulton R. Prior juvenile diagnoses in adults with mental disorder: developmental follow-back of a prospective-longitudinal cohort. Arch Gen Psychiatry. 2003;60:709–17.PubMedCrossRef
68.
go back to reference Kraemer HC, Kazdin AE, Offord DR, Kessler RC, Jensen PS, Kupfer DJ. Coming to terms with the terms of risk. Arch Gen Psychiatry. 1997;54:337–43.PubMedCrossRef Kraemer HC, Kazdin AE, Offord DR, Kessler RC, Jensen PS, Kupfer DJ. Coming to terms with the terms of risk. Arch Gen Psychiatry. 1997;54:337–43.PubMedCrossRef
69.
go back to reference Bernstein DP, Cohen P, Skodol A, Bezirganian S, Brook J. Childhood antecedents of adolescent personality disorders. Am J Psychiatry. 1996;153:907–13.PubMed Bernstein DP, Cohen P, Skodol A, Bezirganian S, Brook J. Childhood antecedents of adolescent personality disorders. Am J Psychiatry. 1996;153:907–13.PubMed
70.
go back to reference Rohde P, Lewinsohn PM, Kahler CW, Seeley JR, Brown RA. Natural course of alcohol use disorders from adolescence to young adulthood. J Am Acad Child Adolesc Psychiatry. 2001;40:83–90.PubMedCrossRef Rohde P, Lewinsohn PM, Kahler CW, Seeley JR, Brown RA. Natural course of alcohol use disorders from adolescence to young adulthood. J Am Acad Child Adolesc Psychiatry. 2001;40:83–90.PubMedCrossRef
71.
go back to reference Thatcher DL, Cornelius JR, Clark DB. Adolescent alcohol use disorders predict adult borderline personality. Addict Behav. 2005;30:1709–24.PubMedCrossRef Thatcher DL, Cornelius JR, Clark DB. Adolescent alcohol use disorders predict adult borderline personality. Addict Behav. 2005;30:1709–24.PubMedCrossRef
72.
go back to reference Zoccolillo M, Pickles A, Quinton D, Rutter M. The outcome of childhood conduct disorder: implications for defining adult personality disorder and conduct disorder. Psychol Med. 1992;22:971–86.PubMedCrossRef Zoccolillo M, Pickles A, Quinton D, Rutter M. The outcome of childhood conduct disorder: implications for defining adult personality disorder and conduct disorder. Psychol Med. 1992;22:971–86.PubMedCrossRef
73.
go back to reference Rey JM, Singh M, Andrews G, Stewart GW. Continuities between psychiatric disorders in adolescents and personality disorders in young adults. Am J Psychiatry. 1995;152:895–900.PubMed Rey JM, Singh M, Andrews G, Stewart GW. Continuities between psychiatric disorders in adolescents and personality disorders in young adults. Am J Psychiatry. 1995;152:895–900.PubMed
74.
go back to reference Helgeland MI, Kjelsberg E, Torgersen S. Continuities between emotional and disruptive behavior disorders in adolescence and personality disorders in adulthood. Am J Psychiatry. 2005;162:1941–7.PubMedCrossRef Helgeland MI, Kjelsberg E, Torgersen S. Continuities between emotional and disruptive behavior disorders in adolescence and personality disorders in adulthood. Am J Psychiatry. 2005;162:1941–7.PubMedCrossRef
75.
go back to reference Lewinsohn PM, Rohde P, Seeley JR, Klein DN. Axis II psychopathology as a function of Axis I disorders in childhood and adolescence. J Am Acad Child Adolesc Psychiatry. 1997;36:1752–9.PubMedCrossRef Lewinsohn PM, Rohde P, Seeley JR, Klein DN. Axis II psychopathology as a function of Axis I disorders in childhood and adolescence. J Am Acad Child Adolesc Psychiatry. 1997;36:1752–9.PubMedCrossRef
76.
go back to reference Stepp SD, Burke JD, Hipwell AE, Loeber R. Trajectories of attention deficit hyperactivity disorder and oppositional defiant disorder symptoms as precursors of borderline personality disorder symptoms in adolescent girls. J Abnorm Child Psychol. 2011. doi:10.1007/s10802-011-9530-6. Stepp SD, Burke JD, Hipwell AE, Loeber R. Trajectories of attention deficit hyperactivity disorder and oppositional defiant disorder symptoms as precursors of borderline personality disorder symptoms in adolescent girls. J Abnorm Child Psychol. 2011. doi:10.​1007/​s10802-011-9530-6.
77.
78.
go back to reference Zanarini MC, Frankenburg FR, Ridolfi ME, Jager-Hyman S, Hennen J, Gunderson JG. Reported childhood onset of self-mutilation among borderline patients. J Personal Disord. 2006;20:9–15.CrossRef Zanarini MC, Frankenburg FR, Ridolfi ME, Jager-Hyman S, Hennen J, Gunderson JG. Reported childhood onset of self-mutilation among borderline patients. J Personal Disord. 2006;20:9–15.CrossRef
79.
go back to reference Patton GC, Hemphill SA, Beyers JM, et al. Pubertal stage and deliberate self-harm in adolescents. J Am Acad Child Adolesc Psychiatry. 2007;46:508–14.PubMedCrossRef Patton GC, Hemphill SA, Beyers JM, et al. Pubertal stage and deliberate self-harm in adolescents. J Am Acad Child Adolesc Psychiatry. 2007;46:508–14.PubMedCrossRef
81.
go back to reference Brunner R, Parzer P, Haffner J, et al. Prevalence and psychological correlates of occasional and repetitive deliberate self-harm in adolescents. Arch Pediatr Adolesc Med. 2007;161:641–9.PubMedCrossRef Brunner R, Parzer P, Haffner J, et al. Prevalence and psychological correlates of occasional and repetitive deliberate self-harm in adolescents. Arch Pediatr Adolesc Med. 2007;161:641–9.PubMedCrossRef
82.
go back to reference Nock MK, Joiner JTE, Gordon KH, Lloyd-Richardson E, Prinstein MJ. Non-suicidal self-injury among adolescents: diagnostic correlates and relation to suicide attempts. Psychiatry Res. 2006;144:65–72.PubMedCrossRef Nock MK, Joiner JTE, Gordon KH, Lloyd-Richardson E, Prinstein MJ. Non-suicidal self-injury among adolescents: diagnostic correlates and relation to suicide attempts. Psychiatry Res. 2006;144:65–72.PubMedCrossRef
83.
go back to reference Muehlenkamp JJ, Ertelt TW, Miller AL, Claes L. Borderline personality symptoms differentiate non-suicidal and suicidal self-injury in ethnically diverse adolescent outpatients. J Child Psychol Psychiatry Allied Discip. 2011;52:148–55.CrossRef Muehlenkamp JJ, Ertelt TW, Miller AL, Claes L. Borderline personality symptoms differentiate non-suicidal and suicidal self-injury in ethnically diverse adolescent outpatients. J Child Psychol Psychiatry Allied Discip. 2011;52:148–55.CrossRef
84.
go back to reference Jacobson CM, Muehlenkamp JJ, Miller AL, Turner JB. Psychiatric impairment among adolescents engaging in different types of deliberate self-harm. J Clin Child Adolesc Psychol. 2008;37:363–75.PubMedCrossRef Jacobson CM, Muehlenkamp JJ, Miller AL, Turner JB. Psychiatric impairment among adolescents engaging in different types of deliberate self-harm. J Clin Child Adolesc Psychol. 2008;37:363–75.PubMedCrossRef
85.
go back to reference Crick NR, Murray-Close D, Woods K. Borderline personality features in childhood: a short-term longitudinal study. Dev Psychopathol. 2005;17:1051–70.PubMedCrossRef Crick NR, Murray-Close D, Woods K. Borderline personality features in childhood: a short-term longitudinal study. Dev Psychopathol. 2005;17:1051–70.PubMedCrossRef
86.
go back to reference • Stepp SD, Pilkonis PA, Hipwell AE, Loeber R, Stouthamer-Loeber M. Stability of borderline personality disorder features in girls. J Personal Disord. 2010;24:460–72. This was the first large-scale, prospective study of the factor structure and stability of underlying BPD features (conceptualized as impulsivity, negative affectivity, and interpersonal aggression) in girls. These features could be reliably measured and were remarkably stable. This opens up the possibility of indicated prevention studies in children. CrossRef • Stepp SD, Pilkonis PA, Hipwell AE, Loeber R, Stouthamer-Loeber M. Stability of borderline personality disorder features in girls. J Personal Disord. 2010;24:460–72. This was the first large-scale, prospective study of the factor structure and stability of underlying BPD features (conceptualized as impulsivity, negative affectivity, and interpersonal aggression) in girls. These features could be reliably measured and were remarkably stable. This opens up the possibility of indicated prevention studies in children. CrossRef
87.
go back to reference Kasen S, Cohen P, Skodol AE, Johnson JG, Brook JS. Influence of child and adolescent psychiatric disorders on young adult personality disorder. Am J Psychiatry. 1999;156:1529–35.PubMed Kasen S, Cohen P, Skodol AE, Johnson JG, Brook JS. Influence of child and adolescent psychiatric disorders on young adult personality disorder. Am J Psychiatry. 1999;156:1529–35.PubMed
88.
go back to reference Bernstein DP, Cohen P, Velez CN, Schwab-Stone M, Siever LJ, Shinsato L. Prevalence and stability of the DSM-III-R personality disorders in a community-based survey of adolescents. Am J Psychiatry. 1993;150:1237–43.PubMed Bernstein DP, Cohen P, Velez CN, Schwab-Stone M, Siever LJ, Shinsato L. Prevalence and stability of the DSM-III-R personality disorders in a community-based survey of adolescents. Am J Psychiatry. 1993;150:1237–43.PubMed
89.
go back to reference Crawford TN, Cohen P, Brook JS. Dramatic-erratic personality disorder symptoms: I. Continuity from early adolescence into adulthood. J Personal Disord. 2001;15:319–35.CrossRef Crawford TN, Cohen P, Brook JS. Dramatic-erratic personality disorder symptoms: I. Continuity from early adolescence into adulthood. J Personal Disord. 2001;15:319–35.CrossRef
90.
go back to reference Crawford TN, Cohen P, Johnson JG, et al. Self-reported personality disorder in the Children in the Community Sample: convergent and prospective validity in late adolescence and adulthood. J Personal Disord. 2005;19:30–52.CrossRef Crawford TN, Cohen P, Johnson JG, et al. Self-reported personality disorder in the Children in the Community Sample: convergent and prospective validity in late adolescence and adulthood. J Personal Disord. 2005;19:30–52.CrossRef
91.
go back to reference Chanen AM, Jackson HJ, McGorry PD, Allott KA, Clarkson V, Yuen HP. Two-year stability of personality disorder in older adolescent outpatients. J Personal Disord. 2004;18:526–41.CrossRef Chanen AM, Jackson HJ, McGorry PD, Allott KA, Clarkson V, Yuen HP. Two-year stability of personality disorder in older adolescent outpatients. J Personal Disord. 2004;18:526–41.CrossRef
92.
go back to reference Stone MH. The borderline syndromes: constitution, personality, and adaptation. McGraw-Hill: New York; 1980. Stone MH. The borderline syndromes: constitution, personality, and adaptation. McGraw-Hill: New York; 1980.
93.
go back to reference Kessler RC, Price RH. Primary prevention of secondary disorders: a proposal and agenda. Am J Community Psychol. 1993;21:607–33.PubMedCrossRef Kessler RC, Price RH. Primary prevention of secondary disorders: a proposal and agenda. Am J Community Psychol. 1993;21:607–33.PubMedCrossRef
94.
go back to reference Chanen AM, Jackson HJ, McCutcheon L, et al. Early intervention for adolescents with borderline personality disorder using cognitive analytic therapy: a randomised controlled trial. Br J Psychiatry. 2008;193:477–84.PubMedCrossRef Chanen AM, Jackson HJ, McCutcheon L, et al. Early intervention for adolescents with borderline personality disorder using cognitive analytic therapy: a randomised controlled trial. Br J Psychiatry. 2008;193:477–84.PubMedCrossRef
95.
go back to reference Chanen AM, McCutcheon L, Germano D, Nistico H, Jackson HJ, McGorry PD. The HYPE Clinic: an early intervention service for borderline personality disorder. J Psychiatr Pract. 2009;15:163–72.PubMedCrossRef Chanen AM, McCutcheon L, Germano D, Nistico H, Jackson HJ, McGorry PD. The HYPE Clinic: an early intervention service for borderline personality disorder. J Psychiatr Pract. 2009;15:163–72.PubMedCrossRef
96.
go back to reference Schuppert H, Giesen-Bloo J, van Gemert T, et al. Effectiveness of an emotion regulation group training for adolescents-a randomized controlled pilot study. Clin Psychol Psychother. 2009;16:467–78.PubMedCrossRef Schuppert H, Giesen-Bloo J, van Gemert T, et al. Effectiveness of an emotion regulation group training for adolescents-a randomized controlled pilot study. Clin Psychol Psychother. 2009;16:467–78.PubMedCrossRef
97.
go back to reference McGorry PD, Hickie IB, Yung AR, Pantelis C, Jackson HJ. Clinical staging of psychiatric disorders: a heuristic framework for choosing earlier, safer and more effective interventions. Aust N Z J Psychiatry. 2006;40:616–22.PubMedCrossRef McGorry PD, Hickie IB, Yung AR, Pantelis C, Jackson HJ. Clinical staging of psychiatric disorders: a heuristic framework for choosing earlier, safer and more effective interventions. Aust N Z J Psychiatry. 2006;40:616–22.PubMedCrossRef
98.
go back to reference McGorry PD. Issues for DSM-V: clinical staging: a heuristic pathway to valid nosology and safer, more effective treatment in psychiatry. Am J Psychiatry. 2007;164:859–60.PubMedCrossRef McGorry PD. Issues for DSM-V: clinical staging: a heuristic pathway to valid nosology and safer, more effective treatment in psychiatry. Am J Psychiatry. 2007;164:859–60.PubMedCrossRef
Metadata
Title
Developmental Pathways to Borderline Personality Disorder
Authors
Andrew M. Chanen
Michael Kaess
Publication date
01-02-2012
Publisher
Current Science Inc.
Published in
Current Psychiatry Reports / Issue 1/2012
Print ISSN: 1523-3812
Electronic ISSN: 1535-1645
DOI
https://doi.org/10.1007/s11920-011-0242-y

Other articles of this Issue 1/2012

Current Psychiatry Reports 1/2012 Go to the issue

MEDICOPSYCHIATRIC DISORDERS (WJ KATON, SECTION EDITOR)

Depression and Mortality in End-Stage Renal Disease

MEDICOPSYCHIATRIC DISORDERS (WJ KATON, SECTION EDITOR)

Serious Psychological Distress and Diabetes: A Review of the Literature

MEDICOPSYCHIATRIC DISORDERS (WJ KATON, SECTION EDITOR)

Asthma and Suicide: Current Knowledge and Future Directions