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Published in: Current Psychiatry Reports 6/2010

01-12-2010

An Overview of Mood Disorders in the DSM-5

Author: Jan Fawcett

Published in: Current Psychiatry Reports | Issue 6/2010

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Abstract

The process of revising the DSM, which is based on new findings in the literature and experience with the current classification, is initiated every 12–18 years. The process for the revision of DSM-IV to the DSM-5 began in 2006—after a series of meeting proceedings and monographs were published during the previous 3 years—with the appointment of diagnostic group chairs by Director Dr. David Kupfer and Vice Director Dr. Darrel Regier. Members were recruited for workgroups to review the existing DSM-IV, to decide what worked well and which areas needed change, to review the available literature and data, and to propose changes based on an appropriate level of evidence in the literature proportional to the significance of the change. At the halfway point in this process, the Mood Disorders Workgroup has made tentative recommendations to be tested in field trials. These recommendations and some of the basis for them are discussed in this review. Final decisions await the data from field trials, possible revisions by the workgroups, and action by the task force. This article describes some of the recommendations made by the Mood Disorders Workgroup at this point in the process.
Literature
1.
go back to reference Moreno C, Laje G, Blanco C, et al.: National trends in the outpatient diagnosis and treatment of bipolar disorder in youth. Arch gen Psychiatry 2007, 64:1032–1039.CrossRefPubMed Moreno C, Laje G, Blanco C, et al.: National trends in the outpatient diagnosis and treatment of bipolar disorder in youth. Arch gen Psychiatry 2007, 64:1032–1039.CrossRefPubMed
2.
go back to reference Spearing M, Post RM, Leverich GS, et al.: Modification of the Clinical Global Impression (CGI) scale for use in bipolar illness: the CGI-BP. Psychiatry Res 1997, 73:159–171.CrossRefPubMed Spearing M, Post RM, Leverich GS, et al.: Modification of the Clinical Global Impression (CGI) scale for use in bipolar illness: the CGI-BP. Psychiatry Res 1997, 73:159–171.CrossRefPubMed
3.
go back to reference Kroenke K, Spitzer RL, Williams JB, Lowe B: The Patient Health Questionnaire, somatic, anxiety and depressive symptom scales: a systematic review. Gen Hosp Psychiatry 2010, 32:345–359.CrossRefPubMed Kroenke K, Spitzer RL, Williams JB, Lowe B: The Patient Health Questionnaire, somatic, anxiety and depressive symptom scales: a systematic review. Gen Hosp Psychiatry 2010, 32:345–359.CrossRefPubMed
4.
go back to reference Keller MB, Lavori PW, Friedman B, et al.: The Longitudinal Interval Follow-up Evaluation. A comprehensive method for assessing outcome in prospective longitudinal studies. Arch Gen Psychiatry 1987, 44:540–548.PubMed Keller MB, Lavori PW, Friedman B, et al.: The Longitudinal Interval Follow-up Evaluation. A comprehensive method for assessing outcome in prospective longitudinal studies. Arch Gen Psychiatry 1987, 44:540–548.PubMed
5.
go back to reference Altman EG, Hedeker D, Peterson JL, Davis JM: The Altman Self-Rating Mania Scale. Biol Psychiatry 1997, 42:948–955.CrossRefPubMed Altman EG, Hedeker D, Peterson JL, Davis JM: The Altman Self-Rating Mania Scale. Biol Psychiatry 1997, 42:948–955.CrossRefPubMed
6.
go back to reference McKibbin C, Patterson T, Jeste DV: Assessing disability in older patients with schizophrenia: results from the WHODAS II. J Nerv Ment Dis 2004, 192:405–413.CrossRefPubMed McKibbin C, Patterson T, Jeste DV: Assessing disability in older patients with schizophrenia: results from the WHODAS II. J Nerv Ment Dis 2004, 192:405–413.CrossRefPubMed
7.
go back to reference • Fava M, Rush AJ, Alpert JD, et al.: Difference in treatment outcome in patients with anxious vs non-anxious depression: a STAR*D report. Am J Psychiatry 2008, 165:342–351. This analysis of STAR*D outcome data in patients with major depression showed that patients with higher levels of anxiety had significantly poorer responses to antidepressant medications. CrossRefPubMed • Fava M, Rush AJ, Alpert JD, et al.: Difference in treatment outcome in patients with anxious vs non-anxious depression: a STAR*D report. Am J Psychiatry 2008, 165:342–351. This analysis of STAR*D outcome data in patients with major depression showed that patients with higher levels of anxiety had significantly poorer responses to antidepressant medications. CrossRefPubMed
8.
go back to reference Papakostas GI, McGrath P, Stewart J, et al.: Psychic and somatic anxiety as predictors of response to fluoxetine in major depressive disorder. Psychiatry Res 2008, 161:116–120.CrossRefPubMed Papakostas GI, McGrath P, Stewart J, et al.: Psychic and somatic anxiety as predictors of response to fluoxetine in major depressive disorder. Psychiatry Res 2008, 161:116–120.CrossRefPubMed
9.
go back to reference Howland RH, Rush AJ, Wisniewshi SR, et al.: Concurrent anxiety and substance abuse disorders among outpatients with major depression: clinical features and effect on treatment outcome. Drug Alcohol Depend 2009, 99:248–260.CrossRefPubMed Howland RH, Rush AJ, Wisniewshi SR, et al.: Concurrent anxiety and substance abuse disorders among outpatients with major depression: clinical features and effect on treatment outcome. Drug Alcohol Depend 2009, 99:248–260.CrossRefPubMed
10.
go back to reference Yang H, Chuzi S, Sinicropi-Yao L, et al.: Type of residual symptom and risk of relapse during the continuation/maintenance phase treatment of major depressive disorder with the selective serotonin reuptake inhibitor fluoxetine. Eur Arch Psychiatry Clin Neurosci 2010, 260:145–150.CrossRefPubMed Yang H, Chuzi S, Sinicropi-Yao L, et al.: Type of residual symptom and risk of relapse during the continuation/maintenance phase treatment of major depressive disorder with the selective serotonin reuptake inhibitor fluoxetine. Eur Arch Psychiatry Clin Neurosci 2010, 260:145–150.CrossRefPubMed
11.
12.
go back to reference • Coryell W, Soloman DA, Fiedorowicz JG, et al.: Anxiety and outcome in bipolar disorder. Am J Psychiatry 2009, 166:1238–1243. This analysis of the Collaborative Depression Study of bipolar patients showed that high psychic and somatic anxiety scores on the SADS-C scales at baseline are associated with a stepwise increase in time spent in a depressive episode over 5-year periods during a 20-year follow-up. CrossRefPubMed • Coryell W, Soloman DA, Fiedorowicz JG, et al.: Anxiety and outcome in bipolar disorder. Am J Psychiatry 2009, 166:1238–1243. This analysis of the Collaborative Depression Study of bipolar patients showed that high psychic and somatic anxiety scores on the SADS-C scales at baseline are associated with a stepwise increase in time spent in a depressive episode over 5-year periods during a 20-year follow-up. CrossRefPubMed
13.
go back to reference Fawcett J, Scheftner WA, Fogg L, et al.: Time related predictors of suicide in major depressive disorder. Am J Psychiatry 1990, 147:1189–1194.PubMed Fawcett J, Scheftner WA, Fogg L, et al.: Time related predictors of suicide in major depressive disorder. Am J Psychiatry 1990, 147:1189–1194.PubMed
14.
go back to reference Busch KA, Fawcett J, Jacobs D: Clinical correlates of inpatient suicide. J Clin Psychiatry 2003, 64:14–19.CrossRefPubMed Busch KA, Fawcett J, Jacobs D: Clinical correlates of inpatient suicide. J Clin Psychiatry 2003, 64:14–19.CrossRefPubMed
15.
go back to reference Simon GE, Hunkeler E, Fireman B, et al.: Risk of suicide and suicide death in patients treated for bipolar disorder. Bipolar Disord 2007, 9:526–530.CrossRefPubMed Simon GE, Hunkeler E, Fireman B, et al.: Risk of suicide and suicide death in patients treated for bipolar disorder. Bipolar Disord 2007, 9:526–530.CrossRefPubMed
16.
go back to reference • Pfeiffer PN, Ganoczy D, Ligen M, et al.: Comorbid anxiety as a suicide risk factor among depressed veterans. Depress Anxiety 2009, 26:752–757. This follow-up study of more than 800,000 depressed veterans found significantly higher rates of suicide among patients with comorbid generalized anxiety disorder, panic disorder, and anxiety NOS disorder, but not in the case of other anxiety disorders, including post-traumatic stress disorder. Furthermore, patients receiving antianxiety treatment had elevated rates of suicide, and these rates were elevated further if the patient was receiving high-dose antianxiety medications, suggesting a relationship between anxiety severity and suicide risk. CrossRefPubMed • Pfeiffer PN, Ganoczy D, Ligen M, et al.: Comorbid anxiety as a suicide risk factor among depressed veterans. Depress Anxiety 2009, 26:752–757. This follow-up study of more than 800,000 depressed veterans found significantly higher rates of suicide among patients with comorbid generalized anxiety disorder, panic disorder, and anxiety NOS disorder, but not in the case of other anxiety disorders, including post-traumatic stress disorder. Furthermore, patients receiving antianxiety treatment had elevated rates of suicide, and these rates were elevated further if the patient was receiving high-dose antianxiety medications, suggesting a relationship between anxiety severity and suicide risk. CrossRefPubMed
17.
go back to reference Clayton PJ, Grove WM, Coryell WM, et al.: Follow up and family study of anxious depression. Am J Psychiatry 1991, 148:1512–1517.PubMed Clayton PJ, Grove WM, Coryell WM, et al.: Follow up and family study of anxious depression. Am J Psychiatry 1991, 148:1512–1517.PubMed
18.
go back to reference Oquendo MA, Malone KM, Ellis SP, et al.: Inadequacy of antidepressant treatment for patients with major depression who are at risk for suicidal behavior. Am J Psychiatry 1999, 156:190.PubMed Oquendo MA, Malone KM, Ellis SP, et al.: Inadequacy of antidepressant treatment for patients with major depression who are at risk for suicidal behavior. Am J Psychiatry 1999, 156:190.PubMed
19.
go back to reference Harris EC, Barraclough B: Suicide as an outcome for mental disorders. A meta-analysis. Br J Psychiatry 1997, 170:205–228.CrossRefPubMed Harris EC, Barraclough B: Suicide as an outcome for mental disorders. A meta-analysis. Br J Psychiatry 1997, 170:205–228.CrossRefPubMed
20.
go back to reference Coryell W, Young EA: Clinical predictors of suicide in primary major depressive disorder. J Clin Psychiatry 2005, 66:412–417.CrossRefPubMed Coryell W, Young EA: Clinical predictors of suicide in primary major depressive disorder. J Clin Psychiatry 2005, 66:412–417.CrossRefPubMed
21.
go back to reference Oquendo M, Currier D, Mann JJ: Prospective studies of suicidal behavior in major depressive and bipolar disorders: what is the evidence for predictive risk factors? Acta Psychiatr Scand 2006, 114:151–158.CrossRefPubMed Oquendo M, Currier D, Mann JJ: Prospective studies of suicidal behavior in major depressive and bipolar disorders: what is the evidence for predictive risk factors? Acta Psychiatr Scand 2006, 114:151–158.CrossRefPubMed
22.
go back to reference Marangell LB, Bauer MS, Dennehy EB, et al.: Prospective predictors of suicide and suicide attempts in 1,556 patients with bipolar disorders followed up to 2 years. Bipolar Disord 2006, 8:566–575.CrossRefPubMed Marangell LB, Bauer MS, Dennehy EB, et al.: Prospective predictors of suicide and suicide attempts in 1,556 patients with bipolar disorders followed up to 2 years. Bipolar Disord 2006, 8:566–575.CrossRefPubMed
23.
go back to reference Baldessarini RJ, Hennen J: Genetics of suicide: an overview. Harv Rev Psychiatry 2004, 12:1–13.PubMed Baldessarini RJ, Hennen J: Genetics of suicide: an overview. Harv Rev Psychiatry 2004, 12:1–13.PubMed
24.
go back to reference Brent DS, Melham N: Familial transmission of suicidal behavior. Psychiatr Clin North Am 2008, 31:157–177.CrossRefPubMed Brent DS, Melham N: Familial transmission of suicidal behavior. Psychiatr Clin North Am 2008, 31:157–177.CrossRefPubMed
25.
go back to reference Sarrchiapone M, Carli V, Giannantonio MD, Roy A: Risk factors for attempting suicide in prisoners. Suicide Life Threat Behav 2009, 39:343–350.CrossRef Sarrchiapone M, Carli V, Giannantonio MD, Roy A: Risk factors for attempting suicide in prisoners. Suicide Life Threat Behav 2009, 39:343–350.CrossRef
26.
go back to reference Roy A, Gorodelsky E, Yuan Q, et al.: Neuropsychopharmacology 2010, 35:1674–1683.PubMed Roy A, Gorodelsky E, Yuan Q, et al.: Neuropsychopharmacology 2010, 35:1674–1683.PubMed
27.
go back to reference Isometsa ET, Lonnqyist JK: Suicide attempts preceding suicide. Br J Psychiatry 1998, 173:531–535.CrossRefPubMed Isometsa ET, Lonnqyist JK: Suicide attempts preceding suicide. Br J Psychiatry 1998, 173:531–535.CrossRefPubMed
28.
go back to reference Isometsa ET, Heikkinen ME, Martunen MJ, et al.: The last appointment before suicide: is suicide intent communicated? Am J Psychiatry 1995, 152:919–922.PubMed Isometsa ET, Heikkinen ME, Martunen MJ, et al.: The last appointment before suicide: is suicide intent communicated? Am J Psychiatry 1995, 152:919–922.PubMed
29.
go back to reference Sachs GS, Nierenberg AA, Calabrese JR, et al.: Effectiveness of adjunctive antidepressant treatment for bipolar depression. N Engl J Med 2007, 356:1711–1722.CrossRefPubMed Sachs GS, Nierenberg AA, Calabrese JR, et al.: Effectiveness of adjunctive antidepressant treatment for bipolar depression. N Engl J Med 2007, 356:1711–1722.CrossRefPubMed
30.
go back to reference Truman CJ, Goldberg JF, Ghaemi SN, et al.: Self-reported history of manic/hypomanic switch associated with antidepressant use: data from Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). J Clin Psychiatry 2007, 68:1472–1479.CrossRefPubMed Truman CJ, Goldberg JF, Ghaemi SN, et al.: Self-reported history of manic/hypomanic switch associated with antidepressant use: data from Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). J Clin Psychiatry 2007, 68:1472–1479.CrossRefPubMed
31.
go back to reference Holma KM, Melartin TK, Holma IA, Isometsa ET: Predictors for switch from unipolar major depressive disorder to bipolar disorder type I or II: a 5 year prospective study. J Clin Psychiatry 2008, 69:1267–1275.CrossRefPubMed Holma KM, Melartin TK, Holma IA, Isometsa ET: Predictors for switch from unipolar major depressive disorder to bipolar disorder type I or II: a 5 year prospective study. J Clin Psychiatry 2008, 69:1267–1275.CrossRefPubMed
32.
go back to reference Ghaemi SN, Ostracher MM, El-Mallakh RS, et al.: Antidepressant discontinuation in bipolar depression: a Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) randomized clinical trial of long-term effectiveness and safety. J Clin Psychiatry 2010, 71:372–380.CrossRefPubMed Ghaemi SN, Ostracher MM, El-Mallakh RS, et al.: Antidepressant discontinuation in bipolar depression: a Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) randomized clinical trial of long-term effectiveness and safety. J Clin Psychiatry 2010, 71:372–380.CrossRefPubMed
33.
go back to reference Goldberg JF, Perlis RH, Bowden CL, et al.: Manic symptoms during depressive episodes in 1,380 patients with bipolar disorder: findings from the STEP-BD. Am J Psychiatry 2009, 166:173–181.CrossRefPubMed Goldberg JF, Perlis RH, Bowden CL, et al.: Manic symptoms during depressive episodes in 1,380 patients with bipolar disorder: findings from the STEP-BD. Am J Psychiatry 2009, 166:173–181.CrossRefPubMed
34.
go back to reference Calabrese JR, Muzina DJ, Kemp DE, et al.: Predictors of bipolar disorder risk among patients currently treated for major depression. MedGenMed 2006, 15:38. Calabrese JR, Muzina DJ, Kemp DE, et al.: Predictors of bipolar disorder risk among patients currently treated for major depression. MedGenMed 2006, 15:38.
35.
go back to reference Zimmermann P, Brucki T, Nocon A, et al.: Heterogeneity of DSM-IV major depressive disorder as a consequence of subthreshold bipolarity. Arch Gen Psychiatry 2009, 66:1341–1352.CrossRefPubMed Zimmermann P, Brucki T, Nocon A, et al.: Heterogeneity of DSM-IV major depressive disorder as a consequence of subthreshold bipolarity. Arch Gen Psychiatry 2009, 66:1341–1352.CrossRefPubMed
36.
go back to reference Agosti V, Stewart JW: Hypomania with and without dysphoria: comparison and clinical characteristics of respondents from a national community sample. J Affect Disord 2008, 108:177–182.CrossRefPubMed Agosti V, Stewart JW: Hypomania with and without dysphoria: comparison and clinical characteristics of respondents from a national community sample. J Affect Disord 2008, 108:177–182.CrossRefPubMed
37.
go back to reference Kendler KS, Myers J, Zisook S: Does bereavement-related major depression differ from major depression associated with other stressful life events? Am J Psychiatry 2008, 165:1449–1455.CrossRefPubMed Kendler KS, Myers J, Zisook S: Does bereavement-related major depression differ from major depression associated with other stressful life events? Am J Psychiatry 2008, 165:1449–1455.CrossRefPubMed
Metadata
Title
An Overview of Mood Disorders in the DSM-5
Author
Jan Fawcett
Publication date
01-12-2010
Publisher
Current Science Inc.
Published in
Current Psychiatry Reports / Issue 6/2010
Print ISSN: 1523-3812
Electronic ISSN: 1535-1645
DOI
https://doi.org/10.1007/s11920-010-0154-2

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