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Current Pain and Headache Reports
Published in: Current Pain and Headache Reports 11/2014

01-11-2014 | Migraine (R Cowan, Section Editor)

Update on Animal Models of Migraine

Authors: Marcela Romero-Reyes, Simon Akerman

Published in: Current Pain and Headache Reports | Issue 11/2014

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Abstract

Migraine is a severe and debilitating disorder of the brain that involves a constellation of neurological symptoms alongside head pain. Its pathophysiology is only beginning to be understood, and is thought to involve activation and sensitization of trigeminovascular nociceptive pathways that innervate the cranial vasculature, and activation of brain stem nuclei. Much of our understanding of migraine pathophysiology stems from research conducted in animal models over the last 30 years, and the development of unique assays in animals that try to model specific aspects of migraine pathophysiology related to particular symptoms. This review will highlight some of the latest findings from these established animal models, as well as discuss the latest in the development of novel approaches in animals to study migraine
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Metadata
Title
Update on Animal Models of Migraine
Authors
Marcela Romero-Reyes
Simon Akerman
Publication date
01-11-2014
Publisher
Springer US
Published in
Current Pain and Headache Reports / Issue 11/2014
Print ISSN: 1531-3433
Electronic ISSN: 1534-3081
DOI
https://doi.org/10.1007/s11916-014-0462-z

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