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01-09-2013 | Neuropathic Pain (E Eisenberg, Section Editor)

Conditioned Pain Modulation: A Predictor for Development and Treatment of Neuropathic Pain

Author: Yelena Granovsky

Published in: Current Pain and Headache Reports | Issue 9/2013

Abstract

Psychophysical evaluation of endogenous pain inhibition via conditioned pain modulation (CPM) represents a new generation of laboratory tests for pain assessment. In this review we discuss recent findings on CPM in neuropathic pain and refer to psychophysical, neurophysiological, and methodological aspects of its clinical implications. Typically, chronic neuropathic pain patients express less efficient CPM, to the extent that incidence of acquiring neuropathic pain (e.g. post-surgery) and its intensity can be predicted by a pre-surgery CPM assessment. Moreover, pre-treatment CPM evaluation may assist in the correct choice of serotonin-noradrenalin reuptake inhibitor analgesic agents for individual patients. Evaluation of pain modulation capabilities can serve as a step forward in individualizing pain medicine.

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Title: Conditioned Pain Modulation: A Predictor for Development and Treatment of Neuropathic Pain
Author: Yelena Granovsky
Publication date: 01-09-2013
Publisher: Springer US
Published in: Current Pain and Headache Reports / Issue 9/2013
Print ISSN: 1531-3433
Electronic ISSN: 1534-3081
DOI: https://doi.org/10.1007/s11916-013-0361-8

At a glance: The STEP trials

Springer Medicine

Conditioned Pain Modulation: A Predictor for Development and Treatment of Neuropathic Pain

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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