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Published in: Current Pain and Headache Reports 1/2012

01-02-2012 | Chronic Daily Headache (SJ Wang, Section Editor)

Obesity and Chronic Daily Headache

Authors: Marcelo E. Bigal, Alan M. Rapoport

Published in: Current Pain and Headache Reports | Issue 1/2012

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Abstract

Obesity may be the greatest epidemic of modern times. It leads to diabetes and heart disease and shortens lifespan. Although not a risk factor for migraine, it is associated with an increased frequency and intensity of migraine. Obesity is also comorbid with chronic daily headache and is a major risk factor for chronification of episodic migraine in adults and children. Although obesity is not a factor in the effectiveness of migraine treatment, it does increase the peripheral and central events in migraine, ultimately increasing the neurologic potential for migraine. Although evidence suggests that obesity is a modifiable risk factor for migraine progression, it is unknown if weight loss is related to decrease in headache frequency. Recent surgical results suggest that this is true. We suggest all possible effective techniques aimed at weight loss be undertaken for migraineurs, especially obese migraineurs, and that carefully monitoring weight changes should be routinely done as part of their migraine care.
Literature
1.
go back to reference Gelber RP, Gaziano JM, Orav EJ, et al. Measures of obesity and cardiovascular risk among men and women. J Am Coll Cardiol. 2008;52:605–15.PubMedCrossRef Gelber RP, Gaziano JM, Orav EJ, et al. Measures of obesity and cardiovascular risk among men and women. J Am Coll Cardiol. 2008;52:605–15.PubMedCrossRef
2.
go back to reference Tzamaloukas AH, Murata GH, Hoffman RM, et al. Classification of the degree of obesity by body mass index or by deviation from ideal weight. JPEN J Parenter Enteral Nutr. 2003;27:340–8.PubMedCrossRef Tzamaloukas AH, Murata GH, Hoffman RM, et al. Classification of the degree of obesity by body mass index or by deviation from ideal weight. JPEN J Parenter Enteral Nutr. 2003;27:340–8.PubMedCrossRef
3.
go back to reference •• National Center for Chronic Disease Prevention and Health Promotion. Overweight and obesity: obesity trends. Vol. 2011, 2011. This is a pivotal source of data on obesity from the Centers for Disease Control. •• National Center for Chronic Disease Prevention and Health Promotion. Overweight and obesity: obesity trends. Vol. 2011, 2011. This is a pivotal source of data on obesity from the Centers for Disease Control.
4.
go back to reference Sturm R. Stemming the global obesity epidemic: what can we learn from data about social and economic trends? Public Health. 2008;122:739–46.PubMedCrossRef Sturm R. Stemming the global obesity epidemic: what can we learn from data about social and economic trends? Public Health. 2008;122:739–46.PubMedCrossRef
5.
go back to reference de Onis M, Blossner M, Borghi E. Global prevalence and trends of overweight and obesity among preschool children. Am J Clin Nutr. 2010;92:1257–64.PubMedCrossRef de Onis M, Blossner M, Borghi E. Global prevalence and trends of overweight and obesity among preschool children. Am J Clin Nutr. 2010;92:1257–64.PubMedCrossRef
6.
go back to reference Deurenberg P, Yap M. The assessment of obesity: methods for measuring body fat and global prevalence of obesity. Baillieres Best Pract Res Clin Endocrinol Metab. 1999;13:1–11.PubMedCrossRef Deurenberg P, Yap M. The assessment of obesity: methods for measuring body fat and global prevalence of obesity. Baillieres Best Pract Res Clin Endocrinol Metab. 1999;13:1–11.PubMedCrossRef
7.
go back to reference Gurney M, Gorstein J. The global prevalence of obesity—an initial overview of available data. World Health Stat Q. 1988;41:251–4.PubMed Gurney M, Gorstein J. The global prevalence of obesity—an initial overview of available data. World Health Stat Q. 1988;41:251–4.PubMed
8.
go back to reference Finkelstein EA, Fiebelkorn IC, Wang G. State-level estimates of annual medical expenditures attributable to obesity. Obes Res. 2004;12:18–24.PubMedCrossRef Finkelstein EA, Fiebelkorn IC, Wang G. State-level estimates of annual medical expenditures attributable to obesity. Obes Res. 2004;12:18–24.PubMedCrossRef
9.
go back to reference Finkelstein EA, Fiebelkorn IC, Wang G. National medical spending attributable to overweight and obesity: how much, and who’s paying? Health Aff (Millwood). 2003;Suppl Web Exclusives:W3-219-226. Finkelstein EA, Fiebelkorn IC, Wang G. National medical spending attributable to overweight and obesity: how much, and who’s paying? Health Aff (Millwood). 2003;Suppl Web Exclusives:W3-219-226.
10.
go back to reference Leonardi M, Steiner TJ, Scher AT, Lipton RB. The global burden of migraine: measuring disability in headache disorders with WHO’s classification of functioning, disability and health (ICF). J Headache Pain. 2005;6:429–40.PubMedCrossRef Leonardi M, Steiner TJ, Scher AT, Lipton RB. The global burden of migraine: measuring disability in headache disorders with WHO’s classification of functioning, disability and health (ICF). J Headache Pain. 2005;6:429–40.PubMedCrossRef
11.
go back to reference Lipton RB, Bigal ME, Diamond M, et al. Migraine prevalence, disease burden, and the need for preventive therapy. Neurology. 2007;68:343–9.PubMedCrossRef Lipton RB, Bigal ME, Diamond M, et al. Migraine prevalence, disease burden, and the need for preventive therapy. Neurology. 2007;68:343–9.PubMedCrossRef
13.
14.
go back to reference Lipton RB, Bigal ME. Migraine: epidemiology, impact, and risk factors for progression. Headache. 2005;45 Suppl 1:S3–S13.PubMedCrossRef Lipton RB, Bigal ME. Migraine: epidemiology, impact, and risk factors for progression. Headache. 2005;45 Suppl 1:S3–S13.PubMedCrossRef
15.
go back to reference Yunus MB, Arslan S, Aldag JC. Relationship between body mass index and fibromyalgia features. Scand J Rheumatol. 2002;31:27–31.PubMedCrossRef Yunus MB, Arslan S, Aldag JC. Relationship between body mass index and fibromyalgia features. Scand J Rheumatol. 2002;31:27–31.PubMedCrossRef
16.
go back to reference Webb R, Brammah T, Lunt M, et al. Prevalence and predictors of intense, chronic, and disabling neck and back pain in the UK general population. Spine (Phila Pa 1976). 2003;28:1195–202. Webb R, Brammah T, Lunt M, et al. Prevalence and predictors of intense, chronic, and disabling neck and back pain in the UK general population. Spine (Phila Pa 1976). 2003;28:1195–202.
17.
go back to reference McCarthy LH, Bigal ME, Katz M, et al. Chronic pain and obesity in elderly people: results from the Einstein aging study. J Am Geriatr Soc. 2009;57:115–9.PubMedCrossRef McCarthy LH, Bigal ME, Katz M, et al. Chronic pain and obesity in elderly people: results from the Einstein aging study. J Am Geriatr Soc. 2009;57:115–9.PubMedCrossRef
18.
go back to reference Bigal ME, Liberman JN, Lipton RB. Obesity and migraine: a population study. Neurology. 2006;66:545–50.PubMedCrossRef Bigal ME, Liberman JN, Lipton RB. Obesity and migraine: a population study. Neurology. 2006;66:545–50.PubMedCrossRef
19.
go back to reference Winter AC, Berger K, Buring JE, Kurth T. Body mass index, migraine, migraine frequency and migraine features in women. Cephalalgia. 2009;29:269–78.PubMedCrossRef Winter AC, Berger K, Buring JE, Kurth T. Body mass index, migraine, migraine frequency and migraine features in women. Cephalalgia. 2009;29:269–78.PubMedCrossRef
20.
go back to reference Scher AI, Stewart WF, Ricci JA, Lipton RB. Factors associated with the onset and remission of chronic daily headache in a population-based study. Pain. 2003;106:81–9.PubMedCrossRef Scher AI, Stewart WF, Ricci JA, Lipton RB. Factors associated with the onset and remission of chronic daily headache in a population-based study. Pain. 2003;106:81–9.PubMedCrossRef
21.
go back to reference Bigal ME, Lipton RB, Holland PR, Goadsby PJ. Obesity, migraine, and CM: possible mechanisms of interaction. Neurology. 2007;68:1851–61.PubMedCrossRef Bigal ME, Lipton RB, Holland PR, Goadsby PJ. Obesity, migraine, and CM: possible mechanisms of interaction. Neurology. 2007;68:1851–61.PubMedCrossRef
22.
go back to reference Bigal ME, Tsang A, Loder E, et al. Body mass index and episodic headaches: a population-based study. Arch Intern Med. 2007;167:1964–70.PubMedCrossRef Bigal ME, Tsang A, Loder E, et al. Body mass index and episodic headaches: a population-based study. Arch Intern Med. 2007;167:1964–70.PubMedCrossRef
24.
go back to reference Shakir SA, Layton D. Causal association in pharmacovigilance and pharmacoepidemiology: thoughts on the application of the Austin Bradford-Hill criteria. Drug Saf. 2002;25:467–71.PubMedCrossRef Shakir SA, Layton D. Causal association in pharmacovigilance and pharmacoepidemiology: thoughts on the application of the Austin Bradford-Hill criteria. Drug Saf. 2002;25:467–71.PubMedCrossRef
25.
go back to reference Recober A, Goadsby PJ. Calcitonin gene-related peptide: a molecular link between obesity and migraine? Drug News Perspect. 2010;23:112–7.PubMedCrossRef Recober A, Goadsby PJ. Calcitonin gene-related peptide: a molecular link between obesity and migraine? Drug News Perspect. 2010;23:112–7.PubMedCrossRef
26.
go back to reference • Hershey AD, Powers SW, Nelson TD, et al. Obesity in the pediatric headache population: a multicenter study. Headache. 2009;49:170–7. This was the first study to demonstrate that obesity was associated with increased headache headache frequency in the pediatric population. PubMedCrossRef • Hershey AD, Powers SW, Nelson TD, et al. Obesity in the pediatric headache population: a multicenter study. Headache. 2009;49:170–7. This was the first study to demonstrate that obesity was associated with increased headache headache frequency in the pediatric population. PubMedCrossRef
27.
go back to reference Kinik ST, Alehan F, Erol I, Kanra AR. Obesity and paediatric migraine. Cephalalgia. 2010;30:105–9.PubMed Kinik ST, Alehan F, Erol I, Kanra AR. Obesity and paediatric migraine. Cephalalgia. 2010;30:105–9.PubMed
28.
go back to reference Tietjen GE, Peterlin BL, Brandes JL, et al. Depression and anxiety: effect on the migraine-obesity relationship. Headache. 2007;47:866–75.PubMedCrossRef Tietjen GE, Peterlin BL, Brandes JL, et al. Depression and anxiety: effect on the migraine-obesity relationship. Headache. 2007;47:866–75.PubMedCrossRef
29.
go back to reference • Peterlin BL, Rosso AL, Rapoport AM, Scher AI. Obesity and migraine: the effect of age, gender and adipose tissue distribution. Headache. 2010;50:52–62. This is a study addressing obesity factors associated with the obesity/migraine influence. PubMedCrossRef • Peterlin BL, Rosso AL, Rapoport AM, Scher AI. Obesity and migraine: the effect of age, gender and adipose tissue distribution. Headache. 2010;50:52–62. This is a study addressing obesity factors associated with the obesity/migraine influence. PubMedCrossRef
30.
go back to reference Bigal ME, Gironda M, Tepper SJ, et al. Headache prevention outcome and body mass index. Cephalalgia. 2006;26:445–50.PubMedCrossRef Bigal ME, Gironda M, Tepper SJ, et al. Headache prevention outcome and body mass index. Cephalalgia. 2006;26:445–50.PubMedCrossRef
31.
go back to reference Bigal ME, Lipton RB, Biondi DM, et al. Weight change and clinical markers of cardiovascular disease risk during preventive treatment of migraine. Cephalalgia. 2009;29:1188–96.PubMedCrossRef Bigal ME, Lipton RB, Biondi DM, et al. Weight change and clinical markers of cardiovascular disease risk during preventive treatment of migraine. Cephalalgia. 2009;29:1188–96.PubMedCrossRef
32.
go back to reference Bigal ME, Lipton RB. Putative mechanisms of the relationship between obesity and migraine progression. Curr Pain Headache Rep. 2008;12:207–12.PubMedCrossRef Bigal ME, Lipton RB. Putative mechanisms of the relationship between obesity and migraine progression. Curr Pain Headache Rep. 2008;12:207–12.PubMedCrossRef
33.
go back to reference Weiller C, May A, Limmroth V, et al. Brain stem activation in spontaneous human migraine attacks. Nat Med. 1995;1:658–60.PubMedCrossRef Weiller C, May A, Limmroth V, et al. Brain stem activation in spontaneous human migraine attacks. Nat Med. 1995;1:658–60.PubMedCrossRef
34.
go back to reference Afridi S, Giffin NJ, Kaube H, et al. A PET study in spontaneous migraine. Arch Neurol. 2005;62:1270–5.PubMedCrossRef Afridi S, Giffin NJ, Kaube H, et al. A PET study in spontaneous migraine. Arch Neurol. 2005;62:1270–5.PubMedCrossRef
35.
go back to reference Matharu MS, Bartsch T, Ward N, et al. Central neuromodulation in chronic migraine patients with suboccipital stimulators: a PET study. Brain. 2004;127:220–30.PubMedCrossRef Matharu MS, Bartsch T, Ward N, et al. Central neuromodulation in chronic migraine patients with suboccipital stimulators: a PET study. Brain. 2004;127:220–30.PubMedCrossRef
36.
go back to reference Afridi S, Matharu MS, Lee L, et al. A PET study exploring the laterality of brainstem activation in migraine using glyceryl trinitrate. Brain. 2005;128:932–9.PubMedCrossRef Afridi S, Matharu MS, Lee L, et al. A PET study exploring the laterality of brainstem activation in migraine using glyceryl trinitrate. Brain. 2005;128:932–9.PubMedCrossRef
37.
go back to reference Bahra A, Matharu MS, Buchel C, et al. Brainstem activation specific to migraine headache. Lancet. 2001;357:1016–7.PubMedCrossRef Bahra A, Matharu MS, Buchel C, et al. Brainstem activation specific to migraine headache. Lancet. 2001;357:1016–7.PubMedCrossRef
38.
go back to reference Raskin NH, Hosobuchi Y, Lamb S. Headache may arise from perturbation of brain. Headache. 1987;27:416–20.PubMedCrossRef Raskin NH, Hosobuchi Y, Lamb S. Headache may arise from perturbation of brain. Headache. 1987;27:416–20.PubMedCrossRef
39.
go back to reference Veloso F, Kumar K, Toth C. Headache secondary to deep brain implantation. Headache. 1998;38:507–15.PubMedCrossRef Veloso F, Kumar K, Toth C. Headache secondary to deep brain implantation. Headache. 1998;38:507–15.PubMedCrossRef
40.
go back to reference Haas DC, Kent PF, Friedman DI. Headache caused by a single lesion of multiple sclerosis in the periaqueductal gray area. Headache. 1993;33:452–5.PubMedCrossRef Haas DC, Kent PF, Friedman DI. Headache caused by a single lesion of multiple sclerosis in the periaqueductal gray area. Headache. 1993;33:452–5.PubMedCrossRef
41.
go back to reference Goadsby PJ. Neurovascular headache and a midbrain vascular malformation- evidence for a role of the brainstem in chronic migraine. Cephalalgia. 2002;22:107–11.PubMedCrossRef Goadsby PJ. Neurovascular headache and a midbrain vascular malformation- evidence for a role of the brainstem in chronic migraine. Cephalalgia. 2002;22:107–11.PubMedCrossRef
42.
go back to reference Afridi S, Goadsby PJ. New onset migraine with a brainstem cavernous angioma. J Neurol Neurosurg Psychiatry. 2003;74:680–2.PubMedCrossRef Afridi S, Goadsby PJ. New onset migraine with a brainstem cavernous angioma. J Neurol Neurosurg Psychiatry. 2003;74:680–2.PubMedCrossRef
43.
go back to reference Obermann M, Gizewski ER, Limmroth V, et al. Symptomatic migraine and pontine vascular malformation: evidence for a key role of the brainstem in the pathophysiology of chronic migraine. Cephalalgia. 2006;26:763–6.PubMedCrossRef Obermann M, Gizewski ER, Limmroth V, et al. Symptomatic migraine and pontine vascular malformation: evidence for a key role of the brainstem in the pathophysiology of chronic migraine. Cephalalgia. 2006;26:763–6.PubMedCrossRef
44.
go back to reference Goadsby PJ, Edvinsson L, Ekman R. Release of vasoactive peptides in the extracerebral circulation of man and the cat during activation of the trigeminovascular system. Ann Neurol. 1988;23:193–6.PubMedCrossRef Goadsby PJ, Edvinsson L, Ekman R. Release of vasoactive peptides in the extracerebral circulation of man and the cat during activation of the trigeminovascular system. Ann Neurol. 1988;23:193–6.PubMedCrossRef
45.
go back to reference Goadsby PJ, Edvinsson L, Ekman R. Vasoactive peptide release in the extracerebral circulation of humans during migraine headache. Ann Neurol. 1990;28:183–7.PubMedCrossRef Goadsby PJ, Edvinsson L, Ekman R. Vasoactive peptide release in the extracerebral circulation of humans during migraine headache. Ann Neurol. 1990;28:183–7.PubMedCrossRef
46.
go back to reference Goadsby PJ. Calcitonin gene-related peptide antagonists as treatments of migraine and other primary headaches. Drugs. 2005;65:2557–67.PubMedCrossRef Goadsby PJ. Calcitonin gene-related peptide antagonists as treatments of migraine and other primary headaches. Drugs. 2005;65:2557–67.PubMedCrossRef
47.
go back to reference Flier JS. The adipocyte: storage depot or node on the energy information superhighway? Cell. 1995;80:15–8.PubMedCrossRef Flier JS. The adipocyte: storage depot or node on the energy information superhighway? Cell. 1995;80:15–8.PubMedCrossRef
48.
go back to reference Badman MK, Flier JS. The adipocyte as an active participant in energy balance and metabolism. Gastroenterology. 2007;132:2103–15.PubMedCrossRef Badman MK, Flier JS. The adipocyte as an active participant in energy balance and metabolism. Gastroenterology. 2007;132:2103–15.PubMedCrossRef
49.
go back to reference Mohamed-Ali V, Goodrick S, Rawesh A, et al. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo. J Clin Endocrinol Metab. 1997;82:4196–200.PubMedCrossRef Mohamed-Ali V, Goodrick S, Rawesh A, et al. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo. J Clin Endocrinol Metab. 1997;82:4196–200.PubMedCrossRef
50.
go back to reference Mohamed-Ali V, Flower L, Sethi J, et al. beta-Adrenergic regulation of IL-6 release from adipose tissue: in vivo and in vitro studies. J Clin Endocrinol Metab. 2001;86:5864–9.PubMedCrossRef Mohamed-Ali V, Flower L, Sethi J, et al. beta-Adrenergic regulation of IL-6 release from adipose tissue: in vivo and in vitro studies. J Clin Endocrinol Metab. 2001;86:5864–9.PubMedCrossRef
51.
go back to reference Curat CA, Wegner V, Sengenes C, et al. Macrophages in human visceral adipose tissue: increased accumulation in obesity and a source of resistin and visfatin. Diabetologia. 2006;49:744–7.PubMedCrossRef Curat CA, Wegner V, Sengenes C, et al. Macrophages in human visceral adipose tissue: increased accumulation in obesity and a source of resistin and visfatin. Diabetologia. 2006;49:744–7.PubMedCrossRef
52.
go back to reference Gram DX, Hansen AJ, Wilken M, et al. Plasma calcitonin gene-related peptide is increased prior to obesity, and sensory nerve desensitization by capsaicin improves oral glucose tolerance in obese Zucker rats. Eur J Endocrinol. 2005;153:963–9.PubMedCrossRef Gram DX, Hansen AJ, Wilken M, et al. Plasma calcitonin gene-related peptide is increased prior to obesity, and sensory nerve desensitization by capsaicin improves oral glucose tolerance in obese Zucker rats. Eur J Endocrinol. 2005;153:963–9.PubMedCrossRef
53.
go back to reference Altink ME, Slaats-Willemse DI, Rommelse NN, et al. Effects of maternal and paternal smoking on attentional control in children with and without ADHD. Eur Child Adolesc Psychiatry. 2009;18:465–75.PubMedCrossRef Altink ME, Slaats-Willemse DI, Rommelse NN, et al. Effects of maternal and paternal smoking on attentional control in children with and without ADHD. Eur Child Adolesc Psychiatry. 2009;18:465–75.PubMedCrossRef
54.
go back to reference Peterlin BL, Bigal ME, Tepper SJ, et al. Migraine and adiponectin: is there a connection? Cephalalgia. 2007;27:435–46.PubMedCrossRef Peterlin BL, Bigal ME, Tepper SJ, et al. Migraine and adiponectin: is there a connection? Cephalalgia. 2007;27:435–46.PubMedCrossRef
55.
go back to reference Peterlin BL, Alexander G, Tabby D, Reichenberger E. Oligomerization state-dependent elevations of adiponectin in chronic daily headache. Neurology. 2008;70:1905–11.PubMedCrossRef Peterlin BL, Alexander G, Tabby D, Reichenberger E. Oligomerization state-dependent elevations of adiponectin in chronic daily headache. Neurology. 2008;70:1905–11.PubMedCrossRef
56.
go back to reference Peterlin BL. The role of the adipocytokines adiponectin and leptin in migraine. J Am Osteopath Assoc. 2009;109:314–7.PubMed Peterlin BL. The role of the adipocytokines adiponectin and leptin in migraine. J Am Osteopath Assoc. 2009;109:314–7.PubMed
57.
go back to reference Kondo M, Shibata R, Miura R, et al. Caloric restriction stimulates revascularization in response to ischemia via adiponectin-mediated activation of endothelial nitric-oxide synthase. J Biol Chem. 2009;284:1718–24.PubMedCrossRef Kondo M, Shibata R, Miura R, et al. Caloric restriction stimulates revascularization in response to ischemia via adiponectin-mediated activation of endothelial nitric-oxide synthase. J Biol Chem. 2009;284:1718–24.PubMedCrossRef
58.
go back to reference Marcus JN, Aschkenasi CJ, Lee CE, et al. Differential expression of orexin receptors 1 and 2 in the rat brain. J Comp Neurol. 2001;435:6–25.PubMedCrossRef Marcus JN, Aschkenasi CJ, Lee CE, et al. Differential expression of orexin receptors 1 and 2 in the rat brain. J Comp Neurol. 2001;435:6–25.PubMedCrossRef
59.
go back to reference Estabrooke IV, McCarthy MT, Ko E, et al. Fos expression in orexin neurons varies with behavioral state. J Neurosci. 2001;21:1656–62.PubMed Estabrooke IV, McCarthy MT, Ko E, et al. Fos expression in orexin neurons varies with behavioral state. J Neurosci. 2001;21:1656–62.PubMed
60.
go back to reference Chemelli RM, Willie JT, Sinton CM, et al. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell. 1999;98:437–51.PubMedCrossRef Chemelli RM, Willie JT, Sinton CM, et al. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell. 1999;98:437–51.PubMedCrossRef
61.
go back to reference Bingham S, Davey PT, Babbs AJ, et al. Orexin-A, an hypothalamic peptide with analgesic properties. Pain. 2001;92:81–90.PubMedCrossRef Bingham S, Davey PT, Babbs AJ, et al. Orexin-A, an hypothalamic peptide with analgesic properties. Pain. 2001;92:81–90.PubMedCrossRef
62.
go back to reference Cheng JK, Chou RC, Hwang LL, Chiou LC. Antiallodynic effects of intrathecal orexins in a rat model of postoperative pain. J Pharmacol Exp Ther. 2003;307:1065–71.PubMedCrossRef Cheng JK, Chou RC, Hwang LL, Chiou LC. Antiallodynic effects of intrathecal orexins in a rat model of postoperative pain. J Pharmacol Exp Ther. 2003;307:1065–71.PubMedCrossRef
63.
go back to reference Kajiyama S, Kawamoto M, Shiraishi S, et al. Spinal orexin-1 receptors mediate anti-hyperalgesic effects of intrathecally-administered orexins in diabetic neuropathic pain model rats. Brain Res. 2005;1044:76–86.PubMedCrossRef Kajiyama S, Kawamoto M, Shiraishi S, et al. Spinal orexin-1 receptors mediate anti-hyperalgesic effects of intrathecally-administered orexins in diabetic neuropathic pain model rats. Brain Res. 2005;1044:76–86.PubMedCrossRef
64.
go back to reference Yamamoto T, Saito O, Shono K, et al. Anti-mechanical allodynic effect of intrathecal and intracerebroventricular injection of orexin-A in the rat neuropathic pain model. Neurosci Lett. 2003;347:183–6.PubMedCrossRef Yamamoto T, Saito O, Shono K, et al. Anti-mechanical allodynic effect of intrathecal and intracerebroventricular injection of orexin-A in the rat neuropathic pain model. Neurosci Lett. 2003;347:183–6.PubMedCrossRef
65.
go back to reference Baranowska B, Wolinska-Witort E, Martynska L, et al. Plasma orexin A, orexin B, leptin, neuropeptide Y (NPY) and insulin in obese women. Neuro Endocrinol Lett. 2005;26:293–6.PubMed Baranowska B, Wolinska-Witort E, Martynska L, et al. Plasma orexin A, orexin B, leptin, neuropeptide Y (NPY) and insulin in obese women. Neuro Endocrinol Lett. 2005;26:293–6.PubMed
66.
go back to reference Smart D. Orexins: a new family of neuropeptides. Br J Anaesth. 1999;83:695–7.PubMed Smart D. Orexins: a new family of neuropeptides. Br J Anaesth. 1999;83:695–7.PubMed
67.
go back to reference Overeem S, van Vliet JA, Lammers GJ, et al. The hypothalamus in episodic brain disorders. Lancet Neurol. 2002;1:437–44.PubMedCrossRef Overeem S, van Vliet JA, Lammers GJ, et al. The hypothalamus in episodic brain disorders. Lancet Neurol. 2002;1:437–44.PubMedCrossRef
68.
go back to reference Holland PR, Akerman S, Goadsby PJ. Orexin 1 receptor activation attenuates neurogenic dural vasodilation in an animal model of trigeminovascular nociception. J Pharmacol Exp Ther. 2005;315:1380–5.PubMedCrossRef Holland PR, Akerman S, Goadsby PJ. Orexin 1 receptor activation attenuates neurogenic dural vasodilation in an animal model of trigeminovascular nociception. J Pharmacol Exp Ther. 2005;315:1380–5.PubMedCrossRef
69.
go back to reference Bigal ME, Lipton RB. Modifiable risk factors for migraine progression. Headache. 2006;46:1334–43.PubMedCrossRef Bigal ME, Lipton RB. Modifiable risk factors for migraine progression. Headache. 2006;46:1334–43.PubMedCrossRef
70.
71.
go back to reference • Young WB. Preventive treatment of migraine: effect on weight. Curr Pain Headache Rep. 2008;12:201–6. This is an interesting review of the effects of preventive medication on weight. PubMedCrossRef • Young WB. Preventive treatment of migraine: effect on weight. Curr Pain Headache Rep. 2008;12:201–6. This is an interesting review of the effects of preventive medication on weight. PubMedCrossRef
72.
go back to reference Peterlin BL, Calhoun AH, Siegel S, Mathew NT. Rational combination therapy in refractory migraine. Headache. 2008;48:805–19.PubMedCrossRef Peterlin BL, Calhoun AH, Siegel S, Mathew NT. Rational combination therapy in refractory migraine. Headache. 2008;48:805–19.PubMedCrossRef
73.
go back to reference Novack V, Fuchs L, Lantsberg L, et al. Changes in headache frequency in premenopausal obese women with migraine after bariatric surgery: a case series. Cephalalgia. Published online 23 June 2011. Novack V, Fuchs L, Lantsberg L, et al. Changes in headache frequency in premenopausal obese women with migraine after bariatric surgery: a case series. Cephalalgia. Published online 23 June 2011.
74.
go back to reference Lee PB. Bariatric surgery in obese migraineurs: mounting evidence but important questions remain. Cephalalgia. 2011;31:1333–5.CrossRef Lee PB. Bariatric surgery in obese migraineurs: mounting evidence but important questions remain. Cephalalgia. 2011;31:1333–5.CrossRef
75.
go back to reference Bigal ME, Lipton RB. Obesity is a risk factor for transformed migraine but not chronic tension-type headache. Neurology. 2006;67:252–7.PubMedCrossRef Bigal ME, Lipton RB. Obesity is a risk factor for transformed migraine but not chronic tension-type headache. Neurology. 2006;67:252–7.PubMedCrossRef
Metadata
Title
Obesity and Chronic Daily Headache
Authors
Marcelo E. Bigal
Alan M. Rapoport
Publication date
01-02-2012
Publisher
Current Science Inc.
Published in
Current Pain and Headache Reports / Issue 1/2012
Print ISSN: 1531-3433
Electronic ISSN: 1534-3081
DOI
https://doi.org/10.1007/s11916-011-0232-0

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