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Current Osteoporosis Reports

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01-02-2020 | Biomechanics (G Niebur and J Wallace, Section Editors)

Spaceflight-Induced Bone Tissue Changes that Affect Bone Quality and Increase Fracture Risk

Authors: Jennifer C. Coulombe, Bhavya Senwar, Virginia L. Ferguson

Published in: Current Osteoporosis Reports | Issue 1/2020

Abstract

Purpose of Review

Bone mineral density and systemic factors are used to assess skeletal health in astronauts. Yet, even in a general population, these measures fail to accurately predict when any individual will fracture. This review considers how long-duration human spaceflight requires evaluation of additional bone structural and material quality measures that contribute to microgravity-induced skeletal fragility.

Recent Findings

In both humans and small animal models following spaceflight, bone mass is compromised via reduced bone formation and elevated resorption levels. Concurrently, bone structural quality (e.g., trabecular microarchitecture) is diminished and the quality of bone material is reduced via impaired tissue mineralization, maturation, and maintenance (e.g., mediated by osteocytes).

Summary

Bone structural and material quality are both affected by microgravity and may, together, jeopardize astronaut operational readiness and lead to increased fracture risk upon return to gravitational loading. Future studies need to directly evaluate how bone quality combines with diminished bone mass to influence bone strength and toughness (e.g., resistance to fracture). Bone quality assessment promises to identify novel biomarkers and therapeutic targets.

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Title: Spaceflight-Induced Bone Tissue Changes that Affect Bone Quality and Increase Fracture Risk
Authors: Jennifer C. Coulombe
Bhavya Senwar
Virginia L. Ferguson
Publication date: 01-02-2020
Publisher: Springer US
Published in: Current Osteoporosis Reports / Issue 1/2020
Print ISSN: 1544-1873
Electronic ISSN: 1544-2241
DOI: https://doi.org/10.1007/s11914-019-00540-y

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Spaceflight-Induced Bone Tissue Changes that Affect Bone Quality and Increase Fracture Risk

Abstract

Purpose of Review

Recent Findings

Summary

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose of Review

Recent Findings

Summary

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