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Current Osteoporosis Reports

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01-08-2019 | Skeletal Biology and Regulation (M Forwood and A Robling, Section Editors)

RNA-seq in Skeletal Biology

Author: Ugur Ayturk

Published in: Current Osteoporosis Reports | Issue 4/2019

Abstract

Purpose of Review

The goal of this paper is to review state-of-the-art transcriptome profiling methods and their recent applications in the field of skeletal biology.

Recent Findings

Next-generation sequencing of mRNA (RNA-seq) methods have been established and routinely used in skeletal biology research. RNA-seq has led to the identification of novel genes and transcription factors involved in skeletal development and disease, through its application in small and large animal models, as well as human tissue and cells. With the availability of advanced techniques such as single-cell RNA-seq, novel cell types in skeletal tissues are being identified.

Summary

As the sequencing technologies are rapidly evolving, the exciting discoveries supported by transcriptomics will continue to emerge and improve our understanding of the biology of the skeleton.

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Title: RNA-seq in Skeletal Biology
Author: Ugur Ayturk
Publication date: 01-08-2019
Publisher: Springer US
Published in: Current Osteoporosis Reports / Issue 4/2019
Print ISSN: 1544-1873
Electronic ISSN: 1544-2241
DOI: https://doi.org/10.1007/s11914-019-00517-x

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

RNA-seq in Skeletal Biology

Abstract

Purpose of Review

Recent Findings

Summary

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose of Review

Recent Findings

Summary

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