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Current Osteoporosis Reports

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Open Access 01-04-2019 | Sarcopenia | Muscle and Bone (L Bonewald and M Hamrick, Section Editors)

Genetics of Bone and Muscle Interactions in Humans

Authors: Katerina Trajanoska, Fernando Rivadeneira, Douglas P. Kiel, David Karasik

Published in: Current Osteoporosis Reports | Issue 2/2019

Abstract

Purpose of Review

To summarize the evidence from recent studies on the shared genetics between bone and muscle in humans.

Recent Findings

Genome-wide association studies (GWAS) have successfully identified a multitude of loci influencing the variability of different bone or muscle parameters, with multiple loci overlapping between the traits. In addition, joint analyses of multiple correlated musculoskeletal traits (i.e., multivariate GWAS) have underscored several genes with possible pleiotropic effects on both bone and muscle including MEF2C and SREBF1. Notably, several of the proposed pleiotropic genes have been validated using human cells or animal models.

Summary

It is clear that the study of pleiotropy may provide novel insights into disease pathophysiology potentially leading to the identification of new treatment strategies that simultaneously prevent or treat both osteoporosis and sarcopenia. However, the role of muscle factors (myokines) that stimulate bone metabolism, as well as osteokines that affect muscles, is in its earliest stage of understanding.

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Title: Genetics of Bone and Muscle Interactions in Humans
Authors: Katerina Trajanoska
Fernando Rivadeneira
Douglas P. Kiel
David Karasik
Publication date: 01-04-2019
Publisher: Springer US
Keywords: Sarcopenia
Osteoporosis
Osteoporosis
Published in: Current Osteoporosis Reports / Issue 2/2019
Print ISSN: 1544-1873
Electronic ISSN: 1544-2241
DOI: https://doi.org/10.1007/s11914-019-00505-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Genetics of Bone and Muscle Interactions in Humans

Abstract

Purpose of Review

Recent Findings

Summary

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose of Review

Recent Findings

Summary

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