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Current Osteoporosis Reports
Published in: Current Osteoporosis Reports 6/2018

01-12-2018 | Kidney and Bone (I Salusky and T Nickolas, Section Editors)

CKD-MBD: from the Pathogenesis to the Identification and Development of Potential Novel Therapeutic Targets

Authors: Rosilene Motta Elias, Maria Aparecida Dalboni, Ana Carolina E. Coelho, Rosa M. A. Moysés

Published in: Current Osteoporosis Reports | Issue 6/2018

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Abstract

Purpose of Review

Although we have seen tremendous advances in the comprehension of CKD-MBD pathophysiology during the last few years, this was not accompanied by a significant change in mortality rate and quality of life. This review will address the traditional and updated pathophysiology of CKD-MBD along with the therapeutic limitations that affect CKD-MBD and proposed alternative treatment targets.

Recent Findings

An innovative concept brings the osteocyte to the center of CKD-MBD pathophysiology, in contrast to the traditional view of the skeleton as a target organ for disturbances in calcium, phosphate, parathyroid hormone, and vitamin D. Osteocytes, through the synthesis of FGF-23, sclerostin, among others, are able to interact with other organs, making bone an endocrine organ. Thus, osteocyte dysregulation might be an early event during the course of CKD.

Summary

This review will revisit general concepts on the pathophysiology of CKD-MBD and discuss new perspectives for its treatment.
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Metadata
Title
CKD-MBD: from the Pathogenesis to the Identification and Development of Potential Novel Therapeutic Targets
Authors
Rosilene Motta Elias
Maria Aparecida Dalboni
Ana Carolina E. Coelho
Rosa M. A. Moysés
Publication date
01-12-2018
Publisher
Springer US
Published in
Current Osteoporosis Reports / Issue 6/2018
Print ISSN: 1544-1873
Electronic ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-018-0486-0

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