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Open Access 01-12-2016 | Bone and Diabetes (A Schwartz and P Vestergaard, Section Editors)

Advanced Glycation End Products, Diabetes, and Bone Strength

Authors: Masahiro Yamamoto, Toshitsugu Sugimoto

Published in: Current Osteoporosis Reports | Issue 6/2016

Abstract

Diabetic patients have a higher fracture risk than expected by their bone mineral density (BMD). Poor bone quality is the most suitable and explainable cause for the elevated fracture risk in this population. Advanced glycation end products (AGEs), which are diverse compounds generated via a non-enzymatic reaction between reducing sugars and amine residues, physically affect the properties of the bone material, one of a component of bone quality, through their accumulation in the bone collagen fibers. On the other hand, these compounds biologically act as agonists for these receptors for AGEs (RAGE) and suppress bone metabolism. The concentrations of AGEs and endogenous secretory RAGE, which acts as a “decoy receptor” that inhibits the AGEs-RAGE signaling axis, are associated with fracture risk in a BMD-independent manner. AGEs are closely associated with the pathogenesis of this unique clinical manifestation through physical and biological mechanisms in patients with diabetes mellitus.

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Title: Advanced Glycation End Products, Diabetes, and Bone Strength
Authors: Masahiro Yamamoto
Toshitsugu Sugimoto
Publication date: 01-12-2016
Publisher: Springer US
Published in: Current Osteoporosis Reports / Issue 6/2016
Print ISSN: 1544-1873
Electronic ISSN: 1544-2241
DOI: https://doi.org/10.1007/s11914-016-0332-1

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Advanced Glycation End Products, Diabetes, and Bone Strength

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

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