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Current Osteoporosis Reports
Published in: Current Osteoporosis Reports 1/2015

01-02-2015 | Skeletal Development (E Schanipani and E Zelzer, Section Editors)

Synovial Joints: from Development to Homeostasis

Authors: Lara Longobardi, Tieshi Li, Lidia Tagliafierro, Joseph D. Temple, Helen H. Willcockson, Ping Ye, Alessandra Esposito, Fuhua Xu, Anna Spagnoli

Published in: Current Osteoporosis Reports | Issue 1/2015

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Abstract

Synovial joint morphogenesis occurs through the condensation of mesenchymal cells into a non-cartilaginous region known as the interzone and the specification of progenitor cells that commit to the articular fate. Although several signaling molecules are expressed by the interzone, the mechanism is poorly understood. For treatments of cartilage injuries, it is critical to discover the presence of joint progenitor cells in adult tissues and their expression gene pattern. Potential stem cell niches have been found in different joint regions, such as the surface zone of articular cartilage, synovium, and groove of Ranvier. Inherited joint malformations as well as joint-degenerating conditions are often associated with other skeletal defects and may be seen as the failure of morphogenic factors to establish the correct microenvironment in cartilage and bone. Therefore, exploring how joints form can help us understand how cartilage and bone are damaged and develop drugs to reactivate this developing mechanism.
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Metadata
Title
Synovial Joints: from Development to Homeostasis
Authors
Lara Longobardi
Tieshi Li
Lidia Tagliafierro
Joseph D. Temple
Helen H. Willcockson
Ping Ye
Alessandra Esposito
Fuhua Xu
Anna Spagnoli
Publication date
01-02-2015
Publisher
Springer US
Published in
Current Osteoporosis Reports / Issue 1/2015
Print ISSN: 1544-1873
Electronic ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-014-0247-7

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