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Published in: Current Oncology Reports 6/2017

01-06-2017 | Cardio-oncology (EH Yang, Section Editor)

Cancer as a Risk Factor for Cardiovascular Disease

Authors: Dana Elena Giza, Gloria Iliescu, Saamir Hassan, Konstantinos Marmagkiolis, Cezar Iliescu

Published in: Current Oncology Reports | Issue 6/2017

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Abstract

Improvements in early diagnosis and cancer treatments have contributed to high survival rates for many cancer patients. However, these patients often die of cardiovascular disease rather than recurrence of their cancer. Heart disease manifesting after cancer may be due to several mechanisms: shared cardiovascular risks between cancer and cardiovascular disease, inflammatory states associated with malignancies, and/or cardiotoxic effects of cancer therapy. Cancer treatment increases the risk of cardiovascular diseases directly by damaging critical structures of the heart or indirectly by promoting accelerated atherosclerosis. Estimating cardiovascular risk by using advanced imaging and monitoring of the cardiac biomarkers can be used for early detection and treatment of subclinical cardiac injury. Better knowledge of these early and late cardiac effects in cancer patients will enable adoption of both primary and secondary prevention measures of long-term treatment complications in cancer survivors.
Literature
1.
go back to reference Siegel R, DeSantis C, Virgo K, et al. Cancer treatment and survivorship statistics, 2012. CA Cancer J Clin. 2012;62(4):220–41.CrossRefPubMed Siegel R, DeSantis C, Virgo K, et al. Cancer treatment and survivorship statistics, 2012. CA Cancer J Clin. 2012;62(4):220–41.CrossRefPubMed
2.
go back to reference •• Weaver KE, Foraker RE, Alfano CM, et al. Cardiovascular risk factors among long-term survivors of breast, prostate, colorectal, and gynecologic cancers: a gap in survivorship care? J Cancer Surviv. 2013;7(2):253–61. We consider the paper of Weaver et al. important as is one of the early articles published on CVD risk factors in cancers survivors, which might be overlooked and may compromise long-term health and well-being.CrossRefPubMedPubMedCentral •• Weaver KE, Foraker RE, Alfano CM, et al. Cardiovascular risk factors among long-term survivors of breast, prostate, colorectal, and gynecologic cancers: a gap in survivorship care? J Cancer Surviv. 2013;7(2):253–61. We consider the paper of Weaver et al. important as is one of the early articles published on CVD risk factors in cancers survivors, which might be overlooked and may compromise long-term health and well-being.CrossRefPubMedPubMedCentral
3.
4.
go back to reference Aleman BM, Moser EC, Nuver J, et al. Cardiovascular disease after cancer therapy. EJC supplements : EJC: official journal of EORTC, European Organization for Research and Treatment of Cancer … [et al]. 2014;12(1):18–28. Aleman BM, Moser EC, Nuver J, et al. Cardiovascular disease after cancer therapy. EJC supplements : EJC: official journal of EORTC, European Organization for Research and Treatment of Cancer … [et al]. 2014;12(1):18–28.
5.
go back to reference • Johnson CB, Davis MK, Law A, Sulpher J. Shared risk factors for cardiovascular disease and cancer: implications for preventive health and clinical care in oncology patients. Can J Cardiol. 2016;32(7):900–7. We consider this paper important because it provides evidence that smoking, obesity, poor diet, and inactivity can affect oncological outcomes and lead to increased cancer mortality is cancer survivors.CrossRefPubMed • Johnson CB, Davis MK, Law A, Sulpher J. Shared risk factors for cardiovascular disease and cancer: implications for preventive health and clinical care in oncology patients. Can J Cardiol. 2016;32(7):900–7. We consider this paper important because it provides evidence that smoking, obesity, poor diet, and inactivity can affect oncological outcomes and lead to increased cancer mortality is cancer survivors.CrossRefPubMed
7.
go back to reference Davignon J, Ganz P. Role of endothelial dysfunction in atherosclerosis. Circulation. 2004;109(23 Suppl 1):III27–32.PubMed Davignon J, Ganz P. Role of endothelial dysfunction in atherosclerosis. Circulation. 2004;109(23 Suppl 1):III27–32.PubMed
8.
go back to reference Sawaya H, Sebag IA, Plana JC, et al. Early detection and prediction of cardiotoxicity in chemotherapy-treated patients. Am J Cardiol. 2011;107(9):1375–80.CrossRefPubMedPubMedCentral Sawaya H, Sebag IA, Plana JC, et al. Early detection and prediction of cardiotoxicity in chemotherapy-treated patients. Am J Cardiol. 2011;107(9):1375–80.CrossRefPubMedPubMedCentral
9.
go back to reference Demers M, Krause DS, Schatzberg D, et al. Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis. Proc Natl Acad Sci U S A. 2012;109(32):13076–81.CrossRefPubMedPubMedCentral Demers M, Krause DS, Schatzberg D, et al. Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis. Proc Natl Acad Sci U S A. 2012;109(32):13076–81.CrossRefPubMedPubMedCentral
10.
11.
go back to reference Goncalves I, den Ruijter H, Nahrendorf M, Pasterkamp G. Detecting the vulnerable plaque in patients. J Intern Med. 2015;278(5):520–30.CrossRefPubMed Goncalves I, den Ruijter H, Nahrendorf M, Pasterkamp G. Detecting the vulnerable plaque in patients. J Intern Med. 2015;278(5):520–30.CrossRefPubMed
12.
go back to reference Fuster V, Moreno PR, Fayad ZA, Corti R, Badimon JJ. Atherothrombosis and high-risk plaque: part I: evolving concepts. J Am Coll Cardiol. 2005;46(6):937–54.CrossRefPubMed Fuster V, Moreno PR, Fayad ZA, Corti R, Badimon JJ. Atherothrombosis and high-risk plaque: part I: evolving concepts. J Am Coll Cardiol. 2005;46(6):937–54.CrossRefPubMed
13.
go back to reference Wang JC, Normand SL, Mauri L, Kuntz RE. Coronary artery spatial distribution of acute myocardial infarction occlusions. Circulation. 2004;110(3):278–84.CrossRefPubMed Wang JC, Normand SL, Mauri L, Kuntz RE. Coronary artery spatial distribution of acute myocardial infarction occlusions. Circulation. 2004;110(3):278–84.CrossRefPubMed
14.
go back to reference Eckert J, Schmidt M, Magedanz A, Voigtlander T, Schmermund A. Coronary CT angiography in managing atherosclerosis. Int J Mol Sci. 2015;16(2):3740–56.CrossRefPubMedPubMedCentral Eckert J, Schmidt M, Magedanz A, Voigtlander T, Schmermund A. Coronary CT angiography in managing atherosclerosis. Int J Mol Sci. 2015;16(2):3740–56.CrossRefPubMedPubMedCentral
15.
go back to reference •• Yeh ET, Tong AT, Lenihan DJ, et al. Cardiovascular complications of cancer therapy: diagnosis, pathogenesis, and management. Circulation. 2004;109(25):3122–31. We consider this paper important because it provides new insights on the cardiotoxicity of anticancer agents that can lead to significant complications that can affect patients treated for various malignancies. In this article, commonly used chemotherapy agents, including several recently approved medications, for their propensity to cause cardiotoxicity are reviewed.CrossRefPubMed •• Yeh ET, Tong AT, Lenihan DJ, et al. Cardiovascular complications of cancer therapy: diagnosis, pathogenesis, and management. Circulation. 2004;109(25):3122–31. We consider this paper important because it provides new insights on the cardiotoxicity of anticancer agents that can lead to significant complications that can affect patients treated for various malignancies. In this article, commonly used chemotherapy agents, including several recently approved medications, for their propensity to cause cardiotoxicity are reviewed.CrossRefPubMed
16.
go back to reference Suter TM, Ewer MS. Cancer drugs and the heart: importance and management. Eur Heart J. 2013;34(15):1102–11.CrossRefPubMed Suter TM, Ewer MS. Cancer drugs and the heart: importance and management. Eur Heart J. 2013;34(15):1102–11.CrossRefPubMed
17.
go back to reference Yeh ET, Bickford CL. Cardiovascular complications of cancer therapy: incidence, pathogenesis, diagnosis, and management. J Am Coll Cardiol. 2009;53(24):2231–47.CrossRefPubMed Yeh ET, Bickford CL. Cardiovascular complications of cancer therapy: incidence, pathogenesis, diagnosis, and management. J Am Coll Cardiol. 2009;53(24):2231–47.CrossRefPubMed
18.
go back to reference Brana I, Tabernero J. Cardiotoxicity. Ann Oncol. 2010;21(Suppl 7):vii 173–9. Brana I, Tabernero J. Cardiotoxicity. Ann Oncol. 2010;21(Suppl 7):vii 173–9.
19.
go back to reference Moudgil R, Yeh ET. Mechanisms of cardiotoxicity of cancer chemotherapeutic agents: cardiomyopathy and beyond. Can J Cardiol. 2016;32(7):863–870.e865.CrossRefPubMed Moudgil R, Yeh ET. Mechanisms of cardiotoxicity of cancer chemotherapeutic agents: cardiomyopathy and beyond. Can J Cardiol. 2016;32(7):863–870.e865.CrossRefPubMed
20.
go back to reference Vejpongsa P, Yeh ET. Topoisomerase 2beta: a promising molecular target for primary prevention of anthracycline-induced cardiotoxicity. Clin Pharmacol Ther. 2014;95(1):45–52.CrossRefPubMed Vejpongsa P, Yeh ET. Topoisomerase 2beta: a promising molecular target for primary prevention of anthracycline-induced cardiotoxicity. Clin Pharmacol Ther. 2014;95(1):45–52.CrossRefPubMed
21.
go back to reference Sudhoff T, Enderle MD, Pahlke M, et al. 5-Fluorouracil induces arterial vasocontractions. Ann Oncol. 2004;15(4):661–4.CrossRefPubMed Sudhoff T, Enderle MD, Pahlke M, et al. 5-Fluorouracil induces arterial vasocontractions. Ann Oncol. 2004;15(4):661–4.CrossRefPubMed
22.
go back to reference Naib T, Steingart RM, Chen CL. Sorafenib-associated multivessel coronary artery vasospasm. Herz. 2011;36(4):348–51.CrossRefPubMed Naib T, Steingart RM, Chen CL. Sorafenib-associated multivessel coronary artery vasospasm. Herz. 2011;36(4):348–51.CrossRefPubMed
23.
go back to reference Stewart T, Pavlakis N, Ward M. Cardiotoxicity with 5-fluorouracil and capecitabine: more than just vasospastic angina. Intern Med J. 2010;40(4):303–7.CrossRefPubMed Stewart T, Pavlakis N, Ward M. Cardiotoxicity with 5-fluorouracil and capecitabine: more than just vasospastic angina. Intern Med J. 2010;40(4):303–7.CrossRefPubMed
24.
go back to reference Lim SH, Wilson SM, Hunter A, Hill J, Beale P. Takotsubo cardiomyopathy and 5-fluorouracil: getting to the heart of the matter. Case Rep Oncol Med. 2013;2013:206765.PubMedPubMedCentral Lim SH, Wilson SM, Hunter A, Hill J, Beale P. Takotsubo cardiomyopathy and 5-fluorouracil: getting to the heart of the matter. Case Rep Oncol Med. 2013;2013:206765.PubMedPubMedCentral
25.
go back to reference Ranpura V, Hapani S, Chuang J, Wu S. Risk of cardiac ischemia and arterial thromboembolic events with the angiogenesis inhibitor bevacizumab in cancer patients: a meta-analysis of randomized controlled trials. Acta Oncol. 2010;49(3):287–97.CrossRefPubMed Ranpura V, Hapani S, Chuang J, Wu S. Risk of cardiac ischemia and arterial thromboembolic events with the angiogenesis inhibitor bevacizumab in cancer patients: a meta-analysis of randomized controlled trials. Acta Oncol. 2010;49(3):287–97.CrossRefPubMed
26.
go back to reference Aichberger KJ, Herndlhofer S, Schernthaner GH, et al. Progressive peripheral arterial occlusive disease and other vascular events during nilotinib therapy in CML. Am J Hematol. 2011;86(7):533–9.CrossRefPubMed Aichberger KJ, Herndlhofer S, Schernthaner GH, et al. Progressive peripheral arterial occlusive disease and other vascular events during nilotinib therapy in CML. Am J Hematol. 2011;86(7):533–9.CrossRefPubMed
27.
go back to reference Tefferi A, Letendre L. Nilotinib treatment-associated peripheral artery disease and sudden death: yet another reason to stick to imatinib as front-line therapy for chronic myelogenous leukemia. Am J Hematol. 2011;86(7):610–1.CrossRefPubMed Tefferi A, Letendre L. Nilotinib treatment-associated peripheral artery disease and sudden death: yet another reason to stick to imatinib as front-line therapy for chronic myelogenous leukemia. Am J Hematol. 2011;86(7):610–1.CrossRefPubMed
28.
29.
go back to reference Stevens PL, Lenihan DJ. Cardiotoxicity due to chemotherapy: the role of biomarkers. Curr Cardiol Rep. 2015;17(7):603.CrossRefPubMed Stevens PL, Lenihan DJ. Cardiotoxicity due to chemotherapy: the role of biomarkers. Curr Cardiol Rep. 2015;17(7):603.CrossRefPubMed
30.
go back to reference Schultz-Hector S, Trott KR. Radiation-induced cardiovascular diseases: is the epidemiologic evidence compatible with the radiobiologic data? Int J Radiat Oncol Biol Phys. 2007;67(1):10–8.CrossRefPubMed Schultz-Hector S, Trott KR. Radiation-induced cardiovascular diseases: is the epidemiologic evidence compatible with the radiobiologic data? Int J Radiat Oncol Biol Phys. 2007;67(1):10–8.CrossRefPubMed
31.
go back to reference Darby SC, Cutter DJ, Boerma M, et al. Radiation-related heart disease: current knowledge and future prospects. Int J Radiat Oncol Biol Phys. 2010;76(3):656–65.CrossRefPubMedPubMedCentral Darby SC, Cutter DJ, Boerma M, et al. Radiation-related heart disease: current knowledge and future prospects. Int J Radiat Oncol Biol Phys. 2010;76(3):656–65.CrossRefPubMedPubMedCentral
32.
go back to reference Darby SC, Ewertz M, McGale P, et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med. 2013;368(11):987–98.CrossRefPubMed Darby SC, Ewertz M, McGale P, et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med. 2013;368(11):987–98.CrossRefPubMed
33.
go back to reference Khakoo AY, Yeh ET. Therapy insight: management of cardiovascular disease in patients with cancer and cardiac complications of cancer therapy. Nat Clin Pract Oncol. 2008;5(11):655–67.CrossRefPubMed Khakoo AY, Yeh ET. Therapy insight: management of cardiovascular disease in patients with cancer and cardiac complications of cancer therapy. Nat Clin Pract Oncol. 2008;5(11):655–67.CrossRefPubMed
34.
go back to reference Fajardo LF, Stewart JR. Coronary artery disease after radiation. N Engl J Med. 1972;286(23):1265–6.PubMed Fajardo LF, Stewart JR. Coronary artery disease after radiation. N Engl J Med. 1972;286(23):1265–6.PubMed
35.
go back to reference van Nimwegen FA, Schaapveld M, Janus CP, et al. Cardiovascular disease after Hodgkin lymphoma treatment: 40-year disease risk. JAMA Intern Med. 2015;175(6):1007–17.CrossRefPubMed van Nimwegen FA, Schaapveld M, Janus CP, et al. Cardiovascular disease after Hodgkin lymphoma treatment: 40-year disease risk. JAMA Intern Med. 2015;175(6):1007–17.CrossRefPubMed
36.
go back to reference Paszat LF, Mackillop WJ, Groome PA, Boyd C, Schulze K, Holowaty E. Mortality from myocardial infarction after adjuvant radiotherapy for breast cancer in the surveillance, epidemiology, and end-results cancer registries. J Clin Oncol Off J Am Soc Clin Oncol. 1998;16(8):2625–31.CrossRef Paszat LF, Mackillop WJ, Groome PA, Boyd C, Schulze K, Holowaty E. Mortality from myocardial infarction after adjuvant radiotherapy for breast cancer in the surveillance, epidemiology, and end-results cancer registries. J Clin Oncol Off J Am Soc Clin Oncol. 1998;16(8):2625–31.CrossRef
37.
go back to reference McEniery PT, Dorosti K, Schiavone WA, Pedrick TJ, Sheldon WC. Clinical and angiographic features of coronary artery disease after chest irradiation. Am J Cardiol. 1987;60(13):1020–4.CrossRefPubMed McEniery PT, Dorosti K, Schiavone WA, Pedrick TJ, Sheldon WC. Clinical and angiographic features of coronary artery disease after chest irradiation. Am J Cardiol. 1987;60(13):1020–4.CrossRefPubMed
38.
go back to reference Heidenreich PA, Schnittger I, Strauss HW, et al. Screening for coronary artery disease after mediastinal irradiation for Hodgkin’s disease. J Clin Oncol Off J Am Soc Clin Oncol. 2007;25(1):43–9.CrossRef Heidenreich PA, Schnittger I, Strauss HW, et al. Screening for coronary artery disease after mediastinal irradiation for Hodgkin’s disease. J Clin Oncol Off J Am Soc Clin Oncol. 2007;25(1):43–9.CrossRef
39.
go back to reference Shimizu Y, Kodama K, Nishi N, et al. Radiation exposure and circulatory disease risk: Hiroshima and Nagasaki atomic bomb survivor data, 1950–2003. BMJ. 2010;340:b 5349.CrossRef Shimizu Y, Kodama K, Nishi N, et al. Radiation exposure and circulatory disease risk: Hiroshima and Nagasaki atomic bomb survivor data, 1950–2003. BMJ. 2010;340:b 5349.CrossRef
40.
go back to reference Hancock SL, Tucker MA, Hoppe RT. Factors affecting late mortality from heart disease after treatment of Hodgkin’s disease. JAMA. 1993;270(16):1949–55.CrossRefPubMed Hancock SL, Tucker MA, Hoppe RT. Factors affecting late mortality from heart disease after treatment of Hodgkin’s disease. JAMA. 1993;270(16):1949–55.CrossRefPubMed
41.
go back to reference Boekel NB, Schaapveld M, Gietema JA, et al. Cardiovascular disease risk in a large, population-based cohort of breast cancer survivors. Int J Radiat Oncol Biol Phys. 2016;94(5):1061–72.CrossRefPubMed Boekel NB, Schaapveld M, Gietema JA, et al. Cardiovascular disease risk in a large, population-based cohort of breast cancer survivors. Int J Radiat Oncol Biol Phys. 2016;94(5):1061–72.CrossRefPubMed
42.
go back to reference Iliescu CA, Grines CL, Herrmann J, et al. SCAI expert consensus statement: evaluation, management, and special considerations of cardio-oncology patients in the cardiac catheterization laboratory (endorsed by the cardiological society of India, and sociedad Latino Americana de Cardiologia intervencionista). Catheter Cardiovasc Interv. 2016;87(5):E202–23.CrossRefPubMed Iliescu CA, Grines CL, Herrmann J, et al. SCAI expert consensus statement: evaluation, management, and special considerations of cardio-oncology patients in the cardiac catheterization laboratory (endorsed by the cardiological society of India, and sociedad Latino Americana de Cardiologia intervencionista). Catheter Cardiovasc Interv. 2016;87(5):E202–23.CrossRefPubMed
43.
go back to reference Darby SC, McGale P, Taylor CW, Peto R. Long-term mortality from heart disease and lung cancer after radiotherapy for early breast cancer: prospective cohort study of about 300, 000 women in US SEER cancer registries. Lancet Oncol. 2005;6(8):557–65.CrossRefPubMed Darby SC, McGale P, Taylor CW, Peto R. Long-term mortality from heart disease and lung cancer after radiotherapy for early breast cancer: prospective cohort study of about 300, 000 women in US SEER cancer registries. Lancet Oncol. 2005;6(8):557–65.CrossRefPubMed
44.
go back to reference Yusuf SW, Daraban N, Abbasi N, Lei X, Durand JB, Daher IN. Treatment and outcomes of acute coronary syndrome in the cancer population. Clin Cardiol. 2012;35(7):443–50.CrossRefPubMed Yusuf SW, Daraban N, Abbasi N, Lei X, Durand JB, Daher IN. Treatment and outcomes of acute coronary syndrome in the cancer population. Clin Cardiol. 2012;35(7):443–50.CrossRefPubMed
45.
go back to reference Krone RJ. Managing coronary artery disease in the cancer patient. Prog Cardiovasc Dis. 2010;53(2):149–56.CrossRefPubMed Krone RJ. Managing coronary artery disease in the cancer patient. Prog Cardiovasc Dis. 2010;53(2):149–56.CrossRefPubMed
46.
go back to reference De Bruyne B, Pijls NH, Kalesan B, et al. Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease. N Engl J Med. 2012;367(11):991–1001.CrossRefPubMed De Bruyne B, Pijls NH, Kalesan B, et al. Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease. N Engl J Med. 2012;367(11):991–1001.CrossRefPubMed
47.
go back to reference Levine GN, Bates ER, Bittl JA, et al. 2016 ACC/AHA guideline focused update on duration of dual antiplatelet therapy in patients with coronary artery disease: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Thorac Cardiovasc Surg. 2016;152(5):1243–75.CrossRefPubMed Levine GN, Bates ER, Bittl JA, et al. 2016 ACC/AHA guideline focused update on duration of dual antiplatelet therapy in patients with coronary artery disease: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Thorac Cardiovasc Surg. 2016;152(5):1243–75.CrossRefPubMed
48.
go back to reference Carrozza Jr JP, Kuntz RE, Levine MJ, et al. Angiographic and clinical outcome of intracoronary stenting: immediate and long-term results from a large single-center experience. J Am Coll Cardiol. 1992;20(2):328–37.CrossRefPubMed Carrozza Jr JP, Kuntz RE, Levine MJ, et al. Angiographic and clinical outcome of intracoronary stenting: immediate and long-term results from a large single-center experience. J Am Coll Cardiol. 1992;20(2):328–37.CrossRefPubMed
49.
go back to reference Colombo A, Hall P, Nakamura S, et al. Intracoronary stenting without anticoagulation accomplished with intravascular ultrasound guidance. Circulation. 1995;91(6):1676–88.CrossRefPubMed Colombo A, Hall P, Nakamura S, et al. Intracoronary stenting without anticoagulation accomplished with intravascular ultrasound guidance. Circulation. 1995;91(6):1676–88.CrossRefPubMed
50.
go back to reference Mueller C, Roskamm H, Neumann FJ, et al. A randomized comparison of clopidogrel and aspirin versus ticlopidine and aspirin after the placement of coronary artery stents. J Am Coll Cardiol. 2003;41(6):969–73.CrossRefPubMed Mueller C, Roskamm H, Neumann FJ, et al. A randomized comparison of clopidogrel and aspirin versus ticlopidine and aspirin after the placement of coronary artery stents. J Am Coll Cardiol. 2003;41(6):969–73.CrossRefPubMed
51.
go back to reference Gross CM, Posch MG, Geier C, et al. Subacute coronary stent thrombosis in cancer patients. J Am Coll Cardiol. 2008;51(12):1232–3.CrossRefPubMed Gross CM, Posch MG, Geier C, et al. Subacute coronary stent thrombosis in cancer patients. J Am Coll Cardiol. 2008;51(12):1232–3.CrossRefPubMed
52.
go back to reference Nuver J, Smit AJ, Wolffenbuttel BH, et al. The metabolic syndrome and disturbances in hormone levels in long-term survivors of disseminated testicular cancer. J Clin Oncol Off J Am Soc Clin Oncol. 2005;23(16):3718–25.CrossRef Nuver J, Smit AJ, Wolffenbuttel BH, et al. The metabolic syndrome and disturbances in hormone levels in long-term survivors of disseminated testicular cancer. J Clin Oncol Off J Am Soc Clin Oncol. 2005;23(16):3718–25.CrossRef
53.
go back to reference Nottage KA, Ness KK, Li C, Srivastava D, Robison LL, Hudson MM. Metabolic syndrome and cardiovascular risk among long-term survivors of acute lymphoblastic leukaemia—from the St. Jude Lifetime Cohort. Br J Haematol. 2014;165(3):364–74.CrossRefPubMedPubMedCentral Nottage KA, Ness KK, Li C, Srivastava D, Robison LL, Hudson MM. Metabolic syndrome and cardiovascular risk among long-term survivors of acute lymphoblastic leukaemia—from the St. Jude Lifetime Cohort. Br J Haematol. 2014;165(3):364–74.CrossRefPubMedPubMedCentral
54.
go back to reference Collier A, Ghosh S, McGlynn B, Hollins G. Prostate cancer, androgen deprivation therapy, obesity, the metabolic syndrome, type 2 diabetes, and cardiovascular disease: a review. Am J Clin Oncol. 2012;35(5):504–9.CrossRefPubMed Collier A, Ghosh S, McGlynn B, Hollins G. Prostate cancer, androgen deprivation therapy, obesity, the metabolic syndrome, type 2 diabetes, and cardiovascular disease: a review. Am J Clin Oncol. 2012;35(5):504–9.CrossRefPubMed
55.
go back to reference Greenland P, Alpert JS, Beller GA, et al. 2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2010;56(25):e50–103.CrossRefPubMed Greenland P, Alpert JS, Beller GA, et al. 2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2010;56(25):e50–103.CrossRefPubMed
56.
go back to reference Vejpongsa P, Yeh ET. Prevention of anthracycline-induced cardiotoxicity: challenges and opportunities. J Am Coll Cardiol. 2014;64(9):938–45.CrossRefPubMed Vejpongsa P, Yeh ET. Prevention of anthracycline-induced cardiotoxicity: challenges and opportunities. J Am Coll Cardiol. 2014;64(9):938–45.CrossRefPubMed
57.
go back to reference Cardinale D, Salvatici M, Sandri MT. Role of biomarkers in cardioncology. Clin Chem Lab Med. 2011;49(12):1937–48.CrossRefPubMed Cardinale D, Salvatici M, Sandri MT. Role of biomarkers in cardioncology. Clin Chem Lab Med. 2011;49(12):1937–48.CrossRefPubMed
58.
go back to reference Newby LK, Ohman EM. Biomarkers: troponin testing—risk stratification to stratified medicine. Nat Rev Cardiol. 2015;12(11):625–6.CrossRefPubMed Newby LK, Ohman EM. Biomarkers: troponin testing—risk stratification to stratified medicine. Nat Rev Cardiol. 2015;12(11):625–6.CrossRefPubMed
59.
go back to reference Lipshultz SE, Miller TL, Scully RE, et al. Changes in cardiac biomarkers during doxorubicin treatment of pediatric patients with high-risk acute lymphoblastic leukemia: associations with long-term echocardiographic outcomes. J Clin Oncol Off J Am Soc Clin Oncol. 2012;30(10):1042–9.CrossRef Lipshultz SE, Miller TL, Scully RE, et al. Changes in cardiac biomarkers during doxorubicin treatment of pediatric patients with high-risk acute lymphoblastic leukemia: associations with long-term echocardiographic outcomes. J Clin Oncol Off J Am Soc Clin Oncol. 2012;30(10):1042–9.CrossRef
60.
go back to reference Cardinale D, Colombo A, Torrisi R, et al. Trastuzumab-induced cardiotoxicity: clinical and prognostic implications of troponin I evaluation. J Clin Oncol Off J Am Soc Clin Oncol. 2010;28(25):3910–6.CrossRef Cardinale D, Colombo A, Torrisi R, et al. Trastuzumab-induced cardiotoxicity: clinical and prognostic implications of troponin I evaluation. J Clin Oncol Off J Am Soc Clin Oncol. 2010;28(25):3910–6.CrossRef
61.
go back to reference D’Errico MP, Grimaldi L, Petruzzelli MF, et al. N-terminal pro-B-type natriuretic peptide plasma levels as a potential biomarker for cardiac damage after radiotherapy in patients with left-sided breast cancer. Int J Radiat Oncol Biol Phys. 2012;82(2):e239–46.CrossRefPubMed D’Errico MP, Grimaldi L, Petruzzelli MF, et al. N-terminal pro-B-type natriuretic peptide plasma levels as a potential biomarker for cardiac damage after radiotherapy in patients with left-sided breast cancer. Int J Radiat Oncol Biol Phys. 2012;82(2):e239–46.CrossRefPubMed
62.
go back to reference Burgdorf C, Nef HM, Haghi D, Kurowski V, Radke PW. Tako-tsubo (stress-induced) cardiomyopathy and cancer. Ann Intern Med. 2010;152(12):830–1.CrossRefPubMed Burgdorf C, Nef HM, Haghi D, Kurowski V, Radke PW. Tako-tsubo (stress-induced) cardiomyopathy and cancer. Ann Intern Med. 2010;152(12):830–1.CrossRefPubMed
63.
go back to reference Akashi YJ, Goldstein DS, Barbaro G, Ueyama T. Takotsubo cardiomyopathy: a new form of acute, reversible heart failure. Circulation. 2008;118(25):2754–62.CrossRefPubMedPubMedCentral Akashi YJ, Goldstein DS, Barbaro G, Ueyama T. Takotsubo cardiomyopathy: a new form of acute, reversible heart failure. Circulation. 2008;118(25):2754–62.CrossRefPubMedPubMedCentral
64.
go back to reference van de Donk NW, America YG, Zelissen PM, Hamer BJ. Takotsubo cardiomyopathy following radioiodine therapy for toxic multinodular goitre. Neth J Med. 2009;67(10):350–2. van de Donk NW, America YG, Zelissen PM, Hamer BJ. Takotsubo cardiomyopathy following radioiodine therapy for toxic multinodular goitre. Neth J Med. 2009;67(10):350–2.
65.
go back to reference Franco TH, Khan A, Joshi V, Thomas B. Takotsubo cardiomyopathy in two men receiving bevacizumab for metastatic cancer. Ther Clin Risk Manag. 2008;4(6):1367–70.CrossRefPubMedPubMedCentral Franco TH, Khan A, Joshi V, Thomas B. Takotsubo cardiomyopathy in two men receiving bevacizumab for metastatic cancer. Ther Clin Risk Manag. 2008;4(6):1367–70.CrossRefPubMedPubMedCentral
66.
go back to reference Smith SA, Auseon AJ. Chemotherapy-induced takotsubo cardiomyopathy. Heart Fail Clin. 2013;9(2):233–42. x CrossRefPubMed Smith SA, Auseon AJ. Chemotherapy-induced takotsubo cardiomyopathy. Heart Fail Clin. 2013;9(2):233–42. x CrossRefPubMed
67.
go back to reference Lee S, Lim SP, Yu JH, et al. Stress-induced cardiomyopathy during pulmonary resection (Takotsubo syndrome)—a case report. Korean J Thorac Cardiovasc Surg. 2011;44(4):294–7.CrossRefPubMedPubMedCentral Lee S, Lim SP, Yu JH, et al. Stress-induced cardiomyopathy during pulmonary resection (Takotsubo syndrome)—a case report. Korean J Thorac Cardiovasc Surg. 2011;44(4):294–7.CrossRefPubMedPubMedCentral
68.
go back to reference Gianni M, Dentali F, Lonn E. 5 Flourouracil-induced apical ballooning syndrome: a case report. Blood Coagul Fibrinolysis. 2009;20(4):306–8.CrossRefPubMed Gianni M, Dentali F, Lonn E. 5 Flourouracil-induced apical ballooning syndrome: a case report. Blood Coagul Fibrinolysis. 2009;20(4):306–8.CrossRefPubMed
69.
go back to reference Geisler BP, Raad RA, Esaian D, Sharon E, Schwartz DR. Apical ballooning and cardiomyopathy in a melanoma patient treated with ipilimumab: a case of takotsubo-like syndrome. J Immunother Cancer. 2015;3:4.CrossRefPubMedPubMedCentral Geisler BP, Raad RA, Esaian D, Sharon E, Schwartz DR. Apical ballooning and cardiomyopathy in a melanoma patient treated with ipilimumab: a case of takotsubo-like syndrome. J Immunother Cancer. 2015;3:4.CrossRefPubMedPubMedCentral
70.
go back to reference Grunwald MR, Howie L, Diaz Jr LA. Takotsubo cardiomyopathy and fluorouracil: case report and review of the literature. J Clin Oncol Off J Am Soc Clin Oncol. 2012;30(2):e11–4.CrossRef Grunwald MR, Howie L, Diaz Jr LA. Takotsubo cardiomyopathy and fluorouracil: case report and review of the literature. J Clin Oncol Off J Am Soc Clin Oncol. 2012;30(2):e11–4.CrossRef
71.
go back to reference Munoz E, Iliescu G, Vejpongsa P, et al. Takotsubo stress cardiomyopathy: “good news” in cancer patients? J Am Coll Cardiol. 2016;68(10):1143–4.CrossRefPubMed Munoz E, Iliescu G, Vejpongsa P, et al. Takotsubo stress cardiomyopathy: “good news” in cancer patients? J Am Coll Cardiol. 2016;68(10):1143–4.CrossRefPubMed
Metadata
Title
Cancer as a Risk Factor for Cardiovascular Disease
Authors
Dana Elena Giza
Gloria Iliescu
Saamir Hassan
Konstantinos Marmagkiolis
Cezar Iliescu
Publication date
01-06-2017
Publisher
Springer US
Published in
Current Oncology Reports / Issue 6/2017
Print ISSN: 1523-3790
Electronic ISSN: 1534-6269
DOI
https://doi.org/10.1007/s11912-017-0601-x

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