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Current Oncology Reports
Published in: Current Oncology Reports 2/2016

01-02-2016 | Gastrointestinal Cancers (J Meyer, Section Editor)

Advances in the Management of Gastric and Gastroesophageal Cancers

Authors: Sophia C. Kamran, Theodore S. Hong, Jennifer Y. Wo

Published in: Current Oncology Reports | Issue 2/2016

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Abstract

Management of gastric and gastroesophageal cancers is a complex, evolving paradigm. Involvement of multimodality specialties is the key. In gastric cancer, data are conflicting with regard to the specific roles of surgery, chemotherapy, and radiation, particularly between Asian and Western studies. However, current ongoing phase III trials will further elucidate the optimal treatment for this heterogeneous disease. For resectable gastroesophageal junction (GEJ) tumors, the publication of a landmark study in 2012 out of the Netherlands revealed a clear benefit in the utilization of trimodality therapy. This changed practice almost immediately around the world. In unresectable gastroesophageal disease, chemoradiation has been firmly established as a paradigm for treatment. The optimal chemotherapy regimen is still in flux. However, for both gastric and GEJ tumors, technological breakthroughs in genomics and pharmacologic targeting will soon provide physicians more options in the armamentarium to fight these diseases and, one day, individually personalize treatment.
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Metadata
Title
Advances in the Management of Gastric and Gastroesophageal Cancers
Authors
Sophia C. Kamran
Theodore S. Hong
Jennifer Y. Wo
Publication date
01-02-2016
Publisher
Springer US
Published in
Current Oncology Reports / Issue 2/2016
Print ISSN: 1523-3790
Electronic ISSN: 1534-6269
DOI
https://doi.org/10.1007/s11912-015-0493-6

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