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Current Oncology Reports
Published in: Current Oncology Reports 6/2013

01-12-2013 | Gynecologic Cancers (NS Reed, Section Editor)

Sentinel Lymph Node in Endometrial Cancer: A Review

Authors: Cyril Touboul, Enrica Bentivegna, Catherine Uzan, Sebastien Gouy, Patricia Pautier, Catherine Lhommé, Pierre Duvillard, Christine Haie-Meder, Philippe Morice

Published in: Current Oncology Reports | Issue 6/2013

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Abstract

Lymph node status is a major prognostic factor in endometrial cancer (EC). Sentinel lymph node (SLN) biopsy has been reported in EC for more than 15 years but has not yet been incorporated as a standard-of-care procedure in EC. Complex uterine drainage, the various modalities of tracer injection, and the lack of large prospective series may explain this situation. In this review, we report an SLN detection rate of 81.7 %, a 10.9 % rate of metastatic SLN involvement, and a false-negative rate of 12.3 % in the main clinical trials. Thirty-five percent of SLN metastases were low-volume disease (micrometastases or isolated tumor cells). These data raise the question of the clinical significance of low-volume disease in EC. SLN biopsy could allow upstaging in supposedly low- or intermediate-risk patients in whom adjuvant therapy could be omitted. Further studies are required to precise the interest on the survival of this procedure in this subset of patients.
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Metadata
Title
Sentinel Lymph Node in Endometrial Cancer: A Review
Authors
Cyril Touboul
Enrica Bentivegna
Catherine Uzan
Sebastien Gouy
Patricia Pautier
Catherine Lhommé
Pierre Duvillard
Christine Haie-Meder
Philippe Morice
Publication date
01-12-2013
Publisher
Springer US
Published in
Current Oncology Reports / Issue 6/2013
Print ISSN: 1523-3790
Electronic ISSN: 1534-6269
DOI
https://doi.org/10.1007/s11912-013-0345-1

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