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Current Neurology and Neuroscience Reports

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01-02-2015 | Neuro-Oncology (LE Abrey, Section Editor)

The Value of Extent of Resection of Glioblastomas: Clinical Evidence and Current Approach

Authors: Joao Paulo Almeida, Kaisorn L. Chaichana, Jordina Rincon-Torroella, Alfredo Quinones-Hinojosa

Published in: Current Neurology and Neuroscience Reports | Issue 2/2015

Abstract

Glioblastomas (GBM), one of the most common tumors of the central nervous system, are associated with poor prognosis, even with all the scientific development of the last decades. Individual survival, however, is not homogenous among GBM patients, and multiple factors are related to their outcome, including age, biological characteristics of the tumor, and extent of treatment. Extent of resection (EOR) plays a major role as an independent modifiable factor associated with improved overall and progression-free survival. Achievement of maximal safe resection, removing as much as possible the tumor while preserving the neurological function, is the main goal of the current surgical treatment of GBM. To reach this objective, different technologies and surgical techniques have been introduced in neuro-oncology surgery, including functional neuronavigation systems, ultrasound surgery, intraoperative MRI scan, and intraoperative cortical and subcortical mapping techniques. In the current manuscript, we examine the impact of EOR on the prognosis of GBM patients and the benefits and limitations of modern adjuvant techniques used for resection of these lesions.

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Title: The Value of Extent of Resection of Glioblastomas: Clinical Evidence and Current Approach
Authors: Joao Paulo Almeida
Kaisorn L. Chaichana
Jordina Rincon-Torroella
Alfredo Quinones-Hinojosa
Publication date: 01-02-2015
Publisher: Springer US
Published in: Current Neurology and Neuroscience Reports / Issue 2/2015
Print ISSN: 1528-4042
Electronic ISSN: 1534-6293
DOI: https://doi.org/10.1007/s11910-014-0517-x

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The Value of Extent of Resection of Glioblastomas: Clinical Evidence and Current Approach

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