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Current Neurology and Neuroscience Reports
Published in: Current Neurology and Neuroscience Reports 6/2010

01-11-2010

The New Classification of Primary Progressive Aphasia into Semantic, Logopenic, or Nonfluent/Agrammatic Variants

Authors: Michael F. Bonner, Sharon Ash, Murray Grossman

Published in: Current Neurology and Neuroscience Reports | Issue 6/2010

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Abstract

Primary progressive aphasia (PPA), typically resulting from a neurodegenerative disease such as frontotemporal lobar degeneration or Alzheimer’s disease, is characterized by a progressive loss of specific language functions with relative sparing of other cognitive domains. Three variants of PPA are now recognized: semantic variant, logopenic variant, and nonfluent/agrammatic variant. We discuss recent work characterizing the neurolinguistic, neuropsychological, imaging and pathologic profiles associated with these variants. Improved reliability of diagnoses will be increasingly important as trials for etiology-specific treatments become available. We also discuss the implications of these syndromes for theories of language function.
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Metadata
Title
The New Classification of Primary Progressive Aphasia into Semantic, Logopenic, or Nonfluent/Agrammatic Variants
Authors
Michael F. Bonner
Sharon Ash
Murray Grossman
Publication date
01-11-2010
Publisher
Current Science Inc.
Published in
Current Neurology and Neuroscience Reports / Issue 6/2010
Print ISSN: 1528-4042
Electronic ISSN: 1534-6293
DOI
https://doi.org/10.1007/s11910-010-0140-4

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