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Current Colorectal Cancer Reports
Published in: Current Colorectal Cancer Reports 6/2018

01-12-2018 | Systemic Therapies in Colorectal Cancer (RD Kim, Section Editor)

Overview of Microsatellite Instability and Immune Checkpoint Inhibitors in Colorectal Cancer

Authors: Dae Won Kim, Jung-Hoon Lee, Kunhwa Kim, Iman Imanirad

Published in: Current Colorectal Cancer Reports | Issue 6/2018

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Abstract

Purpose of Review

This review examines the pathophysiological features of microsatellite instability (MSI) high colorectal cancer and discusses recent clinical studies of immune checkpoint inhibitors for MSI high colorectal cancer.

Recent Findings

Emerging clinical data demonstrated durable clinical activity and safety of PD-1 blockade agents in diverse cancers, and PD-1 blockade agents have led to a paradigm shift in the cancer therapy. Although initial clinical data showed disappointing result of anti-PD-1 therapy in unselected metastatic colorectal cancer, recent data demonstrated promising results with significant anticancer activity of PD-1 blockade in colorectal cancers with microsatellite instability which have highly immunogenic tumor microenvironment.

Summary

Anti-PD-1 therapy demonstrated durable clinical activity and safety, and it has changed the landscape of cancer therapy in MSI high colorectal cancer. Further studies with better understanding of tumor microenvironment will improve clinical outcomes of colorectal cancer.
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Metadata
Title
Overview of Microsatellite Instability and Immune Checkpoint Inhibitors in Colorectal Cancer
Authors
Dae Won Kim
Jung-Hoon Lee
Kunhwa Kim
Iman Imanirad
Publication date
01-12-2018
Publisher
Springer US
Published in
Current Colorectal Cancer Reports / Issue 6/2018
Print ISSN: 1556-3790
Electronic ISSN: 1556-3804
DOI
https://doi.org/10.1007/s11888-018-0413-x

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