Skip to main content
Top
Published in: Current Colorectal Cancer Reports 2/2013

01-06-2013 | Localized Rectal Cancer (R Glynne-Jones, Section Editor)

Quality of Life and Functions After Chemoradiation for Rectal Cancer: A Review of Recent Publications

Authors: Teresa Gavaruzzi, Francesca Giandomenico, Salvatore Pucciarelli

Published in: Current Colorectal Cancer Reports | Issue 2/2013

Login to get access

Abstract

We have systematically reviewed studies published in the last three years on patients’ self-reported evaluations of quality of life (QoL) and functions after chemoradiotherapy (CRT) for rectal cancer. Overall, the findings from 13 studies confirmed that CRT negatively affect functions and, consequently, patients’ QoL, especially for bowel, role, and social function. The studies’ heterogeneity limited the possibility of comparison among findings. We discuss and comment on the ideal characteristics of studies assessing QoL and function. We emphasise how this type of evidence is relevant to decision-making at all levels of health-care practice.
Literature
1.
go back to reference Kosinski L, Habr-Gama A, Ludwig K, Perez R. Shifting concepts in rectal cancer management a review of contemporary primary rectal cancer treatment strategies. CA Cancer J Clin. 2012;62(3):173–202.PubMedCrossRef Kosinski L, Habr-Gama A, Ludwig K, Perez R. Shifting concepts in rectal cancer management a review of contemporary primary rectal cancer treatment strategies. CA Cancer J Clin. 2012;62(3):173–202.PubMedCrossRef
2.
go back to reference Palmer G, Martling A, Cedermark B, Holm T. Preoperative tumour staging with multidisciplinary team assessment improves the outcome in locally advanced primary rectal cancer. Colorectal Dis. 2011;13(12):1361–9.PubMedCrossRef Palmer G, Martling A, Cedermark B, Holm T. Preoperative tumour staging with multidisciplinary team assessment improves the outcome in locally advanced primary rectal cancer. Colorectal Dis. 2011;13(12):1361–9.PubMedCrossRef
3.
go back to reference Burton S, Brown G, Daniels IR, et al. MRI directed multidisciplinary team preoperative treatment strategy: the way to eliminate positive circumferential margins? Br J Cancer. 2006;94(3):351–7.PubMedCrossRef Burton S, Brown G, Daniels IR, et al. MRI directed multidisciplinary team preoperative treatment strategy: the way to eliminate positive circumferential margins? Br J Cancer. 2006;94(3):351–7.PubMedCrossRef
4.
go back to reference Blazeby JM, Avery K, Sprangers M, et al. Health-related quality of life measurement in randomized clinical trials in surgical oncology. J Clin Oncol. 2006;24(19):3178–86.PubMedCrossRef Blazeby JM, Avery K, Sprangers M, et al. Health-related quality of life measurement in randomized clinical trials in surgical oncology. J Clin Oncol. 2006;24(19):3178–86.PubMedCrossRef
5.
go back to reference Langenhoff BS, Krabbe PF, Wobbes T, et al. Quality of life as an outcome measure in surgical oncology. Br J Surg. 2001;88(5):643–52.PubMedCrossRef Langenhoff BS, Krabbe PF, Wobbes T, et al. Quality of life as an outcome measure in surgical oncology. Br J Surg. 2001;88(5):643–52.PubMedCrossRef
6.
go back to reference Lipscomb J, Gotay C, Snyder C. Introduction to outcome assessment in cancer. In: Outcomes assessment in cancer: measures, methods and applications. Cambridge: Cambridge University Press; 2005. p. 11–3. Lipscomb J, Gotay C, Snyder C. Introduction to outcome assessment in cancer. In: Outcomes assessment in cancer: measures, methods and applications. Cambridge: Cambridge University Press; 2005. p. 11–3.
7.
go back to reference • Hadi M, Gibbons E, Fitzpatrick R. A structured review of patient-reported outcome measures for colorectal cancer. Patient-reported Outcome Measurement Group, Department of Public Health, University of Oxford April 2010. Review of the evidence of PROs for colorectal cancer patients, distinguishing between generic, preference-based, and cancer-specific instruments. • Hadi M, Gibbons E, Fitzpatrick R. A structured review of patient-reported outcome measures for colorectal cancer. Patient-reported Outcome Measurement Group, Department of Public Health, University of Oxford April 2010. Review of the evidence of PROs for colorectal cancer patients, distinguishing between generic, preference-based, and cancer-specific instruments.
8.
go back to reference Snyder C, Aaronson NK. Use of patient-reported outcomes in clinical practice. Lancet. 2009;374(9687):369–70.PubMedCrossRef Snyder C, Aaronson NK. Use of patient-reported outcomes in clinical practice. Lancet. 2009;374(9687):369–70.PubMedCrossRef
9.
go back to reference Donaldson MS. Taking PROs and patient-centered care seriously: incremental and disruptive ideas for incorporating PROs in oncology practice. Qual Life Res. 2008;17(10):1323–30.PubMedCrossRef Donaldson MS. Taking PROs and patient-centered care seriously: incremental and disruptive ideas for incorporating PROs in oncology practice. Qual Life Res. 2008;17(10):1323–30.PubMedCrossRef
10.
go back to reference Pieterse AH, Baas-Thijssen MC, Marijnen CA, Stiggelbout AM. Clinician and cancer patient views on patient participation in treatment decision-making: a quantitative and qualitative exploration. Br J Cancer. 2008;99(6):875–82.PubMedCrossRef Pieterse AH, Baas-Thijssen MC, Marijnen CA, Stiggelbout AM. Clinician and cancer patient views on patient participation in treatment decision-making: a quantitative and qualitative exploration. Br J Cancer. 2008;99(6):875–82.PubMedCrossRef
11.
go back to reference Sauer R, Becker H, Hohenberger W, et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med. 2004;351(17):1731–40.PubMedCrossRef Sauer R, Becker H, Hohenberger W, et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med. 2004;351(17):1731–40.PubMedCrossRef
12.
go back to reference Sauer R, Liersch T, Merkel S, et al. Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 years. J Clin Oncol. 2012;30(16):1926–33.PubMedCrossRef Sauer R, Liersch T, Merkel S, et al. Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 years. J Clin Oncol. 2012;30(16):1926–33.PubMedCrossRef
13.
go back to reference Bosset J-F, Collette L, Calais G, et al. Chemotherapy with preoperative radiotherapy in rectal cancer. N Engl J Med. 2006;355(11):1114–23.PubMedCrossRef Bosset J-F, Collette L, Calais G, et al. Chemotherapy with preoperative radiotherapy in rectal cancer. N Engl J Med. 2006;355(11):1114–23.PubMedCrossRef
14.
go back to reference Gérard J-P, Conroy T, Bonnetain F, et al. Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3–4 rectal cancer: results of FFCD 9203. J Clin Oncol. 2006;24(28):4620–5.PubMedCrossRef Gérard J-P, Conroy T, Bonnetain F, et al. Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3–4 rectal cancer: results of FFCD 9203. J Clin Oncol. 2006;24(28):4620–5.PubMedCrossRef
15.
go back to reference Engel J, Kerr J, Schleisinger-Racib A, et al. Quality of life in rectal cancer patients: a four-year prospective study. Ann Surg. 2003;238(2):203–13.PubMed Engel J, Kerr J, Schleisinger-Racib A, et al. Quality of life in rectal cancer patients: a four-year prospective study. Ann Surg. 2003;238(2):203–13.PubMed
16.
go back to reference Neuman HB, Schrag D, Cabral C, et al. Can differences in bowel function after surgery for rectal cancer be identified by the European Organization for Research and Treatment of Cancer quality of life instruments? Ann Surg Oncol. 2007;14(5):1727–34.PubMedCrossRef Neuman HB, Schrag D, Cabral C, et al. Can differences in bowel function after surgery for rectal cancer be identified by the European Organization for Research and Treatment of Cancer quality of life instruments? Ann Surg Oncol. 2007;14(5):1727–34.PubMedCrossRef
17.
go back to reference Pietrzak L, Mujko K, Novacki MP, et al. Quality of life, anorectal and sexual functions after preoperative radiotherapy for rectal cancer: report of a randomized trial. Radiother Oncol. 2007;84(3):217–25.PubMedCrossRef Pietrzak L, Mujko K, Novacki MP, et al. Quality of life, anorectal and sexual functions after preoperative radiotherapy for rectal cancer: report of a randomized trial. Radiother Oncol. 2007;84(3):217–25.PubMedCrossRef
18.
go back to reference Pucciarelli S, Del Bianco P, Efficace F, et al. Health-related quality of life, faecal continence and bowel function in rectal cancer patients after chemoradiotherapy followed by radical surgery. Support Care Cancer. 2010;18(5):601–8.PubMedCrossRef Pucciarelli S, Del Bianco P, Efficace F, et al. Health-related quality of life, faecal continence and bowel function in rectal cancer patients after chemoradiotherapy followed by radical surgery. Support Care Cancer. 2010;18(5):601–8.PubMedCrossRef
19.
go back to reference Rauch P, Miny J, Conroy T, et al. Quality of life among disease-free survivors of rectal cancer. J Clin Oncol. 2004;22(2):354–60.PubMedCrossRef Rauch P, Miny J, Conroy T, et al. Quality of life among disease-free survivors of rectal cancer. J Clin Oncol. 2004;22(2):354–60.PubMedCrossRef
20.
go back to reference Peeters KC, van de Velde CJ, Leer JW, et al. Late side effects of short-course preoperative radiotherapy combined with total mesorectal excision for rectal cancer: increased bowel dysfunction in irradiated patients—a Dutch colorectal cancer group study. J Clin Oncol. 2005;23:6199–206.PubMedCrossRef Peeters KC, van de Velde CJ, Leer JW, et al. Late side effects of short-course preoperative radiotherapy combined with total mesorectal excision for rectal cancer: increased bowel dysfunction in irradiated patients—a Dutch colorectal cancer group study. J Clin Oncol. 2005;23:6199–206.PubMedCrossRef
21.
go back to reference • Brændengen M, Tveit KM, Hjermstad MJ, et al. Health-related quality of life (HRQoL) after multimodal treatment for primarily non-resectable rectal cancer. Long-term results from a phase III study. Eur J Cancer. 2012;48(6):813–9. Prospective evaluation of QoL in a randomised trial, comparing pCRT and pRT and comparing results also with reference data from the general population.PubMedCrossRef • Brændengen M, Tveit KM, Hjermstad MJ, et al. Health-related quality of life (HRQoL) after multimodal treatment for primarily non-resectable rectal cancer. Long-term results from a phase III study. Eur J Cancer. 2012;48(6):813–9. Prospective evaluation of QoL in a randomised trial, comparing pCRT and pRT and comparing results also with reference data from the general population.PubMedCrossRef
22.
go back to reference Brændengen M, Tveit KM, Bruheim K, et al. Late patient-reported toxicity after preoperative radiotherapy or chemoradiotherapy in nonresectable rectal cancer: results from a randomized phase III study. Int J Radiat Oncol Biol Phys. 2011;81(4):1017–24.PubMedCrossRef Brændengen M, Tveit KM, Bruheim K, et al. Late patient-reported toxicity after preoperative radiotherapy or chemoradiotherapy in nonresectable rectal cancer: results from a randomized phase III study. Int J Radiat Oncol Biol Phys. 2011;81(4):1017–24.PubMedCrossRef
23.
go back to reference •• Kang SB, Park JW, Jeong SY, et al. Open versus laparoscopic surgery for mid or low rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): short-term outcomes of a open-label randomised controlled trial. Lancet Oncol. 2010;11(7):637–45. Prospective evaluation of QoL in a randomised trial comparing laparoscopic and open TME. Prospective study with high compliance and adequate sample size.PubMedCrossRef •• Kang SB, Park JW, Jeong SY, et al. Open versus laparoscopic surgery for mid or low rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): short-term outcomes of a open-label randomised controlled trial. Lancet Oncol. 2010;11(7):637–45. Prospective evaluation of QoL in a randomised trial comparing laparoscopic and open TME. Prospective study with high compliance and adequate sample size.PubMedCrossRef
24.
go back to reference Stephens RJ, Thompson LC, Quirke P, et al. Impact of short-course preoperative radiotherapy for rectal cancer on patients’ quality of life: data from the Medical Research Council CR07/National Cancer Institute of Canada Clinical Trials Group C016 randomized clinical trial. J Clin Oncol. 2010;27:4233–9.CrossRef Stephens RJ, Thompson LC, Quirke P, et al. Impact of short-course preoperative radiotherapy for rectal cancer on patients’ quality of life: data from the Medical Research Council CR07/National Cancer Institute of Canada Clinical Trials Group C016 randomized clinical trial. J Clin Oncol. 2010;27:4233–9.CrossRef
25.
go back to reference Tiv M, Puyraveau M, Mineur L, et al. Long-term quality of life in patients with rectal cancer treated with preoperative (chemo)-radiotherapy within a randomized trial. Cancer Radiother. 2010;14(6–7):530–4.PubMedCrossRef Tiv M, Puyraveau M, Mineur L, et al. Long-term quality of life in patients with rectal cancer treated with preoperative (chemo)-radiotherapy within a randomized trial. Cancer Radiother. 2010;14(6–7):530–4.PubMedCrossRef
26.
go back to reference Canda AE, Terzi C, Gorken IB, et al. Effects of preoperative chemoradiotherapy on anal sphincter functions and quality of life in rectal cancer patients. Int J Colorectal Dis. 2010;25(2):197–204.PubMedCrossRef Canda AE, Terzi C, Gorken IB, et al. Effects of preoperative chemoradiotherapy on anal sphincter functions and quality of life in rectal cancer patients. Int J Colorectal Dis. 2010;25(2):197–204.PubMedCrossRef
27.
go back to reference How P, Stelzner S, Branagan G, et al. Comparative Quality of life in patients following abdominoperineal excision and low anterior resection for low rectal cancer. Dis Colon Rectum. 2012;55(4):400–6.PubMedCrossRef How P, Stelzner S, Branagan G, et al. Comparative Quality of life in patients following abdominoperineal excision and low anterior resection for low rectal cancer. Dis Colon Rectum. 2012;55(4):400–6.PubMedCrossRef
28.
go back to reference Kripp M, Wieneke J, Kienle P, et al. Intensified neoadjuvant chemoradiotherapy in locally advanced rectal cancer – impact on long-term quality of life. Eur J Surg Oncol. 2012;38(6):472–7.PubMedCrossRef Kripp M, Wieneke J, Kienle P, et al. Intensified neoadjuvant chemoradiotherapy in locally advanced rectal cancer – impact on long-term quality of life. Eur J Surg Oncol. 2012;38(6):472–7.PubMedCrossRef
29.
go back to reference Maas M, Beets-Tan RG, Lambregts DM, et al. Wait-and-see policy for clinical complete responders after chemoradiation for rectal cancer. J Clin Oncol. 2011;29(35):4633–40.PubMedCrossRef Maas M, Beets-Tan RG, Lambregts DM, et al. Wait-and-see policy for clinical complete responders after chemoradiation for rectal cancer. J Clin Oncol. 2011;29(35):4633–40.PubMedCrossRef
30.
go back to reference Nishizawa Y, Fujii S, Saito N, et al. The association between anal function and neural degeneration after preoperative chemoradiotherapy followed by intersphinteric resection. Dis Colon Rectum. 2011;54(11):1423–9.PubMedCrossRef Nishizawa Y, Fujii S, Saito N, et al. The association between anal function and neural degeneration after preoperative chemoradiotherapy followed by intersphinteric resection. Dis Colon Rectum. 2011;54(11):1423–9.PubMedCrossRef
31.
go back to reference Peng J, Shi D, Goodman KA, et al. Early results of quality of life for curatively treated rectal cancer in Chinese patients with EORTC QLQ-CR29. Radiat Oncol. 2011;6:93.PubMedCrossRef Peng J, Shi D, Goodman KA, et al. Early results of quality of life for curatively treated rectal cancer in Chinese patients with EORTC QLQ-CR29. Radiat Oncol. 2011;6:93.PubMedCrossRef
32.
go back to reference Lupattelli M, Mascioni F, Bellavita R, et al. Long-term anorectal function after postoperative chemoradiotherapy in high-risk rectal cancer patients. Tumori. 2010;96(1):34–41.PubMed Lupattelli M, Mascioni F, Bellavita R, et al. Long-term anorectal function after postoperative chemoradiotherapy in high-risk rectal cancer patients. Tumori. 2010;96(1):34–41.PubMed
33.
go back to reference •• Pucciarelli S, Del Bianco P, Efficace F, et al. Patient-Reported outcomes after neoadjuvant chemoradiotherapy for rectal cancer: a multicenter prospective observational study. Ann Surg. 2011;253(1):71–7. Prospective and multicentre evaluation of QoL, with several assessments, including at baseline, high compliance, and large sample size, focused on the effect of CRT treatment on QoL.PubMedCrossRef •• Pucciarelli S, Del Bianco P, Efficace F, et al. Patient-Reported outcomes after neoadjuvant chemoradiotherapy for rectal cancer: a multicenter prospective observational study. Ann Surg. 2011;253(1):71–7. Prospective and multicentre evaluation of QoL, with several assessments, including at baseline, high compliance, and large sample size, focused on the effect of CRT treatment on QoL.PubMedCrossRef
34.
go back to reference Aaronson NK, Ahmedzai S, Bergam B, et al. European Organisation for research and treatment of cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993;85(5):365–76.PubMedCrossRef Aaronson NK, Ahmedzai S, Bergam B, et al. European Organisation for research and treatment of cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993;85(5):365–76.PubMedCrossRef
35.
go back to reference Sprangers M, Te Velde A, Aaronson N. The construction and testing of the EORTC colorectal cancer-specific quality of life questionnaire module. (QLQ-CR38). Eur J Cancer. 1999;35(2):238–47.PubMedCrossRef Sprangers M, Te Velde A, Aaronson N. The construction and testing of the EORTC colorectal cancer-specific quality of life questionnaire module. (QLQ-CR38). Eur J Cancer. 1999;35(2):238–47.PubMedCrossRef
36.
go back to reference Whistance RN, Conroy T, Chie W, et al. European Organisation for research and treatment of Cancer Quality of Life Group. Clinical and psychometric validation of the EORTC QLQ-CR29 questionnaire module to assess health-related quality of life in patients with colorectal cancer. Eur J Cancer. 2009;45(17):3017–26.PubMedCrossRef Whistance RN, Conroy T, Chie W, et al. European Organisation for research and treatment of Cancer Quality of Life Group. Clinical and psychometric validation of the EORTC QLQ-CR29 questionnaire module to assess health-related quality of life in patients with colorectal cancer. Eur J Cancer. 2009;45(17):3017–26.PubMedCrossRef
37.
go back to reference Rockwood TH, Church JM, Fleshman JW, et al. Fecal incontinence quality of life scale: quality of life instrument for patients with fecal incontinence. Dis Colon Rectum. 2000;43(1):9–16.PubMedCrossRef Rockwood TH, Church JM, Fleshman JW, et al. Fecal incontinence quality of life scale: quality of life instrument for patients with fecal incontinence. Dis Colon Rectum. 2000;43(1):9–16.PubMedCrossRef
38.
go back to reference Ware Jr JE, Sherbourne CD. The MOS 36-item short-form health survey (SF-36): I. Conceptual framework and item selection. Med Care. 1992;30(6):473–83.PubMedCrossRef Ware Jr JE, Sherbourne CD. The MOS 36-item short-form health survey (SF-36): I. Conceptual framework and item selection. Med Care. 1992;30(6):473–83.PubMedCrossRef
39.
go back to reference Prieto L, Thorsen H, Juul K. Development and validation of a quality of life questionnaire for patients with colostomy or ileostomy. Health Qual Life Outcomes. 2005;3:62.PubMedCrossRef Prieto L, Thorsen H, Juul K. Development and validation of a quality of life questionnaire for patients with colostomy or ileostomy. Health Qual Life Outcomes. 2005;3:62.PubMedCrossRef
40.
go back to reference Jorge JM, Wexner SD. Etiology and management of fecal incontinence. Dis Colon Rectum. 1993;36(1):77–97.PubMedCrossRef Jorge JM, Wexner SD. Etiology and management of fecal incontinence. Dis Colon Rectum. 1993;36(1):77–97.PubMedCrossRef
41.
go back to reference Vaizey CJ, Carapeti E, Cahill JA, Kamm MA. Prospective comparison of faecal incontinence grading systems. Gut. 1999;44(1):77–80.PubMedCrossRef Vaizey CJ, Carapeti E, Cahill JA, Kamm MA. Prospective comparison of faecal incontinence grading systems. Gut. 1999;44(1):77–80.PubMedCrossRef
42.
go back to reference Temple LK, Bacik J, Savatta SG, et al. The development of a validated instrument to evaluate bowel function after sphincter-preserving surgery for rectal cancer. Dis Colon Rectum. 2005;48(7):1353–65.PubMedCrossRef Temple LK, Bacik J, Savatta SG, et al. The development of a validated instrument to evaluate bowel function after sphincter-preserving surgery for rectal cancer. Dis Colon Rectum. 2005;48(7):1353–65.PubMedCrossRef
43.
go back to reference Rosen RC, Riley A, Wagner G, Osterloh IH, et al. The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology. 1997;49(6):822–30.PubMedCrossRef Rosen RC, Riley A, Wagner G, Osterloh IH, et al. The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology. 1997;49(6):822–30.PubMedCrossRef
44.
go back to reference Jensen PT, Klee M, Thranov I, Groenvold M. Validation of a questionnaire for self-assessment of sexual function and vaginal changes after gynaecological cancer. Psychooncology. 2004;13(8):577–92.PubMedCrossRef Jensen PT, Klee M, Thranov I, Groenvold M. Validation of a questionnaire for self-assessment of sexual function and vaginal changes after gynaecological cancer. Psychooncology. 2004;13(8):577–92.PubMedCrossRef
45.
go back to reference Brændengen M, Tveit KM, Berglund Å, et al. Randomized phase III study comparing preoperative radiotherapy with chemoradiotherapy in nonresectable rectal cancer. J Clin Oncol. 2008;26(22):3687–94.PubMedCrossRef Brændengen M, Tveit KM, Berglund Å, et al. Randomized phase III study comparing preoperative radiotherapy with chemoradiotherapy in nonresectable rectal cancer. J Clin Oncol. 2008;26(22):3687–94.PubMedCrossRef
46.
go back to reference Sebag-Montefiore D, Stephens RJ, Steele R, et al. Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial. Lancet. 2009;373(9666):811–20.PubMedCrossRef Sebag-Montefiore D, Stephens RJ, Steele R, et al. Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial. Lancet. 2009;373(9666):811–20.PubMedCrossRef
47.
go back to reference Bosset JF, Calais G, Mineur L, et al. Enhanced tumorocidal effect of chemotherapy with preoperative radio- therapy for rectal cancer: preliminary results EORTC 22921. J Clin Oncol. 2005;23(24):5620–7.PubMedCrossRef Bosset JF, Calais G, Mineur L, et al. Enhanced tumorocidal effect of chemotherapy with preoperative radio- therapy for rectal cancer: preliminary results EORTC 22921. J Clin Oncol. 2005;23(24):5620–7.PubMedCrossRef
48.
go back to reference Bosset JF, Calais G, Daban A, et al. Preoperative chemoradiotherapy versus preoperative radiotherapy in rectal cancer patients: assessment of acute toxicity and treatment compliance: Report of the 22921 randomised trial conducted by the EORTC Radiotherapy Group. Eur J Cancer. 2004;40(2):219–24.PubMedCrossRef Bosset JF, Calais G, Daban A, et al. Preoperative chemoradiotherapy versus preoperative radiotherapy in rectal cancer patients: assessment of acute toxicity and treatment compliance: Report of the 22921 randomised trial conducted by the EORTC Radiotherapy Group. Eur J Cancer. 2004;40(2):219–24.PubMedCrossRef
49.
go back to reference Willeke F, Horisberger K, Kraus-Tiefenbacher U, et al. A phase II study of capecitabine and irinotecan in combination with concurrent pelvic radiotherapy (CapIri-RT) as neoadjuvant treatment of locally advanced rectal cancer. Br J Cancer. 2007;96(6):912–7.PubMedCrossRef Willeke F, Horisberger K, Kraus-Tiefenbacher U, et al. A phase II study of capecitabine and irinotecan in combination with concurrent pelvic radiotherapy (CapIri-RT) as neoadjuvant treatment of locally advanced rectal cancer. Br J Cancer. 2007;96(6):912–7.PubMedCrossRef
50.
go back to reference Horisberger K, Treschl A, Mai S, et al. Cetuximab in combination with capecitabine, irinotecan, and radiotherapy for patients with locally advanced rectal cancer: results of a phase II MARGIT trial. Int J Radiation Oncology Biol Phys. 2009;74(5):1487–93.CrossRef Horisberger K, Treschl A, Mai S, et al. Cetuximab in combination with capecitabine, irinotecan, and radiotherapy for patients with locally advanced rectal cancer: results of a phase II MARGIT trial. Int J Radiation Oncology Biol Phys. 2009;74(5):1487–93.CrossRef
51.
go back to reference Hofheinz R, Wenz F, Post S, et al. Capecitabine (cape) versus 5-fluorouracil (5-FU)-based (neo-)adjuvant chemoradiotherapy (CRT) for locally advanced rectal cancer (LARC): safety results of a randomized, phase III trial. J Clinical Oncol. 2009;27(15S):4014. Hofheinz R, Wenz F, Post S, et al. Capecitabine (cape) versus 5-fluorouracil (5-FU)-based (neo-)adjuvant chemoradiotherapy (CRT) for locally advanced rectal cancer (LARC): safety results of a randomized, phase III trial. J Clinical Oncol. 2009;27(15S):4014.
52.
go back to reference Holzer B, Matzel K, Schiedeck T, et al. Do geographic and educational factors influence the quality of life in rectal cancer patients with a permanent colostomy? Dis Col Rectum. 2005;48(12):2209–16.CrossRef Holzer B, Matzel K, Schiedeck T, et al. Do geographic and educational factors influence the quality of life in rectal cancer patients with a permanent colostomy? Dis Col Rectum. 2005;48(12):2209–16.CrossRef
53.
go back to reference Cornish JA, Tilney HS, Heriot AG, et al. A meta-analysis of quality of life for abdominoperineal excision of rectum versus anterior resection for rectal cancer. Ann Surg Oncol. 2007;14(7):2056–68.PubMedCrossRef Cornish JA, Tilney HS, Heriot AG, et al. A meta-analysis of quality of life for abdominoperineal excision of rectum versus anterior resection for rectal cancer. Ann Surg Oncol. 2007;14(7):2056–68.PubMedCrossRef
54.
go back to reference Holzer B, Gyasi A, Schiessel R, Rosen HR. Patients’ expectations of colorectal surgery for cancer. Colorectal Dis. 2006;8(3):186–91.PubMedCrossRef Holzer B, Gyasi A, Schiessel R, Rosen HR. Patients’ expectations of colorectal surgery for cancer. Colorectal Dis. 2006;8(3):186–91.PubMedCrossRef
55.
go back to reference Amsterlaw J, Zikmund-Fisher BJ, Fagerlin A, Ubel PA. Can avoidance of complications lead to biased healthcare decisions? Judgment and Decision Making. 2006;1(1):64–75. Amsterlaw J, Zikmund-Fisher BJ, Fagerlin A, Ubel PA. Can avoidance of complications lead to biased healthcare decisions? Judgment and Decision Making. 2006;1(1):64–75.
56.
go back to reference Bossema A, Stiggelbout A, Baas-Thijssen M, et al. Patients’ preferences for low rectal cancer surgery. Eur J Surg Oncol. 2008;34(1):42–8.PubMedCrossRef Bossema A, Stiggelbout A, Baas-Thijssen M, et al. Patients’ preferences for low rectal cancer surgery. Eur J Surg Oncol. 2008;34(1):42–8.PubMedCrossRef
57.
go back to reference Masya L, Young J, Solomon M, et al. Preferences for outcomes of treatment for rectal cancer: patient and clinician utilities and their application in an interactive computer-based decision aid. Dis Colon Rectum. 2009;52(12):1994–2002.PubMedCrossRef Masya L, Young J, Solomon M, et al. Preferences for outcomes of treatment for rectal cancer: patient and clinician utilities and their application in an interactive computer-based decision aid. Dis Colon Rectum. 2009;52(12):1994–2002.PubMedCrossRef
58.
go back to reference Vironen J, Kairaluoma M, Aalto A, Kellokumpu I. Impact of functional results on quality of life after rectal cancer surgery. Dis Colon Rectum. 2006;49(5):568–78.PubMedCrossRef Vironen J, Kairaluoma M, Aalto A, Kellokumpu I. Impact of functional results on quality of life after rectal cancer surgery. Dis Colon Rectum. 2006;49(5):568–78.PubMedCrossRef
59.
go back to reference Sutherland HJ, Till JE. Quality of life assessments and levels of decision making: differentiating objectives. Qual Life Res. 1993;2(4):297–303.PubMedCrossRef Sutherland HJ, Till JE. Quality of life assessments and levels of decision making: differentiating objectives. Qual Life Res. 1993;2(4):297–303.PubMedCrossRef
60.
go back to reference Stiggelbout AM, de Haes JCJM. Patient preference for cancer therapy: an overview of measurement approaches. J Clin Oncol. 2001;19(1):220–30.PubMed Stiggelbout AM, de Haes JCJM. Patient preference for cancer therapy: an overview of measurement approaches. J Clin Oncol. 2001;19(1):220–30.PubMed
Metadata
Title
Quality of Life and Functions After Chemoradiation for Rectal Cancer: A Review of Recent Publications
Authors
Teresa Gavaruzzi
Francesca Giandomenico
Salvatore Pucciarelli
Publication date
01-06-2013
Publisher
Current Science Inc.
Published in
Current Colorectal Cancer Reports / Issue 2/2013
Print ISSN: 1556-3790
Electronic ISSN: 1556-3804
DOI
https://doi.org/10.1007/s11888-013-0161-x

Other articles of this Issue 2/2013

Current Colorectal Cancer Reports 2/2013 Go to the issue

Colorectal Cancer Hepatic Metastases (KK Tanabe, Section Editor)

The ALPPS Approach for the Management of Colorectal Carcinoma Liver Metastases

Colorectal Cancer Hepatic Metastases (KK Tanabe, Section Editor)

Irreversible Electroporation: a Novel Option for Treatment of Hepatic Metastases

Localized Rectal Cancer (R Glynne-Jones, Section Editor)

How Could the TNM System Be Best Adapted for Staging Rectal Cancer in the Future?

Localized Rectal Cancer (R Glynne-Jones, Section Editor)

The Role of Enhanced Recovery After Surgery for Rectal Cancer

Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine