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Published in: Current Allergy and Asthma Reports 6/2021

01-06-2021 | Anaphylaxis | Anaphylaxis and Drug Allergy (BT Kelly and M Castells, Section Editors)

Drug Desensitizations for Chemotherapy: Safety and Efficacy in Preventing Anaphylaxis

Authors: Joana Caiado, Mariana C. Castells

Published in: Current Allergy and Asthma Reports | Issue 6/2021

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Abstract

Hypersensitivity reactions (HSRs) to antineoplastic drugs are increasing due to the expanding use of classical and new drugs in a wide variety of malignancies.

Purpose of Review

The goal of this review is to provide current best practices in the diagnosis and management of HSRs based on data and evidence.

Recent Findings

A plethora of studies have provided evidence of the safety and efficacy of rapid drug desensitizations (RDD) to allow for the reintroduction of antineoplastic drugs following an HSR, based on risk stratification. Recently described biomarkers such as basophil activation test, total IgE, BRCA genotyping, and serum IL-6 can aid in guiding improved precision desensitization protocols. Personalized premedication regimens and protocols have improved RDD safety and outcomes.

Summary

RDD allows for the continued use of chemotherapeutic drugs without impaired drug efficacy. RDD represents the best approach to maintain cancer patients on their most effective treatments.
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Metadata
Title
Drug Desensitizations for Chemotherapy: Safety and Efficacy in Preventing Anaphylaxis
Authors
Joana Caiado
Mariana C. Castells
Publication date
01-06-2021
Publisher
Springer US
Published in
Current Allergy and Asthma Reports / Issue 6/2021
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-021-01014-x