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Current Allergy and Asthma Reports

Published in:

01-10-2017 | Asthma (WJ Calhoun and V Ortega, Section Editors)

Predictive Biomarkers for Asthma Therapy

Authors: Sarah K. Medrek, Amit D. Parulekar, Nicola A. Hanania

Published in: Current Allergy and Asthma Reports | Issue 10/2017

Abstract

Purpose of Review

Asthma is a heterogeneous disease characterized by multiple phenotypes. Treatment of patients with severe disease can be challenging. Predictive biomarkers are measurable characteristics that reflect the underlying pathophysiology of asthma and can identify patients that are likely to respond to a given therapy. This review discusses current knowledge regarding predictive biomarkers in asthma.

Recent Findings

Recent trials evaluating biologic therapies targeting IgE, IL-5, IL-13, and IL-4 have utilized predictive biomarkers to identify patients who might benefit from treatment. Other work has suggested that using composite biomarkers may offer enhanced predictive capabilities in tailoring asthma therapy.

Summary

Multiple biomarkers including sputum eosinophil count, blood eosinophil count, fractional concentration of nitric oxide in exhaled breath (FeNO), and serum periostin have been used to identify which patients will respond to targeted asthma medications. Further work is needed to integrate predictive biomarkers into clinical practice.

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Title: Predictive Biomarkers for Asthma Therapy
Authors: Sarah K. Medrek
Amit D. Parulekar
Nicola A. Hanania
Publication date: 01-10-2017
Publisher: Springer US
Published in: Current Allergy and Asthma Reports / Issue 10/2017
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI: https://doi.org/10.1007/s11882-017-0739-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Predictive Biomarkers for Asthma Therapy

Abstract

Purpose of Review

Recent Findings

Summary

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose of Review

Recent Findings

Summary

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