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Current Allergy and Asthma Reports

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01-05-2017 | Immunologic/Diagnostic Tests in Allergy (M Chapman and A Pomés, Section Editors)

Natural Evolution of IgE Responses to Mite Allergens and Relationship to Progression of Allergic Disease: a Review

Authors: Daniela Posa, Stephanie Hofmaier, Stefania Arasi, Paolo Maria Matricardi

Published in: Current Allergy and Asthma Reports | Issue 5/2017

Abstract

Purpose of Review

Allergenic molecules of the house dust mite (HDM) are crucially important indoor allergens, contributing to allergic rhinitis and asthma around the globe. In the past years, recombinant molecules for diagnostics opened new pathways to investigate individual sensitization profiles and new chances for the prevention and treatment of HDM allergy. This review summarizes the latest findings on the evolution of IgE responses towards mite allergens.

Recent Findings

Several cross-sectional and longitudinal studies confirmed the role of Der p 1 and Der p 2 as major allergenic proteins of the HDM. A newly identified player is the major allergen Der p 23. Apart from identifying the early sensitization towards this molecule as a risk factor for asthma in school age, a recent longitudinal study described sensitization patterns showing that the production of IgE usually starts towards a group of initiator proteins and may stay monomolecular or expand to an oligo- or even polymolecular stage. This phenomenon also correlates to clinical symptoms. A relation between a broad sensitization pattern and symptom severity has also been shown cross-sectionally.

Summary

Individual sensitization profiles towards HDM allergens provide important information to evaluate a patient’s current stage and risk for clinical symptoms. This knowledge paves the way for an early and adequate prevention and/or treatment.

Tovey ER, Chapman MD, Wells CW, Platts-Mills TA. The distribution of dust mite allergen in the houses of patients with asthma. Am Rev Respir Dis. 1981;124(5):630–5. doi:10.1164/arrd.1981.124.5.630.PubMed

Bousquet PJ, Chinn S, Janson C, Kogevinas M, Burney P, Jarvis D, et al. Geographical variation in the prevalence of positive skin tests to environmental aeroallergens in the European Community Respiratory Health Survey I. Allergy. 2007;62(3):301–9. doi:10.1111/j.1398-9995.2006.01293.x.CrossRefPubMed

Blomme K, Tomassen P, Lapeere H, Huvenne W, Bonny M, Acke F, et al. Prevalence of allergic sensitization versus allergic rhinitis symptoms in an unselected population. Int Arch Allergy Immunol. 2013;160(2):200–7. doi:10.1159/000339853.CrossRefPubMed

Johnston JD, Barney T, Crandall J, Brown M, Westover T, Paulson S, et al. Prevalence of house dust mite allergens in low-income homes with evaporative coolers in a semi-arid climate. Archives of environmental & occupational health. 2017; doi:10.1080/19338244.2017.1282846.

• Calderon MA, Linneberg A, Kleine-Tebbe J, De Blay F, De Hernandez Fernandez Rojas D, Virchow JC, et al. Respiratory allergy caused by house dust mites: what do we really know? J Allergy Clin Immunol. 2015;136(1):38–48. doi:10.1016/j.jaci.2014.10.012. Extensive review on the relationship between exposure to house dust mite, allergic response and development of allergic airways diseases CrossRefPubMed

• Linneberg A, Dam Petersen K, Hahn-Pedersen J, Hammerby E, Serup-Hansen N, Boxall N. Burden of allergic respiratory disease: a systematic review. Clinical and molecular allergy : CMA. 2016;14:12. doi:10.1186/s12948-016-0049-9. This meta-analysis demonstrates the low level of the health-related quality of life (HRQL) of patients with perennial HDM allergy in comparison with patients with seasonal pollen allergy CrossRefPubMedPubMedCentral

Asher MI, Montefort S, Bjorksten B, Lai CK, Strachan DP, Weiland SK, et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet. 2006;368(9537):733–43. doi:10.1016/S0140-6736(06)69283-0.CrossRefPubMed

Ellwood P, Asher MI, Billo NE, Bissell K, Chiang CY, Ellwood EM, et al. The Global Asthma Network rationale and methods for Phase I global surveillance: prevalence, severity, management and risk factors. Eur Respir J. 2017;49(1) doi:10.1183/13993003.01605-2016.

Gandhi VD, Davidson C, Asaduzzaman M, Nahirney D, Vliagoftis H. House dust mite interactions with airway epithelium: role in allergic airway inflammation. Curr Allergy Asthma Rep. 2013;13(3):262–70. doi:10.1007/s11882-013-0349-9.CrossRefPubMed

10.

Marks GB, Mihrshahi S, Kemp AS, Tovey ER, Webb K, Almqvist C, et al. Prevention of asthma during the first 5 years of life: a randomized controlled trial. J Allergy Clin Immunol. 2006;118(1):53–61. doi:10.1016/j.jaci.2006.04.004.CrossRefPubMed

11.

Sporik R, Chapman MD, Platts-Mills TA. House dust mite exposure as a cause of asthma. Clinical and experimental allergy: journal of the British Society for Allergy and Clinical Immunology. 1992;22(10):897–906.CrossRef

12.

Morgan WJ, Crain EF, Gruchalla RS, O'Connor GT, Kattan M, Evans 3rd R, et al. Results of a home-based environmental intervention among urban children with asthma. N Engl J Med. 2004;351(11):1068–80. doi:10.1056/NEJMoa032097.CrossRefPubMed

13.

van Schayck OC, Maas T, Kaper J, Knottnerus AJ, Sheikh A. Is there any role for allergen avoidance in the primary prevention of childhood asthma? J Allergy Clin Immunol. 2007;119(6):1323–8. doi:10.1016/j.jaci.2007.02.024.CrossRefPubMed

14.

Calderon MA, Kleine-Tebbe J, Linneberg A, De Blay F, Hernandez Fernandez de Rojas D, Virchow JC, et al. House dust mite respiratory allergy: an overview of current therapeutic strategies. The journal of allergy and clinical immunology In practice. 2015;3(6):843–55. doi:10.1016/j.jaip.2015.06.019.CrossRefPubMed

15.

Ciprandi G, Natoli V, Puccinelli P, Incorvaia C, Italian Cometa Study Group. Allergic rhinitis: the eligible candidate to mite immunotherapy in the real world. Allergy, asthma, and clinical immunology: official journal of the Canadian Society of Allergy and Clin Immunol. 2017;13:11. doi:10.1186/s13223-017-0185-x.CrossRef

16.

Valenta R, Lidholm J, Niederberger V, Hayek B, Kraft D, Gronlund H. The recombinant allergen-based concept of component-resolved diagnostics and immunotherapy (CRD and CRIT). Clinical and experimental allergy: journal of the British Society for Allergy and Clinical Immunology. 1999;29(7):896–904.CrossRef

17.

Matricardi PM, Kleine-Tebbe J. Molecular allergology between Precision Medicine and the Choosing Wisely initiative. Clinical and experimental allergy: journal of the British Society for Allergy and Clinical Immunology. 2016;46(5):664–7. doi:10.1111/cea.12679.CrossRef

18.

Casset A, Mari A, Purohit A, Resch Y, Weghofer M, Ferrara R, et al. Varying allergen composition and content affects the in vivo allergenic activity of commercial Dermatophagoides pteronyssinus extracts. Int Arch Allergy Immunol. 2012;159(3):253–62. doi:10.1159/000337654.CrossRefPubMedPubMedCentral

19.

Brunetto B, Tinghino R, Braschi MC, Antonicelli L, Pini C, Iacovacci P. Characterization and comparison of commercially available mite extracts for in vivo diagnosis. Allergy. 2010;65(2):184–90. doi:10.1111/j.1398-9995.2009.02150.x.CrossRefPubMed

20.

Sastre J. Molecular diagnosis in allergy. Clinical and experimental allergy: journal of the British Society for Allergy and Clinical Immunology. 2010;40(10):1442–60. doi:10.1111/j.1365-2222.2010.03585.x.CrossRef

21.

Treudler R, Simon JC. Overview of component resolved diagnostics. Curr Allergy Asthma Rep. 2013;13(1):110–7. doi:10.1007/s11882-012-0318-8.CrossRefPubMed

22.

Borres MP, Ebisawa M, Eigenmann PA. Use of allergen components begins a new era in pediatric allergology. Pediatric allergy and immunology: official publication of the European Society of Pediatric Allergy and Immunology. 2011;22(5):454–61. doi:10.1111/j.1399-3038.2011.01197.x.CrossRef

23.

Canonica GW, Ansotegui IJ, Pawankar R, Schmid-Grendelmeier P, van Hage M, Baena-Cagnani CE, et al. A WAO - ARIA - GA(2)LEN consensus document on molecular-based allergy diagnostics. The World Allergy Organization journal. 2013;6(1):17. doi:10.1186/1939-4551-6-17.CrossRefPubMedPubMedCentral

24.

•• Matricardi PM, Kleine-Tebbe J, Hoffmann HJ, Valenta R, Hilger C, Hofmaier S, et al. EAACI molecular allergology user's guide. Pediatric allergy and immunology: official publication of the European Society of Pediatric Allergy and Immunology. 2016;27(Suppl 23):1–250. doi:10.1111/pai.12563. Detailed summary of important allergens, description of diagnostic option through the use of component-resolved diagnostics and integration of molecular allergology into clinical practice CrossRef

25.

•• Hamilton RG, Kleine-Tebbe J. Molecular allergy diagnostics: analytical features that support clinical decisions. Curr Allergy Asthma Rep. 2015;15(9):57. doi:10.1007/s11882-015-0556-7. This paper provides documentation for the use of selected allergenic molecules to improve the clinician’s prediction of the risk of a serious allergic reaction CrossRefPubMed

26.

Sastre J, Landivar ME, Ruiz-Garcia M, Andregnette-Rosigno MV, Mahillo I. How molecular diagnosis can change allergen-specific immunotherapy prescription in a complex pollen area. Allergy. 2012;67(5):709–11. doi:10.1111/j.1398-9995.2012.02808.x.CrossRefPubMed

27.

Stringari G, Tripodi S, Caffarelli C, Dondi A, Asero R, Di Rienzo BA, et al. The effect of component-resolved diagnosis on specific immunotherapy prescription in children with hay fever. J Allergy Clin Immunol. 2014;134(1):75–81. doi:10.1016/j.jaci.2014.01.042.CrossRefPubMed

28.

Valenta R. The future of antigen-specific immunotherapy of allergy. Nat Rev Immunol. 2002;2(6):446–53. doi:10.1038/nri824.PubMed

29.

Chen KW, Blatt K, Thomas WR, Swoboda I, Valent P, Valenta R, et al. Hypoallergenic Der p 1/Der p 2 combination vaccines for immunotherapy of house dust mite allergy. J Allergy Clin Immunol. 2012;130(2):435–43. e4 doi:10.1016/j.jaci.2012.05.035.CrossRefPubMedPubMedCentral

30.

Vrtala S, Huber H, Thomas WR. Recombinant house dust mite allergens. Methods. 2014;66(1):67–74. doi:10.1016/j.ymeth.2013.07.034.CrossRefPubMed

31.

Asturias JA, Ibarrola I, Arilla MC, Vidal C, Ferrer A, Gamboa PM, et al. Engineering of major house dust mite allergens Der p 1 and Der p 2 for allergen-specific immunotherapy. Clinical and experimental allergy: journal of the British Society for Allergy and Clinical Immunology. 2009;39(7):1088–98. doi:10.1111/j.1365-2222.2009.03264.x.CrossRef

32.

•• Thomas WR. House dust mite allergens: new discoveries and relevance to the allergic patient. Curr Allergy Asthma Rep. 2016;16(9):69. doi:10.1007/s11882-016-0649-y. A comprehensive review on house dust allergens with important information about clinical and biological activity CrossRefPubMed

33.

Jeong KY, Lee JY, Son M, Yi MH, Yong TS, Shin JU, et al. Profiles of IgE sensitization to Der f 1, Der f 2, Der f 6, Der f 8, Der f 10, and Der f 20 in Korean house dust mite allergy patients. Allergy Asthma Immunol Res. 2015;7(5):483–8. doi:10.4168/aair.2015.7.5.483.CrossRefPubMedPubMedCentral

34.

Caraballo L, Puerta L, Martinez B, Moreno L. Identification of allergens from the mite Blomia tropicalis. Clinical and experimental allergy: journal of the British Society for Allergy and Clinical Immunology. 1994;24(11):1056–60.CrossRef

35.

Herman J, Thelen N, Smargiasso N, Mailleux AC, Luxen A, Cloes M, et al. Der p 1 is the primary activator of Der p 3, Der p 6 and Der p 9 the proteolytic allergens produced by the house dust mite Dermatophagoides pteronyssinus. Bba-Gen Subjects. 2014;1840(3):1117–24. doi:10.1016/j.bbagen2013.11.017.CrossRef

36.

Pacciani V, Corrente S, Gregori S, Pierantozzi A, Silenzi R, Chianca M, et al. Correlation of Der p 2 T-cell responses with clinical characteristics of children allergic to house dust mite. Ann Allergy Asthma Immunol. 2012;109(6):442–7. doi:10.1016/j.anai.2012.09.001.CrossRefPubMed

37.

Stewart GA, Kollinger MR, King CM, Thompson PJ. A comparative study of three serine proteases from Dermatophagoides pteronyssinus and Dermatophagoides farinae. Allergy. 1994;49(7):553–60.CrossRefPubMed

38.

Bronnert M, Mancini J, Birnbaum J, Agabriel C, Liabeuf V, Porri F, et al. Component-resolved diagnosis with commercially available D. pteronyssinus Der p 1, Der p 2 and Der p 10: relevant markers for house dust mite allergy. Clinical and experimental allergy: journal of the British Society for Allergy and Clinical Immunology. 2012;42(9):1406–15. doi:10.1111/j.1365-2222.2012.04035.x.CrossRef

39.

Vidal C, Lojo S, Juangorena M, Gonzalez-Quintela A. Association between asthma and sensitization to allergens of Dermatophagoides pteronyssinus. Journal of investigational allergology & clinical immunology. 2016;26(5):304–9. doi:10.18176/jiaci.0048.CrossRef

40.

Simpson A, Lazic N, Belgrave DC, Johnson P, Bishop C, Mills C, et al. Patterns of IgE responses to multiple allergen components and clinical symptoms at age 11 years. J Allergy Clin Immunol. 2015;136(5):1224–31. doi:10.1016/j.jaci.2015.03.027.CrossRefPubMedPubMedCentral

41.

Reese G, Ayuso R, Lehrer SB. Tropomyosin: an invertebrate pan-allergen. Int Arch Allergy Immunol. 1999;119(4):247–58. doi: 24201 CrossRefPubMed

42.

Resch Y, Weghofer M, Seiberler S, Horak F, Scheiblhofer S, Linhart B, et al. Molecular characterization of Der p 10: a diagnostic marker for broad sensitization in house dust mite allergy. Clinical and experimental allergy: journal of the British Society for Allergy and Clinical Immunology. 2011;41(10):1468–77. doi:10.1111/j.1365-2222.2011.03798.x.CrossRef

43.

• Custovic A, Sonntag HJ, Buchan IE, Belgrave D, Simpson A, Prosperi MC. Evolution pathways of IgE responses to grass and mite allergens throughout childhood. J Allergy Clin Immunol. 2015;136(6):1645–52 e1-8. doi:10.1016/j.jaci.2015.03.041. A longitudinal study on the development of the IgE response to grass and to mites in relation with clinical outcomes in the Manchester Asthma and Allergy Study (MAAS) CrossRefPubMed

44.

Dumez ME, Herman J, Campizi V, Galleni M, Jacquet A, Chevigne A. Orchestration of an uncommon maturation cascade of the house dust mite protease allergen quartet. Front Immunol. 2014;5:138. doi:10.3389/fimmu.2014.00138.CrossRefPubMedPubMedCentral

45.

Weghofer M, Grote M, Resch Y, Casset A, Kneidinger M, Kopec J, et al. Identification of Der p 23, a peritrophin-like protein, as a new major Dermatophagoides pteronyssinus allergen associated with the peritrophic matrix of mite fecal pellets. J Immunol. 2013;190(7):3059–67. doi:10.4049/jimmunol.1202288.CrossRefPubMedPubMedCentral

46.

•• Thomas WR. Hierarchy and molecular properties of house dust mite allergens. Allergology international: official journal of the Japanese Society of Allergology. 2015;64(4):304–11. doi:10.1016/j.alit.2015.05.004. Review on the spectrum of house dust mite allergic molecules with classification in serodominant, mid-tier and minor allergens CrossRef

47.

Mueller GA, Randall TA, Glesner J, Pedersen LC, Perera L, Edwards LL, et al. Serological, genomic and structural analyses of the major mite allergen Der p 23. Clinical and experimental allergy: journal of the British Society for Allergy and Clinical Immunology. 2016;46(2):365–76. doi:10.1111/cea.12680.CrossRef

48.

• Banerjee S, Resch Y, Chen KW, Swoboda I, Focke-Tejkl M, Blatt K, et al. Der p 11 is a major allergen for house dust mite-allergic patients suffering from atopic dermatitis. The Journal of investigative dermatology. 2015;135(1):102–9. doi:10.1038/jid.2014.271. The study reports a high prevalence of IgE reactivity to Der p 11, a paramyosin that occurs predominantly in muscle of Dermatophagoides pteronyssinus , in house dust mite allergic patients suffering from AD CrossRefPubMed

49.

Weghofer M, Grote M, Dall'Antonia Y, Fernandez-Caldas E, Krauth MT, van Hage M, et al. Characterization of folded recombinant Der p 5, a potential diagnostic marker allergen for house dust mite allergy. Int Arch Allergy Immunol. 2008;147(2):101–9. doi:10.1159/000135696.CrossRefPubMed

50.

O'Neil SE, Heinrich TK, Hales BJ, Hazell LA, Holt DC, Fischer K, et al. The chitinase allergens Der p 15 and Der p 18 from Dermatophagoides pteronyssinus. Clinical and experimental allergy: journal of the British Society for Allergy and Clinical Immunology. 2006;36(6):831–9. doi:10.1111/j.1365-2222.2006.02497.x.CrossRef

51.

Hales BJ, Elliot CE, Chai LY, Pearce LJ, Tipayanon T, Hazell L, et al. Quantitation of IgE binding to the chitinase and chitinase-like house dust mite allergens Der p 15 and Der p 18 compared to the major and mid-range allergens. Int Arch Allergy Immunol. 2013;160(3):233–40. doi:10.1159/000339760.CrossRefPubMed

52.

Weghofer M, Dall'Antonia Y, Grote M, Stocklinger A, Kneidinger M, Balic N, et al. Characterization of Der p 21, a new important allergen derived from the gut of house dust mites. Allergy. 2008;63(6):758–67. doi:10.1111/j.1398-9995.2008.01647.x.CrossRefPubMed

53.

Batard T, Baron-Bodo V, Martelet A, Le Mignon M, Lemoine P, Jain K, et al. Patterns of IgE sensitization in house dust mite-allergic patients: implications for allergen immunotherapy. Allergy. 2016;71(2):220–9. doi:10.1111/all.12796.CrossRefPubMed

54.

Weghofer M, Thomas WR, Kronqvist M, Mari A, Purohit A, Pauli G, et al. Variability of IgE reactivity profiles among European mite allergic patients. Eur J Clin Investig. 2008;38(12):959–65. doi:10.1111/j.1365-2362.2008.02048.x.CrossRef

55.

•• Resch Y, Michel S, Kabesch M, Lupinek C, Valenta R, Vrtala S. Different IgE recognition of mite allergen components in asthmatic and nonasthmatic children. J Allergy Clin Immunol. 2015;136(4):1083–91. doi:10.1016/j.jaci.2015.03.024. A cross-sectional study demonstrating that IgE response to Dermatophagoides pteronyssinus in asthmatic children is characterized by an expanded molecular repertoire and by an increased number of sIgE CrossRefPubMedPubMedCentral

56.

Hatzler L, Panetta V, Lau S, Wagner P, Bergmann RL, Illi S, et al. Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever. J Allergy Clin Immunol. 2012;130(4):894–901. e5 doi:10.1016/j.jaci.2012.05.053.CrossRefPubMed

57.

•• Posa D, Perna S, Resch Y, Lupinek C, Panetta V, Hofmaier S, et al. Evolution and predictive value of IgE responses toward a comprehensive panel of house dust mite allergens during the first 2 decades of life. J Allergy Clin Immunol. 2017;139(2):541–9 e8. doi:10.1016/j.jaci.2016.08.014. Birth cohort study that explores the IgE response to 12 molecules of Dermatophagoides pteronyssinus and its risk factors, and evaluate IgE patterns in relation to the evolution of clinical symptoms CrossRefPubMed

58.

Matricardi PM. Allergen-specific immunoprophylaxis: toward secondary prevention of allergic rhinitis? Pediatric allergy and immunology: official publication of the European Society of Pediatric Allergy and Immunology. 2014;25(1):15–8. doi:10.1111/pai.12200.

59.

Charpin D, Kleisbauer JP, Lanteaume A, Razzouk H, Vervloet D, Toumi M, et al. Asthma and allergy to house-dust mites in populations living in high altitudes. Chest. 1988;93(4):758–61.CrossRefPubMed

60.

Platts-Mills TA, Tovey ER, Mitchell EB, Moszoro H, Nock P, Wilkins SR. Reduction of bronchial hyperreactivity during prolonged allergen avoidance. Lancet. 1982;2(8300):675–8.CrossRefPubMed

61.

Boner AL, Niero E, Antolini I, Valletta EA, Gaburro D. Pulmonary function and bronchial hyperreactivity in asthmatic children with house dust mite allergy during prolonged stay in the Italian Alps (Misurina, 1756 m). Annals of allergy. 1985;54(1):42–5.PubMed

62.

Tsurikisawa N, Saito A, Oshikata C, Yasueda H, Akiyama K. Effective allergen avoidance for reducing exposure to house dust mite allergens and improving disease management in adult atopic asthmatics. The Journal of asthma: official journal of the Association for the Care of Asthma. 2016;53(8):843–53. doi:10.3109/02770903.2016.1155218.CrossRef

63.

Illi S, von Mutius E, Lau S, Niggemann B, Gruber C, Wahn U, et al. Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study. Lancet. 2006;368(9537):763–70. doi:10.1016/S0140-6736(06)69286-6.CrossRefPubMed

64.

Bachert C, Larche M, Bonini S, Canonica GW, Kundig T, Larenas-Linnemann D, et al. Allergen immunotherapy on the way to product-based evaluation—a WAO statement. The World Allergy Organization journal. 2015;8(1):29. doi:10.1186/s40413-015-0078-8.CrossRefPubMedPubMedCentral

65.

•• Kristiansen M, Dhami S, Netuveli G, Halken S, Muraro A, Roberts G, et al. Allergen immunotherapy for the prevention of allergy: a systematic review and meta-analysis. Pediatric allergy and immunology: official publication of the European Society of Pediatric Allergy and Immunology. 2017;28(1):18–29. doi:10.1111/pai.12661. Detailed review on the role of Immunotherapy in the prevention of Allergy: evaluation of 32 studies about SCIT, oral and SLIT including children and/or adults CrossRef

66.

Pifferi M, Baldini G, Marrazzini G, Baldini M, Ragazzo V, Pietrobelli A, et al. Benefits of immunotherapy with a standardized Dermatophagoides pteronyssinus extract in asthmatic children: a three-year prospective study. Allergy. 2002;57(9):785–90.CrossRefPubMed

67.

Szepfalusi Z, Bannert C, Ronceray L, Mayer E, Hassler M, Wissmann E, et al. Preventive sublingual immunotherapy in preschool children: first evidence for safety and pro-tolerogenic effects. Pediatric allergy and immunology: official publication of the European Society of Pediatric Allergy and Immunology. 2014;25(8):788–95. doi:10.1111/pai.12310.CrossRef

68.

• Zolkipli Z, Roberts G, Cornelius V, Clayton B, Pearson S, Michaelis L, et al. Randomized controlled trial of primary prevention of atopy using house dust mite allergen oral immunotherapy in early childhood. J Allergy Clin Immunol. 2015;136(6):1541–7 e1-11. doi:10.1016/j.jaci.2015.04.045. This is the first primary prevention study of allergen immunotherapy in infancy evaluating a potential protective effect of high-dose HDM allergen extract on the development of atopy CrossRefPubMed

69.

Jacobsen L, Niggemann B, Dreborg S, Ferdousi HA, Halken S, Host A, et al. Specific immunotherapy has long-term preventive effect of seasonal and perennial asthma: 10-year follow-up on the PAT study. Allergy. 2007;62(8):943–8. doi:10.1111/j.1398-9995.2007.01451.x.CrossRefPubMed

70.

Cromwell O, Matricardi PM, Fiebig H. Patient-tailored recombinant allergen products—mission impossible? Arbeiten aus dem Paul-Ehrlich-Institut. 2009;96:210–7. discussion 7-8

71.

• Berings M, Arasi S, De Ruyck N, Perna S, Resch Y, Lupinek C, et al. Reliable mite-specific IgE testing in nasal secretions by means of allergen microarray. J Allergy Clin Immunol. 2017; doi:10.1016/j.jaci.2016.11.047. The first study performed with a customized microarray for IgE to allergen components of House Dust Mite in nasal secretions of patients suffering from HDM allergic rhinitis PubMed

Title: Natural Evolution of IgE Responses to Mite Allergens and Relationship to Progression of Allergic Disease: a Review
Authors: Daniela Posa
Stephanie Hofmaier
Stefania Arasi
Paolo Maria Matricardi
Publication date: 01-05-2017
Publisher: Springer US
Published in: Current Allergy and Asthma Reports / Issue 5/2017
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI: https://doi.org/10.1007/s11882-017-0697-y

At a glance: The STEP trials

Springer Medicine

Natural Evolution of IgE Responses to Mite Allergens and Relationship to Progression of Allergic Disease: a Review

Abstract

Purpose of Review

Recent Findings

Summary

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose of Review

Recent Findings

Summary

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