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01-08-2013 | AUTOIMMUNITY (TK TARRANT, SECTION EDITOR)

Autoimmunity in Immunodeficiency

Authors: Krista Todoric, Jessica B. Koontz, Daniel Mattox, Teresa K. Tarrant

Published in: Current Allergy and Asthma Reports | Issue 4/2013

Abstract

Primary immunodeficiencies (PID) comprise a diverse group of clinical disorders with varied genetic defects. Paradoxically, a substantial proportion of PID patients develop autoimmune phenomena in addition to having increased susceptibility to infections from their impaired immunity. Although much of our understanding comes from data gathered through experimental models, there are several well-characterized PID that have improved our knowledge of the pathways that drive autoimmunity. The goals of this review will be to discuss these immunodeficiencies and to review the literature with respect to the proposed mechanisms for autoimmunity within each put forth to date.

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Title: Autoimmunity in Immunodeficiency
Authors: Krista Todoric
Jessica B. Koontz
Daniel Mattox
Teresa K. Tarrant
Publication date: 01-08-2013
Publisher: Springer US
Published in: Current Allergy and Asthma Reports / Issue 4/2013
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI: https://doi.org/10.1007/s11882-013-0350-3

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Autoimmunity in Immunodeficiency

Abstract

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Abstract

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