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Open Access 01-01-2010

Chronic Helminth Infections Protect Against Allergic Diseases by Active Regulatory Processes

Authors: Hermelijn H. Smits, Bart Everts, Franca C. Hartgers, Maria Yazdanbakhsh

Published in: Current Allergy and Asthma Reports | Issue 1/2010

Abstract

Developed countries are suffering from an epidemic rise in immunologic disorders, such as allergy-related diseases and certain autoimmunities. Several studies have demonstrated a negative association between helminth infections and inflammatory diseases (eg, allergy), providing a strong case for the involvement of helminth infections in this respect. However, some studies point in the opposite direction. The discrepancy may be explained by differences in frequency, dose, time, and type of helminth. In this review, new studies are discussed that may support the concept that chronic helminth infections in particular—but not acute infections—are associated with the expression of regulatory networks necessary for downmodulating allergic immune responses to harmless antigens. Furthermore, different components of regulatory networks are highlighted, such as the role of regulatory T and B cells, modulation of dendritic cells, early innate signals from structural cells (eg, epithelial cells), and their individual contributions to protection against allergic diseases. It is of great interest to define and characterize specific helminth molecules that have profound immunomodulatory capacities as targets for therapeutic application in the treatment or prophylaxis of allergic manifestations.

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Title: Chronic Helminth Infections Protect Against Allergic Diseases by Active Regulatory Processes
Authors: Hermelijn H. Smits
Bart Everts
Franca C. Hartgers
Maria Yazdanbakhsh
Publication date: 01-01-2010
Publisher: Current Science Inc.
Published in: Current Allergy and Asthma Reports / Issue 1/2010
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI: https://doi.org/10.1007/s11882-009-0085-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Chronic Helminth Infections Protect Against Allergic Diseases by Active Regulatory Processes

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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