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Journal of Children's Orthopaedics
Published in: Journal of Children's Orthopaedics 4/2013

01-10-2013 | Original Clinical Article

Congenital pseudarthrosis of the tibia: the results of an evolving protocol of management

Authors: N. Nicolaou, A. Ghassemi, R. A. Hill

Published in: Journal of Children's Orthopaedics | Issue 4/2013

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Abstract

Purpose

This retrospective cohort study assesses the outcomes of a protocol of management, based on the recommendations of the European Paediatric Orthopaedic Society (EPOS) multi-centre study, for the management of congenital pseudarthrosis of the tibia.

Methods

Utilising an incremental protocol of bracing, intramedullary rods and circular frame fixation with or without bone morphogenetic protein-2 (BMP-2), 11 patients had reached skeletal maturity or had follow up of 5 years from radiological union of the pseudarthrosis. Demographic data, deformity parameters before and after treatment, and functional outcome scores were recorded.

Results

Ten of the 11 patients successfully healed and two sustained a refracture. All deformity parameters improved and a mean leg length discrepancy of 2.5 cm (range 0–7.5 cm) existed at the time of the last follow up. Some pseudarthroses healed with deformity correction and rod insertion alone. Six of the 11 patients had a confirmed diagnosis of neurofibromatosis and nine had sustained a fracture before 4 years of age. Refracture was associated with malalignment after healing.

Conclusion

This method of treatment provides a successful stepwise protocol for the management of this complex disorder, avoiding the use of aggressive limb reconstruction techniques at a young age in some cases.
Level of evidenceCase series Level IV.
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Metadata
Title
Congenital pseudarthrosis of the tibia: the results of an evolving protocol of management
Authors
N. Nicolaou
A. Ghassemi
R. A. Hill
Publication date
01-10-2013
Publisher
Springer Berlin Heidelberg
Published in
Journal of Children's Orthopaedics / Issue 4/2013
Print ISSN: 1863-2521
Electronic ISSN: 1863-2548
DOI
https://doi.org/10.1007/s11832-013-0499-2

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