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Journal of Cancer Survivorship
Published in: Journal of Cancer Survivorship 6/2019

01-12-2019 | Review

Social attainment in survivors of pediatric central nervous system tumors: a systematic review and meta-analysis from the Children’s Oncology Group

Authors: Fiona Schulte, Alicia S. Kunin-Batson, Barbara A. Olson-Bullis, Pia Banerjee, Matthew C. Hocking, Laura Janzen, Lisa S. Kahalley, Hayley Wroot, Caitlin Forbes, Kevin R. Krull

Published in: Journal of Cancer Survivorship | Issue 6/2019

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Abstract

Purpose

Improved therapies for pediatric central nervous system (CNS) tumors have increased survival rates; however, many survivors experience significant long-term functional limitations. Survivors of pediatric CNS tumors can experience deficits in social attainment. The aim of this review was to systematically amalgamate findings pertaining to social attainment (i.e., educational attainment, marriage, employment outcomes) in survivors of pediatric CNS tumors.

Methods

PubMed (web-based), PsycINFO (EBSCO), EMBASE (Ovid), and Web of Science (Thomson Reuters) were used to identify articles published between January 2011 and September 2018. Eligible studies reported outcomes for survivors of pediatric CNS tumors diagnosed before age 21 years and > 5 years from diagnosis and/or > 2 years off therapy. All data were independently abstracted by two reviewers. Random-effects meta-analyses were performed using Review Manager 5.0.

Results

The search yielded 7021 unique publications. Forty-six were included in the current review. Meta-analyses revealed survivors of CNS tumors were significantly more likely to have completed compulsory education only (OR = 1.87, 95% CI = 1.66, 2.12, p < 0.00001), less likely to be married (OR = 4.70, 95% CI = 3.89, 5.68, p < 0.00001), and more likely to be unemployed (OR = 2.84, 95% CI = 2.62, 3.08, p < 0.00001) compared to non-cancer controls. Cranial radiation therapy, neurocognitive deficits, and younger age at diagnosis were associated with poorer outcomes. Hearing loss and bilateral blindness were also related to poorer outcomes. Sex did not impact social attainment outcomes.

Conclusions

Survivors of pediatric CNS tumors are at elevated risk for poor attainment of key adult social outcomes.

Implications for Cancer Survivors

There is a critical need to develop interventions to support survivors in becoming independent and productive adults.
Appendix
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Metadata
Title
Social attainment in survivors of pediatric central nervous system tumors: a systematic review and meta-analysis from the Children’s Oncology Group
Authors
Fiona Schulte
Alicia S. Kunin-Batson
Barbara A. Olson-Bullis
Pia Banerjee
Matthew C. Hocking
Laura Janzen
Lisa S. Kahalley
Hayley Wroot
Caitlin Forbes
Kevin R. Krull
Publication date
01-12-2019
Publisher
Springer US
Published in
Journal of Cancer Survivorship / Issue 6/2019
Print ISSN: 1932-2259
Electronic ISSN: 1932-2267
DOI
https://doi.org/10.1007/s11764-019-00808-3

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