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Journal of Cancer Survivorship
Published in: Journal of Cancer Survivorship 4/2015

01-12-2015

Depression and quality of life before and after breast cancer diagnosis in older women from the Women’s Health Initiative

Authors: Salene M. W. Jones, Andrea Z. LaCroix, Wenjun Li, Oleg Zaslavsky, Sylvia Wassertheil-Smoller, Julie Weitlauf, Gretchen A. Brenes, Rami Nassir, Judith K. Ockene, Graciela Caire-Juvera, Suzanne C. Danhauer

Published in: Journal of Cancer Survivorship | Issue 4/2015

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Abstract

Purpose

Distress and reduced quality of life (QOL) are common among people with cancer. No study has compared these variables after breast cancer diagnosis to pre-cancer diagnosis levels.

Methods

Data on women with breast cancer 50 years of age or older (n = 6949) were analyzed from the Women’s Health Initiative (1993–2013). Health-related QOL (physical function, mental health) was measured using Rand-36. Depressive symptoms were measured with the six-item Center for Epidemiologic Studies Depression scale. Assessments occurred before and after the cancer diagnosis. Hierarchical linear modeling compared pre-cancer QOL and depressive symptoms to levels post-diagnosis and tested whether pre-cancer physical activity, stressful life events, sleep disturbance, and pain predicted post-diagnosis outcomes.

Results

Compared with pre-cancer levels, depressive symptoms increased (20.0 % increase at 0–6 months, 12.9 % increase at 6–12 months), while physical function (−3.882 points at 0–6 months, −3.545 at 6–12 months) and mental health decreased (−2.899 points at 0–6 months, −1.672 at 6–12 months) in the first year after diagnosis (all p < .01). Depressive symptoms returned to pre-cancer levels after 10 years, but QOL remained significantly lower. At more than 10 years post-diagnosis, physical function was 2.379 points lower than pre-cancer levels (p < 0.01) while mental health was 1.922 points lower (p < 0.01). All pre-cancer predictors were associated with all outcomes. Pain predicted uniquely greater decreases in physical function post-diagnosis.

Conclusions

Depressive symptoms increased and QOL decreased following breast cancer diagnosis compared with pre-cancer levels, particularly in the first year.

Implications for Cancer Survivors

QOL may remain lower for years after breast cancer diagnosis, although decreases are small.
Appendix
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Metadata
Title
Depression and quality of life before and after breast cancer diagnosis in older women from the Women’s Health Initiative
Authors
Salene M. W. Jones
Andrea Z. LaCroix
Wenjun Li
Oleg Zaslavsky
Sylvia Wassertheil-Smoller
Julie Weitlauf
Gretchen A. Brenes
Rami Nassir
Judith K. Ockene
Graciela Caire-Juvera
Suzanne C. Danhauer
Publication date
01-12-2015
Publisher
Springer US
Published in
Journal of Cancer Survivorship / Issue 4/2015
Print ISSN: 1932-2259
Electronic ISSN: 1932-2267
DOI
https://doi.org/10.1007/s11764-015-0438-y

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