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01-09-2015

A meta-analysis of body mass index of adolescent and adult survivors of pediatric acute lymphoblastic leukemia

Authors: Gina E. Nam, Sapna Kaul, Yelena P. Wu, Richard E. Nelson, Jennifer Wright, Mark N. Fluchel, Claire C. Hacking, Anne C. Kirchhoff

Published in: Journal of Cancer Survivorship | Issue 3/2015

Abstract

Purpose

We conducted a meta-analysis of existing studies to examine body mass index (BMI) of adolescent and adult survivors of pediatric acute lymphoblastic leukemia (ALL) compared to individuals without cancer.

Methods

Studies were identified and reviewed using specific inclusion criteria. The effect size was odds ratio (OR) of the prevalence of overweight/obese BMI (≥25 kg/m²) in ALL survivors versus comparison groups. Study data were coded and validated. Fixed-effects (FE) and random-effects (RE) estimates of the effect size were estimated.

Results

A total of 9 studies met our inclusion criteria. Survivors were more likely to be overweight/obese compared to comparison groups (FE OR = 1.12, 95 % CI 1.06–1.18 and RE OR = 1.28, 95 % CI 1.07–1.53). When limited to studies from North American samples, female survivors were overweight/obese more often than the comparison groups (FE OR = 1.30, 95 % CI 1.19–1.43).

Conclusions

Adolescent and adult survivors of pediatric ALL, especially female survivors, may be at a higher risk of being overweight/obese compared to individuals without cancer. However, few studies provided detailed information on patient and treatment factors (e.g., cranial radiation) that can impact BMI. Standardized reporting of study content is vital for providing robust information on the risk of developing late effects among cancer survivors.

Implications for cancer survivors

Adolescent and adult survivors of pediatric ALL require additional weight management resources such as targeted counseling for physical activity and dietician support both early in treatment and after the end of their therapy. Female survivors may need additional guidance to develop healthy eating practices and to participate in exercise programs.

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Title: A meta-analysis of body mass index of adolescent and adult survivors of pediatric acute lymphoblastic leukemia
Authors: Gina E. Nam
Sapna Kaul
Yelena P. Wu
Richard E. Nelson
Jennifer Wright
Mark N. Fluchel
Claire C. Hacking
Anne C. Kirchhoff
Publication date: 01-09-2015
Publisher: Springer US
Published in: Journal of Cancer Survivorship / Issue 3/2015
Print ISSN: 1932-2259
Electronic ISSN: 1932-2267
DOI: https://doi.org/10.1007/s11764-014-0415-x

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