Skip to main content
Top
Published in: General Thoracic and Cardiovascular Surgery 9/2019

01-09-2019 | Aortic Dissection | Original Article

Treatment outcomes for acute type A aortic dissection with patent false lumen in patients over the age of 80

Authors: Nobuo Kondo, Kentaro Tamura, Arudo Hiraoka, Toshinori Totsugawa, Genta Chikazawa, Taichi Sakaguchi, Hidenori Yoshitaka

Published in: General Thoracic and Cardiovascular Surgery | Issue 9/2019

Login to get access

Abstract

Objectives

While reports which focus on the outcomes of conservative treatments for acute type A aortic dissection in patients over the age of 80 are worth considering, recently many studies have reported improved outcomes of surgical treatment. Accordingly, we analyzed the outcomes of surgical and conservative treatments for acute type A aortic dissection with patent false lumen in patients over the age of 80.

Methods

We retrospectively investigated 70 patients over 80 years in age out of 248 consecutive patients with acute type A aortic dissection between January, 2010, and May, 2015. Of the 70 patients, 44 underwent surgical treatments (ascending replacement in 33 and total arch replacement in 11) and 23 patients underwent conservative medical treatments.

Results

In the surgical treatment, the 30-day mortality rate was 14% (6/44) and the rate of morbidity was 34%. And 17 patients (39%) were discharged home without ambulatory assistance. The actuarial survival rates in the surgical treatment group were 83% and 60% at 1 and 3 years, respectively. The in-hospital death rate of conservative medical treatment was 43% (10/23). Only 26% of the patients having had conservative treatment were discharged home without ambulatory assistance. The actuarial survival rate in the conservative medical group was 8.7% at 1 year.

Conclusion

Surgical outcomes of acute type A aortic dissection with patent false lumen were satisfactory in patients aged over 80 in this study by meticulously determining operative indications, depending on the background of each patient.
Literature
1.
go back to reference Mehta RH, Suzuki T, Hagan PG, Bossone E, Gilon D, Armstrong WF, et al. Predicting death in patients with acute type A aortic dissection. Circulation. 2002;105:200–6.CrossRef Mehta RH, Suzuki T, Hagan PG, Bossone E, Gilon D, Armstrong WF, et al. Predicting death in patients with acute type A aortic dissection. Circulation. 2002;105:200–6.CrossRef
2.
go back to reference Neri E, Toscano T, Massetti M, Capannini G, Carone E, Tucci E, et al. Operation for acute type A aortic dissection in patients 80 years or older: Is it justified? J Thorac Cardiovasc Surg. 2001;121:259–67.CrossRef Neri E, Toscano T, Massetti M, Capannini G, Carone E, Tucci E, et al. Operation for acute type A aortic dissection in patients 80 years or older: Is it justified? J Thorac Cardiovasc Surg. 2001;121:259–67.CrossRef
3.
go back to reference Shiono M, Hata M, Sezai A, Iida M, Yagi S, Negishi N. Emergency surgery for acute type A aortic dissection in patients 80 years or older. Ann Thorac Surg. 2006;82:554–9.CrossRef Shiono M, Hata M, Sezai A, Iida M, Yagi S, Negishi N. Emergency surgery for acute type A aortic dissection in patients 80 years or older. Ann Thorac Surg. 2006;82:554–9.CrossRef
4.
go back to reference Hata M, Sezai A, Niino T, Yoda M, Unosawa S, Furukawa N, et al. Should emergency surgical intervention be performed for an octogenarian with type A acute aortic dissection? J Thorac Cardiovasc Surg. 2008;135:1042–6.CrossRef Hata M, Sezai A, Niino T, Yoda M, Unosawa S, Furukawa N, et al. Should emergency surgical intervention be performed for an octogenarian with type A acute aortic dissection? J Thorac Cardiovasc Surg. 2008;135:1042–6.CrossRef
5.
go back to reference Piccardo A, Regesta T, Zannis K, Gariboldi V, Pansini S, Tapia M, et al. Outcomes after surgical treatment for type A acute aortic dissection in patients 80 years or older: a multicenter study. Ann Thorac Surg. 2009;88:491–7.CrossRef Piccardo A, Regesta T, Zannis K, Gariboldi V, Pansini S, Tapia M, et al. Outcomes after surgical treatment for type A acute aortic dissection in patients 80 years or older: a multicenter study. Ann Thorac Surg. 2009;88:491–7.CrossRef
6.
go back to reference Gilbert HL, Ramin M, Cindy J, Masashi K, Steven L, David S. Surgery for acute type A aortic dissection in patients 80 years or older is justified. J Thorac Cardiovasc Surg. 2013;145:186–90.CrossRef Gilbert HL, Ramin M, Cindy J, Masashi K, Steven L, David S. Surgery for acute type A aortic dissection in patients 80 years or older is justified. J Thorac Cardiovasc Surg. 2013;145:186–90.CrossRef
7.
go back to reference Chiappini B, Tan ME, Morshuis W, Kelder H, Schepens M. Surgery for acute type A aortic dissection: is advanced age a contraindication? Ann Thorac Surg. 2003;78:585–90.CrossRef Chiappini B, Tan ME, Morshuis W, Kelder H, Schepens M. Surgery for acute type A aortic dissection: is advanced age a contraindication? Ann Thorac Surg. 2003;78:585–90.CrossRef
8.
go back to reference Yanagisawa S, Yuasa T, Suzuki N, Hirai T, Yasuda N. Comparison of medically versus surgically treated acute type A aortic dissection in patients < 80 years old versus patients ≧ 80 years old. Am J Cardiol. 2011;108:453–9.CrossRef Yanagisawa S, Yuasa T, Suzuki N, Hirai T, Yasuda N. Comparison of medically versus surgically treated acute type A aortic dissection in patients < 80 years old versus patients ≧ 80 years old. Am J Cardiol. 2011;108:453–9.CrossRef
9.
go back to reference Masuda Y, Yamada Z, Morooka N, Watanabe S, Inagaki Y. Prognosis of patients with medically treated aortic dissections. Circulation. 1991;84:1117–13. Masuda Y, Yamada Z, Morooka N, Watanabe S, Inagaki Y. Prognosis of patients with medically treated aortic dissections. Circulation. 1991;84:1117–13.
10.
go back to reference Morley JE, Vellas B, van Kan GA, Vandewoude MF, Walston J, et al. Frailty consensus: a call to action. J Am Med Dir Assor. 2013;14(6):392–7.CrossRef Morley JE, Vellas B, van Kan GA, Vandewoude MF, Walston J, et al. Frailty consensus: a call to action. J Am Med Dir Assor. 2013;14(6):392–7.CrossRef
11.
go back to reference JCS Joint Working Group. Guidelines for diagnosis and treatment of aortic aneurysm and aortic dissection. Circ J. 2013;77:789–828.CrossRef JCS Joint Working Group. Guidelines for diagnosis and treatment of aortic aneurysm and aortic dissection. Circ J. 2013;77:789–828.CrossRef
12.
go back to reference 10 Hagan PG, Nienaber CA, Isselbacher EM, Bruckman D, Karavite DJ, Eagle KA, et al. The international registry of acute aortic dissection (IRAD): new insights into an old disease. JAMA. 2000;283:897–903.CrossRef 10 Hagan PG, Nienaber CA, Isselbacher EM, Bruckman D, Karavite DJ, Eagle KA, et al. The international registry of acute aortic dissection (IRAD): new insights into an old disease. JAMA. 2000;283:897–903.CrossRef
13.
go back to reference Omura A, Matsuda H, Minami H, Nakai H, Nobuhiko M, Mukohara N, et al. Early and late outcomes of operation for acute type A aortic dissection in patients aged 80 years and older. Ann Thorac Surg. 2017;103:131–8.CrossRef Omura A, Matsuda H, Minami H, Nakai H, Nobuhiko M, Mukohara N, et al. Early and late outcomes of operation for acute type A aortic dissection in patients aged 80 years and older. Ann Thorac Surg. 2017;103:131–8.CrossRef
14.
go back to reference Bachet J, Guilmet D, Goudot B, Dreyfus GD, Delentdecker P, Brodaty D, et al. Antegrade cerebral perfusion with cold blood: a 13-year experience. Ann Thorac Surg. 1999;67:1874–8.CrossRef Bachet J, Guilmet D, Goudot B, Dreyfus GD, Delentdecker P, Brodaty D, et al. Antegrade cerebral perfusion with cold blood: a 13-year experience. Ann Thorac Surg. 1999;67:1874–8.CrossRef
15.
go back to reference Kamiya H, Hagal C, Kropivnniskaya I, Bohig D, Kallenbach K, Khaladj N, et al. The safety of moderate hypothermic lower body circulatory arrest with selective cerebral perfusion: a propensity score analysis. J Thorac Cardiovasc Surg. 2007;133:501–9.CrossRef Kamiya H, Hagal C, Kropivnniskaya I, Bohig D, Kallenbach K, Khaladj N, et al. The safety of moderate hypothermic lower body circulatory arrest with selective cerebral perfusion: a propensity score analysis. J Thorac Cardiovasc Surg. 2007;133:501–9.CrossRef
16.
go back to reference Okita Y, Okada K, Omura A, Kano H, Minami H, Miyahara S, et al. Total arch replacement using antegrade cerebral perfusion. J Thorac Cardiovasc Surg. 2013;145:63–71.CrossRef Okita Y, Okada K, Omura A, Kano H, Minami H, Miyahara S, et al. Total arch replacement using antegrade cerebral perfusion. J Thorac Cardiovasc Surg. 2013;145:63–71.CrossRef
17.
go back to reference Okita Y, Minatoya K, Tagusari O, ando M, Nagatsuka K, Kitamura S. Prospective comparative study of brain protection in total arch replacement: deep hypothermic circulatory arrest with retrograde cerebral perfusion or selective antegrade cerebral perfusion. Ann Thorac Surg. 2001;72:72–9.CrossRef Okita Y, Minatoya K, Tagusari O, ando M, Nagatsuka K, Kitamura S. Prospective comparative study of brain protection in total arch replacement: deep hypothermic circulatory arrest with retrograde cerebral perfusion or selective antegrade cerebral perfusion. Ann Thorac Surg. 2001;72:72–9.CrossRef
18.
go back to reference Merkkola P, Tulla H, Ronkainen A, Soppi V, Oksala A, Koivisto T, et al. Incomplete circle of Willis and right axillary artery perfusion. Ann Thorac Surg. 2006;82:74–9.CrossRef Merkkola P, Tulla H, Ronkainen A, Soppi V, Oksala A, Koivisto T, et al. Incomplete circle of Willis and right axillary artery perfusion. Ann Thorac Surg. 2006;82:74–9.CrossRef
19.
go back to reference Biancari F, Vasques F, Benenati V, Juvonen T. Contemporary results after surgical repair of type A aortic dissection in patients aged 80 years and older: a systematic review and meta-analysis. Euro J Cadiovasc Surg. 2011;40:1058–65. Biancari F, Vasques F, Benenati V, Juvonen T. Contemporary results after surgical repair of type A aortic dissection in patients aged 80 years and older: a systematic review and meta-analysis. Euro J Cadiovasc Surg. 2011;40:1058–65.
20.
go back to reference David HT, Benjamin W, Paul GB, Martin M, Scott AL, Tristan DY, et al. A meta-analysis of deep hypothermic circulatory arrest versus moderate hypothermic arrest with selective antegrade cerebral perfusion. Ann Cardiovasc Surg. 2013;2:148–58. David HT, Benjamin W, Paul GB, Martin M, Scott AL, Tristan DY, et al. A meta-analysis of deep hypothermic circulatory arrest versus moderate hypothermic arrest with selective antegrade cerebral perfusion. Ann Cardiovasc Surg. 2013;2:148–58.
21.
go back to reference Januzzi JL, Eagle KA, Cooper JV, Fang J, Sechtem U, Isselbacher EM, et al. Acute aortic dissection presenting with congestive heart failure: results from the International Registry of Acute Aortic Dissection. J Am Coll Cardiol. 2005;46:733–5.CrossRef Januzzi JL, Eagle KA, Cooper JV, Fang J, Sechtem U, Isselbacher EM, et al. Acute aortic dissection presenting with congestive heart failure: results from the International Registry of Acute Aortic Dissection. J Am Coll Cardiol. 2005;46:733–5.CrossRef
22.
go back to reference Gilon D, Mehta RH, Oh JK, Januzzi JL Jr, Bossone E, Isselbacher EM, et al. Characteristics and in-hospital outcomes of patients with cardiac tamponade complicating type A acute aortic dissection. Am J Cardiol. 2009;103:1029–31.CrossRef Gilon D, Mehta RH, Oh JK, Januzzi JL Jr, Bossone E, Isselbacher EM, et al. Characteristics and in-hospital outcomes of patients with cardiac tamponade complicating type A acute aortic dissection. Am J Cardiol. 2009;103:1029–31.CrossRef
23.
go back to reference Metha RH, O’Gara PT, Bossone E, Nienaber CA, Myrmel T, Gilon D, et al. International Registry of Acute Aortic Dissection (IRAD) Investigators. Acute type A aortic dissection in the elderly: clinical characteristics, management, and outcomes in the current era. J Am Coll Cardiol. 2002;40:685–92.CrossRef Metha RH, O’Gara PT, Bossone E, Nienaber CA, Myrmel T, Gilon D, et al. International Registry of Acute Aortic Dissection (IRAD) Investigators. Acute type A aortic dissection in the elderly: clinical characteristics, management, and outcomes in the current era. J Am Coll Cardiol. 2002;40:685–92.CrossRef
24.
go back to reference Dumfarth J, Petrss S, Luehr M, Etz CD, Schachner T, Mohr FW, et al. Acute type A dissection in patients 80 years or older: does emergency surgery impact in-hospital outcome or long-term survival? Eur J Cardiothorac Surg. 2017;51:472–7.CrossRef Dumfarth J, Petrss S, Luehr M, Etz CD, Schachner T, Mohr FW, et al. Acute type A dissection in patients 80 years or older: does emergency surgery impact in-hospital outcome or long-term survival? Eur J Cardiothorac Surg. 2017;51:472–7.CrossRef
25.
go back to reference McKneally MF. “We don’t expect dementia and diapers”: reflections on the Nihon experience with type A aortic dissection in octogenarians. J Thorac Cardio Vasc Surg. 2008;135:984–5.CrossRef McKneally MF. “We don’t expect dementia and diapers”: reflections on the Nihon experience with type A aortic dissection in octogenarians. J Thorac Cardio Vasc Surg. 2008;135:984–5.CrossRef
26.
go back to reference Kodolitsch Y, Csosz SK, Koschyk DH, Schalwat I, Loose R, Nienaber CA, et al. Intramural hematoma of the aorta: predictors of progression to dissection and rupture. Circulation. 2003;107:1158–63.CrossRef Kodolitsch Y, Csosz SK, Koschyk DH, Schalwat I, Loose R, Nienaber CA, et al. Intramural hematoma of the aorta: predictors of progression to dissection and rupture. Circulation. 2003;107:1158–63.CrossRef
27.
go back to reference Song JK. Diagnosis of aortic intramural haematoma. Heart. 2004;90:368–71.CrossRef Song JK. Diagnosis of aortic intramural haematoma. Heart. 2004;90:368–71.CrossRef
Metadata
Title
Treatment outcomes for acute type A aortic dissection with patent false lumen in patients over the age of 80
Authors
Nobuo Kondo
Kentaro Tamura
Arudo Hiraoka
Toshinori Totsugawa
Genta Chikazawa
Taichi Sakaguchi
Hidenori Yoshitaka
Publication date
01-09-2019
Publisher
Springer Singapore
Published in
General Thoracic and Cardiovascular Surgery / Issue 9/2019
Print ISSN: 1863-6705
Electronic ISSN: 1863-6713
DOI
https://doi.org/10.1007/s11748-019-01111-9

Other articles of this Issue 9/2019

General Thoracic and Cardiovascular Surgery 9/2019 Go to the issue