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Published in: General Thoracic and Cardiovascular Surgery 10/2019

01-10-2019 | Arterial Diseases | Original Article

Enhanced outcomes for coronary artery disease obtained by a multidisciplinary heart team approach

Authors: Manabu Yamasaki, Kohei Abe, Rihito Horikoshi, Eri Hoshino, Hiromi Yanagisawa, Kunihiko Yoshino, Hiroyasu Misumi, Atsushi Mizuno, Nobuyuki Komiyama

Published in: General Thoracic and Cardiovascular Surgery | Issue 10/2019

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Abstract

Background

We implemented our multidisciplinary heart team (MHT) approach since 2012 for patients with coronary artery disease (CAD) and assessed the effectiveness of it by comparing outcomes in patients treated before and after the introduction of the MHT approach.

Methods

Percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) for CAD were performed in 802 and 57 patients from 2009 to 2011 in Group NH, and were performed in 867 and 160 patients from 2012 to 2014 in Group H, respectively. The primary outcome was major adverse cardiovascular and cerebrovascular events (MACCE), defined as the composite of all-cause death, myocardial infarction, stroke, cardiac-related readmission and target vessel repeat revascularisation (TVR) for PCI or revascularisation on grafted vessels for CABG.

Results

MACCE occurred significantly more often in Group NH than in Group H at 3 years postoperatively (28.1% vs 21.1%) (log rank P = 0.001). Cox regression analysis showed that the MHT approach [hazard ratio (HR), 0.737; 95% confidence interval (CI), 0.60–0.91; P = 0.004] and ejection fraction (HR 0.976; 95% CI, 0.97–0.98; P < 0.0001) were associated with significantly lower rates of MACCE events, while SYNTAX score (HR 1.023; 95% CI 1.00–1.03, P < 0.0001) and EuroSCORE II (HR 1.014, 95% CI 0.60–0.91, P = 0.004) were associated with a higher rate of MACCE events.

Conclusion

Our MHT approach was able to reduce the MACCE events of treatment for CAD. The dedicated MHT approach might be beneficial for patients with CAD.
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Literature
1.
go back to reference Serruys PW, Morice MC, Kappetein AP, Colombo A, Holmes DR, Mack MJ, et al. SYNTAX Investigators. Percutaneous coronary intervention versus coronary-artery bypass grafting for severe coronary artery disease. N Engl J Med. 2009; 360(10):961–72.CrossRefPubMed Serruys PW, Morice MC, Kappetein AP, Colombo A, Holmes DR, Mack MJ, et al. SYNTAX Investigators. Percutaneous coronary intervention versus coronary-artery bypass grafting for severe coronary artery disease. N Engl J Med. 2009; 360(10):961–72.CrossRefPubMed
2.
go back to reference Kolh P, Wijns W, Danchin N, et al. Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS); European Association for Percutaneous Cardiovascular Interventions (EAPCI). Guidelines on myocardial revascularization. Eur J Cardiothorac Surg. 2010; 38:S1–S52.CrossRefPubMed Kolh P, Wijns W, Danchin N, et al. Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS); European Association for Percutaneous Cardiovascular Interventions (EAPCI). Guidelines on myocardial revascularization. Eur J Cardiothorac Surg. 2010; 38:S1–S52.CrossRefPubMed
3.
go back to reference Windecker S, Kolh P, Alfonso F, Collet JP, Cremer J, Falk V, et al. 2014 ESC/EACTS Guidelines on myocardial revascularization: The task force on myocardial revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)Developed with the special contribution of the European Association of percutaneous cardiovascular interventions (EAPCI). Eur Heart J. 2014;35(37):2541–619.CrossRefPubMed Windecker S, Kolh P, Alfonso F, Collet JP, Cremer J, Falk V, et al. 2014 ESC/EACTS Guidelines on myocardial revascularization: The task force on myocardial revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)Developed with the special contribution of the European Association of percutaneous cardiovascular interventions (EAPCI). Eur Heart J. 2014;35(37):2541–619.CrossRefPubMed
4.
go back to reference Sanchez CE, Badhwar V, Dota A, Schindler J, Chu D, Smith AJ, et al. Practical implementation of the coronary revascularization heart team. Circ Cardiovasc Qual Outcomes. 2013;6(5):598–603.CrossRefPubMed Sanchez CE, Badhwar V, Dota A, Schindler J, Chu D, Smith AJ, et al. Practical implementation of the coronary revascularization heart team. Circ Cardiovasc Qual Outcomes. 2013;6(5):598–603.CrossRefPubMed
5.
go back to reference Chu D, Anastacio MM, Mulukutla SR, Lee JS, Smith AJ, Marroquin OC, et al. Safety and efficacy of implementing a multidisciplinary heart team approach for revascularization in patients with complex coronary artery disease: an observational cohort pilot study. JAMA Surg. 2014;149(11):1109–12.CrossRefPubMed Chu D, Anastacio MM, Mulukutla SR, Lee JS, Smith AJ, Marroquin OC, et al. Safety and efficacy of implementing a multidisciplinary heart team approach for revascularization in patients with complex coronary artery disease: an observational cohort pilot study. JAMA Surg. 2014;149(11):1109–12.CrossRefPubMed
6.
go back to reference Bypass Angioplasty Revascularization Investigation (BARI) Investigators. Comparison of coronary bypass surgery with angioplasty in patients with multivessel disease. N Engl J Med. 1996;335(4):217–25.CrossRef Bypass Angioplasty Revascularization Investigation (BARI) Investigators. Comparison of coronary bypass surgery with angioplasty in patients with multivessel disease. N Engl J Med. 1996;335(4):217–25.CrossRef
7.
go back to reference Serruys PW, Unger F, Sousa JE, Jatene A, Bonnier HJ, Schönberger JP, et al, Arterial Revascularization Therapies Study Group. Comparison of coronary-artery bypass surgery and stenting for the treatment of multivessel disease. N Engl J Med. 2001;344(15):1117–24.CrossRefPubMed Serruys PW, Unger F, Sousa JE, Jatene A, Bonnier HJ, Schönberger JP, et al, Arterial Revascularization Therapies Study Group. Comparison of coronary-artery bypass surgery and stenting for the treatment of multivessel disease. N Engl J Med. 2001;344(15):1117–24.CrossRefPubMed
8.
go back to reference Hannan EL, Racz MJ, Walford G, Jones RH, Ryan TJ, Bennett E, et al. Long-term outcomes of coronary-artery bypass grafting versus stent implantation. N Engl J Med. 2005;352(21):2174–83.CrossRefPubMed Hannan EL, Racz MJ, Walford G, Jones RH, Ryan TJ, Bennett E, et al. Long-term outcomes of coronary-artery bypass grafting versus stent implantation. N Engl J Med. 2005;352(21):2174–83.CrossRefPubMed
9.
go back to reference Hlatky MA, Boothroyd DB, Bravata DM, Boersma E, Booth J, Brooks MM, et al. Coronary artery bypass surgery compared with percutaneous coronary interventions for multivessel disease: a collaborative analysis individual patient data from ten randomised trials. Lancet. 2009;373(9670):1190–7.CrossRefPubMed Hlatky MA, Boothroyd DB, Bravata DM, Boersma E, Booth J, Brooks MM, et al. Coronary artery bypass surgery compared with percutaneous coronary interventions for multivessel disease: a collaborative analysis individual patient data from ten randomised trials. Lancet. 2009;373(9670):1190–7.CrossRefPubMed
10.
go back to reference Serruys PW, Onuma Y, Garg S, Vranckx P, De Bruyne B, Morice MC, et al. ARTS II Investigators. 5-year clinical outcomes of the ARTS (arterial revascularization therapies study II) of the sirolimus-eluting stent in the treatment of patients with multivessel de novo coronary artery lesions. J Am Coll Cardiol. 2010;55(11):1093–101.CrossRefPubMed Serruys PW, Onuma Y, Garg S, Vranckx P, De Bruyne B, Morice MC, et al. ARTS II Investigators. 5-year clinical outcomes of the ARTS (arterial revascularization therapies study II) of the sirolimus-eluting stent in the treatment of patients with multivessel de novo coronary artery lesions. J Am Coll Cardiol. 2010;55(11):1093–101.CrossRefPubMed
11.
go back to reference Mohr FW, Morice M, Kappetein AP, Feldman TE, Ståhle E, Colombo A, et al. Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial. Lancet. 2013;381(9867):629–38.CrossRefPubMed Mohr FW, Morice M, Kappetein AP, Feldman TE, Ståhle E, Colombo A, et al. Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial. Lancet. 2013;381(9867):629–38.CrossRefPubMed
12.
go back to reference Stone GW, Sabik JF, Serruys PW, Simonton CA, Généreux P, Puskas J, et al. EXCEL Investigators. Everolimus-eluting stents or bypass surgery for left main coronary artery disease. N Engl J Med. 2016;375(23):2223–35.CrossRefPubMed Stone GW, Sabik JF, Serruys PW, Simonton CA, Généreux P, Puskas J, et al. EXCEL Investigators. Everolimus-eluting stents or bypass surgery for left main coronary artery disease. N Engl J Med. 2016;375(23):2223–35.CrossRefPubMed
13.
go back to reference Mäkikallio T, Holm NR, Lindsay M, Spence MS, Erglis A, Menown IB, et al; NOBLE study investigators. Percutaneous coronary angioplasty versus coronary artery bypass grafting in treatment of unprotected left main stenosis (NOBLE): a prospective, randomised, open-label, non-inferiority trial. Lancet. 2016;388(10061):2743–2752.CrossRefPubMed Mäkikallio T, Holm NR, Lindsay M, Spence MS, Erglis A, Menown IB, et al; NOBLE study investigators. Percutaneous coronary angioplasty versus coronary artery bypass grafting in treatment of unprotected left main stenosis (NOBLE): a prospective, randomised, open-label, non-inferiority trial. Lancet. 2016;388(10061):2743–2752.CrossRefPubMed
14.
go back to reference Ahn JM, Roh JH, Kim YH, Park DW, Yun SC, Lee PH, et al. Randomized trial of stents versus bypass surgery for left main coronary artery disease: 5-year outcomes of the PRECOMBAT study. J Am Coll Cardiol. 2015;65(20):2198–206.CrossRefPubMed Ahn JM, Roh JH, Kim YH, Park DW, Yun SC, Lee PH, et al. Randomized trial of stents versus bypass surgery for left main coronary artery disease: 5-year outcomes of the PRECOMBAT study. J Am Coll Cardiol. 2015;65(20):2198–206.CrossRefPubMed
15.
go back to reference Park SJ, Ahn JM, Kim YH, Park DW, Yun SC, Lee JY, et al. BEST Trial Investigators. Trial of everolimus-eluting stents or bypass surgery for coronary disease. N Engl J Med. 2015;372(13):1204–12.CrossRefPubMed Park SJ, Ahn JM, Kim YH, Park DW, Yun SC, Lee JY, et al. BEST Trial Investigators. Trial of everolimus-eluting stents or bypass surgery for coronary disease. N Engl J Med. 2015;372(13):1204–12.CrossRefPubMed
16.
go back to reference Mack M, Baumgarten H, Lytle B. Why surgery won the SYNTAX trial and why it matters. J Thorac Cardiovasc Surg. 2016;152:1237–40.CrossRefPubMed Mack M, Baumgarten H, Lytle B. Why surgery won the SYNTAX trial and why it matters. J Thorac Cardiovasc Surg. 2016;152:1237–40.CrossRefPubMed
17.
go back to reference Borras JM, Albreht T, Audisio R, et al. European Partnership Action Against Cancer consensus group. Policy statement on multidisciplinary cancer care. Eur J Cancer. 2014;50(3):475–80.CrossRefPubMed Borras JM, Albreht T, Audisio R, et al. European Partnership Action Against Cancer consensus group. Policy statement on multidisciplinary cancer care. Eur J Cancer. 2014;50(3):475–80.CrossRefPubMed
18.
go back to reference Martin JE, Zavala EY. The expanding role of the transplant pharmacist in the multidisciplinary practice of transplantation. Clin Transplant. 2004;18(suppl 12):50–4.CrossRefPubMed Martin JE, Zavala EY. The expanding role of the transplant pharmacist in the multidisciplinary practice of transplantation. Clin Transplant. 2004;18(suppl 12):50–4.CrossRefPubMed
19.
go back to reference Takeda A, Taylor SJ, Taylor RS, Khan F, Krum H, Underwood M. Clinical service organisation for heart failure. Cochrane Database Syst Rev. 2012;9:CD002752. Takeda A, Taylor SJ, Taylor RS, Khan F, Krum H, Underwood M. Clinical service organisation for heart failure. Cochrane Database Syst Rev. 2012;9:CD002752.
20.
go back to reference Perry J, Lanzberg M, Franklin W, Webb G, Chang AC. Cardiac intensive care of the adult with congenital heart disease: basic principles in the management of common problems. World J Pediatr Congenit Heart Surg. 2011;2(3):430–44.CrossRefPubMed Perry J, Lanzberg M, Franklin W, Webb G, Chang AC. Cardiac intensive care of the adult with congenital heart disease: basic principles in the management of common problems. World J Pediatr Congenit Heart Surg. 2011;2(3):430–44.CrossRefPubMed
21.
go back to reference Cohen DJ, Nallamothu BK. No “i” in Heart Team: incentivizing multidisciplinary care in cardiovascular medicine. Circ Cardiovasc Qual Outcomes. 2012;5:410–3.CrossRefPubMed Cohen DJ, Nallamothu BK. No “i” in Heart Team: incentivizing multidisciplinary care in cardiovascular medicine. Circ Cardiovasc Qual Outcomes. 2012;5:410–3.CrossRefPubMed
22.
go back to reference Edmondson AC. Teaming: how organizations learn, innovate, and compete in the knowledge economy. New York: Jossey-Bass; 2012. p. 352. Edmondson AC. Teaming: how organizations learn, innovate, and compete in the knowledge economy. New York: Jossey-Bass; 2012. p. 352.
23.
go back to reference Baber U, Mehran R, Sharma SK, Brar S, Yu J, Suh JW, et al. Impact of the everolimus-eluting stent on stent thrombosis: a meta-analysis of 13 randomized trials. J Am Coll Cardiol. 2011;58(15):1569–77.CrossRefPubMed Baber U, Mehran R, Sharma SK, Brar S, Yu J, Suh JW, et al. Impact of the everolimus-eluting stent on stent thrombosis: a meta-analysis of 13 randomized trials. J Am Coll Cardiol. 2011;58(15):1569–77.CrossRefPubMed
24.
go back to reference Tonino PA, De Bruyne B, Pijls NH, Siebert U, Ikeno F, van’ t Veer M, et al. FAME Study Investigators. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N Engl J Med. 2009;360(3):213–24.CrossRefPubMed Tonino PA, De Bruyne B, Pijls NH, Siebert U, Ikeno F, van’ t Veer M, et al. FAME Study Investigators. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N Engl J Med. 2009;360(3):213–24.CrossRefPubMed
25.
go back to reference Toth G, De Bruyne B, Casselman F, De Vroey F, Pyxaras S, Di Serafino L, et al. Fractional flow reserve-guided versus angiography-guided coronary artery bypass graft surgery. Circulation. 2013;128(13):1405–11.CrossRefPubMed Toth G, De Bruyne B, Casselman F, De Vroey F, Pyxaras S, Di Serafino L, et al. Fractional flow reserve-guided versus angiography-guided coronary artery bypass graft surgery. Circulation. 2013;128(13):1405–11.CrossRefPubMed
Metadata
Title
Enhanced outcomes for coronary artery disease obtained by a multidisciplinary heart team approach
Authors
Manabu Yamasaki
Kohei Abe
Rihito Horikoshi
Eri Hoshino
Hiromi Yanagisawa
Kunihiko Yoshino
Hiroyasu Misumi
Atsushi Mizuno
Nobuyuki Komiyama
Publication date
01-10-2019
Publisher
Springer Singapore
Published in
General Thoracic and Cardiovascular Surgery / Issue 10/2019
Print ISSN: 1863-6705
Electronic ISSN: 1863-6713
DOI
https://doi.org/10.1007/s11748-019-01108-4

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