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Published in: General Thoracic and Cardiovascular Surgery 9/2018

01-09-2018 | Original Article

A risk score to predict postoperative complications after lobectomy in elderly lung cancer patients

Authors: Yo Kawaguchi, Jun Hanaoka, Yasuhiko Ohshio, Tomoyuki Igarashi, Yoko Kataoka, Keigo Okamoto, Ryosuke Kaku, Kazuki Hayashi

Published in: General Thoracic and Cardiovascular Surgery | Issue 9/2018

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Abstract

Objective

In elderly patients with lung cancer, the presumed fear of postoperative complications has resulted in the delivery of limited resection. Surgical decision-making for such patients would become easier if clinicians could predict who is at high risk of postoperative complications. The purpose of this study is to propose a scoring system to predict the risk of postoperative complications for elderly patients with lung cancer.

Methods

We reviewed patients aged 75 years or older who underwent lobectomy for lung cancer at a single hospital (n = 199). A multivariable logistic regression model was utilized to determine risk factors for postoperative complications.

Results

Six risk factors for postoperative complications were identified, and we derived a risk score by assigning weights to these factors based on their odds ratios, as follows: Risk score = 7 × (performance status of 2) + 6 × (coronary artery disease) + 3 × (a history of cerebrovascular accident) + 2 × (restrictive ventilatory impairment) + 1 × (male sex) + 1 × (interstitial pneumonia). The postoperative complication rates in patients with risk scores of 0, 1–2, 3–5, 6–8, and 9–14 were 19, 29, 56, 68, and 90%, respectively.

Conclusions

The proposed risk score was able to predict the incidence of postoperative complications. The risk score can be used to identify high-risk patients and to select proper treatment strategies.
Literature
1.
go back to reference Berry MF, Onaitis MW, Tong BC, Harpole DH, D’Amico TA. A model for morbidity after lung cancer resection in oncogenarians. Eur J Cardiothorac Surg. 2011;39:989–94.CrossRefPubMed Berry MF, Onaitis MW, Tong BC, Harpole DH, D’Amico TA. A model for morbidity after lung cancer resection in oncogenarians. Eur J Cardiothorac Surg. 2011;39:989–94.CrossRefPubMed
2.
go back to reference Berry MF, Hanna J, Tong BC, Burfeind WR, Harpole DH, D’Amico TA, et al. Risk factors for morbidity after lobectomy for lung cancer in elderly patients. Ann Thorac Surg. 2009;88:1093–9.CrossRefPubMed Berry MF, Hanna J, Tong BC, Burfeind WR, Harpole DH, D’Amico TA, et al. Risk factors for morbidity after lobectomy for lung cancer in elderly patients. Ann Thorac Surg. 2009;88:1093–9.CrossRefPubMed
3.
go back to reference Goldstraw P, Chansky K, Crowley J, Rami-Porta R, Asamura H, Eberhardt WE, et al. The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (eighth) edition of the TNM classification for lung cancer. J Thorac Oncol. 2016;11:39–51.CrossRefPubMed Goldstraw P, Chansky K, Crowley J, Rami-Porta R, Asamura H, Eberhardt WE, et al. The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (eighth) edition of the TNM classification for lung cancer. J Thorac Oncol. 2016;11:39–51.CrossRefPubMed
4.
go back to reference Takamochi K, Oh S, Matsuoka J, Suzuki K. Risk factors for morbidity after pulmonary resection for lung cancer in younger and elderly patients. Interact Cardiovasc Thorac Surg. 2011;12:739–43.CrossRefPubMed Takamochi K, Oh S, Matsuoka J, Suzuki K. Risk factors for morbidity after pulmonary resection for lung cancer in younger and elderly patients. Interact Cardiovasc Thorac Surg. 2011;12:739–43.CrossRefPubMed
5.
go back to reference Miura N, Kohno M, Ito K, Senba M, Kajiwara K, Hamaguchi N, et al. Lung cancer surgery in patients aged 80 years or older: an analysis of risk factors, morbidity, and mortality. Gen Thorac Cardiovasc Surg. 2015;63:401–5.CrossRefPubMed Miura N, Kohno M, Ito K, Senba M, Kajiwara K, Hamaguchi N, et al. Lung cancer surgery in patients aged 80 years or older: an analysis of risk factors, morbidity, and mortality. Gen Thorac Cardiovasc Surg. 2015;63:401–5.CrossRefPubMed
6.
go back to reference Ambrogi V, Pompeo E, Elia S, Pistolese GR, Mineo TC. The impact of cardiovascular comorbidity on the outcome of surgery for stage I and II non-small-cell lung cancer. Eur J Cardiothorac Surg. 2003;23:811–7.CrossRefPubMed Ambrogi V, Pompeo E, Elia S, Pistolese GR, Mineo TC. The impact of cardiovascular comorbidity on the outcome of surgery for stage I and II non-small-cell lung cancer. Eur J Cardiothorac Surg. 2003;23:811–7.CrossRefPubMed
7.
go back to reference Kawaguchi Y, Hanaoka J, Oshio Y, Hashimoto M, Igarashi T, Kataoka Y, et al. Decrease in performance status after lobectomy mean poor prognosis in elderly lung cancer patients. J Thorac Dis. 2017;9:1525–30.CrossRefPubMedPubMedCentral Kawaguchi Y, Hanaoka J, Oshio Y, Hashimoto M, Igarashi T, Kataoka Y, et al. Decrease in performance status after lobectomy mean poor prognosis in elderly lung cancer patients. J Thorac Dis. 2017;9:1525–30.CrossRefPubMedPubMedCentral
8.
go back to reference Sato T, Kondo H, Watanabe A, Nakajima J, Niwa H, Horio H, et al. A simple risk scoring system for predicting acute exacerbation of interstitial pneumonia after pulmonary resection in lung cancer patients. Gen Thorac Cardiovasc Surg. 2015;63:164–72.CrossRefPubMed Sato T, Kondo H, Watanabe A, Nakajima J, Niwa H, Horio H, et al. A simple risk scoring system for predicting acute exacerbation of interstitial pneumonia after pulmonary resection in lung cancer patients. Gen Thorac Cardiovasc Surg. 2015;63:164–72.CrossRefPubMed
9.
go back to reference Gulack BC, Yang CJ, Speicher PJ, Yerokun BA, Tong BC, Onaitis MW, et al. A risk score to assist selecting lobectomy versus sublobar resection for early stage non-small cell lung cancer. Ann Thorac Surg. 2016;102:1814–20.CrossRefPubMedPubMedCentral Gulack BC, Yang CJ, Speicher PJ, Yerokun BA, Tong BC, Onaitis MW, et al. A risk score to assist selecting lobectomy versus sublobar resection for early stage non-small cell lung cancer. Ann Thorac Surg. 2016;102:1814–20.CrossRefPubMedPubMedCentral
10.
go back to reference Endo S, Ikeda N, Kondo T, Nakajima J, Kondo H, Yokoi K, et al. Model of lung cancer surgery risk derived from a Japanese nationwide web-based database of 78594 patients during 2014–2015. Eur J Cardiothorac Surg. 2017;52:1182–9.CrossRefPubMedPubMedCentral Endo S, Ikeda N, Kondo T, Nakajima J, Kondo H, Yokoi K, et al. Model of lung cancer surgery risk derived from a Japanese nationwide web-based database of 78594 patients during 2014–2015. Eur J Cardiothorac Surg. 2017;52:1182–9.CrossRefPubMedPubMedCentral
11.
go back to reference Walter U, Knoblich R, Steinhagen V, Donat M, Benecke R, Kloth A. Predictors of pneumonia in acute stroke patients admitted to a neurological intensive care unit. J Neurol. 2007;254:1323–9.CrossRefPubMed Walter U, Knoblich R, Steinhagen V, Donat M, Benecke R, Kloth A. Predictors of pneumonia in acute stroke patients admitted to a neurological intensive care unit. J Neurol. 2007;254:1323–9.CrossRefPubMed
Metadata
Title
A risk score to predict postoperative complications after lobectomy in elderly lung cancer patients
Authors
Yo Kawaguchi
Jun Hanaoka
Yasuhiko Ohshio
Tomoyuki Igarashi
Yoko Kataoka
Keigo Okamoto
Ryosuke Kaku
Kazuki Hayashi
Publication date
01-09-2018
Publisher
Springer Japan
Published in
General Thoracic and Cardiovascular Surgery / Issue 9/2018
Print ISSN: 1863-6705
Electronic ISSN: 1863-6713
DOI
https://doi.org/10.1007/s11748-018-0960-8

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