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General Thoracic and Cardiovascular Surgery

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01-12-2017 | Case Report

Successful management of antibody-mediated rejection after cardiac transplantation in a patient supported by a left ventricular assist device for more than 3 years

Authors: Masatoshi Akiyama, Shingo Takahara, Satoshi Kawatsu, Yoichi Endo, Junko Fujiwara, Osamu Adachi, Kiichiro Kumagai, Shunsuke Kawamoto, Yoshikatsu Saiki

Published in: General Thoracic and Cardiovascular Surgery | Issue 12/2017

Abstract

Due to donor shortage, patients with refractory heart failure need to be supported on mechanical circulatory support (MCS). Critically, patients undergo several deployments of MCS in stages inevitably requiring blood products transfusion. MCSs per se along with blood products can trigger immune allosensitization. Antibody-mediated rejection (AMR) is associated with significant mortality after heart transplantation. Here, we present the case with high panel-reactive antibody over 95% who developed AMR early after heart transplantation. This life-threatening complication was successfully treated with multi-modal treatment including anti-CD20 antibody, rituximab.

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Title: Successful management of antibody-mediated rejection after cardiac transplantation in a patient supported by a left ventricular assist device for more than 3 years
Authors: Masatoshi Akiyama
Shingo Takahara
Satoshi Kawatsu
Yoichi Endo
Junko Fujiwara
Osamu Adachi
Kiichiro Kumagai
Shunsuke Kawamoto
Yoshikatsu Saiki
Publication date: 01-12-2017
Publisher: Springer Japan
Published in: General Thoracic and Cardiovascular Surgery / Issue 12/2017
Print ISSN: 1863-6705
Electronic ISSN: 1863-6713
DOI: https://doi.org/10.1007/s11748-017-0763-3

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Successful management of antibody-mediated rejection after cardiac transplantation in a patient supported by a left ventricular assist device for more than 3 years

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

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