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General Thoracic and Cardiovascular Surgery

Published in:

01-05-2017 | Original Article

A non-randomized confirmatory trial of segmentectomy for clinical T1N0 lung cancer with dominant ground glass opacity based on thin-section computed tomography (JCOG1211)

Authors: Keiju Aokage, Hisashi Saji, Kenji Suzuki, Tomonori Mizutani, Hiroshi Katayama, Taro Shibata, Syunichi Watanabe, Hisao Asamura, on behalf of the Lung Cancer Surgical Study Group of the Japan Clinical Oncology Group

Published in: General Thoracic and Cardiovascular Surgery | Issue 5/2017

Abstract

Introduction

Lobectomy has been the standard surgery for even stage I lung cancer since the validity of limited resection for stage I lung cancer was denied by the randomized study reported in 1995. The aim of this non-randomized confirmatory going on since September 2013 is to confirm the efficacy of a segmentectomy for clinical T1N0 lung cancer with dominant ground glass opacity based on thin-slice computed tomography.

Method

A total of 390 patients from 42 Japanese institutions are recruited within 4 years. The primary endpoint of this study is a 5-year relapse-free survival in all of the patients who undergo a segmentectomy for a lung nodule. The secondary endpoints are overall survival, annual relapse-free survival, disease-free survival, proportion of local relapse, postoperative pulmonary function, proportion of segmentectomy completion, proportion of R0 resection completion by segmentectomy, adverse events, and serious adverse events. This trial has been registered at the UMIN Clinical Trials Registry as UMIN000011819 (http://www.umin.ac.jp/ctr/).

Results

Patient’s accrual has been already finished in November, 2015 and the primary analysis will be performed in 2021.

Conclusion

This study is one of the pivotal trial of lung segmentectomy for early lung cancer. The result will provide a clear evidence for our daily clinics and will be possible contribution to preserving pulmonary function for lung cancer patients.

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Title: A non-randomized confirmatory trial of segmentectomy for clinical T1N0 lung cancer with dominant ground glass opacity based on thin-section computed tomography (JCOG1211)
Authors: Keiju Aokage
Hisashi Saji
Kenji Suzuki
Tomonori Mizutani
Hiroshi Katayama
Taro Shibata
Syunichi Watanabe
Hisao Asamura
on behalf of the Lung Cancer Surgical Study Group of the Japan Clinical Oncology Group
Publication date: 01-05-2017
Publisher: Springer Japan
Published in: General Thoracic and Cardiovascular Surgery / Issue 5/2017
Print ISSN: 1863-6705
Electronic ISSN: 1863-6713
DOI: https://doi.org/10.1007/s11748-016-0741-1

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A non-randomized confirmatory trial of segmentectomy for clinical T1N0 lung cancer with dominant ground glass opacity based on thin-section computed tomography (JCOG1211)

Abstract

Introduction

Method

Results

Conclusion

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