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General Thoracic and Cardiovascular Surgery
Published in: General Thoracic and Cardiovascular Surgery 9/2016

01-09-2016 | Current Topics Review Article

Biology of lung cancer: genetic mutation, epithelial-mesenchymal transition, and cancer stem cells

Author: Takashi Aoi

Published in: General Thoracic and Cardiovascular Surgery | Issue 9/2016

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Abstract

At present, most cases of unresectable cancer cannot be cured. Genetic mutations, EMT, and cancer stem cells are three major issues linked to poor prognosis in such cases, all connected by inter- and intra-tumor heterogeneity. Issues on inter-/intra-tumor heterogeneity of genetic mutation could be resolved with recent and future technologies of deep sequencers, whereas, regarding such issues as the “same genome, different epigenome/phenotype”, we expect to solve many of these problems in the future through further research in stem cell biology. We herein review and discuss the three major issues in the biology of cancers, especially from the standpoint of stem cell biology.
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Metadata
Title
Biology of lung cancer: genetic mutation, epithelial-mesenchymal transition, and cancer stem cells
Author
Takashi Aoi
Publication date
01-09-2016
Publisher
Springer Japan
Published in
General Thoracic and Cardiovascular Surgery / Issue 9/2016
Print ISSN: 1863-6705
Electronic ISSN: 1863-6713
DOI
https://doi.org/10.1007/s11748-016-0682-8

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