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Published in: General Thoracic and Cardiovascular Surgery 8/2015

01-08-2015 | Original Article

Early and late outcomes of AVR with aortic annular enlargement in octogenarian

Authors: Yuki Okamoto, Kazuo Yamamoto, Tsutomu Sugimoto, Shinpei Yoshii

Published in: General Thoracic and Cardiovascular Surgery | Issue 8/2015

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Abstract

Objective

There is no clear consensus on the procedures for octogenarians with a small aortic annulus who require aortic valve replacement (AVR). We evaluated surgical results in octogenarians who underwent AVR with aortic annular enlargement, Nicks procedure, for aortic stenosis with a small aortic annulus.

Methods

Between January 2001 and March 2014, 131 octogenarian patients were treated at our institution. Nineteen patients received AVR with aortic annular enlargement (AAE group), and the others received standard AVR without annular enlargement (sAVR group). We compared early and late outcomes between the two groups.

Results

There were no significant differences in early complications between the groups. The rates for use of a mechanical valve (32 vs 22 %, p = 0.590), in-hospital mortality (5.3 vs 5.4 %, p = 1.000), and severe patient–prosthesis mismatch (PPM) (0 vs 6.3 %, p = 0.593) were also similar between the AAE and sAVR group. In the AAE group, there was no cardiac-related death, bleeding event, thromboembolism, or stroke during the follow-up period (mean 37.6 months). The rates of freedom from cardiac events at 8 years were 94 % in the AAE group and 57 % in the sAVR group (p = 0.292). The overall survival rates at 8 years were 77 % in the AAE group and 77 % in sAVR group (p = 0.462). There were no significant differences in these rates between the groups.

Conclusion

AVR with aortic annular enlargement in octogenarians with small aortic annulus was safe and led to good operative and long-term outcomes.
Literature
2.
go back to reference Kulik A, Al-Saigh M, Chan V, Masters RG, Bédard P, Lam BK, et al. Enlargement of the small aortic root during aortic valve replacement: is there a benefit? Ann Thorac Surg. 2008;85:94–100.CrossRefPubMed Kulik A, Al-Saigh M, Chan V, Masters RG, Bédard P, Lam BK, et al. Enlargement of the small aortic root during aortic valve replacement: is there a benefit? Ann Thorac Surg. 2008;85:94–100.CrossRefPubMed
3.
go back to reference Dhareshwar J, Sundt TM 3rd, Dearani JA, Schaff HV, Cook DJ, Orszulak TA. Aortic root enlargement: what are the operative risks? J Thorac Cardiovasc Surg. 2007;134:916–24.CrossRefPubMed Dhareshwar J, Sundt TM 3rd, Dearani JA, Schaff HV, Cook DJ, Orszulak TA. Aortic root enlargement: what are the operative risks? J Thorac Cardiovasc Surg. 2007;134:916–24.CrossRefPubMed
4.
go back to reference Peterson MD, Borger MA, Feindel CM, David TE. Aortic annular enlargement during aortic valve replacement: improving results with time. Ann Thorac Surg. 2007;83:2044–9.CrossRefPubMed Peterson MD, Borger MA, Feindel CM, David TE. Aortic annular enlargement during aortic valve replacement: improving results with time. Ann Thorac Surg. 2007;83:2044–9.CrossRefPubMed
6.
7.
go back to reference Pibarot P, Honos GN, Durand LG, Dumesnil JG. The effect of prosthesis-patient mismatch on aortic bioprosthetic valve hemodynamic performance and patient clinical status. Can J Cardiol. 1996;12:379–87.PubMed Pibarot P, Honos GN, Durand LG, Dumesnil JG. The effect of prosthesis-patient mismatch on aortic bioprosthetic valve hemodynamic performance and patient clinical status. Can J Cardiol. 1996;12:379–87.PubMed
8.
go back to reference Urso S, Sadaba R, Aldamiz-Echevarria G. Is patient–prosthesis mismatch an independent risk factor for early and mid-term overall mortality in adult patients undergoing aortic valve replacement? Interact Cardiovasc Thorac Surg. 2009;9:510–8.CrossRefPubMed Urso S, Sadaba R, Aldamiz-Echevarria G. Is patient–prosthesis mismatch an independent risk factor for early and mid-term overall mortality in adult patients undergoing aortic valve replacement? Interact Cardiovasc Thorac Surg. 2009;9:510–8.CrossRefPubMed
9.
go back to reference Head SJ, Mokhles MM, Osnabrugge RL, Pibarot P, Mack MJ, Takkenberg JJ, et al. The impact of prosthesis-patient mismatch on long-term survival after aortic valve replacement: a systematic review and meta-analysis of 34 observational studies comprising 27 186 patients with 133 141 patient-years. Eur Heart J. 2012;33:1518–29.CrossRefPubMed Head SJ, Mokhles MM, Osnabrugge RL, Pibarot P, Mack MJ, Takkenberg JJ, et al. The impact of prosthesis-patient mismatch on long-term survival after aortic valve replacement: a systematic review and meta-analysis of 34 observational studies comprising 27 186 patients with 133 141 patient-years. Eur Heart J. 2012;33:1518–29.CrossRefPubMed
10.
go back to reference Chen J, Lin Y, Kang B, Wang Z. Indexed effective orifice area is a significant predictor of higher mid- and long-term mortality rates following aortic valve replacement in patients with prosthesis-patient mismatch. Eur J Cardiothorac Surg. 2014;45:234–40.CrossRefPubMed Chen J, Lin Y, Kang B, Wang Z. Indexed effective orifice area is a significant predictor of higher mid- and long-term mortality rates following aortic valve replacement in patients with prosthesis-patient mismatch. Eur J Cardiothorac Surg. 2014;45:234–40.CrossRefPubMed
11.
go back to reference Bleiziffer S, Ali A, Hettich IM, Akdere D, Laubender RP, Ruzicka D, et al. Impact of the indexed effective orifice area on mid-term cardiac-related mortality after aortic valve replacement. Heart. 2010;96:865–71.CrossRefPubMed Bleiziffer S, Ali A, Hettich IM, Akdere D, Laubender RP, Ruzicka D, et al. Impact of the indexed effective orifice area on mid-term cardiac-related mortality after aortic valve replacement. Heart. 2010;96:865–71.CrossRefPubMed
12.
go back to reference Tully PJ, Aty W, Rice GD, Bennetts JS, Knight JL, Baker RA. Aortic valve prosthesis-patient mismatch and long-term outcomes: 19-year single-center experience. Ann Thorac Surg. 2013;96:844–50.CrossRefPubMed Tully PJ, Aty W, Rice GD, Bennetts JS, Knight JL, Baker RA. Aortic valve prosthesis-patient mismatch and long-term outcomes: 19-year single-center experience. Ann Thorac Surg. 2013;96:844–50.CrossRefPubMed
13.
go back to reference Moon MR, Pasque MK, Munfakh NA, Melby SJ, Lawton JS, Moazami N, et al. Prosthesis-patient mismatch after aortic valve replacement: impact of age and body size on late survival. Ann Thorac Surg. 2006;81:481–8.CrossRefPubMed Moon MR, Pasque MK, Munfakh NA, Melby SJ, Lawton JS, Moazami N, et al. Prosthesis-patient mismatch after aortic valve replacement: impact of age and body size on late survival. Ann Thorac Surg. 2006;81:481–8.CrossRefPubMed
14.
go back to reference Mohty D, Dumesnil JG, Echahidi N, Mathieu P, Dagenais F, Voisine P, et al. Impact of prosthesis-patient mismatch on long-term survival after aortic valve replacement: influence of age, obesity, and left ventricular dysfunction. J Am Coll Cardiol. 2009;53:39–47.CrossRefPubMed Mohty D, Dumesnil JG, Echahidi N, Mathieu P, Dagenais F, Voisine P, et al. Impact of prosthesis-patient mismatch on long-term survival after aortic valve replacement: influence of age, obesity, and left ventricular dysfunction. J Am Coll Cardiol. 2009;53:39–47.CrossRefPubMed
15.
go back to reference Price J, Toeg H, Lam BK, Lapierre H, Mesana TG, Ruel M. The impact of prosthesis-patient mismatch after aortic valve replacement varies according to age at operation. Heart. 2014;100:1099–106.CrossRefPubMed Price J, Toeg H, Lam BK, Lapierre H, Mesana TG, Ruel M. The impact of prosthesis-patient mismatch after aortic valve replacement varies according to age at operation. Heart. 2014;100:1099–106.CrossRefPubMed
16.
go back to reference Bleiziffer S, Eichinger WB, Hettich I, Guenzinger R, Ruzicka D, Bauernschmitt R, et al. Prediction of valve prosthesis-patient mismatch prior to aortic valve replacement: which is the best method? Heart. 2006;93:615–20.PubMedCentralCrossRefPubMed Bleiziffer S, Eichinger WB, Hettich I, Guenzinger R, Ruzicka D, Bauernschmitt R, et al. Prediction of valve prosthesis-patient mismatch prior to aortic valve replacement: which is the best method? Heart. 2006;93:615–20.PubMedCentralCrossRefPubMed
17.
go back to reference Takaseya T, Kawara T, Tokunaga S, Kohno M, Oishi Y, Morita S. Aortic valve replacement with 17-mm St. Jude Medical prostheses for a small aortic root in elderly patients. Ann Thorac Surg. 2007;83:2050–3.CrossRefPubMed Takaseya T, Kawara T, Tokunaga S, Kohno M, Oishi Y, Morita S. Aortic valve replacement with 17-mm St. Jude Medical prostheses for a small aortic root in elderly patients. Ann Thorac Surg. 2007;83:2050–3.CrossRefPubMed
18.
go back to reference Okamura H, Yamaguchi A, Tanaka M, Naito K, Kimura N, Kimura C, et al. The 17-mm St. Jude Medical Regent valve is a valid option for patients with a small aortic annulus. Ann Thorac Surg. 2009;87:90–4.CrossRefPubMed Okamura H, Yamaguchi A, Tanaka M, Naito K, Kimura N, Kimura C, et al. The 17-mm St. Jude Medical Regent valve is a valid option for patients with a small aortic annulus. Ann Thorac Surg. 2009;87:90–4.CrossRefPubMed
19.
go back to reference Nakamura Y, Nakano K, Tagusari O, Kataoka G, Seike Y, Domoto S, et al. An alternative option for elderly patients with a small aortic annulus: the 16 mm ATS valve. J Heart Valve Dis. 2009;18:691–7.PubMed Nakamura Y, Nakano K, Tagusari O, Kataoka G, Seike Y, Domoto S, et al. An alternative option for elderly patients with a small aortic annulus: the 16 mm ATS valve. J Heart Valve Dis. 2009;18:691–7.PubMed
20.
go back to reference Brennan JM, Edwards FH, Zhao Y, O’Brien S, Booth ME, Dokholyan RS, et al. Long-term safety and effectiveness of mechanical versus biologic aortic valve prostheses in older patients: results from the Society of Thoracic Surgeons Adult Cardiac Surgery National Database. Circulation. 2013;127:1647–55.CrossRefPubMed Brennan JM, Edwards FH, Zhao Y, O’Brien S, Booth ME, Dokholyan RS, et al. Long-term safety and effectiveness of mechanical versus biologic aortic valve prostheses in older patients: results from the Society of Thoracic Surgeons Adult Cardiac Surgery National Database. Circulation. 2013;127:1647–55.CrossRefPubMed
21.
go back to reference Milano A, Guglielmi C, De Carlo M, Di Gregorio O, Borzoni G, Verunelli F, et al. Valve-related complications in elderly patients with biological and mechanical aortic valves. Ann Thorac Surg. 1998;66:S82–7.CrossRefPubMed Milano A, Guglielmi C, De Carlo M, Di Gregorio O, Borzoni G, Verunelli F, et al. Valve-related complications in elderly patients with biological and mechanical aortic valves. Ann Thorac Surg. 1998;66:S82–7.CrossRefPubMed
22.
go back to reference Ennker J, Dalladaku F, Rosendahl U, Ennker IC, Mauser M, Florath I. The stentless freestyle bioprosthesis: impact of age over 80 years on quality of life, perioperative, and mid-term outcome. J Card Surg. 2006;21:379–85.CrossRefPubMed Ennker J, Dalladaku F, Rosendahl U, Ennker IC, Mauser M, Florath I. The stentless freestyle bioprosthesis: impact of age over 80 years on quality of life, perioperative, and mid-term outcome. J Card Surg. 2006;21:379–85.CrossRefPubMed
23.
go back to reference Petracek MR. Assessing options for the small aortic root. J Heart Valve Dis. 2002;11:S50–5.PubMed Petracek MR. Assessing options for the small aortic root. J Heart Valve Dis. 2002;11:S50–5.PubMed
24.
go back to reference Urbanski PP, Dinstak W, Rents W, Heinz N, Diegeler A. Long-term results after aortic root replacement using self-assembled valve composite grafts in patients with small aortic annulus. Interact Cardiovasc Thorac Surg. 2014;18:159–63.PubMedCentralCrossRefPubMed Urbanski PP, Dinstak W, Rents W, Heinz N, Diegeler A. Long-term results after aortic root replacement using self-assembled valve composite grafts in patients with small aortic annulus. Interact Cardiovasc Thorac Surg. 2014;18:159–63.PubMedCentralCrossRefPubMed
25.
go back to reference Ozaki S, Kawase I, Yamashita H, Nozawa Y, Takatoh M, Hagiwara S, et al. Aortic valve reconstruction using autologous pericardium for ages over 80 years. Asian Cardiovasc Thorac Ann. 2014;22:903–8.CrossRefPubMed Ozaki S, Kawase I, Yamashita H, Nozawa Y, Takatoh M, Hagiwara S, et al. Aortic valve reconstruction using autologous pericardium for ages over 80 years. Asian Cardiovasc Thorac Ann. 2014;22:903–8.CrossRefPubMed
26.
go back to reference Makkar RR, Fontana GP, Jilaihawi H, Kapadia S, Pichard AD, Douglas PS, et al. Transcatheter aortic-valve replacement for inoperable severe aortic stenosis. N Engl J Med. 2012;366:1696–704.CrossRefPubMed Makkar RR, Fontana GP, Jilaihawi H, Kapadia S, Pichard AD, Douglas PS, et al. Transcatheter aortic-valve replacement for inoperable severe aortic stenosis. N Engl J Med. 2012;366:1696–704.CrossRefPubMed
Metadata
Title
Early and late outcomes of AVR with aortic annular enlargement in octogenarian
Authors
Yuki Okamoto
Kazuo Yamamoto
Tsutomu Sugimoto
Shinpei Yoshii
Publication date
01-08-2015
Publisher
Springer Japan
Published in
General Thoracic and Cardiovascular Surgery / Issue 8/2015
Print ISSN: 1863-6705
Electronic ISSN: 1863-6713
DOI
https://doi.org/10.1007/s11748-015-0559-2

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