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General Thoracic and Cardiovascular Surgery
Published in: General Thoracic and Cardiovascular Surgery 6/2016

01-06-2016 | Case Report

Complete resection of a large phosphaturic mesenchymal tumour by chest wall resection and reconstruction

Authors: Lawrence Okiror, Haitham Khalil, Sumathi Vaiyapuri, Maninder Kalkat

Published in: General Thoracic and Cardiovascular Surgery | Issue 6/2016

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Abstract

Phosphaturic mesenchymal tumour is an extremely rare mesenchymal neoplasm of bone or soft tissue. It is associated with paraneoplastic oncogenic osteomalacia through secretion of fibroblast growth factor-23 (FGF-23) which inhibits renal proximal tubule phosphate re-uptake. We report a case of a 36-year-old woman with a large chest wall tumour completely excised by extensive chest wall resection and reconstruction with polypropylene mesh–methylmethacrylate composite and pedicled muscle flaps.
Literature
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Ledford CK, Zelenski NA, Cardona DM, Brigman BE, Eward WC. The phosphaturic mesenchymal tumor: why is definitive diagnosis and curative surgery often delayed? Clin Orthop Relat Res. 2013;471:3618–25.CrossRefPubMedPubMedCentral
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Fletcher CDM, Bridge JA, Hogendoorn P, Mertens F (eds) WHO classification of tumours of soft tissue and bone. Geneva: WHO Press; 2013. pp 167–176.
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Folpe A. Tumors of miscellaneous type or uncertain lineage. In: Folpe A, Inwards C, editors. Bone and soft tissue pathology. Philadelphia: Churchill Livingstone; 2010. p. 288–90.
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Shelekhova KV, Kazakov DV, Michal M. Sinonasal phosphaturic mesenchymal tumor (mixed connective tissue variant): report of 2 cases. Am J Surg Pathol. 2010;34:596–7.CrossRefPubMed
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Rocco G. Chest wall resection and reconstruction according to the principles of biomimesis. Semin Thorac Cardiovasc Surg. 2011;23:307–13.CrossRefPubMed
Metadata
Title
Complete resection of a large phosphaturic mesenchymal tumour by chest wall resection and reconstruction
Authors
Lawrence Okiror
Haitham Khalil
Sumathi Vaiyapuri
Maninder Kalkat
Publication date
01-06-2016
Publisher
Springer Japan
Published in
General Thoracic and Cardiovascular Surgery / Issue 6/2016
Print ISSN: 1863-6705
Electronic ISSN: 1863-6713
DOI
https://doi.org/10.1007/s11748-014-0505-8

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