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General Thoracic and Cardiovascular Surgery

Published in:

01-09-2014 | Original Article

Focusing on delayed clearance for identifying small-sized metastatic lung tumors using synchrotron radiation angiography with a highly sensitive receiver

Authors: Hiromichi Ito, Shonosuke Matsushita, Kazuyuki Hyodo, Hideo Tsurushima, Yukio Sato, Yuzuru Sakakibara

Published in: General Thoracic and Cardiovascular Surgery | Issue 9/2014

Abstract

Objectives

To detect metastatic lung tumors of less than 1 mm in size by focusing on the clearance of contrast material using synchrotron radiation (SR) angiography characterized by high spatial resolution and high-sensitivity receiver.

Methods

C6 cells, derived from rat glioma cells, were injected to the rat tail vein. Two weeks after injection, the rats underwent SR angiography using a high-gain avalanche rushing amorphous photoconductor (HARP) receiver of extra-high sensitivity with high contrast resolution. The 256-grayscale value was employed in the analysis of images.

Results

19 nodules were identified in images. The tumors were confirmed histopathologically. The average tumor size was 621 ± 193 µm. The clearance curve of the densities was expressed as a logarithm function. Tumors showed delayed clearance of contrast material, taking up to 28 s, compared with arteries, which cleared rapidly at 8 s. In 256 grayscale, the distance was 50. This gap in density clearance made it possible to identify tumors.

Conclusions

SR angiography with a HARP receiver provides high sensitivity and spatial resolution and makes it possible to diagnose metastatic lung tumors of less than 1 mm in size by focusing on differences in the clearance times of contrast material.

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Title: Focusing on delayed clearance for identifying small-sized metastatic lung tumors using synchrotron radiation angiography with a highly sensitive receiver
Authors: Hiromichi Ito
Shonosuke Matsushita
Kazuyuki Hyodo
Hideo Tsurushima
Yukio Sato
Yuzuru Sakakibara
Publication date: 01-09-2014
Publisher: Springer Japan
Published in: General Thoracic and Cardiovascular Surgery / Issue 9/2014
Print ISSN: 1863-6705
Electronic ISSN: 1863-6713
DOI: https://doi.org/10.1007/s11748-014-0430-x

At a glance: The STEP trials

Springer Medicine

Focusing on delayed clearance for identifying small-sized metastatic lung tumors using synchrotron radiation angiography with a highly sensitive receiver

Abstract

Objectives

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

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