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Obesity Surgery
Published in: Obesity Surgery 12/2020

01-12-2020 | Obesity | Original Contributions

Gut Microbiota Modifications and Weight Regain in Morbidly Obese Women After Roux-en-Y Gastric Bypass

Authors: Silvia Leite Faria, Andrey Santos, Daniéla Oliveira Magro, Everton Cazzo, Heloisa Balan Assalin, Dioze Guadagnini, Flavio Teixeira Vieira, Eliane Said Dutra, Mario José Abdalla Saad, Marina K. Ito

Published in: Obesity Surgery | Issue 12/2020

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Abstract

Introduction

The relationship between late post-bariatric surgery weight regain and gut microbiota is not completely understood.

Objective

To analyze the profile of gut microbiota among patients with and without late weight regain after post-Roux-en-Y gastric bypass (RYGB) and to compare it with a control group (CG) comprised of obese Brazilian individuals.

Methods

This is a cross-sectional study which enrolled 34 morbidly obese women divided into 3 groups: post-Roux-en-Y gastric bypass without (RYGB_non-regain), and with weight regain (RYGB_regain) at least 5 years after surgery, and a CG of preoperative individuals. Gut microbiota was determined by metagenomic analyses.

Results

The alpha diversity was higher in groups RYGB non-regain and RYGB regain when compared with CG (p < 0.05). Both RYGB non-regain and RYGB regain groups showed a lower abundance of the phylum Bacteroidetes when compared with CG (p < 0.01). The genera Bacteroides and SMB53 were increased in CG (p < 0.05). Group RYGB non-regain showed more abundance of the Akkermansia genus when compared with CG and group RYGB regain (p < 0.05). RYGB non-regain showed a greater abundance of the Phascolarctobacterium genus and lower of the SMB53 genus when compared with CG (p < 0.05). RYGB non-regain showed a greater abundance of the Phascolarctobacterium genus and a lower of the SMB53 genus when compared with CG (p < 0.05).

Conclusion

The gut microbiota of individuals which presented late weight regain after RYGB was significantly different in comparison to individuals with a successful weight loss, a finding that points towards a significant role of gut microbiota on weight loss and maintenance after surgery.
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Metadata
Title
Gut Microbiota Modifications and Weight Regain in Morbidly Obese Women After Roux-en-Y Gastric Bypass
Authors
Silvia Leite Faria
Andrey Santos
Daniéla Oliveira Magro
Everton Cazzo
Heloisa Balan Assalin
Dioze Guadagnini
Flavio Teixeira Vieira
Eliane Said Dutra
Mario José Abdalla Saad
Marina K. Ito
Publication date
01-12-2020
Publisher
Springer US
Published in
Obesity Surgery / Issue 12/2020
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-020-04956-9

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