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01-05-2020 | Obesity | Review

Sarcopenia: What a Surgeon Should Know

Published in: Obesity Surgery | Issue 5/2020

Abstract

Sarcopenia is an increasingly frequent syndrome characterized by generalized and progressive loss of muscle mass, reduction in muscle strength, and resultant functional impairment. This condition is associated with increased risk of falls and fractures, disability, and increased risk of death. When a sarcopenic patient undergoes major surgery, it has a higher risk of complications and postoperative mortality because of less resistance to surgical stress. It is not easy to recognize a sarcopenic patient preoperatively, but this is essential to evaluate the correct risk to benefit ratio. The role of sarcopenia in surgical patients has been studied for both oncological and non-oncological surgery. For correct surgical planning, data about sarcopenia are essential to design a correct tailored treatment.

Rosenberg IH. Summary comments [Internet]. Am J Clin Nutr. 1989:1231–3. https://doi.org/10.1093/ajcn/50.5.1231.

Kim TN, Choi KM. Sarcopenia: definition, epidemiology, and pathophysiology [Internet]. J Bone Metab. 2013:1. https://doi.org/10.11005/jbm.2013.20.1.1.PubMedPubMedCentral

Goodpaster BH, Park SW, Harris TB, et al. The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study. J Gerontol A Biol Sci Med Sci. 2006;61:1059–64.PubMed

Cruz-Jentoft AJ, Baeyens JP, Bauer JM, et al. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People [Internet]. Age and Ageing. 2010:412–23. https://doi.org/10.1093/ageing/afq034.PubMedPubMedCentral

Santilli V. Clinical definition of sarcopenia [Internet]. Clinical Cases in Mineral and Bone Metabolism. 2014; https://doi.org/10.11138/ccmbm/2014.11.3.177.

Lauretani F, Russo CR, Bandinelli S, et al. Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia [Internet]. Journal of Applied Physiology. 2003:1851–60. https://doi.org/10.1152/japplphysiol.00246.2003.PubMed

Sayer A, Stewart C, Patel H, et al. The developmental origins of sarcopenia: from epidemiological evidence to underlying mechanisms. J Dev Orig Health Dis. 2010;1:150–7.

Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype [Internet]. J Gerontol Ser A Biol Med Sci. 2001:M146–57. https://doi.org/10.1093/gerona/56.3.m146.

Vanhoutte G, van de Wiel M, Wouters K, et al. Cachexia in cancer: what is in the definition? BMJ Open Gastroenterol. 2016;3:e000097.PubMedPubMedCentral

10.

Thomas DR. Loss of skeletal muscle mass in aging: examining the relationship of starvation, sarcopenia and cachexia [Internet]. Clin Nutr. 2007:389–99. https://doi.org/10.1016/j.clnu.2007.03.008.PubMed

11.

Ghoch ME, El Ghoch M, Calugi S, et al. Sarcopenic obesity: definition, health consequences and clinical management [Internet]. Open Nutr J. 2018:70–3. https://doi.org/10.2174/1874288201812010070.

12.

Polyzos SA, Margioris AN. Sarcopenic obesity. Hormones. 2018;17:321–31.PubMed

13.

Edwards MH, Buehring B. Novel approaches to the diagnosis of sarcopenia [Internet]. J Clin Densitom. 2015:472–7. https://doi.org/10.1016/j.jocd.2015.04.010.PubMed

14.

Snih SA, Al Snih S, Markides KS, et al. Hand grip strength and incident ADL disability in elderly Mexican Americans over a seven-year period [Internet]. Aging Clin Exp Res. 2004:481–6. https://doi.org/10.1007/bf03327406.PubMed

15.

Beaudart C, McCloskey E, Bruyère O, et al. Sarcopenia in daily practice: assessment and management. BMC Geriatr. 2016;16:170.PubMedPubMedCentral

16.

Sandini M, Pinotti E, Persico I, et al. Systematic review and meta-analysis of frailty as a predictor of morbidity and mortality after major abdominal surgery. BJS Open. 2017;1:128–37.PubMedPubMedCentral

17.

Hanaoka M, Yasuno M, Ishiguro M, et al. Morphologic change of the psoas muscle as a surrogate marker of sarcopenia and predictor of complications after colorectal cancer surgery. Int J Color Dis. 2017;32:847–56.

18.

Nakanishi R, Oki E, Sasaki S, et al. Sarcopenia is an independent predictor of complications after colorectal cancer surgery. Surg Today. 2018;48:151–7.PubMed

19.

Hopkins JJ, Reif RL, Bigam DL, et al. The impact of muscle and adipose tissue on long-term survival in patients with stage I to III colorectal cancer [Internet]. Dis Colon Rectum. 2019:549–60. https://doi.org/10.1097/dcr.0000000000001352.

20.

Charette N, Vandeputte C, Ameye L, et al. Prognostic value of adipose tissue and muscle mass in advanced colorectal cancer: a post hoc analysis of two non-randomized phase II trials. BMC Cancer. 2019;19:134.PubMedPubMedCentral

21.

Gruber ES, Jomrich G, Tamandl D, et al. Sarcopenia and sarcopenic obesity are independent adverse prognostic factors in resectable pancreatic ductal adenocarcinoma. PLoS One. 2019;14:e0215915.PubMedPubMedCentral

22.

Choi MH, Yoon SB, Lee K, et al. Preoperative sarcopenia and post-operative accelerated muscle loss negatively impact survival after resection of pancreatic cancer. J Cachexia Sarcopenia Muscle. 2018;9:326–34.PubMedPubMedCentral

23.

Tan BHL, Birdsell LA, Martin L, et al. Sarcopenia in an overweight or obese patient is an adverse prognostic factor in pancreatic cancer [Internet]. Clin Cancer Res. 2009:6973–9. https://doi.org/10.1158/1078-0432.ccr-09-1525.PubMed

24.

Ozola Zalite I, Zykus R, Francisco Gonzalez M, et al. Influence of cachexia and sarcopenia on survival in pancreatic ductal adenocarcinoma: a systematic review. Pancreatology. 2015;15:19–24.PubMed

25.

Nishida Y, Kato Y, Kudo M, et al. Preoperative sarcopenia strongly influences the risk of postoperative pancreatic fistula formation after pancreaticoduodenectomy. J Gastrointest Surg. 2016;20:1586–94.PubMed

26.

Zhang Y, Wang JP, Wang XL, et al. Computed tomography-quantified body composition predicts short-term outcomes after gastrectomy in gastric cancer. Curr Oncol. 2018;25:e411–22.PubMedPubMedCentral

27.

Shen Y, Hao Q, Zhou J, et al. The impact of frailty and sarcopenia on postoperative outcomes in older patients undergoing gastrectomy surgery: a systematic review and meta-analysis. BMC Geriatr. 2017;17:188.PubMedPubMedCentral

28.

Kawamura T, Makuuchi R, Tokunaga M, et al. Long-term outcomes of gastric cancer patients with preoperative sarcopenia. Ann Surg Oncol. 2018;25:1625–32.PubMed

29.

Voron T, Tselikas L, Pietrasz D, et al. Sarcopenia impacts on short- and long-term results of hepatectomy for hepatocellular carcinoma [Internet]. Ann Surg. 2015:1173–83. https://doi.org/10.1097/sla.0000000000000743.PubMed

30.

Harimoto N, Shirabe K, Yamashita Y-I, et al. Sarcopenia as a predictor of prognosis in patients following hepatectomy for hepatocellular carcinoma. Br J Surg. 2013;100:1523–30.PubMed

31.

Levolger S, van Vledder MG, Muslem R, et al. Sarcopenia impairs survival in patients with potentially curable hepatocellular carcinoma. J Surg Oncol. 2015;112:208–13.PubMed

32.

Dirks RC, Edwards BL, Tong E, et al. Sarcopenia in emergency abdominal surgery. J Surg Res. 2017;207:13–21.PubMed

33.

Rangel EL, Rios-Diaz AJ, Uyeda JW, et al. Sarcopenia increases risk of long-term mortality in elderly patients undergoing emergency abdominal surgery. J Trauma Acute Care Surg. 2017;83:1179–86.PubMed

34.

Du Y, Karvellas CJ, Baracos V, et al. Acute Care and Emergency Surgery (ACES) Group. Sarcopenia is a predictor of outcomes in very elderly patients undergoing emergency surgery. Surgery. 2014;156:521–7.PubMed

35.

Meeks AC, Madill J. Sarcopenia in liver transplantation: a review. Clin Nutr ESPEN. 2017;22:76–80.PubMed

36.

DiMartini A, Cruz RJ, Dew MA, et al. Muscle mass predicts outcomes following liver transplantation [Internet]. Liver Transpl. 2013:1172–80. https://doi.org/10.1002/lt.23724.PubMedPubMedCentral

37.

Tandon P, Ney M, Irwin I, et al. Severe muscle depletion in patients on the liver transplant wait list: its prevalence and independent prognostic value. Liver Transpl. 2012;18:1209–16.PubMed

38.

Barnes LA, Li AY, Wan DC, et al. Determining the impact of sarcopenia on postoperative complications after ventral hernia repair. J Plast Reconstr Aesthet Surg. 2018;71:1260–8.PubMed

39.

Siegal SR, Guimaraes AR, Lasarev MR, et al. Sarcopenia and outcomes in ventral hernia repair: a preliminary review. Hernia. 2018;22:645–52.PubMed

40.

Rinaldi JM, Geletzke AK, Phillips BE, et al. Sarcopenia and sarcopenic obesity in patients with complex abdominal wall hernias. Am J Surg. 2016;212:903–11.PubMed

41.

Lorenzo AD, De Lorenzo A. New obesity classification criteria as a tool for bariatric surgery indication [Internet]. World J Gastroenterol. 2016:681. https://doi.org/10.3748/wjg.v22.i2.681.PubMedPubMedCentral

42.

Roubenoff R. Sarcopenic obesity: does muscle loss cause fat gain?: lessons from rheumatoid arthritis and osteoarthritisa [Internet]. Ann N Y Acad Sci. 2006:553–7. https://doi.org/10.1111/j.1749-6632.2000.tb06515.x.

43.

Schrager MA, Jeffrey Metter E, Simonsick E, et al. Sarcopenic obesity and inflammation in the InCHIANTI study [Internet]. J Appl Physiol. 2007:919–25. https://doi.org/10.1152/japplphysiol.00627.2006.PubMed

44.

Baumgartner RN. Body composition in healthy aging [Internet]. Ann N Y Acad Sci. 2006:437–48. https://doi.org/10.1111/j.1749-6632.2000.tb06498.x.

45.

Voican CS, Lebrun A, Maitre S, et al. Predictive score of sarcopenia occurrence one year after bariatric surgery in severely obese patients. PLoS One. 2018;13:e0197248.PubMedPubMedCentral

46.

Gaillard M, Tranchart H, Maitre S, et al. Preoperative detection of sarcopenic obesity helps to predict the occurrence of gastric leak after sleeve gastrectomy. Obes Surg. 2018;28:2379–85.PubMed

47.

Mastino D, Robert M, Betry C, et al. Bariatric surgery outcomes in sarcopenic obesity. Obes Surg. 2016;26:2355–62.PubMed

48.

Crisp AH, Verlengia R, Ravelli MN, et al. Changes in physical activities and body composition after Roux-Y gastric bypass surgery. Obes Surg. 2018;28:1665–71.PubMed

49.

Davidson LE, Yu W, Goodpaster BH, et al. Fat-free mass and skeletal muscle mass five years after bariatric surgery. Obesity. 2018;26:1130–6.PubMed

50.

Beaudart C, Dawson A, Shaw SC, et al. Nutrition and physical activity in the prevention and treatment of sarcopenia: systematic review. Osteoporos Int. 2017;28:1817–33.PubMedPubMedCentral

51.

Naseeb MA, Volpe SL. Protein and exercise in the prevention of sarcopenia and aging [Internet]. Nutr Res. 2017:1–20. https://doi.org/10.1016/j.nutres.2017.01.001.PubMed

52.

Bosaeus I, Rothenberg E. Nutrition and physical activity for the prevention and treatment of age-related sarcopenia [Internet]. Proc Nutr Soc. 2016:174–80. https://doi.org/10.1017/s002966511500422x.

53.

Dronkers JJ, Lamberts H, Reutelingsperger IMMD, et al. Preoperative therapeutic programme for elderly patients scheduled for elective abdominal oncological surgery: a randomized controlled pilot study. Clin Rehabil. 2010;24:614–22.PubMed

54.

Valkenet K, van de Port IGL, Dronkers JJ, et al. The effects of preoperative exercise therapy on postoperative outcome: a systematic review. Clin Rehabil. 2011;25:99–111.PubMed

55.

King WC, Bond DS. The importance of preoperative and postoperative physical activity counseling in bariatric surgery. Exerc Sport Sci Rev. 2013;41:26–35.PubMedPubMedCentral

56.

Whittle J, Wischmeyer PE, Grocott MPW, et al. Surgical prehabilitation: nutrition and exercise. Anesthesiol Clin. 2018;36:567–80.PubMed

57.

Correia MITD, Waitzberg DL. The impact of malnutrition on morbidity, mortality, length of hospital stay and costs evaluated through a multivariate model analysis. Clin Nutr. 2003;22:235–9.PubMed

58.

Weimann A, Braga M, Carli F, et al. ESPEN guideline: clinical nutrition in surgery. Clin Nutr. 2017;36:623–50.PubMed

Title: Sarcopenia: What a Surgeon Should Know
Publication date: 01-05-2020
Keywords: Obesity
Obesity
Sarcopenia
Bariatric Surgery
Bariatric Surgery
Published in: Obesity Surgery / Issue 5/2020
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI: https://doi.org/10.1007/s11695-020-04516-1

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