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Obesity Surgery
Published in: Obesity Surgery 10/2018

01-10-2018 | Original Contributions

Histopathological Findings in Morbid Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy: Does H. pylori Infection Effective on Pathological Changes?

Authors: Ramazan İlyas Öner, Sabri Özdaş

Published in: Obesity Surgery | Issue 10/2018

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Abstract

Aım

To determine the prevalence of histopathological findings requiring clinical follow-up in morbidly obese patients undergoing laparoscopic sleeve gastrectomy (LSG) and evaluate the relationship between these findings and Helicobacter pylori as well as to add more data to the published literature in this regard.

Materıal and Methods

Overall, 161 morbidly obese patients with body mass index (BMI) > 40 kg/m2 who underwent LSG between May 1, 2014 and May 31, 2017 were retrospectively included in the study. The findings of the histopathological evaluation of the resected gastric material and the relationship between these findings and histopathologically detected H. pylori infection were investigated.

Results

The study included 114 women (70.8%) and 47 men (29.2%). The mean age of the patients was 36.82 ± 10.41 years, and the mean BMI was 46.05 ± 3.76 kg/m2. H. pylori infection was detected in 103 (64%), chronic gastritis in 156, chronic active gastritis in 47, intestinal metaplasia in eight, and atrophy in seven patients. The rate of H. pylori-associated chronic gastritis was 64%, that of chronic active gastritis was 24.2%, that of lymphoid aggregation was 62.2%, and that of intestinal metaplasia and atrophy was 3.1%. There was a significant relationship between H. pylori infection and chronic gastritis, chronic active gastritis, and lymphoid aggregation; however, no significant relationship was found between intestinal metaplasia and atrophy.

Conclusıon

Clinicians should be aware of the histopathological findings requiring clinical follow-up for LSG-treated patients. Given the complications of H. pylori infection such as lymphoma and malignancy, periodic follow-up of patients and eradication therapy may be a suitable approach for treating intestinal metaplasia and atrophic changes.
Literature
1.
Gill RS, Birch DW, Shi X, et al. Sleeve gastrectomy and type 2 diabetes mellitus: a systematic review. Surg Obes Relat Dis. 2010;6(6):707–13.
2.
Watanabe S, Hojo M, Nagahara A. Metabolic syndrome and gastrointestinal diseases. J Gastroenterol. 2007;42(4):267–74.CrossRefPubMed
3.
Che J, Wu Y, Mui L, et al. Obesity is associated with increased transient lower esophageal sphincter relaxation. Gastroenterology. 2007;132:883–9.
4.
Parsonnet J, Hansen S, Rodriguez L, et al. Helicobacter pylori infection and gastric lymphoma. N Engl J Med. 1994;330(18):1267–71.
5.
Sipponen P, Kekki M, Siurala M. The Sydney system: epidemiology and natural history of chronic gastritis. J Gastroenterol Hepatol. 1991;6(December 1990):244–51.CrossRefPubMed
6.
Aydemir S, Bayraktaroglu T, Sert M, et al. The effect of helicobacter pylori on insulin resistance. Dig Dis Sci. 2005;50(11):2090–3.
7.
Arslan E, At H, Yava İ. European journal of internal medicine the prevalence of helicobacter pylori in obese subjects. Eur J Intern Med. 2009;20:695–7.CrossRefPubMed
8.
Clapp B. Histopathologic findings in the resected specimen of a sleeve gastrectomy. JSLS. 2015;19(1):2013–5.
9.
Almazeedi S, Al-sabah S, Al-mulla A, et al. Gastric Histopathologies in patients undergoing laparoscopic sleeve Gastrectomies. Obes Surg. 2013;2015:314–9.
10.
Safaan T, Bashah M, El AW, et al. Histopathological changes in laparoscopic sleeve gastrectomy specimens : prevalence, risk factors, and value of routine histopathologic examination. Obes Surg. 2017;27(7):1741–9.
11.
Franklin AL, Koeck ES, Hamrick MC, et al. Prevalence of chronic gastritis or helicobacter pylori infection in adolescent sleeve gastrectomy patients Does not correlate with symptoms or surgical outcomes. Surg Infect. 2015;16(4):401–4.
12.
13.
Dogan U, Suren D, Oruc MT, et al. Spectrum of gastric histopathologies in morbidly obese Turkish patients undergoing laparoscopic sleeve gastrectomy. Eur Rev Med Pharmacol Sci. 2017;21(23):5430–6.
14.
Raess PW, Baird-Howell M, Aggarwal R, et al. Vertical sleeve gastrectomy specimens have a high prevalence of unexpected histopathologic findings requiring additional clinical management. Surg Obes Relat Dis. 2015;11(5):1020–3.
15.
Yamamoto S, Watabe K, Takehara T. Is obesity a new risk factor for gastritis? Digestion. 2012;85(2):108–10.CrossRefPubMed
16.
Rossetti G, Moccia F, Marra T, et al. Does helicobacter pylori infection have influence on outcome of laparoscopic sleeve gastrectomy for morbid obesity ? Int J Surg. 2014;12(Suppl 1):S68–71.
17.
18.
Onzi TR, d'Acampora AJ, de Araújo FM, et al. Gastric histopathology in laparoscopic sleeve gastrectomy: pre- and post-operative comparison. Obes Surg. 2014;24:371–6.
19.
Danciu M, Simion L, Poroch V, et al. The role of histological evaluation of helicobacter pylori infection in obese patients referred to laparoscopic sleeve gastrectomy. Romanian J Morphol Embryol. 2016;57(4):1303–11.
20.
Sonnenberg A, Lash RH, Genta RM. A national study of helicobactor pylori infection in gastric biopsy specimens. Gastroenterology. 2010;139(6):1894–901.CrossRefPubMed
21.
Eshraghian A. Epidemiology of helicobacter pylori infection among the healthy population in Iran and countries of the eastern Mediterranean region: a systematic review of prevalence and risk factors. World J Gastroenterol. 2014;20(46):17618–25.CrossRefPubMedPubMedCentral
22.
Nouraie M, Latifi-navid S, Rezvan H, et al. Childhood hygienic practice and family education status determine the prevalence of helicobacter pylori infection in Iran. Helicobacter. 2009;14(1):40–6.
23.
Bor S, Vardar R, Ormeci N, et al. Prevalence patterns of gastric cancers in Turkey: model of a developing country with high occurrence of helicobacter pylori. J Gastroenterol Hepatol. 2007;22(12):2242–5.
24.
Miller GC, Reid AS, Brown IS. The pathological findings seen in laparoscopic sleeve gastrectomies for weight loss. Pathology. 2016;48(3):228–32.CrossRefPubMed
25.
Ohanessian SE, Rogers AM, Karamchandani DM. Spectrum of gastric Histopathologies in severely obese American patients undergoing sleeve gastrectomy. Obes Surg. 2016;26(3):595–602.CrossRefPubMed
26.
Kara N, Urganci N, Kalyoncu D, et al. The association between helicobacter pylori gastritis and lymphoid aggregates, lymphoid follicles and intestinal metaplasia in gastric mucosa of children. J Paediatr Child Health. 2014;50(8):605–9.
27.
Ernst PB, Peura DA, Crowe SE. The translation of helicobacter pylori basic research to patient care. Gastroenterology. 2006;130(1):188–206.CrossRefPubMed
Metadata
Title
Histopathological Findings in Morbid Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy: Does H. pylori Infection Effective on Pathological Changes?
Authors
Ramazan İlyas Öner
Sabri Özdaş
Publication date
01-10-2018
Publisher
Springer US
Published in
Obesity Surgery / Issue 10/2018
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-018-3250-8

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