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Obesity Surgery
Published in: Obesity Surgery 11/2017

01-11-2017 | Review Article

Does Bariatric Surgery Affect the Incidence of Breast Cancer Development? A Systematic Review

Authors: Alec A. Winder, Malsha Kularatna, Andrew D. MacCormick

Published in: Obesity Surgery | Issue 11/2017

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Abstract

We reviewed the evidence for bariatric surgery reducing the risk of breast cancer. Data was extracted from multiple libraries, including PubMed, EMBASE, and Medline, to perform a systematic review. Abstracts were reviewed by two independent reviewers. Thirty-eight full-text articles were identified from 1171 abstracts. Four studies were included for meta-analysis; 114 of 10,533 (1.1%) patients receiving bariatric surgery versus 516 of 20,130 (2.6%) controls developed breast cancer, odds ratio 0.564 (95% CI 0.453 to 0.702) using a fixed effects model (P < 0.001) and odds ratio 0.585 (95% CI 0.247 to 1.386) using a random effects model (P 0.223). Bariatric surgery may reduce the risk of breast cancer. More research is required due to heterogeneity of studies, difficulty in identifying accurate controls, and limited follow-up.
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Literature
1.
Wang YC, McPherson K, Marsh T, et al. Health and economic burden of the projected obesity trends in the USA and the UK. Lancet. 2011;378(9793):815–25.CrossRefPubMed
2.
Esposito K, Chiodini P, Colao A, et al. Metabolic syndrome and risk of cancer: a systematic review and meta-analysis. Diabetes Care. 2012;35(11):2402–11.CrossRefPubMedPubMedCentral
3.
Reeves MJ, Newcomb PA, Remington PL, et al. Body mass and breast cancer. Relationship between method of detection and stage of disease. Cancer. 1996;77(2):301–7.CrossRefPubMed
4.
Chlebowski RT, Aiello E, McTiernan A. Weight loss in breast cancer patient management. J Clin Oncol Off J Am Soc Clin Oncol. 2002;20(4):1128–43.CrossRef
5.
Subbaramaiah K, Howe LR, Bhardwaj P, et al. Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland. Cancer Prev Res (Phila). 2011;4(3):329–46.CrossRef
6.
Key TJ, Appleby PN, Reeves GK, et al. Circulating sex hormones and breast cancer risk factors in postmenopausal women: reanalysis of 13 studies. Br J Cancer. 2011;105(5):709–22.CrossRefPubMed
7.
Byers T, Sedjo RL. Does intentional weight loss reduce cancer risk? Diabetes, Obes & Metab. 2011;13(12):1063–72.CrossRef
8.
Fabian CJ, Kimler BF, Donnelly JE, et al. Favorable modulation of benign breast tissue and serum risk biomarkers is associated with >10% weight loss in postmenopausal women. Breast Cancer Res Treat. 2013;142(1):119–32.CrossRefPubMedPubMedCentral
9.
Sjostrom L, Gummesson A, Sjostrom CD, et al. Effects of bariatric surgery on cancer incidence in obese patients in Sweden (Swedish Obese Subjects Study): a prospective, controlled intervention trial. Lancet Oncol. 2009;10(7):653–62.CrossRefPubMed
10.
Dixon JB, O'Brien PE, Playfair J, et al. Adjustable gastric banding and conventional therapy for type 2 diabetes: a randomized controlled trial. JAMA. 2008;299(3):316–23.CrossRefPubMed
11.
Casagrande DS, Rosa DD, Umpierre D, et al. Incidence of cancer following bariatric surgery: systematic review and meta-analysis. Obes Surg. 2014;24(9):1499–509.CrossRefPubMed
12.
Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA. 2000;283(15):2008–12.CrossRefPubMed
13.
Saruc M, Boler D, Karaarslan M, et al. Intragastric balloon treatment of obesity must be combined with bariatric surgery: a pilot study in Turkey. Turk J Gastroenterol Off J Turk Soc Gastroenterol. 2010;21(4):333–7.
14.
Wells G, Shea B, O'Connell D, Peterson J, Welch V, Losos M. Newcastle-Ottawa Quality Assessment Scale, cohort studies. 2014.
15.
16.
Christou NV, Lieberman M, Sampalis F, et al. Bariatric surgery reduces cancer risk in morbidly obese patients. Surg Obes Relat Dis. 2008;4(6):691–5.CrossRefPubMed
17.
McCawley GM, Ferriss JS, Geffel D, et al. Cancer in obese women: potential protective impact of bariatric surgery. J Am Coll Surg. 2009;208(6):1093–8.CrossRefPubMed
18.
Gagne DJ, Papasavas PK, Maalouf M, et al. Obesity surgery and malignancy: our experience after 1500 cases. Surg Obes Relat Dis. 2009;5(2):160–4.CrossRefPubMed
19.
Hunsinger MA. Maximizing weight loss after Roux-en-Y gastric bypass may decrease risk of incident organ cancer.
20.
Ostlund MP, Lu Y, Lagergren J. Risk of obesity-related cancer after obesity surgery in a population-based cohort study. Ann Surg. 2010;252(6):972–6.CrossRefPubMed
21.
Gusenoff JA, Koltz PF, O'Malley WJ, et al. Breast cancer and bariatric surgery: temporal relationships of diagnosis, treatment, and reconstruction. Plast Reconstr Surg. 2009;124(4):1025–32.CrossRefPubMed
22.
Renehan A. Obesity and overall cancer risk. European Journal of Cancer, Supplement. Conference:Joint ECCO 15 - 34th ESMO Multidisciplinary Congress. Berlin Germany. Conference Start: 20090920. Conference End: 4. Conference Publication: (var.pagings). 2009. 7 (2–3) (pp 79).
23.
Renehan A. Obesity is a new major cause of cancer. Obesity facts. Conference: European Obesity Summit(EOS):1st Joint Congress of EASO and IFSO-EC. Gothenburg Sweden. Conference Start: 20160601. Conference End: 4. Conference Publication: (var.pagings). 2016. 9 (pp 17).
24.
25.
Ungefroren H, Gieseler F, Fliedner S, et al. Obesity and cancer. Horm Mol Biol Clin Invest. 2015;21(1):5–15.
26.
Arditi JD, Venihaki M, Karalis KP, et al. Antiproliferative effect of adiponectin on MCF7 breast cancer cells: a potential hormonal link between obesity and cancer. Horm Metab Res. 2007;39(01):9–13.CrossRefPubMed
27.
Sanchez RC, Ibanez C, Klaassen J. The link between obesity and cancer. Revista Medica De Chile. 2014;142(2):211–21.CrossRef
28.
Modesitt SC, Hallowell PT, Slack-Davis JK, et al. Women at extreme risk for obesity-related carcinogenesis: baseline endometrial pathology and impact of bariatric surgery on weight, metabolic profiles and quality of life. Gynecol Oncol. 2015;138(2):238–45.CrossRefPubMed
29.
Fuerst M. Evidence that obesity raises risk of death in young women with ER-positive breast cancer. Oncol Times. 2014;36(12):12–4.CrossRef
30.
Rothman KJ. BMI-related errors in the measurement of obesity. Int J Obes. 2008;32:S56–S9.CrossRef
31.
Ward KK, Roncancio AM, Shah NR, et al. Bariatric surgery decrease the risk of uterine malignancy. Gynecol Oncol. 2014;133:63–6.CrossRefPubMed
Metadata
Title
Does Bariatric Surgery Affect the Incidence of Breast Cancer Development? A Systematic Review
Authors
Alec A. Winder
Malsha Kularatna
Andrew D. MacCormick
Publication date
01-11-2017
Publisher
Springer US
Published in
Obesity Surgery / Issue 11/2017
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-017-2901-5

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