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Obesity Surgery
Published in: Obesity Surgery 8/2017

01-08-2017 | Brief Communication

Laparoscopic Sleeve Gastrectomy Resolves Low GHRP-2-Stimulated Growth Hormone Levels in Obese Patients

Authors: Emi Ohara, Hirotake Tokuyama, Takumi Kitamoto, Aya Kitahara, Aiko Hayashi, Hideki Hayashi, Minoru Takemoto, Koutaro Yokote

Published in: Obesity Surgery | Issue 8/2017

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Abstract

Because growth hormone (GH) secretion is reportedly decreased in obese patients, we examined not only the factors associated with the decreased GH secretion but also GH response to the GH-releasing peptide (GHRP)-2-load test before and after laparoscopic gastrectomy (LSG). The study comprised 28 individuals aged 19–65 years [mean body mass index (BMI), 39.4 ± 9.4 kg/m2]. In the univariate analysis, GH secretion peaks correlated negatively with BMI (r = −0.59, p = 0.001), visceral adipose tissue (r = −0.47, p = 0.005), and subcutaneous adipose tissue (r = −0.40, p = 0.04). In the two obese patients, the response to the GHRP-2-load test markedly improved by weight loss 12 months after LSG. In conclusion, GH secretion was decreased in obese patients and improved by LSG.
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Metadata
Title
Laparoscopic Sleeve Gastrectomy Resolves Low GHRP-2-Stimulated Growth Hormone Levels in Obese Patients
Authors
Emi Ohara
Hirotake Tokuyama
Takumi Kitamoto
Aya Kitahara
Aiko Hayashi
Hideki Hayashi
Minoru Takemoto
Koutaro Yokote
Publication date
01-08-2017
Publisher
Springer US
Published in
Obesity Surgery / Issue 8/2017
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-017-2769-4

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