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Published in: Obesity Surgery 12/2017

01-12-2017 | Original Contributions

Reflux, Sleeve Dilation, and Barrett’s Esophagus after Laparoscopic Sleeve Gastrectomy: Long-Term Follow-Up

Authors: Daniel Moritz Felsenreich, Ronald Kefurt, Martin Schermann, Philipp Beckerhinn, Ivan Kristo, Michael Krebs, Gerhard Prager, Felix B. Langer

Published in: Obesity Surgery | Issue 12/2017

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Abstract

Background

Laparoscopic sleeve gastrectomy (SG) has become the most frequently performed bariatric procedure worldwide. De novo reflux might impact patients’ quality of life, requiring lifelong proton pump inhibitor medication. It also increases the risk of esophagitis and formation of Barrett’s metaplasia. Besides weight regain, gastroesophageal reflux disease (GERD) is the most common reason for conversion to Roux-en-Y gastric bypass.

Methods

We performed 24-h pH metries, manometries, gastroscopies, and questionnaires focusing on reflux (GIQLI, RSI) in SG patients with a follow-up of more than 10 years who did not suffer from symptomatic reflux or hiatal hernia preoperatively.

Results

From a total of 53 patients, ten patients after adjustable gastric banding were excluded. From the remaining 43, six patients (14.0%) were converted to RYGB due to intractable reflux over a period of 130 months. Ten out of the remaining non-converted patients (n = 26) also suffered from symptomatic reflux. Gastroscopies revealed de novo hiatal hernias in 45% of the patients and Barrett’s metaplasia in 15%. SG patients suffering from symptomatic reflux scored significantly higher in the RSI (p = 0.04) and significantly lower in the GIQLI (p = 0.02) questionnaire.

Conclusions

This study shows a high incidence of Barrett’s esophagus and hiatal hernias at more than 10 years after SG. Its results therefore suggest maintaining pre-existing large hiatal hernia, GERD, and Barrett’s esophagus as relative contraindications to SG. The limitations of this study—its small sample size as well as the fact that it was based on early experience with SG—make drawing any general conclusions about this procedure difficult.
Literature
1.
go back to reference Angrisani L, Santonicola A, Iovino P et al. Bariatric Surgery Worldwide 2013. Obes Surg. 2015 Angrisani L, Santonicola A, Iovino P et al. Bariatric Surgery Worldwide 2013. Obes Surg. 2015
2.
go back to reference Drahos J, Li L, Jick SS, et al. Metabolic syndrome in relation to Barrett’s esophagus and esophageal adenocarcinoma: results from a large population-based case-control study in the clinical practice research Datalink. Cancer Epidemiol. 2016;42:9–14.CrossRefPubMedPubMedCentral Drahos J, Li L, Jick SS, et al. Metabolic syndrome in relation to Barrett’s esophagus and esophageal adenocarcinoma: results from a large population-based case-control study in the clinical practice research Datalink. Cancer Epidemiol. 2016;42:9–14.CrossRefPubMedPubMedCentral
3.
go back to reference van Rutte PW, Smulders JF, de Zoete JP, et al. Outcome of sleeve gastrectomy as a primary bariatric procedure. Br J Surg. 2014;101:661–8.CrossRefPubMed van Rutte PW, Smulders JF, de Zoete JP, et al. Outcome of sleeve gastrectomy as a primary bariatric procedure. Br J Surg. 2014;101:661–8.CrossRefPubMed
4.
go back to reference Spivak H, Rubin M, Sadot E, et al. Laparoscopic sleeve gastrectomy using 42-French versus 32-French bougie: the first-year outcome. Obes Surg. 2014;24:1090–3.CrossRefPubMed Spivak H, Rubin M, Sadot E, et al. Laparoscopic sleeve gastrectomy using 42-French versus 32-French bougie: the first-year outcome. Obes Surg. 2014;24:1090–3.CrossRefPubMed
5.
go back to reference Rebecchi F, Allaix ME, Giaccone C, et al. Gastroesophageal reflux disease and laparoscopic sleeve gastrectomy: a physiopathologic evaluation. Ann Surg. 2014;260:909–14. discussion 914-905CrossRefPubMed Rebecchi F, Allaix ME, Giaccone C, et al. Gastroesophageal reflux disease and laparoscopic sleeve gastrectomy: a physiopathologic evaluation. Ann Surg. 2014;260:909–14. discussion 914-905CrossRefPubMed
6.
go back to reference Chiu S, Birch DW, Shi X, et al. Effect of sleeve gastrectomy on gastroesophageal reflux disease: a systematic review. Surg Obes Relat Dis. 2011;7:510–5.CrossRefPubMed Chiu S, Birch DW, Shi X, et al. Effect of sleeve gastrectomy on gastroesophageal reflux disease: a systematic review. Surg Obes Relat Dis. 2011;7:510–5.CrossRefPubMed
7.
go back to reference Braghetto I, Csendes A. Prevalence of Barrett’s esophagus in bariatric patients undergoing sleeve gastrectomy. Obes Surg. 2015 Braghetto I, Csendes A. Prevalence of Barrett’s esophagus in bariatric patients undergoing sleeve gastrectomy. Obes Surg. 2015
8.
go back to reference Himpens J, Dobbeleir J, Peeters G. Long-term results of laparoscopic sleeve gastrectomy for obesity. Ann Surg. 2010;252:319–24.CrossRefPubMed Himpens J, Dobbeleir J, Peeters G. Long-term results of laparoscopic sleeve gastrectomy for obesity. Ann Surg. 2010;252:319–24.CrossRefPubMed
9.
go back to reference Deitel M, Crosby RD, Gagner M. The first international consensus summit for sleeve Gastrectomy (SG), New York City, October 25-27, 2007. Obes Surg. 2008;18:487–96.CrossRefPubMed Deitel M, Crosby RD, Gagner M. The first international consensus summit for sleeve Gastrectomy (SG), New York City, October 25-27, 2007. Obes Surg. 2008;18:487–96.CrossRefPubMed
10.
go back to reference Langer FB, Bohdjalian A, Shakeri-Leidenmuhler S, et al. Conversion from sleeve gastrectomy to Roux-en-Y gastric bypass—indications and outcome. Obes Surg. 2010;20:835–40.CrossRefPubMed Langer FB, Bohdjalian A, Shakeri-Leidenmuhler S, et al. Conversion from sleeve gastrectomy to Roux-en-Y gastric bypass—indications and outcome. Obes Surg. 2010;20:835–40.CrossRefPubMed
11.
go back to reference Homan J, Betzel B, Aarts EO, et al. Secondary surgery after sleeve gastrectomy: Roux-en-Y gastric bypass or biliopancreatic diversion with duodenal switch. Surg Obes Relat Dis. 2015;11:771–7.CrossRefPubMed Homan J, Betzel B, Aarts EO, et al. Secondary surgery after sleeve gastrectomy: Roux-en-Y gastric bypass or biliopancreatic diversion with duodenal switch. Surg Obes Relat Dis. 2015;11:771–7.CrossRefPubMed
12.
go back to reference Weiner RA, Theodoridou S, Weiner S. Failure of laparoscopic sleeve gastrectomy—further procedure? Obes Facts. 2011;4(Suppl 1):42–6.PubMed Weiner RA, Theodoridou S, Weiner S. Failure of laparoscopic sleeve gastrectomy—further procedure? Obes Facts. 2011;4(Suppl 1):42–6.PubMed
13.
go back to reference Desart K, Rossidis G, Michel M, et al. Gastroesophageal reflux management with the LINX(R) system for gastroesophageal reflux disease following laparoscopic sleeve Gastrectomy. J Gastrointest Surg. 2015;19:1782–6.CrossRefPubMed Desart K, Rossidis G, Michel M, et al. Gastroesophageal reflux management with the LINX(R) system for gastroesophageal reflux disease following laparoscopic sleeve Gastrectomy. J Gastrointest Surg. 2015;19:1782–6.CrossRefPubMed
14.
go back to reference Nedelcu M, Noel P, Iannelli A, et al. Revised sleeve gastrectomy (re-sleeve). Surg Obes Relat Dis. 2015;11:1282–8.CrossRefPubMed Nedelcu M, Noel P, Iannelli A, et al. Revised sleeve gastrectomy (re-sleeve). Surg Obes Relat Dis. 2015;11:1282–8.CrossRefPubMed
15.
go back to reference Silecchia G, De Angelis F, Rizzello M, et al. Residual fundus or neofundus after laparoscopic sleeve gastrectomy: is fundectomy safe and effective as revision surgery? Surg Endosc. 2015;29:2899–903.CrossRefPubMed Silecchia G, De Angelis F, Rizzello M, et al. Residual fundus or neofundus after laparoscopic sleeve gastrectomy: is fundectomy safe and effective as revision surgery? Surg Endosc. 2015;29:2899–903.CrossRefPubMed
16.
go back to reference Galvez-Valdovinos R, Cruz-Vigo JL, Marin-Santillan E, et al. Cardiopexy with ligamentum teres in patients with hiatal hernia and previous sleeve gastrectomy: an alternative treatment for gastroesophageal reflux disease. Obes Surg. 2015;25:1539–43.CrossRefPubMed Galvez-Valdovinos R, Cruz-Vigo JL, Marin-Santillan E, et al. Cardiopexy with ligamentum teres in patients with hiatal hernia and previous sleeve gastrectomy: an alternative treatment for gastroesophageal reflux disease. Obes Surg. 2015;25:1539–43.CrossRefPubMed
17.
18.
go back to reference Eypasch E, Wood-Dauphinee S, Williams JI, et al. The gastrointestinal quality of life index. A clinical index for measuring patient status in gastroenterologic surgery. Chirurg. 1993;64:264–74.PubMed Eypasch E, Wood-Dauphinee S, Williams JI, et al. The gastrointestinal quality of life index. A clinical index for measuring patient status in gastroenterologic surgery. Chirurg. 1993;64:264–74.PubMed
19.
go back to reference Belafsky PC, Postma GN, Koufman JA. Validity and reliability of the reflux symptom index (RSI). J Voice. 2002;16:274–7.CrossRefPubMed Belafsky PC, Postma GN, Koufman JA. Validity and reliability of the reflux symptom index (RSI). J Voice. 2002;16:274–7.CrossRefPubMed
20.
go back to reference Vage V, Sande VA, Mellgren G, et al. Changes in obesity-related diseases and biochemical variables after laparoscopic sleeve gastrectomy: a two-year follow-up study. BMC Surg. 2014;14:8.CrossRefPubMedPubMedCentral Vage V, Sande VA, Mellgren G, et al. Changes in obesity-related diseases and biochemical variables after laparoscopic sleeve gastrectomy: a two-year follow-up study. BMC Surg. 2014;14:8.CrossRefPubMedPubMedCentral
21.
go back to reference Gibson SC, Le Page PA, Taylor CJ. Laparoscopic sleeve gastrectomy: review of 500 cases in single surgeon Australian practice. ANZ J Surg. 2015;85:673–7.CrossRefPubMed Gibson SC, Le Page PA, Taylor CJ. Laparoscopic sleeve gastrectomy: review of 500 cases in single surgeon Australian practice. ANZ J Surg. 2015;85:673–7.CrossRefPubMed
22.
go back to reference Daes J, Jimenez ME, Said N, et al. Improvement of gastroesophageal reflux symptoms after standardized laparoscopic sleeve gastrectomy. Obes Surg. 2014;24:536–40.CrossRefPubMed Daes J, Jimenez ME, Said N, et al. Improvement of gastroesophageal reflux symptoms after standardized laparoscopic sleeve gastrectomy. Obes Surg. 2014;24:536–40.CrossRefPubMed
23.
go back to reference Sharma A, Aggarwal S, Ahuja V, et al. Evaluation of gastroesophageal reflux before and after sleeve gastrectomy using symptom scoring, scintigraphy, and endoscopy. Surg Obes Relat Dis. 2014;10:600–5.CrossRefPubMed Sharma A, Aggarwal S, Ahuja V, et al. Evaluation of gastroesophageal reflux before and after sleeve gastrectomy using symptom scoring, scintigraphy, and endoscopy. Surg Obes Relat Dis. 2014;10:600–5.CrossRefPubMed
24.
go back to reference Ece I, Yilmaz H, Acar F et al. A new algorithm to reduce the incidence of gastroesophageal reflux symptoms after laparoscopic sleeve gastrectomy. Obes Surg. 2016. Ece I, Yilmaz H, Acar F et al. A new algorithm to reduce the incidence of gastroesophageal reflux symptoms after laparoscopic sleeve gastrectomy. Obes Surg. 2016.
25.
go back to reference Sheppard CE, Sadowski DC, de Gara CJ, et al. Rates of reflux before and after laparoscopic sleeve gastrectomy for severe obesity. Obes Surg. 2015;25:763–8.CrossRefPubMed Sheppard CE, Sadowski DC, de Gara CJ, et al. Rates of reflux before and after laparoscopic sleeve gastrectomy for severe obesity. Obes Surg. 2015;25:763–8.CrossRefPubMed
26.
go back to reference DuPree CE, Blair K, Steele SR, et al. Laparoscopic sleeve gastrectomy in patients with preexisting gastroesophageal reflux diseasennn: a national analysis. JAMA Surg. 2014;149:328–34.CrossRefPubMed DuPree CE, Blair K, Steele SR, et al. Laparoscopic sleeve gastrectomy in patients with preexisting gastroesophageal reflux diseasennn: a national analysis. JAMA Surg. 2014;149:328–34.CrossRefPubMed
27.
go back to reference Kular KS, Manchanda N, Rutledge R. Analysis of the five-year outcomes of sleeve gastrectomy and mini gastric bypass: a report from the Indian sub-continent. Obes Surg. 2014;24:1724–8.CrossRefPubMed Kular KS, Manchanda N, Rutledge R. Analysis of the five-year outcomes of sleeve gastrectomy and mini gastric bypass: a report from the Indian sub-continent. Obes Surg. 2014;24:1724–8.CrossRefPubMed
28.
go back to reference Samakar K, McKenzie TJ, Tavakkoli A, et al. The effect of laparoscopic sleeve gastrectomy with concomitant hiatal hernia repair on gastroesophageal reflux disease in the morbidly obese. Obes Surg. 2016;26:61–6.CrossRefPubMed Samakar K, McKenzie TJ, Tavakkoli A, et al. The effect of laparoscopic sleeve gastrectomy with concomitant hiatal hernia repair on gastroesophageal reflux disease in the morbidly obese. Obes Surg. 2016;26:61–6.CrossRefPubMed
29.
go back to reference Sucandy I, Chrestiana D, Bonanni F, et al. Gastroesophageal reflux symptoms after laparoscopic sleeve gastrectomy for morbid obesity. The importance of preoperative evaluation and selection. N Am J Med Sci. 2015;7:189–93.CrossRefPubMedPubMedCentral Sucandy I, Chrestiana D, Bonanni F, et al. Gastroesophageal reflux symptoms after laparoscopic sleeve gastrectomy for morbid obesity. The importance of preoperative evaluation and selection. N Am J Med Sci. 2015;7:189–93.CrossRefPubMedPubMedCentral
30.
go back to reference Lyon A, Gibson SC, De-loyde K, et al. Gastroesophageal reflux in laparoscopic sleeve gastrectomy: hiatal findings and their management influence outcome. Surg Obes Relat Dis. 2015;11:530–7.CrossRefPubMed Lyon A, Gibson SC, De-loyde K, et al. Gastroesophageal reflux in laparoscopic sleeve gastrectomy: hiatal findings and their management influence outcome. Surg Obes Relat Dis. 2015;11:530–7.CrossRefPubMed
31.
go back to reference Sieber P, Gass M, Kern B, et al. Five-year results of laparoscopic sleeve gastrectomy. Surg Obes Relat Dis. 2014;10:243–9.CrossRefPubMed Sieber P, Gass M, Kern B, et al. Five-year results of laparoscopic sleeve gastrectomy. Surg Obes Relat Dis. 2014;10:243–9.CrossRefPubMed
32.
go back to reference Soricelli E, Iossa A, Casella G, et al. Sleeve gastrectomy and crural repair in obese patients with gastroesophageal reflux disease and/or hiatal hernia. Surg Obes Relat Dis. 2013;9:356–61.CrossRefPubMed Soricelli E, Iossa A, Casella G, et al. Sleeve gastrectomy and crural repair in obese patients with gastroesophageal reflux disease and/or hiatal hernia. Surg Obes Relat Dis. 2013;9:356–61.CrossRefPubMed
33.
go back to reference Boules M, Corcelles R, Guerron AD, et al. The incidence of hiatal hernia and technical feasibility of repair during bariatric surgery. Surgery. 2015;158:911–6. discussion 916-918CrossRefPubMed Boules M, Corcelles R, Guerron AD, et al. The incidence of hiatal hernia and technical feasibility of repair during bariatric surgery. Surgery. 2015;158:911–6. discussion 916-918CrossRefPubMed
34.
go back to reference Rebecchi F, Allaix ME, Ugliono E, et al. Increased esophageal exposure to weakly acidic reflux 5 years after laparoscopic Roux-en-Y gastric bypass. Ann Surg. 2016;264:871–7.CrossRefPubMed Rebecchi F, Allaix ME, Ugliono E, et al. Increased esophageal exposure to weakly acidic reflux 5 years after laparoscopic Roux-en-Y gastric bypass. Ann Surg. 2016;264:871–7.CrossRefPubMed
35.
go back to reference Bonavina L, DeMeester T, Fockens P, et al. Laparoscopic sphincter augmentation device eliminates reflux symptoms and normalizes esophageal acid exposure: one- and 2-year results of a feasibility trial. Ann Surg. 2010;252:857–62.CrossRefPubMed Bonavina L, DeMeester T, Fockens P, et al. Laparoscopic sphincter augmentation device eliminates reflux symptoms and normalizes esophageal acid exposure: one- and 2-year results of a feasibility trial. Ann Surg. 2010;252:857–62.CrossRefPubMed
36.
go back to reference Reynolds JL, Zehetner J, Wu P, et al. Laparoscopic magnetic sphincter augmentation vs laparoscopic Nissen fundoplication: a matched-pair analysis of 100 patients. J Am Coll Surg. 2015;221:123–8.CrossRefPubMed Reynolds JL, Zehetner J, Wu P, et al. Laparoscopic magnetic sphincter augmentation vs laparoscopic Nissen fundoplication: a matched-pair analysis of 100 patients. J Am Coll Surg. 2015;221:123–8.CrossRefPubMed
37.
go back to reference Crawford C, Gibbens K, Lomelin D et al. Sleeve gastrectomy and anti-reflux procedures. Surg Endosc. 2016. Crawford C, Gibbens K, Lomelin D et al. Sleeve gastrectomy and anti-reflux procedures. Surg Endosc. 2016.
38.
go back to reference Ronkainen J, Aro P, Storskrubb T, et al. Prevalence of Barrett’s esophagus in the general population: an endoscopic study. Gastroenterology. 2005;129:1825–31.CrossRefPubMed Ronkainen J, Aro P, Storskrubb T, et al. Prevalence of Barrett’s esophagus in the general population: an endoscopic study. Gastroenterology. 2005;129:1825–31.CrossRefPubMed
39.
go back to reference Gagner M. Is sleeve gastrectomy always an absolute contraindication in patients with Barrett’s? Obes Surg. 2016;26:715–7.CrossRefPubMed Gagner M. Is sleeve gastrectomy always an absolute contraindication in patients with Barrett’s? Obes Surg. 2016;26:715–7.CrossRefPubMed
40.
go back to reference Gorodner V, Buxhoeveden R, Clemente G, et al. Barrett’s esophagus after Roux-en-Y gastric bypass: does regression occur? Surg Endosc. 2017;31:1849–54.CrossRefPubMed Gorodner V, Buxhoeveden R, Clemente G, et al. Barrett’s esophagus after Roux-en-Y gastric bypass: does regression occur? Surg Endosc. 2017;31:1849–54.CrossRefPubMed
41.
go back to reference Kindel TL, Oleynikov D. The improvement of gastroesophageal reflux disease and Barrett’s after bariatric surgery. Obes Surg. 2016;26:718–20.CrossRefPubMed Kindel TL, Oleynikov D. The improvement of gastroesophageal reflux disease and Barrett’s after bariatric surgery. Obes Surg. 2016;26:718–20.CrossRefPubMed
42.
go back to reference Overs SE, Freeman RA, Zarshenas N, et al. Food tolerance and gastrointestinal quality of life following three bariatric procedures: adjustable gastric banding, Roux-en-Y gastric bypass, and sleeve gastrectomy. Obes Surg. 2012;22:536–43.CrossRefPubMed Overs SE, Freeman RA, Zarshenas N, et al. Food tolerance and gastrointestinal quality of life following three bariatric procedures: adjustable gastric banding, Roux-en-Y gastric bypass, and sleeve gastrectomy. Obes Surg. 2012;22:536–43.CrossRefPubMed
Metadata
Title
Reflux, Sleeve Dilation, and Barrett’s Esophagus after Laparoscopic Sleeve Gastrectomy: Long-Term Follow-Up
Authors
Daniel Moritz Felsenreich
Ronald Kefurt
Martin Schermann
Philipp Beckerhinn
Ivan Kristo
Michael Krebs
Gerhard Prager
Felix B. Langer
Publication date
01-12-2017
Publisher
Springer US
Published in
Obesity Surgery / Issue 12/2017
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-017-2748-9

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