Skip to main content
Top
Published in: Obesity Surgery 10/2016

01-10-2016 | Original Contributions

A Pilot Study of an Acceptance-Based Behavioral Intervention for Weight Regain After Bariatric Surgery

Authors: Lauren E. Bradley, Evan M. Forman, Stephanie G. Kerrigan, Meghan L. Butryn, James D. Herbert, David B. Sarwer

Published in: Obesity Surgery | Issue 10/2016

Login to get access

Abstract

Background

Tens of thousands of bariatric surgery patients each year experience sub-optimal weight loss, significant regain, or both. Weight regain can contribute to a worsening of weight-related co-morbidities, and for some, leads to secondary surgical procedures. Poor weight outcomes have been associated with decreased compliance to the recommended postoperative diet. Decreased compliance may be partially due to a lack of psychological skills necessary to engage in healthy eating behaviors over the long term, especially as the effects of surgery (on appetite, hunger, and desire for food) decrease. Many behavioral interventions do not sufficiently address these challenges and often have limited effectiveness. The study aimed to evaluate the feasibility, acceptability, and preliminary effectiveness of a novel 10-week acceptance-based behavioral intervention to stop postoperative weight regain.

Methods

A sample of bariatric surgery patients (n = 11) who regained at least 10 % of their maximum lost postoperative weight was recruited. All participants received the intervention, which emphasized psychological skills thought to be integral to successful weight control post-surgery.

Results

The intervention was shown to be feasible and acceptable, with 72 % retention and high mean rating (4.25 out of 5.00) of program satisfaction among completers. Weight regain was stopped, and even reversed, with a mean total body weight loss of 3.58 ± 3.02 % throughout the 10-week intervention. There were also significant improvements in eating-related and acceptance-related variables.

Conclusions

These findings provide initial support for the use of a psychological acceptance-based intervention for weight regain in bariatric surgery patients.
Literature
1.
go back to reference Maggard MA, Shugarman LR, Suttorp M, et al. Meta-analysis: surgical treatment of obesity. Ann Intern Med. 2005;142(7):547–59.CrossRefPubMed Maggard MA, Shugarman LR, Suttorp M, et al. Meta-analysis: surgical treatment of obesity. Ann Intern Med. 2005;142(7):547–59.CrossRefPubMed
2.
go back to reference Sjostrom L, Narbro K, Sjostrom CD, et al. Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med. 2007;357(8):741–52.CrossRefPubMed Sjostrom L, Narbro K, Sjostrom CD, et al. Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med. 2007;357(8):741–52.CrossRefPubMed
3.
go back to reference Sjostrom L, Lindroos AK, Peltonen M, et al. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med. 2004;351(26):2683–93.CrossRefPubMed Sjostrom L, Lindroos AK, Peltonen M, et al. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med. 2004;351(26):2683–93.CrossRefPubMed
4.
go back to reference Courcoulas AP, Christian NJ, Belle SH, et al. Weight change and health outcomes at 3 years after bariatric surgery among individuals with severe obesity. JAMA. 2013;310(22):2416–25.PubMedPubMedCentral Courcoulas AP, Christian NJ, Belle SH, et al. Weight change and health outcomes at 3 years after bariatric surgery among individuals with severe obesity. JAMA. 2013;310(22):2416–25.PubMedPubMedCentral
6.
go back to reference DiGiorgi M, Rosen DJ, Choi JJ, et al. Re-emergence of diabetes after gastric bypass in patients with mid- to long-term follow-up. Surg Obes Relat Dis. 2010;6(3):249–53.CrossRefPubMed DiGiorgi M, Rosen DJ, Choi JJ, et al. Re-emergence of diabetes after gastric bypass in patients with mid- to long-term follow-up. Surg Obes Relat Dis. 2010;6(3):249–53.CrossRefPubMed
7.
go back to reference Sarwer DB, Wadden TA, Moore RH, et al. Preoperative eating behavior, postoperative dietary adherence, and weight loss after gastric bypass surgery. Surg Obes Relat Dis. 2008;4(5):640–6.CrossRefPubMedPubMedCentral Sarwer DB, Wadden TA, Moore RH, et al. Preoperative eating behavior, postoperative dietary adherence, and weight loss after gastric bypass surgery. Surg Obes Relat Dis. 2008;4(5):640–6.CrossRefPubMedPubMedCentral
8.
go back to reference Mechanick JI, Youdim A, Jones DB, et al. Clinical practice guidelines for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient—2013 update: cosponsored by American Association of Clinical Endocrinologists, The Obesity Society, and American Society for Metabolic & Bariatric Surgery. Obesity (Silver Spring). 2013;21 Suppl 1:S1–27.CrossRef Mechanick JI, Youdim A, Jones DB, et al. Clinical practice guidelines for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient—2013 update: cosponsored by American Association of Clinical Endocrinologists, The Obesity Society, and American Society for Metabolic & Bariatric Surgery. Obesity (Silver Spring). 2013;21 Suppl 1:S1–27.CrossRef
9.
go back to reference Bradley LE, Sarwer DB, Forman EM, Kerrigan SG, Butryn ML, Herbert JD. A survey of bariatric surgery patients’ interest in postoperative interventions. Obes Surg. 2015 Jun 18. Bradley LE, Sarwer DB, Forman EM, Kerrigan SG, Butryn ML, Herbert JD. A survey of bariatric surgery patients’ interest in postoperative interventions. Obes Surg. 2015 Jun 18.
10.
go back to reference Stewart K, Olbrisch M, Bean M. Back on track: confronting post-surgical weight gain. Bariatric Nurs Surg Patient Care. 2010;5:179–85.CrossRef Stewart K, Olbrisch M, Bean M. Back on track: confronting post-surgical weight gain. Bariatric Nurs Surg Patient Care. 2010;5:179–85.CrossRef
11.
go back to reference Kruseman M, Leimgruber A, Zumbach F, et al. Dietary, weight, and psychological changes among patients with obesity, 8 years after gastric bypass. J Am Diet Assoc. 2010;110(4):527–34.CrossRefPubMed Kruseman M, Leimgruber A, Zumbach F, et al. Dietary, weight, and psychological changes among patients with obesity, 8 years after gastric bypass. J Am Diet Assoc. 2010;110(4):527–34.CrossRefPubMed
12.
go back to reference Colles SL, Dixon JB, O’Brien PE. Grazing and loss of control related to eating: two high-risk factors following bariatric surgery. Obesity (Silver Spring). 2008;16(3):615–22.CrossRef Colles SL, Dixon JB, O’Brien PE. Grazing and loss of control related to eating: two high-risk factors following bariatric surgery. Obesity (Silver Spring). 2008;16(3):615–22.CrossRef
13.
go back to reference Poole NA, Al Atar A, Kuhanendran D, et al. Compliance with surgical after-care following bariatric surgery for morbid obesity: a retrospective study. Obes Surg. 2005;15(2):261–5.CrossRefPubMed Poole NA, Al Atar A, Kuhanendran D, et al. Compliance with surgical after-care following bariatric surgery for morbid obesity: a retrospective study. Obes Surg. 2005;15(2):261–5.CrossRefPubMed
14.
go back to reference Conceicao EM, Mitchell JE, Engel SG, et al. What is “grazing”? Reviewing its definition, frequency, clinical characteristics, and impact on bariatric surgery outcomes, and proposing a standardized definition. Surg Obes Relat Dis. 2014;10(5):973–82.CrossRefPubMed Conceicao EM, Mitchell JE, Engel SG, et al. What is “grazing”? Reviewing its definition, frequency, clinical characteristics, and impact on bariatric surgery outcomes, and proposing a standardized definition. Surg Obes Relat Dis. 2014;10(5):973–82.CrossRefPubMed
15.
go back to reference Canetti L, Berry EM, Elizur Y. Psychosocial predictors of weight loss and psychological adjustment following bariatric surgery and a weight-loss program: the mediating role of emotional eating. Int J Eat Disord. 2009;42(2):109–17.CrossRefPubMed Canetti L, Berry EM, Elizur Y. Psychosocial predictors of weight loss and psychological adjustment following bariatric surgery and a weight-loss program: the mediating role of emotional eating. Int J Eat Disord. 2009;42(2):109–17.CrossRefPubMed
16.
go back to reference Hsu LK, Betancourt S, Sullivan SP. Eating disturbances before and after vertical banded gastroplasty: a pilot study. Int J Eat Disord. 1996;19(1):23–34.CrossRefPubMed Hsu LK, Betancourt S, Sullivan SP. Eating disturbances before and after vertical banded gastroplasty: a pilot study. Int J Eat Disord. 1996;19(1):23–34.CrossRefPubMed
17.
go back to reference Kalarchian MA, Marcus MD, Wilson GT, et al. Binge eating among gastric bypass patients at long-term follow-up. Obes Surg. 2002;12(2):270–5.CrossRefPubMed Kalarchian MA, Marcus MD, Wilson GT, et al. Binge eating among gastric bypass patients at long-term follow-up. Obes Surg. 2002;12(2):270–5.CrossRefPubMed
18.
go back to reference Mitchell JE, Lancaster KL, Burgard MA, et al. Long-term follow-up of patients’ status after gastric bypass. Obes Surg. 2001;11(4):464–8.CrossRefPubMed Mitchell JE, Lancaster KL, Burgard MA, et al. Long-term follow-up of patients’ status after gastric bypass. Obes Surg. 2001;11(4):464–8.CrossRefPubMed
19.
go back to reference White MA, Kalarchian MA, Masheb RM, et al. Loss of control over eating predicts outcomes in bariatric surgery patients: a prospective, 24-month follow-up study. J Clin Psychiatry. 2010;71(2):175–84.CrossRefPubMed White MA, Kalarchian MA, Masheb RM, et al. Loss of control over eating predicts outcomes in bariatric surgery patients: a prospective, 24-month follow-up study. J Clin Psychiatry. 2010;71(2):175–84.CrossRefPubMed
20.
go back to reference Burgmer R, Grigutsch K, Zipfel S, et al. The influence of eating behavior and eating pathology on weight loss after gastric restriction operations. Obes Surg. 2005;15(5):684–91.CrossRefPubMed Burgmer R, Grigutsch K, Zipfel S, et al. The influence of eating behavior and eating pathology on weight loss after gastric restriction operations. Obes Surg. 2005;15(5):684–91.CrossRefPubMed
21.
go back to reference Karlsson J, Sjostrom L, Sullivan M. Swedish obese subjects (SOS)—an intervention study of obesity. Two-year follow-up of health-related quality of life (HRQL) and eating behavior after gastric surgery for severe obesity. Int J Obes Relat Metab Disord. 1998;22(2):113–26.CrossRefPubMed Karlsson J, Sjostrom L, Sullivan M. Swedish obese subjects (SOS)—an intervention study of obesity. Two-year follow-up of health-related quality of life (HRQL) and eating behavior after gastric surgery for severe obesity. Int J Obes Relat Metab Disord. 1998;22(2):113–26.CrossRefPubMed
22.
go back to reference Odom J, Zalesin KC, Washington TL, et al. Behavioral predictors of weight regain after bariatric surgery. Obes Surg. 2010;20(3):349–56.CrossRefPubMed Odom J, Zalesin KC, Washington TL, et al. Behavioral predictors of weight regain after bariatric surgery. Obes Surg. 2010;20(3):349–56.CrossRefPubMed
23.
go back to reference Harbottle L. Audit of nutritional and dietary outcomes of bariatric surgery patients. Obes Rev. 2011;12(3):198–204.CrossRefPubMed Harbottle L. Audit of nutritional and dietary outcomes of bariatric surgery patients. Obes Rev. 2011;12(3):198–204.CrossRefPubMed
24.
go back to reference Himpens J, Dapri G, Cadiere GB. A prospective randomized study between laparoscopic gastric banding and laparoscopic isolated sleeve gastrectomy: results after 1 and 3 years. Obes Surg. 2006;16(11):1450–6.CrossRefPubMed Himpens J, Dapri G, Cadiere GB. A prospective randomized study between laparoscopic gastric banding and laparoscopic isolated sleeve gastrectomy: results after 1 and 3 years. Obes Surg. 2006;16(11):1450–6.CrossRefPubMed
25.
go back to reference Sarwer DB, Moore RH, Spitzer JC, et al. A pilot study investigating the efficacy of postoperative dietary counseling to improve outcomes after bariatric surgery. Surg Obes Relat Dis. 2012;8(5):561–8.CrossRefPubMed Sarwer DB, Moore RH, Spitzer JC, et al. A pilot study investigating the efficacy of postoperative dietary counseling to improve outcomes after bariatric surgery. Surg Obes Relat Dis. 2012;8(5):561–8.CrossRefPubMed
26.
go back to reference Kalarchian MA, Marcus MD, Courcoulas AP, et al. Optimizing long-term weight control after bariatric surgery: a pilot study. Surg Obes Relat Dis. 2012;8(6):710–5.CrossRefPubMed Kalarchian MA, Marcus MD, Courcoulas AP, et al. Optimizing long-term weight control after bariatric surgery: a pilot study. Surg Obes Relat Dis. 2012;8(6):710–5.CrossRefPubMed
27.
go back to reference Rudolph A, Hilbert A. Post-operative behavioural management in bariatric surgery: a systematic review and meta-analysis of randomized controlled trials. Obes Rev. 2013;14(4):292–302.CrossRefPubMed Rudolph A, Hilbert A. Post-operative behavioural management in bariatric surgery: a systematic review and meta-analysis of randomized controlled trials. Obes Rev. 2013;14(4):292–302.CrossRefPubMed
28.
go back to reference Forman EM, Herbert JD. New directions in cognitive behavior therapy: acceptance-based therapies. General principles and empirically supported techniques of cognitive behavior therapy. 2009:77-101. Forman EM, Herbert JD. New directions in cognitive behavior therapy: acceptance-based therapies. General principles and empirically supported techniques of cognitive behavior therapy. 2009:77-101.
29.
go back to reference Hayes SC, Strosahl KD, Wilson KG. Acceptance and commitment therapy: the process and practice of mindful change. Guilford Press; 2011. Hayes SC, Strosahl KD, Wilson KG. Acceptance and commitment therapy: the process and practice of mindful change. Guilford Press; 2011.
30.
go back to reference Forman EM, Butryn ML, Juarascio AS, et al. The mind your health project: a randomized controlled trial of an innovative behavioral treatment for obesity. Obesity (Silver Spring). 2013;21(6):1119–26.CrossRef Forman EM, Butryn ML, Juarascio AS, et al. The mind your health project: a randomized controlled trial of an innovative behavioral treatment for obesity. Obesity (Silver Spring). 2013;21(6):1119–26.CrossRef
31.
go back to reference Niemeier HM, Leahey T, Palm Reed K, et al. An acceptance-based behavioral intervention for weight loss: a pilot study. Behav Ther. 2012;43(2):427–35.CrossRefPubMed Niemeier HM, Leahey T, Palm Reed K, et al. An acceptance-based behavioral intervention for weight loss: a pilot study. Behav Ther. 2012;43(2):427–35.CrossRefPubMed
32.
go back to reference Weineland S, Arvidsson D, Kakoulidis TP, et al. Acceptance and commitment therapy for bariatric surgery patients, a pilot RCT. Obes Res Clin Pract. 2012;6(1):e1–90.CrossRefPubMed Weineland S, Arvidsson D, Kakoulidis TP, et al. Acceptance and commitment therapy for bariatric surgery patients, a pilot RCT. Obes Res Clin Pract. 2012;6(1):e1–90.CrossRefPubMed
33.
go back to reference Weineland S, Hayes SC, Dahl J. Psychological flexibility and the gains of acceptance-based treatment for post-bariatric surgery: six-month follow-up and a test of the underlying model. Clin Obes. 2012;2(1-2):15–24.CrossRefPubMed Weineland S, Hayes SC, Dahl J. Psychological flexibility and the gains of acceptance-based treatment for post-bariatric surgery: six-month follow-up and a test of the underlying model. Clin Obes. 2012;2(1-2):15–24.CrossRefPubMed
34.
go back to reference Leahey TM, Crowther JH, Irwin SR. A cognitive-behavioral mindfulness group therapy intervention for the treatment of binge eating in bariatric surgery patients. Cogn Behav Pract. 2008;15(4):364–75.CrossRef Leahey TM, Crowther JH, Irwin SR. A cognitive-behavioral mindfulness group therapy intervention for the treatment of binge eating in bariatric surgery patients. Cogn Behav Pract. 2008;15(4):364–75.CrossRef
35.
go back to reference Engstrom D. Eating mindfully and cultivating satisfaction: modifying eating patterns in a bariatric surgery patient. Bariatric Nurs Surg Patient Care. 2007;2(4):245–50.CrossRef Engstrom D. Eating mindfully and cultivating satisfaction: modifying eating patterns in a bariatric surgery patient. Bariatric Nurs Surg Patient Care. 2007;2(4):245–50.CrossRef
36.
go back to reference Forman EM, Butryn ML, Hoffman KL, et al. An open trial of an acceptance-based behavioral intervention for weight loss. Cogn Behav Pract. 2009;16(2):223–35.CrossRef Forman EM, Butryn ML, Hoffman KL, et al. An open trial of an acceptance-based behavioral intervention for weight loss. Cogn Behav Pract. 2009;16(2):223–35.CrossRef
37.
go back to reference Arnow B, Kenardy J, Agras WS. The emotional eating scale: the development of a measure to assess coping with negative affect by eating. Int J Eat Disord. 1995;18(1):79–90.CrossRefPubMed Arnow B, Kenardy J, Agras WS. The emotional eating scale: the development of a measure to assess coping with negative affect by eating. Int J Eat Disord. 1995;18(1):79–90.CrossRefPubMed
38.
go back to reference Cepeda-Benito A, Gleaves DH, Fernandez MC, et al. The development and validation of Spanish versions of the State and trait food cravings questionnaires. Behav Res Ther. 2000;38(11):1125–38.CrossRefPubMed Cepeda-Benito A, Gleaves DH, Fernandez MC, et al. The development and validation of Spanish versions of the State and trait food cravings questionnaires. Behav Res Ther. 2000;38(11):1125–38.CrossRefPubMed
39.
go back to reference Stunkard AJ, Messick S. Eating inventory manual. New York: Psychological Corporation; 1998. Stunkard AJ, Messick S. Eating inventory manual. New York: Psychological Corporation; 1998.
40.
go back to reference Foster GD, Wadden TA, Swain RM, et al. The eating inventory in obese women: clinical correlates and relationship to weight loss. Int J Obes Relat Metab Disord. 1998;22(8):778–85.CrossRefPubMed Foster GD, Wadden TA, Swain RM, et al. The eating inventory in obese women: clinical correlates and relationship to weight loss. Int J Obes Relat Metab Disord. 1998;22(8):778–85.CrossRefPubMed
41.
go back to reference Mond JM, Hay PJ, Rodgers B, et al. Validity of the Eating Disorder Examination Questionnaire (EDE-Q) in screening for eating disorders in community samples. Behav Res Ther. 2004;42(5):551–67.CrossRefPubMed Mond JM, Hay PJ, Rodgers B, et al. Validity of the Eating Disorder Examination Questionnaire (EDE-Q) in screening for eating disorders in community samples. Behav Res Ther. 2004;42(5):551–67.CrossRefPubMed
42.
go back to reference Cardaciotto L, Herbert JD, Forman EM, et al. The assessment of present-moment awareness and acceptance: the Philadelphia Mindfulness Scale. Assessment. 2008;15(2):204–23.CrossRefPubMed Cardaciotto L, Herbert JD, Forman EM, et al. The assessment of present-moment awareness and acceptance: the Philadelphia Mindfulness Scale. Assessment. 2008;15(2):204–23.CrossRefPubMed
43.
go back to reference Forman EM, Herbert JD, Juarascio AS, et al. The Drexel Defusion Scale: a new measure of experiential distancing. J Contextual Behav Sci. 2012;1(1):55–65.CrossRef Forman EM, Herbert JD, Juarascio AS, et al. The Drexel Defusion Scale: a new measure of experiential distancing. J Contextual Behav Sci. 2012;1(1):55–65.CrossRef
44.
go back to reference Juarascio A, Forman E, Timko CA, et al. The development and validation of the food craving acceptance and action questionnaire (FAAQ). Eat Behav. 2011;12(3):182–7.CrossRefPubMed Juarascio A, Forman E, Timko CA, et al. The development and validation of the food craving acceptance and action questionnaire (FAAQ). Eat Behav. 2011;12(3):182–7.CrossRefPubMed
45.
go back to reference Butryn ML, Arigo D, Raggio GA, et al. Measuring the ability to tolerate activity-related discomfort: initial validation of the Physical Activity Acceptance Questionnaire (PAAQ). J Phys Act Health. 2015;12(5):717–6.CrossRefPubMed Butryn ML, Arigo D, Raggio GA, et al. Measuring the ability to tolerate activity-related discomfort: initial validation of the Physical Activity Acceptance Questionnaire (PAAQ). J Phys Act Health. 2015;12(5):717–6.CrossRefPubMed
46.
go back to reference Kalarchian MA, Marcus MD, Courcoulas AP, et al. Preoperative lifestyle intervention in bariatric surgery: a randomized clinical trial. Surg Obes Relat Dis. 2016;12(1):180–7.CrossRefPubMed Kalarchian MA, Marcus MD, Courcoulas AP, et al. Preoperative lifestyle intervention in bariatric surgery: a randomized clinical trial. Surg Obes Relat Dis. 2016;12(1):180–7.CrossRefPubMed
47.
go back to reference Belle SH, Berk PD, Chapman WH, et al. Baseline characteristics of participants in the longitudinal assessment of bariatric surgery-2 (LABS-2) study. Surg Obes Relat Dis. 2013;9(6):926–35.CrossRefPubMedPubMedCentral Belle SH, Berk PD, Chapman WH, et al. Baseline characteristics of participants in the longitudinal assessment of bariatric surgery-2 (LABS-2) study. Surg Obes Relat Dis. 2013;9(6):926–35.CrossRefPubMedPubMedCentral
48.
go back to reference Gradaschi R, Noli G, Cornicelli M, et al. Do clinical and behavioural correlates of obese patients seeking bariatric surgery differ from those of individuals involved in conservative weight loss programme? J Hum Nutr Diet. 2013;26 Suppl 1:34–8.CrossRefPubMed Gradaschi R, Noli G, Cornicelli M, et al. Do clinical and behavioural correlates of obese patients seeking bariatric surgery differ from those of individuals involved in conservative weight loss programme? J Hum Nutr Diet. 2013;26 Suppl 1:34–8.CrossRefPubMed
49.
go back to reference Forman EM, Hoffman KL, McGrath KB, et al. A comparison of acceptance- and control-based strategies for coping with food cravings: an analog study. Behav Res Ther. 2007;45(10):2372–86.CrossRefPubMed Forman EM, Hoffman KL, McGrath KB, et al. A comparison of acceptance- and control-based strategies for coping with food cravings: an analog study. Behav Res Ther. 2007;45(10):2372–86.CrossRefPubMed
50.
go back to reference Alberts HJ, Mulkens S, Smeets M, et al. Coping with food cravings. Investigating the potential of a mindfulness-based intervention. Appetite. 2010;55(1):160–3.CrossRefPubMed Alberts HJ, Mulkens S, Smeets M, et al. Coping with food cravings. Investigating the potential of a mindfulness-based intervention. Appetite. 2010;55(1):160–3.CrossRefPubMed
51.
go back to reference Song Z, Reinhardt K, Buzdon M, et al. Association between support group attendance and weight loss after Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2008;4(2):100–3.CrossRefPubMed Song Z, Reinhardt K, Buzdon M, et al. Association between support group attendance and weight loss after Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2008;4(2):100–3.CrossRefPubMed
Metadata
Title
A Pilot Study of an Acceptance-Based Behavioral Intervention for Weight Regain After Bariatric Surgery
Authors
Lauren E. Bradley
Evan M. Forman
Stephanie G. Kerrigan
Meghan L. Butryn
James D. Herbert
David B. Sarwer
Publication date
01-10-2016
Publisher
Springer US
Published in
Obesity Surgery / Issue 10/2016
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-016-2125-0

Other articles of this Issue 10/2016

Obesity Surgery 10/2016 Go to the issue