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Obesity Surgery
Published in: Obesity Surgery 10/2016

01-10-2016 | Original Contributions

Preventative Sleeve Gastrectomy Contributes to Maintaining β Cell Function in db/db Diabetic Mouse

Authors: Feng Li, Chunjun Sheng, Kexiu Song, Manna Zhang, Le Bu, Peng Yang, Hui Sheng, Hong Li, Shen Qu

Published in: Obesity Surgery | Issue 10/2016

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Abstract

Background

We used the leptin-receptor (LPR)-deficient mice model (db/db), a spontaneous model of type 2 diabetes with early β cell dysfunction to determine whether a preventative sleeve gastrectomy (SG) is an effective technique for the treatment of β cell failure.

Methods

The animals operated at an early stage of life, prior to metabolic alterations, were used to study the molecular mechanisms of β cell function improvement after a SG.

Results

β cell function was significantly increased, and islet morphology remained normal, after the SG. The expression of Glut2, Pdx1, MafA, and Nkx6.1 were significantly increased after the SG. The expression of GLP-1 in the colonic tissue, as well as GLP-1R and PKC in islets, was significantly increased after the SG.

Conclusions

β cell dysfunction can be ameliorated by a preventative SG for db/db mice. Maintaining the GLP-1 pathway and key transcript factor (TF) activation contributes to the improvement of β cell function after a preventative SG.
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Metadata
Title
Preventative Sleeve Gastrectomy Contributes to Maintaining β Cell Function in db/db Diabetic Mouse
Authors
Feng Li
Chunjun Sheng
Kexiu Song
Manna Zhang
Le Bu
Peng Yang
Hui Sheng
Hong Li
Shen Qu
Publication date
01-10-2016
Publisher
Springer US
Published in
Obesity Surgery / Issue 10/2016
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-016-2112-5

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